Home  - Health_Conditions - Tangier Disease

Books Baby Camera Phones Computers Games DVD Electronics Kitchen Magazines Music Garden Software Tools Toys Video Apparel & Accessories Jewelry & Watches Musical Instruments Health & Personal Care Beauty Sports & Outdoors Office Products

e99.com Bookstore

Images

Newsgroups

1-20 of 105    1  | 2  | 3  | 4  | 5  | 6  | Next 20

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Tangier Disease:     more detail

Tangier disease: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Lisa, MS, CGC Andres, 2005 Tangier Disease - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-19 Tangier Disease Tonsils and apolipoproteins;: Lessons about plasma lipoproteins derived from Tangier disease and other mutants (Jiménez Díaz memorial lecture) by Donald S Fredrickson, 1976

lists with details

1. Tangier Disease By Jackie Newman
   An article about this rare disease, its history, characteristics of the disease and the treatments.  
   http://www-personal.umd.umich.edu/~jcthomas/JCTHOMAS/1997 Case Studies/J. Newman
   
   Extractions: Tangier Disease is an extremely rare autosomal recessive metabolic disorder. Documentation shows that as of 1988, 27 cases of Tangier Disease had been reported (Makrides pg.465) and in 1992 the reported cases were still fewer than 50 persons worldwide (Thoene pg.265). The majority of the cases tend to localize in one single area of the U.S., Tangier Island, Virginia. The fact that most of the people that are affected by Tangier disease all live in close proximity to one another could be due to Founder's effect. The original settlers to the island came in 1686 and it is possible that one or two of them were carriers of the disease or actually had the symptoms and passed it down through the blood line. Characteristics of Tangier Disease include increased levels or even a complete absence of high-density lipoproteins (HDL) concentrations in one's plasma, low cholesterol levels in the plasma, increased cholesteryl esters in the tonsils, spleen, liver, skin and lymph nodes. One easily visual characteristic usually found in children with Tangier disease is the presence of enlarged, yellow-orange tonsils. Initial research of Tangier disease showed a marked decrease in the HDL concentrations when compared to normal controls. In some cases the reduction was as great as 50% (Schmitz pg.6306). Scientists studied the HDL concentrations and looked for any possible links in its involvement with the disease. They specifically looked at the apo A-I (apolipoprotein) concentrations, which is a major protein component of HDL.

2. Tangier Disease
   Genes and disease provides short descriptions of inherited disorders. It is hostedby the National Center for Biotechnology Information (NCBI),  
   http://www.ncbi.nlm.nih.gov/disease/tangier.html
   
   Extractions: TANGIER DISEASE (TD) is a genetic disorder of cholesterol transport named for the secluded island of Tangier, located off the coast of Virginia. TD was first identified in a five-year-old inhabitant of the island who had characteristic orange tonsils, very low levels of high density lipoprotein (HDL) or 'good cholesterol', and an enlarged liver and spleen. TD is caused by mutations in the (ATP-binding cassette) gene on chromosome 9q31. codes for a protein that helps rid cells of excess cholesterol. This cholesterol is then picked up by HDL particles in the blood and carried to the liver, which processes the cholesterol to be reused in cells throughout the body. Individuals with TD are unable to eliminate cholesterol from cells, leading to its buildup in the tonsils and other organs. The discovery of this important cholesterol transport gene may lead to a better understanding of the inverse relationship between HDL levels and coronary artery disease, an important killer in the US. New drugs that regulate HDL levels may be developed and such drugs would not only help individuals with TD, but also people with more common disorders such as familial HDL deficiency. This is a good illustration of how research into rare diseases can sometimes help more common disorders.

3. Tangier Disease
   An explanation of this disease and its name, its causes and treatment.  
   http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.

4. Tangier Disease
   tangier disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins .  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. OMIM - TANGIER DISEASE; TGD
   http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=205400

6. Tangier Disease Research Has Widespread Implications
   Larry Husten, "Gene behind tangier disease may help reveal HDL's secrets " The Lancet. v354 i9178, August 14, 1999 p574.  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. The Scientist The Race To Find The Tangier Disease Gene, Oct. 1
   The Race to Find the tangier disease Gene. By Brendan A. Maher return to webpage. Want to read more? This article is in our premium content  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. Tangier Disease
   tangier disease is an inherited blood disorder involving decreased concentrationsof fat compounds in the blood called high density lipoproteins.  
   http://www.bchealthguide.org/kbase/nord/nord385.htm
   
   Extractions: It is possible that the main title of the report Tangier Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Tangier Disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins. Large amounts of these compounds may accumulate in certain organs of the body causing tissue discoloration. In later stages, these accumulations may cause organ enlargement and/or blood circulation problems. National Tay-Sachs and Allied Diseases Association, Inc.

