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Stiff-person Syndrome:     more detail

The Official Patient's Sourcebook on Stiff-Person Syndrome: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-10-10 Stiff Person Syndrome Stiff person syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Bruno Azevedo, Iuri, MD, PhD Louro, 2005 Rare disease may offer clues to MS. (Moersch-Woltman syndrome): An article from: Inside MS by Phyllis Shaw, 1989-06-22

lists with details

61. Motor Cortex Excitability In Stiff-person Syndrome -- Sandbrink Et Al. 123 (11):
    Muscle stiffness in stiffperson syndrome (SPS) is produced by continuous, Stiff person syndrome Quantification, specificity, and intrathecal synthesis  
    http://brain.oxfordjournals.org/cgi/content/abstract/123/11/2231
    
    Extractions: This Article Full Text FREE Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles Search for citing articles in: Oxford University Press Friedhelm Sandbrink Nadir Ali Syed Mavis D. Fujii Marinos C. Dalakas and Mary Kay Floeter Electromyography Section and Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA Correspondence to: Dr Mary Kay Floeter, 10 Center Drive, MSC 1404, Bethesda, MD 20892-1404, USA E-mail: Muscle stiffness in stiff-person syndrome (SPS) is produced by continuous, involuntary firing of motor units that is thought

62. Motor Cortex Excitability In Stiff-person Syndrome -- Sandbrink Et Al. 123 (11):
    Muscle stiffness in stiffperson syndrome (SPS) is produced by continuous, Key Words stiff-person syndrome; transcranial magnetic stimulation;  
    http://brain.oxfordjournals.org/cgi/content/full/123/11/2231
    
    Extractions: This Article Abstract FREE Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles Search for citing articles in: Oxford University Press Friedhelm Sandbrink Nadir Ali Syed Mavis D. Fujii Marinos C. Dalakas and Mary Kay Floeter Electromyography Section and Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA Correspondence to: Dr Mary Kay Floeter, 10 Center Drive, MSC 1404, Bethesda, MD 20892-1404, USA E-mail:

63. JNNP -- Sign In Page
    Keywords stiffperson syndrome; myasthenia; thymoma. Stiff person syndrome (SPS)is a rare disorder of the central nervous system characterised by  
    http://jnnp.bmjjournals.com/cgi/content/full/76/1/141
    
    Extractions: Password Forgotten your user name or password? Subscribe Buy the article Pay per Article - You may access this article (from the computer you are currently using) for 2 days for US$12.00 SitePass - You may access all content in Journal of Neurology, Neurosurgery, and Psychiatry Online (from the computer you are currently using) for 30 days for US$30.00. Regain access to an already purchased article if the access period has not yet expired. This Article Extract Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Thomas, S

64. NEJM -- High-Dose Intravenous Immune Globulin For Stiff-Person Syndrome
    Background stiffperson syndrome is a disabling central nervous system disorderwith no IV Immune Globulin Effective for stiff-person syndrome, But.  
    http://content.nejm.org/cgi/content/abstract/345/26/1870
    
    Extractions: Add to Personal Archive ... PubMed Citation ABSTRACT Background Stiff-person syndrome is a disabling central nervous system disorder with no satisfactory treatment that is characterized by muscle rigidity, episodic muscle spasms, high titers of antibodies against glutamic acid decarboxylase (GAD65), and a frequent association with autoimmune disorders. Because stiff-person syndrome is most likely immune-mediated, we evaluated the efficacy of intravenous immune globulin. Methods We assigned 16 patients who had stiff-person syndrome and anti-GAD65 antibodies, in random order, to receive intravenous immune globulin or placebo for three months, followed by a one-month washout period and then by three months of therapy with the alternative agent. Efficacy was judged by improvements in scores

65. NEJM -- Sign In
    intravenous immune globulin for the treatment of stiffperson syndrome.stiff-person syndrome is a devastating disorder, and evidence of the associated  
    http://content.nejm.org/cgi/content/full/346/22/1747
    
    Extractions: SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. Log in via Athens. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.

