Aniridia For a child to be considered as having wagr syndrome, he / she must exhibit aminimum of two of the four conditions * S Aniridia factsheet http://ibis-birthdefects.org/start/aniridia.htm
Extractions: Shaw et al. (1960) ascertained 176 cases of aniridia in the lower Michigan peninsula ... mutation rate about 4 x 10(-6) per gamete per generation. Affected persons may be visually handicapped because of nystagmus, cataract or glaucoma ... Undoubtedly more than one "cause" of aniridia exists ... Gove et al. (1961) identified 77 cases of aniridia descended from an affected woman born in 1824 ... Delleman and Winkelman (1973) emphasized that atypical colobomata and slitlike defects of the iris stroma may be partial expressions of aniridia ... a fourth type associated with Wilms tumor, genital abnormalities, and deletion of 11p13 ( WAGR syndrome ) ...
Cancer Syndromes wagr syndrome ANIRIDIA AND ABSENT PATELLA WILMS TUMOR 1 ECTOPIA PUPILLAE . The syndrome subsequently became known as the wagr syndrome. http://ibis-birthdefects.org/start/cancersy.htm
Extractions: Rather numerous instances of multiple sibs with Wilms tumor have been described ... The syndrome of aniridia, hemihypertrophy and other congenital anomalies with Wilms tumor, subsequently known as the WAGR syndrome, was first described by Miller et al. (1964) ... . Riccardi et al. (1978) observed a triad of aniridia, ambiguous genitalia and mental retardation (AGR triad) in 3 patients with an interstitial deletion of the short arm of chromosome 11 ... Marshall et al. (1982) studied 14 patients with aniridia .... 6 had interstitial deletion of 11p of various lengths. Band 11p13 was included in the deletion in all 6 cases ...
Netwd Health Directory: WAGR Syndrome Information and resources from Netwd health directory wagr syndrome. http://netwd.com/diseases/genetic-disorders/wagr-syndrome.html
Results Of The Search Focal segmental glomerulosclerosis in solitary kidney in wagr syndrome. M Merta . Aniridia as part of a wagr syndrome in a girl whose brother presented http://invention.swmed.edu/trite/abstracts/user-1015659130/results.shtml
Wilms Tumor wagr syndrome the acronym WAGR stands for the four diseases present in WAGRsyndrome, including Wilms tumor, aniridia (absence of the iris, http://www.healthsystem.virginia.edu/uvahealth/peds_oncology/wilms.cfm
Extractions: [ Skip Navigation ] Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation Search This Site Wilms tumor, also called nephroblastoma, is a malignant (cancerous) tumor originating in the cells of the kidney. It is the most common type of renal (kidney) cancer and accounts for about 6 percent of all childhood cancers. Approximately 500 children in the US are diagnosed with Wilms tumor each year.
Wilms' Tumour - Genetics Medline Search Wilms tumor AND wagr syndrome (PubMed) Limit search to Last Related Resources; wagr syndrome (Online Mendelian Inheritance in Man, http://www.cancerindex.org/geneweb/X210202.htm
Extractions: Familial Wilms' tumour (defined as either bilateral disease or a family history of Wilms' tumour) account for approximately 5% of cases. For those with sporadic (unilateral) disease the risk of Wilms' tumour among their offspring is low: in a series of 179 children from 96 survivors of unilateral Wilms' (Li, 1988) non had developed the disease (upper 95% CI 2%). Children with
Health Library - 12.42.224.150/library/healthguide/enus/SelfHelp/t 12.42.224.150/library/healthguide/en-us/illnesscon 137357 GENITOURINARY DYSPLASIA COMPONENT OF wagr syndrome; GUDIn the wagr syndrome, the G stands for genitourinary dysplasia, the other featuresbeing aniridia and mental retardation. The evidence from studies of http://12.31.13.113/library/healthguide/en-us/illnessconditions/topic.asp?hwid=n
Oncology - Wilm's Tumor wagr syndrome the acronym WAGR stands for the four diseases present in WAGRsyndrome, including Wilms tumor, aniridia (absence of the iris, http://www.chkd.org/Oncology/wilms.asp
Extractions: Adolescent Medicine Allergy/Immunology Anesthesiology Arthritis Burns Cardiology Craniofacial Dental Medicine Dermatology Developmental Peds Diabetes Digestive Ear, Nose, Throat Genetics Gastroenterology Growth Hematology High Risk Newborn High Risk Pregnancy Infectious Disease Mental Health Neonatology Nephrology Neurology Normal Newborn Normal Pregnancy Oncology Ophthalmology Orthopedics Otolaryngology Pediatric Intensive Care Pediatric Surgery Pediatrics Physical Medicine Plastic Surgery Respiratory/Pulmonology Rheumatology Safety Surgery Terminal Transplant Urology Site Search Wilms tumor, also called nephroblastoma, is a malignant (cancerous) tumor originating in the cells of the kidney. It is the most common type of renal (kidney) cancer and accounts for about 6 percent of all childhood cancers. Approximately 500 children in the US are diagnosed with a Wilms tumor each year. The disease can occur at any age between infancy and 15 years, but, in most cases, the tumor is detected by the age of 3. This cancer affects males and females equally.
