Extractions: AAFP Home Page Journals Vol. 64/No. 3 (August 1, 2001) Purpura is the result of hemorrhage into the skin or mucosal membrane. It may represent a relatively benign condition or herald the presence of a serious underlying disorder. Purpura may be secondary to thrombocytopenia, platelet dysfunction, coagulation factor deficiency or vascular defect. Investigation to confirm a diagnosis or to seek reassurance is important. Frequently, the diagnosis can be established on the basis of a careful history and physical examination, and a few key laboratory tests. Indicated tests include a complete blood cell count with platelet count, a peripheral blood smear, and prothrombin and activated partial thromboplastin times. (Am Fam Physician 2001;64:419-28.) A PDF version of this document is available.
The Health Library Genetics And Birth Defects Thrombocytopenia and Absent Radius (TAR) Syndrome. Thrombocytopenia Absent RadiusSyndromeNORD Review of tar syndrometar syndrome Support Group, UK http://healthlibrary.stanford.edu/resources/internet/bodysystems/genetic_mca_sw.
Extractions: Diseases and Disorders Use these links to jump directly to your topic of interest in Genetics and Birth Defects: Genetics: General Genetics Gene Therapy Genetic Counseling Genetic Testing ... Genetics of Specific Diseases Birth Defects: General Birth Defects Cardiovascular Defects Connective Tissue Disorders Craniofacial Anomalies ... S - W Multiple Congenital Anomalies (S - W) Jump to: A B C D ... P Q R S T U ... W X Y Z Septo-Optic Dysplasia Septo-Optic Dysplasia:NINDS De Morsier Syndrome:Madisons Foundation Septo-Optic Dysplasia / Optic Nerve Hypoplasia:MAGIC Foundation Sex Chromosome Variations Sex Determination Genes and Disease: SRY: Sex Determination:National Center for Biotechnology Information Variations in Females 45,X, see Turner Syndrome Trisomy X:Madisons Foundation 47,XXX Syndrome:PacNoRGG [PDF] Triple X Syndrome: Genetics Home Reference, NLM Variations in Males XX Male Syndrome:MedicineNet XX Male Syndrome:GeneReviews 47,XXY, see Kleinfelter Syndrome XYY Syndrome:NORD 47,XYY Syndrome:PacNoRGG [PDF] 47,XYY Syndrome: Genetics Home Reference, NLM Smith-Lemli-Opitz Syndrome Smith Lemli Opitz Syndrome:Madisons Foundation SLO/RSH:Smith-Lemli-Opitz Syndrome Advocacy and Exchange Smith-Lemli-Opitz Syndrome:Genetics Home Reference, NLM
Blackwell Synergy - Cookie Absent As the first child of our patient was affected by tar syndrome, a conditioninherited in an autosomal recessive pattern, a targeted ultrasound scan in order http://www.blackwell-synergy.com/doi/abs/10.1046/j.1469-0705.2002.00683.x
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Megan And Cho's Syndrome Of The Week - Week 27 Journal of Pediatric Orthopaedics Fulltext Volume 19(3) May Charts and radiographs of 23 patients with tar syndrome were reviewed, with extremity Despite the numerous articles on tar syndrome in the literature, http://info.med.yale.edu/pediat/pedres/syndrome/week27.html
Extractions: Feedback Thesaurus Legend: Synonyms Related Words Antonyms Noun Tar Heel State - a state in southeastern United States; one of the original 13 colonies NC North Carolina Old North State Great Smoky Mountains National Park - a national park in Tennessee and North Carolina that includes the highest mountain in the eastern United States American state - one of the 50 states of the United States U.S.A. United States United States of America US ... U.S. - North American republic containing 50 states - 48 conterminous states in North America plus Alaska in northwest North America and the Hawaiian Islands in the Pacific Ocean; achieved independence in 1776 Confederacy Confederate States Confederate States of America Dixie ... South - the southern states that seceded from the United States in 1861 Cape Fear - a cape in southeastern North Carolina extending into the Atlantic Ocean Cape Hatteras - a promontory on Hatteras Island off the Atlantic coast of North Carolina; "frequent storms drive ships to their destruction on Cape Hatteras"
Neonatal Hematology - Cambridge University Press cardiac defects, tar syndrome 220. cardiac disease, cord stem cell transplantation382 tar syndrome see thrombocytopenia and absent radii (TAR) syndrome http://www.cambridge.org/uk/catalogue/catalogue.asp?isbn=0521780705&ss=ind