66. Entrez PubMed
    The cause of the stiffperson syndrome is unknown; however, an autoimmunepathogenesis is suspected because of 1) the presence of antibodies against  
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9

67. Case Reports
    is a clinical diagnosis.10 Mander suggested even though the disorder is notedmore in men than women, SMS should be entitled “stiffperson syndrome.”27  
    http://www.aanem.org/education/noncme/hayat.cfm
    
    Extractions: INTRODUCTION Stiff-man syndrome (SMS), a rare neurological disorder, is characterized by marked rigidity of the axial and proximal limb muscles. Patients fluctuate between being asymptomatic to having extreme spasms extending to the hands, feet, and face. The spasms are usually precipitated by anxiety, sudden motion or other external stimuli, and can be severe enough to fracture a bone. The condition was initially described by Moersch and Woltman in 1956. They observed 14 patients over 32 years who had fluctuating and progressive muscle rigidity. They named the condition “stiff-man syndrome” as 83% of all cases were men. Over the last few years' research suggests the etiology of SMS may be autoimmune in nature. Some patients do respond favorably to immune modulating therapy.

68. Stiff-Person Syndrome - Evaluation, Treatment And Research At The National Insti
    The National Institute of Neurological Disorders and Stroke is actively seekingpatients with stiffperson syndrome to receive free evaluation and/or  
    http://patientinfo.ninds.nih.gov/StiffPersonSyndrome.aspx

69. The Stiff-Person Syndrome: An Autoimmune Disorder Affecting Neurotransmission Of
    The cause of the stiffperson syndrome is unknown; however, an autoimmunepathogenesis is Increased brainstem excitability in stiff-person syndrome  
    http://www.annals.org/cgi/content/abstract/131/7/522
    
    Extractions: (PDFs free after 6 months) Figures/Tables List Services Send comment/rapid response letter Notify a friend about this article Alert me when this article is cited Add to Personal Archive ... ACP Search PubMed Articles in PubMed by Author: Levy, L. M. Floeter, M. K. Related Articles in PubMed PubMed Citation ... PubMed Lucien M. Levy, MD, PhD, Moderator: Marinos C. Dalakas, MD, Discussants: ... Discussants: The stiff-person syndrome, a rare and disabling disorder, is characterized by muscle rigidity and episodic spasms that involve axial and limb musculature. Continuous contraction of agonist and antagonist muscles caused by involuntary motor-unit firing at rest are the hallmark clinical and electrophysiologic signs of the disease. Except for global muscle stiffness, results of neurologic examination are usually normal. Results of conventional

70. Ann Intern Med -- Sign In Page
    available for most Figures at Annals.org. The stiffperson syndrome AnAutoimmune Disorder Affecting Neurotransmission of {gamma} -Aminobutyric Acid  
    http://www.annals.org/cgi/content/figsonly/131/7/522
    
    Extractions: Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$20.00 Pay for Admission - You may access all content in Annals of Internal Medicine Online (from the computer you are currently using) for 24 hours for US$29.00. Regain Access - You can regain access to a recent Pay per Article or Pay for Admission purchase if your access period has not yet expired. Sign Up Subscribe to the Journal - Subscribe to the print and/or online journal. Home Current Issue Past Issues Search ... ACP Online

71. The Neurologist - Abstract: Volume 10(3) May 2004 P 131-137 Stiff-Person Syndrom
    Background stiffperson syndrome (SPS) is a rare neurologic disorder withautoimmune features. It is characterized by progressive, severe muscle rigidity  
    http://www.theneurologist.org/pt/re/neurologist/abstract.00127893-200405000-0000
    
    Extractions: Background: Stiff-person syndrome (SPS) is a rare neurologic disorder with autoimmune features. It is characterized by progressive, severe muscle rigidity or stiffness most prominently affecting the spine and lower extremities. Review Summary: Superimposed muscle spasms result in simultaneous contraction of agonist and antagonist muscles which are detectable by electromyography (EMG) and relieved by administration of benzodiazepines. The exacerbation of SPS by emotional stressors often results in the referral of these patients for psychiatric assessment although this was more common before the discovery of an association with antibodies to glutamic acid decarboxylase (GAD antibodies). Formerly known as stiff-man syndrome, the female to male ratio is 2:1 and the principle paraneoplastic variant is associated with breast cancer. Although rare, this is a disease of middle age that severely curtails the functional capacity of those it strikes. It is frequently associated with diabetes and other autoimmune diseases. IVIg is recently demonstrated to be effective in the treatment of SPS; diazepam remains useful in managing the symptoms. Conclusions: This article summarizes the history of SPS, describes important clinical features, discusses management, touches upon areas of uncertainty, and postulates some avenues for research.

