Current Opinion In Lipidology - UserLogin sitosterolemia was mapped to the sitosterolemia (STSL) locus on human chromosome Betasitosterolemia and xanthomatosis a newly described lipid storage http://www.co-lipidology.com/pt/re/colipidology/fulltext.00041433-200308000-0000
Extractions: Advanced Search document.write(hashTable['Home'].parentMenu) Home Research Center for Human Nutrition (2001 Spring) Key Players In Cholesterol Absorption Uncovered By UT Southwestern Researchers Home About the Center Facilities Research ... CHN Newsletters process by which the body regulatescholesterol and other sterols from the diet. It also provides new insights into the way the body acquires and gets rid of cholesterol and other sterols. The disorder, sitosterolemia, is characterized by hyperabsorption of cholesterol and plant sterols. This leads to an excessive presence of cholesterol in the blood, which ultimately causes premature heart disease. "The main benefit of this study is that we identified a key protein in two very poorly understood pathwaysthe mechanisms by which cholesterol and other sterols are secreted into the bile," said Dr. Helen Hobbs, professor of internal medicine and molecular genetics and senior author of the study. "Now we have a handle on one of the key players in cholesterol absorption." she said. Until this discovery, which was published in Science , the key proteins involved in the regulation of cholesterol absorption and its secretion into the bile were not known, said Dr. Hobbs, director of the Eugene McDermott Center for Human Growth and Development.
Dr. Hobbs , Dr. Helen Hobbs, Dr. Helen Haskell Hobbs sitosterolemia is due to mutations in two coordinately regulated genes, ABCG5and ABCG8, which encode proteins that play crucial roles in the uptake and http://www8.utsouthwestern.edu/findfac/research/0,2357,13232,00.html
Extractions: Academic Title: Professor Administrative Title: Investigator, Howard Hughes Medical Institute; Center Director, Internal Medicine Molecular Genetics Primary Appointment: Eugene McDermott Center For Growth and Development Secondary Appointment: Internal Medicine - Clinical Genetics School: Southwestern Medical School
All Showcase - Sitosterolemia PDF ABC Transporters and Sterol Absorption http://www.allshowcase.com/Health_and_Fitness/Conditions_and_Diseases/S/Sitoster
ABCG8 - ATP-binding Cassette, Sub-family G, Member 8 The ABCG5 and ABCG8 transporters, defective in betasitosterolemia, The rolesof polymorphisms of the sitosterolemia genes ABCG5 and ABCG8 in the http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/102055.html
Extractions: We found no differences in hepatic expression of the ATP binding cassette transporter genes Mdr2, Bsep ( bile salt export pump), and (implicated in cholesterol transport), the bile salt-uptake systems Ntcp (Na(+)-taurocholate co- transporting polypeptide gene) and (organic anion- transporting polypeptide 1 gene) or in bile formation between wild-type and Ppar alpha ((-/-)) mice. Abstract-9658385
Abcg8 - ATP-binding Cassette, Sub-family G, Member 8 Mutations in ABCG5 (G5) or ABCG8 (G8) cause sitosterolemia, an autosomal In patients with sitosterolemia, mutations in either of two ATPbinding http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/133681.html
Extractions: We found no differences in hepatic expression of the ATP binding cassette transporter genes Mdr2, Bsep ( bile salt export pump), and (implicated in cholesterol transport), the bile salt-uptake systems Ntcp (Na(+)-taurocholate co- transporting polypeptide gene) and (organic anion- transporting polypeptide 1 gene) or in bile formation between wild-type and Ppar alpha ((-/-)) mice. Abstract-9658385
Sitosterolemia - Talk Medical Identification of a gene, ABCG5, important in the regulation of In sitosterolemia, a rare autosomal recessive disorder, affected individualshyperabsorb not Mutational analyses in ABCG5 in sitosterolemia probands. http://www.talkmedical.com/medical-dictionary/13054/Sitosterolemia
Extractions: Tell a friend Sitosterolemia: A genetic disease involving lipids (fats) in which there is excessive intestinal absorption of dietary sterols and impaired clearance of these sterols from the liver into the bile. These sterols include cholesterol and the plant sterol sitosterol (from which comes the name of the disease). Patients with the disease have abnormally high blood levels of sterols and a tendency to develop coronary artery disease at an unusually early age (in the teens). The high blood fat levels also lead to abnormal red blood cells (causing chronic anemia) and fatty deposits (xanthomas) on tendons. Sitosterolemia is inherited as a rare autosomal recessive condition. It affects males and females alike. It is caused by mutations in ABCG5 and ABCG8, two adjacent and oppositely oriented genes located in chromosome 2 in band 2p21. These two genes, ABCG5 and ABCG8, encode proteins with homology (similarity) to genes known as the "ATP binding cassette (ABC) transporters" which are also involved in cholesterol transport. The disorder is treated by strictly limiting cholesterol in the diet, reducing the intake of foods rich in plant sterols (e.g., vegetable oils) and giving cholestyramine resin to promote sterol excretion from the body.