Library Page Numbers 10 To 15 A submicroscopic deletion of 11p13 associated with the wagr syndrome, Third Case of wagr syndrome with severe obseity and constitutional deletion of http://www.chromodisorder.org/sytrix/card_list.php3?dbid=80&maxlist=10
Please Help CDO Chromosome Deletion Outreach, Inc. Chromosome 11 Deletion/wagr syndrome Support Group www.wagr.org Spanish Associationof Aniridia. 10q information home.comcast.net/~daryl59/10q/ http://www.chromodisorder.org/support2.htm
Wilms' Tumor - Children's Hospital Boston wagr syndrome the acronym WAGR stands for the four diseases present in WAGRsyndrome, including Wilms tumor, aniridia (absence of the iris, http://www.childrenshospital.org/az/Site1808/mainpageS1808P0.html
Extractions: or find by letter: A-F G-L M-R S-Z My Child Has... Home Wilms' Tumor Wilms' Tumor Programs that treat this condition or perform this procedure Urologic Tumors Center for Perinatal Urology Stem Cell Transplantation Kidney Tumors ... General Surgery Program What is Wilms' tumor (WT)? Wilms' tumor, also called nephroblastoma, is a malignant (cancerous) tumor originating in the cells of the kidney. It is the most common type of renal (kidney) cancer and accounts for about 6 percent of all childhood cancers. Approximately 400 children in the United States are diagnosed with a Wilms' tumor each year. The disease can occur at any age between infancy and 15 years, but, in most cases, the tumor is detected by the age of 3. This cancer affects males and females equally. The tumor can be very large and it may spread (metastasize) to other body tissues. The most common site for Wilm's tumor to metastasize is the lungs. Lesions may also occur, however, in the liver, the other kidney, brain, and/or bones. In approximately 5 to 10 percent of children with Wilms' tumor, both kidneys are involved. As you read further below, you will find general information about Wilms' tumor. If you would like to view summary information about cancer first, see the cancer overview.
Extractions: UniGene LocusLink OMIM GenAtlas ... Genome Browser Aliases Chromosomal Location Chromosome/Cytoband Microarray Gene Expression Data Data available Show Gene Expression Data LocusLink Information Locus Link Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. SwissProt Information SwissProt Accession No.
MEDIS-Research-Division Of Human Genetics-Members-J.Crolla B., Verloes, A. Three patients with hallucal polydactyly and wagr syndrome, Perotti, D. Bilateral preaxial polydactyly in a wagr syndrome patient. http://www.som.soton.ac.uk/research/geneticsdiv/members/jcrolla.htm
Extractions: I am a clinical molecular cytogeneticist at the Wessex Regional Genetics Laboratory. The Molecular Cytogenetics laboratory facilitates the use of FISH technology, principally to metaphase chromosomes, but also comparative genomic hybridization (CGH) for the genetic analysis of paediatric tumours. My research interests are focused on three areas. de novo constitutional chromosome rearrangement found in patients with clinically abnormal phenotypes. This work is being carried out in collaboration with the Sanger Centre, Cambridge, who are providing us with the locus specific genomic clones. The principal aim of this work is to identify clones which span the breakpoints, and following sequencing, to identify genes which may be disrupted by the chromosomal rearrangement. Secondly, in collaboration with Dr Veronica van Heyningen at the MRC Human Genetics Unit in Edinburgh, I have been using FISH with a library of locus-specific probes to determine the overall frequency of chromosomal mutations in distal 11p13 in patients ascertained with aniridia (both sporadic and familial).
Prague Medical Report Focal segmental glomerulosclerosis in solitary kidney in wagr syndrome. page 069 Abstract wagr syndrome consists of Wilms tumour, aniridia, http://www.lf1.cuni.cz/article.asp?nArticleID=1318&nLanguageID=1
Wilms Tumor - Children's Memorial Hospital (Chicago, IL) wagr syndrome. The acronym WAGR stands for the four diseases present in WAGRsyndrome, including Wilms tumor, aniridia (absence of the iris, http://www.childrensmemorial.org/depts/cancer/wilms1.asp
Extractions: @import "/styles/colorBlue.css"; @import "/styles/master.css"; Skip to main content Find a doctor Employment Store ... Links Wilms tumor, also called nephroblastoma, is a malignant (cancerous) tumor originating in the cells of the kidney. It is the most common type of renal (kidney) cancer and accounts for about 6 percent of all childhood cancers. Approximately 400 children in the US are diagnosed with a Wilms tumor each year. The disease can occur at any age between infancy and 15 years, but, in most cases, the tumor is detected by the age of 3. This cancer affects males and females equally. The tumor can be very large and it may spread (metastasize) to other body tissues. The most common site for Wilms tumor to metastasize is the lungs. Lesions may also occur, however, in the liver, the other kidney, brain, and/or bones. In approximately 5 to 10 percent of children with Wilms tumor, both kidneys are involved. Other tumors such as rhabdoid tumors of the kidney, clear cell sarcoma of the kidney, and mesoblastic nephroma occur in the kidney but are not Wilms tumors and have different prognoses and treatment. What causes Wilms tumor?