72. Stiff-Person Syndrome Terms And Definitions At Www.MedicalGlossary.org
    stiffperson syndrome Definitions and Terms. MedicalGlossary.org is designed asa free, browsable resource for all. The medical terms and definitions are  
    http://www.medicalglossary.org/autoimmune_diseases_of_the_nervous_system_stiffpe
    
    Extractions: Definition: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93) Previously Indexed: Autoimmune Diseases (1988-1991),Central Nervous System Diseases (1986-1991),Fibromyalgia (1966-1976),Muscular Diseases (1966-1982),Neuromuscular Diseases (1972-1991) MedicalGlossary.org is designed as a free, browsable resource for all. The medical terms and definitions are not intended to replace medical informaion provided by licensed healthcare professionals. Please see a doctor if you need medical assistance. Don't see the medical term you were researching? Send us an e-mail from our "about us" page. We will do our best to research and classify new medical terms in a timely manner. Our current list of medical terms is over 26,000. Data sources include the U.S. National Library of Medicine, 2004 Medical Subject Headings. About Us Link to Us Main Categories: Anatomy Organisms Diseases Chemicals and Drugs ... Analytical, Diagnostic and Therapeutic Techniques and Equipment

73. Deutsche Gesellschaft Für Neurologie: Stiff Man-Syndrom (SMS; Synonym: Stiff Pe
    Stiff person-Syndrom) B. The clinical spectrumof anti-GAD antibodypositive patients with stiff-person syndrome.  
    http://www.dgn.org/133.0.html
    
    Extractions: Das Stiff man-Syndrom ist klinisch charakterisiert durch massive rigide Steigerung des Muskeltonus mit schmerzhaft einschießenden Spasmen, episodische adrenerge autonome Dysregulation und agoraphobische Angststörung. Die Muskeldehnungsreflexe können gesteigert sein, weitere neurologische Symptome fehlen. Beschränkung der Hauptsymptome auf eine Gliedmaße (Stiff limb-Syndrom, SLS) kommt als "Minusvariante" vor. Bei der "Plusvariante" des SMS (progressive Enzephalomyelitis mit Rigidität und Myoklonien, PERM) treten u.U. nur flüchtige neurologische Symptome (z.B. Augenbewegungsstörungen, Pyramidenbahnzeichen, Ataxie, Paresen) hinzu. Der Nachweis von Autoantikörpern gegen Glutamat-Dekarboxylase (GAD) mit intrathekaler Antikörperproduktion bei ca 70 % der Patienten und assoziierte Autoimmunerkrankungen bei ca. 50 % (vor allem Typ 1 Diabetes mellitus, Autoimmun-Hyperthyreose) sind Argumente für eine immunologische Genese. Erkrankungsalter 13 - 72 Jahre (Mittel 46 Jahre) Spontanverlauf und –prognose schleichende Progression über Monate, nachfolgend Stabilität über Jahrzehnte, selten auch schubförmige Verschlechterung (vor allem bei der Plusvariante PERM). Im Krankheitsverlauf können neue neurologische Symptome hinzukommen (z.B. Augenbewegungsstörungen, Pyramidenbahnzeichen, Ataxie, Paresen). Spontanheilungen sind extrem selten.

74. HighWire -- Browse Journals - Stiff-Person Syndrome
    Browse Journals publishing on stiffperson syndrome, (return to Topic List page) Journals focusing on stiff-person syndrome (in order by highest focus)  
    http://highwire.stanford.edu/lists/topic_dir/608683/618131/620438/620490/620491/
    
    Extractions: Sort by: Alphabet Frequency of articles in Stiff-Person Syndrome Focus of journal on Stiff-Person Syndrome What's this? Journals focusing on Stiff-Person Syndrome (in order by highest focus) Annals of Internal Medicine info free ISSUES New England Journal of Medicine ... Neuromuscular Diseases Stiff-Person Syndrome Home Adv. Search For Institutions For Publishers ... partners/suppliers

