Extractions: From Porter Novelli ORLANDO, Fla., Nov. 10, 2003 Results from a nested, case-control study showed that patients with both high coronary risk and higher blood levels of sitosterol (1) (a plant sterol) were at an increased risk of a major coronary event compared to similar patients with lower blood levels of the plant sterol. These results were presented today at the 2003 American Heart Association's Scientific Sessions. Very high levels of plant sterols in the blood (levels ranging from 200 to 1570 µmol/L [2,3]) have been previously confirmed as a risk factor for coronary heart disease.(4) In this study, 177 cases (patients who suffered myocardial infarction [MI] or sudden coronary death within 10 years of follow-up) were selected from the PROCAM (Prospective Cardiovascular Muenster) study population. Each case was matched to two controls (n=354) from PROCAM based on age, gender, smoking status and date of investigation. Phytosterol concentrations, including sitosterol, were measured in samples collected at baseline in order to determine an association between phytosterol blood levels and increased risk for future coronary events. Results from the study, which was funded in part by Merck/Schering-Plough
The Scientist :: Cholesterol Efflux Genes, Nov. 19, 2002 sitosterolemia is a rare inherited disease in which plantderived KE Berge,et al., Accumulation of dietary cholesterol in sitosterolemia caused by http://www.the-scientist.com/news/20021119/02
Extractions: Please login or register DAILY E-MAIL RSS HANDHELD CURRENT ISSUE DAILY NEWS UPFRONT FEATURE ... ARCHIVES Nov. 19, 2002 Previous Archive Next DAILY NEWS By Tudor P. Toma Sitosterolemia is a rare inherited disease in which plant-derived sterols (sitosterol) accumulate in the body and lead to premature atherosclerotic plaques. The disease is caused by mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8 , but the exact role of these genes in the trafficking of sterols has been unclear. In November 18 early edition of Proceedings of the National Academy of Sciences , Liqing Yu and colleagues at the University of Texas Southwestern Medical Center at Dallas, USA, show that ABCG5 and ABCG8 are the major hepatobiliary transporter of both dietary and endogenously synthesized neutral sterols ( PNAS , cgi/doi/10.1073/pnas.252582399, November 18, 2002). Yu et al. generated mice homozygous for a disrupted Abcg5 and Abcg8 allele (G5G8 ), which they examined for the absorption and secretion of the major dietary plant and animal sterols. They observed that G5G8
The Scientist :: Cholesterol Efflux Genes, Nov. 19, 2002 AK Bhattacharyya, et al., Betasitosterolemia and xanthomatosis. A newly describedlipid storage disease in two sisters, Journal of Clinical Investigation http://www.the-scientist.com/news/20021119/02/printerfriendly
Extractions: Nov. 19, 2002 return to webpage DAILY NEWS By Tudor P. Toma Sitosterolemia is a rare inherited disease in which plant-derived sterols (sitosterol) accumulate in the body and lead to premature atherosclerotic plaques. The disease is caused by mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8 , but the exact role of these genes in the trafficking of sterols has been unclear. In November 18 early edition of Proceedings of the National Academy of Sciences , Liqing Yu and colleagues at the University of Texas Southwestern Medical Center at Dallas, USA, show that ABCG5 and ABCG8 are the major hepatobiliary transporter of both dietary and endogenously synthesized neutral sterols ( PNAS , cgi/doi/10.1073/pnas.252582399, November 18, 2002). Yu et al. generated mice homozygous for a disrupted Abcg5 and Abcg8 allele (G5G8 ), which they examined for the absorption and secretion of the major dietary plant and animal sterols. They observed that G5G8 mice had a two to threefold increase in the fractional absorption of dietary plant sterols, which was associated with an approximate 30-fold increase in plasma sitosterol. In addition they also observed a selective and profound reduction in biliary cholesterol levels and an accumulation of cholesterol in the liver after cholesterol feeding.