Extractions: HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Cancer Research Clinical Cancer Research Molecular Cancer Therapeutics Molecular Cancer Research This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Breslow, N. E. Articles by Green, D. M. Cancer Research 60, 4030-4032, August 1, 2000] American Association for Cancer Research Norman E. Breslow Janice R. Takashima Michael L. Ritchey Louise C. Strong and Daniel M. Green Department of Biostatistics, University of Washington, Seattle Washington 98195-7232 [N. E. B.]; Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 [J. R. T.]; Department of Surgery, University of Texas [M. L. R.] and Department of Experimental Pediatrics/Genetics, M. D. Anderson Cancer Center [L. C. S.], Houston, Texas 77030; and Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, New York 14203 [D. M. G.]
WAGR-oireyhtymä - Kehitysvammahuollon Tietopankki WAGRoireyhtymä on varsin harvinainen sairaus, jonka nimi tulee wagr syndrome,OMIM, Victor A. McKusick 11p13, WT1 to 11p11.2, MDK, The OMIM Gene map http://www.saunalahti.fi/kup/syndroma/wagr.htm
Extractions: WAGR-oireyhtymä on varsin harvinainen sairaus, jonka nimi tulee englanninkielisistä sanoista W ilms tumor ( Wilmsin kasvain A niridia (silmän värikalvon puuttuminen), G enitourinary abnormalities (epämuodostuneet suku- ja virtsaelimet) ja Mental R etardation ( kehitysvammaisuus ). Nimi antaa hyvän kuvan sairauden ilmenemistavasta. Oireet voivat tosin jossain määrin vaihdella ja niitä voi olla enemmänkin. WAGR-oireyhtymä johtuu useimmiten sattumanvaraisesta sikiökehityksen aikaisesta mutaatiosta. Joissakin tapauksissa on tosin tavattu autosomaalisesti vallitsevaa periytyvyyttä Millerin ja kumppaninen v. 1964 kuvaama oireyhtymä on 11. kromosomin (11p13) mikrodeleetion aiheuttama useamman geenin häiriötila. Wilmsin tuumorin esiintyvyys on n. 8/1.000.000. Noin 30 %:lla 11p13-deleetioiden vammauttamista on tuo kasvain. Lisätietoja: WAGR SYNDROME, OMIM, Victor A. McKusick
Wilm's Tumor wagr syndrome the acronym WAGR stands for the four diseases present in WAGRsyndrome, including Wilm s tumor, aniridia (absence of the iris, http://www.chw.org/display/PPF/DocID/1997/router.asp
Extractions: The tumor can be very large and it may spread (metastasize) to other body tissues. The most common site for Wilm's tumor to metastasize is the lungs. Lesions may also occur, however, in the liver, the other kidney, brain or bones. In approximately 5 to 10 percent of children with Wilm's tumor, both kidneys are involved. What causes Wilm's tumor? It is uncommon for Wilm's tumor to run in families. Less than 2 percent of cases will have an affected relative. Most cases of Wilm's are considered sporadic (occur by chance) and are the result of genetic mutations that affect cell growth in the kidney. These mutations generally arise after birth, but, in some cases, children are born with a genetic alteration that predisposes them to cancer.
ULTRASOUND Messages For March, 1999: Re: Adrenal, Enlarged, Fetal NEPHROBLASTOMATOSIS, AND FETAL GIGANTISM 194072 wagr syndrome *147470 INSULINLIKE CAT 137357 GENITOURINARY DYSPLASIA COMPONENT OF wagr syndrome; http://forums.obgyn.net/ultrasound/ULTRASOUND.9903/0053.html
Extractions: Thu Mar 11 04:50:18 1999 Dr Morader, I agree this is an adrenal and appears large. I believe that the spleen is seen in your first image lateral to it. The idea of fetal "stress" is an interesting one. I would also rule out CAH, but the right should be also. If it is truly unilateral, then a renal or adrenal tumor is likely. In the fetal age group two come to mind: it should be followed for neuroblastoma or possible Wilm's Tumor from that kidney, especially as some syndromes are associated with it, and another anomaly is found: Searching OMIM, for jejunal atresia we get:
The Health Library Genetics And Birth Defects Waardenburg Syndrome Type 1GeneReviews. wagr syndrome. wagr syndromeWAGR.org wagr syndromeeMedicine wagr syndromeOMIM, NCBI. Williams Syndrome http://healthlibrary.stanford.edu/resources/internet/bodysystems/genetic_mca_sw.
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