75. Graves’ Disease And Stiff-person (stiff-man) Syndrome: Case Report And Lit
    Free information and resources on counselling and psychotherapy, mental healthand wellness plus lowcost online therapy.  
    http://counsellingresource.com/medications-research/2005/07/17/graves-disease-an
    
    Extractions: Orija IB, Gupta M, Zimmerman RS This article was last updated on Sunday, 17th July 2005 at 1:06 am and is filed in the Clonazepam section. You can follow replies to this entry through the RSS 2.0 feed. You can leave a response , or trackback from your own site. There are no comments yet on this article would you like to be the first to post a response? Join the Discussion! Name (required) E-mail (for verification, never published) Website or URI (A valid email address is required to enable you to personally verify and authorize your comment for posting. It will not be displayed in your post or used in any other way. SPAM comments will be deleted immediately.) Your Comment: XHTML: You can use these tags: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <code> <em> <i> <strike> <strong> About Advertising This site is provided for educational and informational purposes only and is not intended as a substitute for the advice of a qualified mental health professional. Please see the

76. Syndrome De Stiff-Person : Sites Et Documents Francophones
    stiff-person ; hommeraide, syndrome . Synonyme(s) MeSH Stiff-Man, syndrome ; syndrome de  
    http://www.chu-rouen.fr/ssf/pathol/stiffpersonsyndrome.html
    
    Extractions: Site éditeur Orphanet base de données sur les maladies rares et les médicaments orphelins. Direction Générale de la Santé / INSERM ; description de la maladie, signes cliniques, autres sites Internet, types de consultations adaptées, association de patients ; pays : France ; langue : français ; format : html ; accès : gratuit ; non parrainé ; daté de : 2004 ; visité le : 04/05/2004].

77. Stiff-person, Syndrome : Arborescences MeSH
    page PubMed du motclef page CISMeF du motclef  
    http://www.chu-rouen.fr/navimesh/S/navistiffpersonsyndrome.html

78. EMedicine - Stiff Person Syndrome : Article By Nancy Rodgers-Neame, MD
    Stiff Person syndrome Stiff person syndrome is rather unique among neurologicdiagnoses because of its lack of significant similarity to any other  
    http://www.emedicine.com/neuro/topic353.htm
    
    Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Neuromuscular Diseases Last Updated: October 27, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: SPS, stiff man syndrome, SMS, stiff baby syndrome, SBS, hyperekplexia, Moersch-Woltmann syndrome, stiff woman syndrome, stiff limb syndrome AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Nancy Rodgers-Neame, MD , Assistant Professor, Department of Pharmacology and Therapeutics, University of South Florida, Florida Comprehensive Epilepsy and Seizure Disorders Program Nancy Rodgers-Neame, MD, is a member of the following medical societies: American Academy of Neurology American Epilepsy Society American Medical Women's Association American Society for Clinical Pharmacology and Therapeutics ... Southern Clinical Neurological Society , and Southern Medical Association Editor(s): Paul E Barkhaus, MD

79. EMedicine - Schwartz-Jampel Syndrome : Article By Stephen Berman, MD, PhD
    Stiff Person syndrome. Other Problems to be Considered. Isaacs syndrome Malignanthyperthermia StuveWiedermann syndrome Becker dystrophy  
    http://www.emedicine.com/neuro/topic337.htm
    
    Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Neuromuscular Diseases Last Updated: May 25, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: Schwartz Jampel syndrome, chondrodystrophic myotonia, myotonic myopathy, dwarfism, chondrodystrophy, ocular and facial anomalies, Schwartz-Jampel-Aberfeld syndrome, SJA syndrome, SJS AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Stephen Berman, MD, PhD , Professor, Department of Internal Medicine, Section of Neurology, Dartmouth Medical School; Chief, White River Junction VA Neurology Service, White River Junction VA Hospital Stephen Berman, MD, PhD, is a member of the following medical societies: American Academy of Neurology Editor(s): Daniel H Jacobs, MD , Clinical Associate Professor, Department of Neurology, University of Florida;

80. Stiff Person Syndrome
    Links to information and resources for Stiff Person syndrome, also known asStiffman syndrome or Moersch-Woltmann syndrome.  
    http://rarediseases.about.com/cs/stiffpersonsynd/
    
    Extractions: zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/7.htm','');w(xb+xb); Sign Up Now for the Rare / Orphan Diseases newsletter!

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