MGI_3.22 - References Query Results (Details) Title A mouse model of sitosterolemia absence of Abcg8/sterolin2 results infailure Based upon the genetics of sitosterolemia, ABCG5/sterolin-1 and http://www.informatics.jax.org/searches/reference.cgi?95750
MGI_3.22 - References Query Results (Details) Title sitosterolemia in ABCTransporter G5-deficient mice is aggravated onactivation of the liver-X receptor. Authors Plosch T; Bloks VW; Terasawa Y; http://www.informatics.jax.org/searches/reference.cgi?88191
Extractions: National Heart, Lung, and Blood Institute (NHLBI) Overview of NHLBI Rare Diseases Research Activities The National Heart, Lung, and Blood Institute (NHLBI) provides leadership for a national program in the causes, diagnosis, treatment, and prevention of diseases of the heart, blood vessels, lungs, and blood; in sleep disorders; and in the uses of blood and the management of blood resources. Through research in its own intramural laboratories and through extramural research grants and contracts, it conducts and supports an integrated program that includes basic research, clinical trials, epidemiological studies, and demonstration and education projects. Although the major part of the research supported by the NHLBI addresses common conditions such as hypertension, coronary heart disease, and chronic obstructive pulmonary disease, a significant amount of research is devoted to rare diseases in children and adults. NHLBI activities related to rare disease research in fiscal year (FY) 2004 are described below. Recent Scientific Advances in Rare Diseases Research Heart and Vascular Diseases Programs Abetalipoproteinemia Antiphospholipid Syndrome Antiphospholipid syndrome (APS) symptoms include recurrent blood clotting disorders, a history of fetal deaths, and autoimmune diseases such as thrombocytopenia. APS also increases the risk of developing atherosclerosis. Many patients with the disorder also have systemic lupus erythematosus (SLE). APS is characterized by the presence of circulating autoantibodies to certain phospholipid-binding proteins such as B
Science -- Sign In A striking exception occurs in sitosterolemia, an autosomal recessive disordercharacterized Phenotypic heterogeneity of sitosterolemia. J. Lipid Res. http://dx.doi.org/10.1126/science.290.5497.1771
Extractions: You do not have access to this item: Abstract : Berge et al., Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in..., Science You are on the site via Free Public Access. What content can I view with Free Public Access If you have a personal user name and password, please login below. SCIENCE Online Sign In Options For Viewing This Content User Name Password this computer. Help with Sign In If you don't use cookies, sign in here Join AAAS and subscribe to Science for free full access. Sign Up More Info Register for Free Partial Access including abstracts, summaries and special registered free full text content. Register More Info Regain Access to a recent Pay per Article purchase Need More Help? Can't get past this page? Forgotten your user name or password? AAAS Members activate your FREE Subscription
Log In Problems However, in the condition termed sitosterolemia, sitosterol levels are 1530 Notably, patients with sitosterolemia harbored mutations in one or the http://www.medscape.com/viewarticle/459766
NHLBI Rare Diseases Report, 2001 Betasitosterolemia is a rare inborn error of metabolism characterized by NHLBI supports research into beta-sitosterolemia through its intramural http://www.nhlbi.nih.gov/resources/docs/raredisrpt01.htm
Extractions: NHLBI provides leadership for a national program in the causes, diagnosis, treatment, and prevention of diseases of the heart, blood vessels, lungs, and blood, and sleep disorders, and in the uses of blood and the management of blood resources. It conducts and supports, through research in its own laboratories and through extramural research grants and contracts, an integrated and coordinated program that includes basic investigations, clinical trials, epidemiological studies, and demonstration and education projects. Although the major part of the research supported by NHLBI addresses common conditions such as hypertension, coronary heart disease, and chronic obstructive pulmonary disease, a significant amount of research is devoted to rare diseases in children and adults. NHLBI activities related to rare disease research in fiscal year (FY) 2001 are described below.
Dmoz.fr Health Conditions And Diseases Nutrition And Metabolism Disorders Choles Colegio Farmacéuticos de la Provincia de Santa Fe 1ª Circunscripción - Translate this page Agosto, 2003. sitosterolemia (Fitosterolemia). La sitosterolemia es una enfermedadextremadamente rara del metabolismo de los lípidos, caracterizada por el http://dmoz.fr/Health/Conditions_and_Diseases/Nutrition_and_Metabolism_Disorders
News At AHA Higher Blood Levels Of Sitosterol May Be Associated binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia. Hum.Mutat . (4) Betasitosterolemia. National Heart Lung and Blood Institute 2001 http://www.prnewswire.co.uk/cgi/news/release?id=111580
