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Stiff-person Syndrome: more detail

The Official Patient's Sourcebook on Stiff-Person Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-10-10
Stiff Person Syndrome
Stiff person syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Bruno Azevedo, Iuri, MD, PhD Louro, 2005
Rare disease may offer clues to MS. (Moersch-Woltman syndrome): An article from: Inside MS by Phyllis Shaw, 1989-06-22

lists with details

Stiff Person Syndrome
Health and Nutrition from a Christian perspective.
http://www.fitnessforoneandall.com/difficulties/subject/stiff_person.htm

Extractions: Fitness for One and All Home Page Dealing with Health Difficulties Stiff Person Syndrome Stiff Person Syndrome: Part One Stiff Person Syndrome: Part Two Stiff Person Syndrome: Part Three Stiff Person Syndrome: Part Four ... Fitness for One and All Home Page www.FitnessforOneandAll.com/difficulties/subject/stiff_person.htm
Stiff Person Syndrome Sites
Web sites devoted to health, nutrition, and fitness.
http://www.fitnessforoneandall.com/links/health/stiff_person.htm

Extractions: Fitness for One and All Home Page Stiff Person Syndrome Sites Fitness for One and All's Stiff Person Syndrome pages Most of the links below are direct links to pages on stiff person syndrome (SPS, a.k.a. stiff man syndrome) on the indicated Web sites. There are few entire Web sties devoted to this rare disorder. - By the American Academy of Physical Medicine and Rehabilitation. BrainTalk Communities - A forum on stiff person syndrome. Medical Library Stiff Person Syndrome - From a holistic/ natural health oriented Web site. NINDS Stiff-Person Syndrome Information Page - by the National Institute of Neurological Disorders and Stroke. NORD - Stiff Person Syndrome - By National Organization for Rare Disorders, Inc. OMIM Stiff Man Syndrome - On the Online Mendelian Inheritance in Man database. Stiff Man Syndrome Neurological Home Page - By Yale University. Contains one of the best descriptions of SPS I have found, along with a SPS Roundtable Prednisone Prednisone is one of the more commonly prescribed drugs for SPS. The pages below provide info on this drug. ADAP drugs: Prednisone - By The Access Project.
Clinical Trial: Rituximab To Treat Stiff Person Syndrome
Stiff Person syndrome with elevated antiGAD antibody titers. The stiff-personsyndrome an autoimmune disorder affecting neurotransmission of
http://www.clinicaltrials.gov/ct/show/NCT00091897

Extractions: Verified by National Institutes of Health Clinical Center (CC) August 22, 2005 Sponsored by: National Institute of Neurological Disorders and Stroke (NINDS) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose This study will test whether rituximab (RITUXAN (Trademark)) can relieve symptoms of stiff person syndrome (SPS), a progressive disease that causes stiffness of the muscles and muscle spasms induced by unexpected noises, touches, or stressful events. People with SPS may have certain proteins in their blood called anti-GAD antibodies that may cause some of the symptoms of the disease. Rituximab, a drug approved to treat lymphomas, targets certain white blood cells that produce antibodies. This study will see if rituximab can also be effective in patients with SPS who have high anti-GAD antibodies. Patients between 25 and 80 years of age with SPS may be eligible for this study. Candidates are screened with a medical history, physical examination, and blood tests. Participants undergo the following tests and procedures:
Neurology -- Collected Resources : Stiff Person Syndrome
Stiff person syndrome does not always occur with maternal passive transfer of Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and
http://www.neurology.org/cgi/collection/stiff_person_syndrome
Stiff Person Syndrome
Stiff person syndrome is an extremely rare neurological disorder characterizedby progressive muscle
http://my.webmd.com/hw/health_guide_atoz/nord326.asp

Extractions: Stiff-person syndrome is an extremely rare neurological disorder characterized by progressive muscle stiffness (rigidity) and spasms. It usually begins in young adults, first involving muscles of the trunk and progressing to affect muscles of the legs. This syndrome may begin as recurring (intermittent) episodes of stiffness and spasms, often precipitated by surprise or minor physical contact. Those affected have a characteristic stiff-legged way of walking (gait) and increase in the curvature of the spine (lordotic posture). The exact cause of stiff person syndrome is not known. Resources
Diagnose-Me: Stiff Person Syndrome
The Analyst (TM) Comprehensive Online Evaluations For Those Seeking Answers ToTheir Health Problems. Travel-Free Results, Now!
http://www.diagnose-me.com/glossary/G1654.html

Extractions: Definition Stiff Person Syndrome (SPS) is a rare, progressive neuromuscular condition in which a hyperactive startle reflex results in constant painful contraction of the muscles, thus causing violent spasms of the voluntary muscles, particularly the muscles of the back and upper legs. These spasms are capable of slamming the victim into walls and furniture. The disorder's cause is unknown.
The Bioline EPrints Archive - Stiff Person Syndrome And Myasthenia Gra
Association of stiff person syndrome, an immune related disorder of anterior horncells and Keywords, Stiff person syndrome, Myasthenia gravis ni02026
http://bioline.utsc.utoronto.ca/archive/00000356/