Extractions: NATURE.COM NEWS@NATURE.COM NATUREJOBS NATUREEVENTS ... Help SEARCH my account e-alerts subscribe register ... Site features NPG Subject areas Access material from all our publications in your subject area: Biotechnology Cancer Chemistry NEW! Dentistry Development Drug Discovery Earth Sciences ... Physics September 2004, Volume 12, Number 9, Pages 752-761 Table of contents Previous Next Full text ... PDF Article A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents Derek Gordon , Chad Haynes , Christopher Johnnidis , Shailendra B Patel , Anne M Bowcock Laboratory of Statistical Genetics, Rockefeller University, Box 192, 1230 York Avenue, New York, NY 10021, USA Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29403, USA Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA Correspondence to: Dr D Gordon, Tel: +1 212 327 7987; Fax: +1 212 327 7996; E-mail: gordon@linkage.rockefeller.edu
Explore HGNC Transport Nomenclature: ABCG8 Accumulation of dietary cholesterol in sitosterolemia caused by mutations A striking exception occurs in sitosterolemia, an autosomal recessive disorder http://www.tcdb.org/hgnc_explore3.php?symbol=ABCG8
Directory Of Open Access Journals Title, A mouse model of sitosterolemia absence of Abcg8/sterolin2 results infailure Based upon the genetics of sitosterolemia, ABCG5/sterolin-1 and http://www.doaj.org/abstract?id=83892&toc=y
Directory Of Open Access Journals respectively) have been shown to be responsible for causing sitosterolemia inhumans. mechanisms involved in the human disease of sitosterolemia. http://www.doaj.org/abstract?id=82260&toc=y
Treatment Methods Patent 0003 sitosterolemia is a genetic lipid storage disorder characterized by increased 0006 An improved treatment for sitosterolemia is needed which can http://www.freshpatents.com/Treatment-methods-dt20050414ptan20050080071.php
Extractions: Browse Patent Applications: Prev Next USPTO Class 514 The present invention is directed to the use of sterol absorption inhibiting compounds, pharmaceutical compositions thereof, therapeutic combinations and their use in combination with other lipid lowering agents to treat or prevent sitosterolemia and/or to lower the concentration of sterol(s) other than cholesterol in plasma or tissue of a mammal. Methods of treating or preventing vascular disease and coronary events also are provided.