9. [Tangier Disease Collage] [1960s]
   Lipid Metabolism and Genetic Disease, 19531974 Relation tangier disease Tonsils May Cure Hearts 1967 Box Number MD7 Unique Identifier  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Tangier Disease
    tangier disease is an inherited blood disorder involving decreased concentrationsof fat compounds in  
    http://my.webmd.com/hw/health_guide_atoz/nord385.asp
    
    Extractions: Tangier Disease is an inherited blood disorder involving decreased concentrations of fat compounds in the blood called high density lipoproteins. Large amounts of these compounds may accumulate in certain organs of the body causing tissue discoloration. In later stages, these accumulations may cause organ enlargement and/or blood circulation problems.

11. Tangier Disease By Jackie Newman
    tangier disease by Jackie Newman tangier disease is an extremely rare autosomal recessive metabolic disorder.  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. High Density Lipoproteins In Health And In Disease
    may lead to disease in humans. A novel class of intracellular cholesterol transport defects underlie the cellular defect in tangier disease or  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. MyDNA.com - Tangier Disease
    myDNA is a consumer focused health, genetics, and genomics information provideroffering disease condition information, health wellness tips,  
    http://www.mydna.com/genes/genetics/disorders/disease/nutritional/tangier.html
    
    Extractions: Page Tools Print This Page E-Mail This Page Add to Favorites Genetics Genetics News Ask Dr. DNA Top Tens Genetics 101 Genetic Testing Genetic Disorders Genes and Disease Blood Diseases Cancer Digestive System Ear, Nose and Throat Female-Specific Disease Glands and Hormones Heart and Blood Vessels Immune System Male Specific Disease Muscle and Bone Neonatal Diseases Nervous System Nutritional and Metabolic Respiratory Diseases Skin, Connective Tissue

14. Postprandial Hypertriglyceridaemia In Patients With Tangier
    Postprandial hypertriglyceridaemia in patients with tangier disease G Kolovou1 , D Daskalova1 , K Anagnostopoulou1 , I Hoursalas1 , V Voudris1  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. MyDNA.com - Genes And Disease
    tangier disease tangier disease Spinocerebellar Ataxia Spinocerebellar Ataxia TaySachs Disease Tay-Sachs Disease  
    http://www.mydna.com/genes/genetics/disorders/disease
    
    Extractions: Page Tools Print This Page E-Mail This Page Add to Favorites Genetics Genetics News Ask Dr. DNA Top Tens Genetics 101 Genetic Testing Genetic Disorders Genes and Disease Blood Diseases Cancer Digestive System Ear, Nose and Throat Female-Specific Disease Glands and Hormones Heart and Blood Vessels Immune System Male Specific Disease Muscle and Bone Neonatal Diseases Nervous System Nutritional and Metabolic Respiratory Diseases Skin, Connective Tissue

16. Human ATP-binding Cassette Transporter 1 (ABC1) Genomic
    binding cassette transporter 1 (ABC1) Genomic organization and identification of the genetic defect in the original tangier disease kindred  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. The A B Cs Of Tangier Disease
    Patients with tangier disease have very low levels of HDL due to mutations in aprotein called ABCA1. Exactly how ABCA1 controls HDL formation was not clear  
    http://www.medicalnewstoday.com/medicalnews.php?newsid=22493

18. Generation Of Pre- 1-HDL And Conversion Into {alpha}-HDL
    Evidence for Disturbed HDL Conversion in tangier disease Yadong Huang ; Arnold von Eckardstein ; Shili Wu ; Claus Langer ; Gerd Assmann  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Mutations In Transporter Protein Effect HDL Levels In The General Population
    Individuals with tangier disease have essentially no HDL in the blood. tangier disease develops. Given the ABCA1 transporter s essential role in HDL  
    http://www.medicalnewstoday.com/medicalnews.php?newsid=15775

20. The A B Cs Of Tangier Disease
    The A B Cs of tangier disease 13 Apr 2005. High levels of HDL, the "good" cholesterol, are associated with low cardiovascular disease risk.  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

1-20 of 105    1  | 2  | 3  | 4  | 5  | 6  | Next 20