Rarelink.net - Diagnoselisten TAR Syndrom (TAR Syndrome) Du er her Hjem Diagnoselisten TAR syndrom (tar syndrome) Norskdysmeliforening tar syndrome Support Group http://www.rarelink.no/diagnosedetail.jsp?diagnoseId=266&synonymId=482
Rarelink.net - Diagnoselisten TAR Syndrom (Trombocytopenia TAR syndrom (Trombocytopeniaabsent radius syndrome) Landsforeningen for arm-og bendefekte Norsk dysmeliforening tar syndrome Support Group http://www.rarelink.no/diagnosedetail.jsp?diagnoseId=266&synonymId=558
TAR Syndrome Support Group - Patient UK tar syndrome Support Group Patient UK. A directory of UK health, disease,illness and related medical websites that provide patient information. http://www.patient.co.uk/showdoc/26739613/
Extractions: Best time to telephone: 8.00pm - 9.00pm, Monday - Friday TAR Syndrome (Thrombocytopenia with absent radii) is a rare disorder characterised by a reduction of the number of platelets in the blood and bilateral absence of the radii (forearm bones). The TAR Syndrome Support Group is a small, parent-led group with limited funds. The aims of the group are as follows. The Group publishes an annual newsletter and leaflets including: What is a blood platelet?, Heart Defects and TAR Syndrome
Tar Syndrome - Patient UK tar syndrome Patient UK. A directory of UK health, disease, illness and relatedmedical websites that provide patient information. http://www.patient.co.uk/showdoc/40001753/
Extractions: PatientPlus articles are written for doctors and so the language can be technical. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people. Synonyms: Thrombocytopenia with absent Radius Syndrome, Tetraphocomelia-thrombocytopenia syndrome Rare autosomal recessive condition. Thrombocytopenia presents early but is usually transient. Neonatal death rate is ~40%. Presentation - neonatally with developmental abnormalities which may include: Head and neck - Intracranial bleed ±mental retardation, cerebellar hypoplasia, brachycephaly, micrognathia, squint ptosis , small upturned nose, naevus flammeus on forehead. Upper limb abnormalities: Bilateral absence of radii, hypoplasia or absence of ulna (may be bilateral), abnormal humerus, carpal bone hypoplasia or fusion, hypoplastic phalanges (but thumbs always present) Abdomen: Pancreatic cysts, Meckel's diverticulum Spine and pelvis: Spina bifida ±delayed motor development, hip dislocation, coxa valga Lower limb anomalies (47%): Knee subluxation, patella dislocation, femoral or tibial torsion, fibula may be absent.
Wests Glass: TAR tar syndrome. Meg Anne West (DOB 4th December 1998) ..Latest Update 31stJanuary 2005 .. We created this site to provide information for families with http://www.westsglass.com.au/home.asp?ct=TAR
Skeleton - DIAGNOSIS OF FETAL ABNORMALITIES - THE 18-23 WEEKS SCAN absent radius (tar syndrome) and Grebe syndrome (autosomal recessive condition, (such as Fanconis pancytopenia, tar syndrome and Aase syndrome), http://www.centrus.com.br/DiplomaFMF/SeriesFMF/18-23-weeks/chapter-09/skeleton.h
Extractions: Normal Sonography Anatomy Limb buds are first seen by ultrasound at about the 8th week of gestation; the femur and humerus are seen from 9 weeks, the tibia/fibula and radius/ulna from 10 weeks and the digits of the hands and the feet from 11 weeks. All long bones are consistently seen from 11 weeks. Body movements (wiggling) are seen at 9 weeks and, by 11 weeks, limbs move about readily. The lengths of the humerus, radius/ulna, femur and tibia/fibula are similar and increase linearly with gestation. At the 1823-week scan, the three segments of each extremity should be visualized, but it is only necessary to measure the length of one femur. The relationship of leg and foot should also be assessed to rule out clubfoot. Clubfoot - 2D Ultrasound Clubfoot - 3D Ultrasound (rendering mode) SKELETAL ANOMALIES Prevalence Skeletal dysplasia is found in about 1 per 4000 births; about 25% of affected fetuses are stillborn and about 30% die in the neonatal period. The birth prevalences of the most common dysplasias are shown in the Table on the next page.