Extractions: @import url(http://bioline.utsc.utoronto.ca/eprints.css); @import url(http://bioline.utsc.utoronto.ca/eprints.css); @import url(http://bioline.utsc.utoronto.ca/print.css); Home About Browse Search ... Help Saravanan, P.K. and Paul, J. and Sayeed, Zaheer Ahmed Stiff Person Syndrome and Myasthenia Gra Neurology India pp.Â 98-99 Full text available as: PDF - Requires Adobe Acrobat Reader or other PDF viewer. Association of stiff person syndrome, an immune related disorder of anterior horn cells and myasthenia gravis an endplate disorder with similar pathogenesis, is rare. This communication documents this association in the Indian literature for the first time. Item Type: Journal (Paginated) Keywords: Stiff person syndrome, Myasthenia gravis ni02026 Subjects: Medicine Neurology ID Code: Deposited By: Sun, Yibing Deposited On: 12 June 2003 Alternative Locations: http://www.bioline.org.br/abstract?ni02026 http://www.neurologyindia.com/vol50-1/FullArticles/shortreport04.pdf Repository Contact Information Â© 2005 Bioline International
Stiff Person Syndrome And Myasthenia Gravis. Saravanan PK, Paul J, Sayeed Zaheer
Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India.
http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2002;volume=50;iss
Stiff Person Syndrome And Myasthenia Gravis., Saravanan PK, Paul J, Sayeed Zahee
Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India.
http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2002;volume=50;iss
NORD - National Organization For Rare Disorders, Inc.
Dramatic Results Reported in Stiff Person syndrome Study The incidence ofStiff Person syndrome (formerly known as Stiffman s Disease) has been
http://www.rarediseases.org/news/stiff

Extractions: Check here to read about events on Capitol Hill, funding for rare-disease research, and other topics of interest from NORD's office in Washington, DC. News Briefs Dramatic Results Reported in Stiff Person Syndrome Study On Dec. 27, 2001, The New England Journal of Medicine reported that intravenous immunoglobulin (IVIg) has brought dramatic relief from symptoms to patients with the rare disorder known as Stiff Person Syndrome (SPS). The authors believe their research supports the theory that SPS results from an autoimmune response gone awry in the brain and spinal cord of the person with this ailment. SPS is an extremely rare neurological disorder characterized by progressive stiffness and spasms of certain muscles in the trunk and limbs. It sometimes begins with intermittent episodes, often precipitated by surprise or minor physical contact. The incidence of Stiff Person Syndrome (formerly known as Stiffman's Disease) has been estimated at one in a million.
NORD - National Organization For Rare Disorders, Inc.
National Organization for Rare Disorders is dedicated to helping people withrare, orphan diseases. Rarediseases.org contains information on the prevention,
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Stiff Person
Treatment Of Stiff Person Syndrome With Rituximab - Neurological Journal Update
Treatment of stiff person syndrome with rituximab. 7/25/2005 Journal Journal ofNeurology Citation Journal of Neurology Neurosurgery and Psychiatry 2005
http://www.medcompare.com/litupdate.asp?ArticleID=6757
Hill Health Topics A-Z - Stiff Person Syndrome
Stiff Person syndrome. National Organization for Rare Disorders. Important It ispossible that the main title of the report Stiff Person syndrome is not the
http://www.healthwise.net/hillhealth/Content/StdDocument.aspx?DOCHWID=nord326&SE
BrainTalk Communities - Anyone Know The Prognosis For Stiff Person Syndrome
Smile anyone know the prognosis for stiff person syndrome. i have been diagnosedwith stiff person syndrome and am trying to find out about it and the
http://brain.hastypastry.net/forums/showthread.php?t=41831
BrainTalk Communities - Trying To Find Others With Stiff Person Syndrome
i have been diagnosed with stiff person syndrome and am trying to contact otherswith sps and to find out info especially long term prognosis,
http://brain.hastypastry.net/forums/showthread.php?t=43955
Immunotherapy Treatment Shows Dramatic Results For Rare Neurological Disorder: S
intravenous immunoglobulin (IVIg), administered to patients suffering fromstiff person syndrome (SPS), provides dramatic relief from disabling symptoms
http://www.docguide.com/dg.nsf/PrintPrint/6D1B23434D3DB53285256B2F005F0E66