Extractions: Standard Views Handbook of Fetal Abnormalities Algorithm Appendix ANTENATAL SONOGRAPHIC FINDINGS IN SKELETAL DYSPLASIAS Type of limb shortening Rhizomelia Mesomelia Micromelia Altered thoracic dimensions Long narrow thorax Short thorax Hand and foot abnormalities Postaxial polydactyly Chondroectodermal dysplasia Short rib-polydactyly syndrome (type I, type III)
*TITLE* tar syndrome TAR stands for Thrombocytopenia (low blood platelets) andAplasia (absence) of Thrombocytopeniaabsent radius syndrome See tar syndrome. http://www.kemc.edu/t.html
Extractions: T: T-cell: A white blood cell made in the thymus gland, a lymphoid structure in the upper chest. (The T in T-cell stands for Thymus). The T-cells coordinate the immune system by secreting lymphokine hormones. There are 3 fundamentally different types of T cells : helper, killer, and suppressor. Each has many subdivisions. T-cells are also called T lymphocytes. Triiodothyronine, a thyroid hormone. (The number 3 is usually in subscript.) Thyroid hormones are essential for the function of every cell in the body. They help regulate growth and the rate of chemical reactions (metabolism) in the body. Thyroxine, a thyroid hormone. (The number 4 is usually in subscript.) Thyroid hormones are essential for the function of every cell in the body. They help regulate growth and the rate of chemical reactions (metabolism) in the body. T4 cell: Immune cells that are triggered by antibodies to seek and attack invading organisms. Cells called macrophanges summon T4 cells to the site of the infection and present a protruding antigen onto which the T4 cell locks, thus "recognizing" the invading substance. The T4 cell then reproduces and secretes its potent lymphokine hormones that stimulate B-cell production of antibodies; signal "natural killer" or cytotoxic (cell-killing) T-cells; and summon more macrophanges to the site of the infection. T4 cells are normally twice as common as T8 cells. If a person has AIDS, the proportion of T4 to T8 cells is often reversed. T4 cell are also called T-helper cells.
Extractions: Thalidomide malformations are almost all bilateral/symmetrical. That means both sides of the body are affected in the same way (both arms, both legs, all four). When taken during pregnancy (particularly the first trimester) thalidomide causes malformations to almost any part of the body that is developing at the time the drug is taken. These are just some resulting malformations: Missing or malformed limbs (bilateral) No ears or deafness Missing or extra fingers or toes Partial or total loss of sight Improper formation of the heart, kidney and other internal organs
Extractions: Some mothers truly believed they had exposure to thalidomide during pregnancy they remembered taking a pill or being given something . Families faced with the shock of children being born with limb defects and/or other deformities, compounded with the media frenzy surrounding thalidomide, naturally, made a connection between the defects and the widely available drug. This just wasn’t always true. It is known "that 2 to 3% of all babies born have significant birth defects, and while thalidomide consumption was widespread in 1960 to 1961, some mothers who undoubtedly took the drug when pregnant (though probably outside the sensitive period) gave birth to babies with defects quite unrelated to thalidomide. It is also possible for a baby exposed to thalidomide during the sensitive period to be born with a variety of defects, of which some, but not all, are drug induced."