Extractions: BETHESDA, MD December 27, 2001 An immunologic therapy, intravenous immunoglobulin (IVIg), administered to patients suffering from stiff person syndrome (SPS), provides dramatic relief from disabling symptoms, according to a study appearing in the December 27, 2001, issue of The New England Journal of Medicine . The study's principal author, Marinos C. Dalakas, M.D., chief of the Neuromuscular Diseases Section of the National Institute of Neurological Disorders and Stroke, says that the success of the treatment supports the theory that SPS is the result of an autoimmune response gone awry in the brain and spinal cord. SPS is characterized by fluctuating muscle rigidity in the trunk and limbs and a heightened sensitivity to stimuli such as noise, touch, and emotional distress that can set off muscular spasms. People with SPS are often too disabled to walk or move, or are afraid to leave the house because of stimuli-triggered spasms and frequent falls. The incidence of SPS has been estimated at one in every one million persons, but according to Dr. Dalakas, "the disorder is so often misdiagnosed as Parkinson's disease, multiple sclerosis, fibromyalgia, psychosomatic illness, or anxiety and phobia that its actual incidence is probably much higher."
AAPM&R - Case No. 47, Cont
Onset of stiff person syndrome is generally in the fourth or fifth decades Diagnostic criteria for stiff person syndrome include (1) insidious onset of
http://www.aapmr.org/education/archive/emg0010e.htm

Extractions: What is a Physiatrist? Legislative, Business and Clinical Practice Issues Annual Assembly Medical Education ... EMG Diagnostic Impression The presence of continuous motor unit activity associated with this individual's clinical history of muscles twitching involving predominantly the abdominal muscles and her history of insulin dependent diabetes mellitus is suggestive of stiff person syndrome. Commentary V Stiff person syndrome is characterized by slowly progressive increasing stiffness affecting the axial musculature, predominantly the paraspinal and abdominal muscles as well as the lower and upper limbs. On rare occasion symptoms may be confined to a limb or an upper or lower extremity. Over time there is an increasing frequency in the rate of muscle spasms. Some attacks of muscle spasms are so severe that individual may be thrown to the floor. Attacks may be triggered by alterations in emotion, startle, and loud noises. Severe cases may have marked contraction of the hip and knee extensors, ankle dorsiflexors, and abdominal and paraspinal muscles. In advanced cases contraction of the paraspinal, abdominal and intercostals muscles may be seen. Hyperlordosis of the lumbosacral spine is common secondary to lumbosacral paraspinal muscles contraction, as is hunching of the shoulders secondary to cervical paraspinal hypertrophy.
AAPM&R - Case No. 47, Cont
Stiff person syndrome involves the abdominal muscles and is frequently associated Individuals with stiff person syndrome tend to have a marked startle
http://www.aapmr.org/education/archive/emg0010b.htm

Extractions: What is a Physiatrist? Legislative, Business and Clinical Practice Issues Annual Assembly Medical Education ... EMG History A 22-year-old woman with a 4-year history of insulin dependent diabetes mellitus and hypothyroidism presents to the electrodiagnostic laboratory with a chief complaint of involuntary muscle tightening and spasms. She has not experienced pain in association with the spasms, and she has no muscle cramps. She denies weakness. Her symptoms began 8 years ago while she was in high school, and the muscle tightening and spasms have been slowly progressive in severity and duration. The episodic tightening or twitching of her muscles involves her abdominal, hand, and lower limb muscles bilaterally. These paroxysmal episodes last for approximately 5 seconds and occur many times during the day. On occasion, she notices that objects fall from her hands. She believes that cold may induce her symptoms. Initially, she was not concerned about the abdominal spasms since they helped maintain her muscle tone. Prior to continuing, please develop a differential diagnosis and list each possible diagnosis in order of likelihood.
Stiffman Syndrome
Also known as Stiff Person syndrome or MoerschWoltman. A rare, progressiveneurological disease with symptoms of severe spasm, rigidity and falls.
http://www.stiffman.org/

Extractions: Moersch-Woltman Stiff-person syndrome is an extremely rare neurological disorder characterized by progressive muscle stiffness (rigidity) and spasms. It usually begins in young adults, first involving muscles of the trunk and progressing to affect muscles of the legs. This syndrome may begin as recurring (intermittent) episodes of stiffness and spasms, often precipitated by surprise or minor physical contact. Those affected have a characteristic stiff-legged way of walking (gait) and increase in the curvature of the spine (lordotic posture). The exact cause of stiff person syndrome is not known. NORD - National Organization for Rare Disorders I was diagnosed with Stiffman Syndrome in 1994. May you find answers along with the whisper of hope. Welcome. Please click to enter website. It is difficult to say what is impossible, for the dream of yesterday is the hope of today and the reality of tomorrow. ~ Robert H. Goddard ~
Stiff Person Syndrome Synonyms, Eastern Carolina
Stiff Person syndrome Synonyms University Health Systems of Eastern Carolinaserves tarboro, ahoskie, edento, winsor, maxhead, dear county,
http://www.uhseast.com/114295.cfm

Extractions: It is possible that the main title of the report Stiff Person Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Stiff-person syndrome is an extremely rare neurological disorder characterized by progressive muscle stiffness (rigidity) and spasms. It usually begins in young adults, first involving muscles of the trunk and progressing to affect muscles of the legs. This syndrome may begin as recurring (intermittent) episodes of stiffness and spasms, often precipitated by surprise or minor physical contact. Those affected have a characteristic stiff-legged way of walking (gait) and increase in the curvature of the spine (lordotic posture). The exact cause of stiff person syndrome is not known. American Autoimmune Related Diseases Association, Inc.

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