Extractions: This is an open-access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Keywords: Ezetimibe, Zetia, Cholesterol Absorption Inhibitors, Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Atherosclerosis, Sitosterolemia, Pleiotropic Effects of Statins, homozygous familial hypercholesterolemia
Online CME Evidence from patients with the rare condition sitosterolemia suggests that Patients with sitosterolemia have levels of phytosterols of 2501560 µM, http://www-cme.erep.uab.edu/onlineCourses/hyperlipidemia_treatment/ID0188.html
Events At The New York Academy Of Sciences genetic causes for diseases such as sitosterolemia and Tangiers have advanced ameliorates both hypercholesterolemia and sitosterolemia in humans. http://www.nyas.org/events/eventDetail.asp?eventID=154&date=3/30/2004 1:00:00 PM
FALK 2004 sitosterolemia IN ABCG5NULL MICE IS AGGRAVATED UPON ACTIVATION OF THE LIVERX-RECEPTOR. Torsten Plösch1, Vincent W. Bloks1, Yuko Terasawa2, Sara Berdy2, http://www.rug.nl/umcg/faculteit/disciplinegroepen/kindergeneeskunde/liverdigest
Extractions: Geavanceerd zoeken english site-info contact ... login Informatie voor... Studenten Medewerkers Postdocs en Senior Onderzoekers AIO's Alumni Studiekiezers Informatie voor... Nieuws UMCG nieuws Promoties en Oraties UMCG RUG nieuws Polsslag Triakel Universiteitskrant (UK) Nieuws Onderwijs Over onderwijs Opleidingen Onderwijsinstituut Internationalisering NESTOR, de elektronische leeromgeving Ga direct naar.... Onderwijs Onderzoek Over onderzoek Onderzoekscholen Interfacultaire Instituten Bureau Onderzoek Financieringsmogelijkheden Internationale projecten Commissies Publicaties Wetenschapswinkel Onderzoek Faculteit Faculteit Faculteitsbureau Bestuur en commissies Disciplinegroepen Adresgegevens en openingstijden Faculteit Bibliotheek Welkom Nieuws Informatie Collectie Elektronische collectie Cursussen Instructie/Handleidingen Bibliotheek Vacatures Algemene informatie Vacatures bij het UMCG Vacatures bij de Rijksuniversiteit Groningen Academic Transfer Noorderlink UMCG Tenure Track: loopbaanperspectief voor onderzoekstalent Vacatures Home RUG Home UMCG Faculteit ... Liver, Digestive and Metabolic Diseases
ELC 2003 sitosterolemia in ABCG5null mice is aggravated upon activation of the liverX-receptor LXR. Torsten Plösch1, Vincent W. Bloks1, Yuko Terasawa2, http://www.rug.nl/umcg/faculteit/disciplinegroepen/kindergeneeskunde/liverdigest
Extractions: Geavanceerd zoeken english site-info contact ... login Informatie voor... Studenten Medewerkers Postdocs en Senior Onderzoekers AIO's Alumni Studiekiezers Informatie voor... Nieuws UMCG nieuws Promoties en Oraties UMCG RUG nieuws Polsslag Triakel Universiteitskrant (UK) Nieuws Onderwijs Over onderwijs Opleidingen Onderwijsinstituut Internationalisering NESTOR, de elektronische leeromgeving Ga direct naar.... Onderwijs Onderzoek Over onderzoek Onderzoekscholen Interfacultaire Instituten Bureau Onderzoek Financieringsmogelijkheden Internationale projecten Commissies Publicaties Wetenschapswinkel Onderzoek Faculteit Faculteit Faculteitsbureau Bestuur en commissies Disciplinegroepen Adresgegevens en openingstijden Faculteit Bibliotheek Welkom Nieuws Informatie Collectie Elektronische collectie Cursussen Instructie/Handleidingen Bibliotheek Vacatures Algemene informatie Vacatures bij het UMCG Vacatures bij de Rijksuniversiteit Groningen Academic Transfer Noorderlink UMCG Tenure Track: loopbaanperspectief voor onderzoekstalent Vacatures Home RUG Home UMCG Faculteit ... Liver, Digestive and Metabolic Diseases
Gigablast Search Results Karger PublishersThe gene for sitosterolemia, a disorder involving abnormal sterol To testfor an involvement of ABCG5 in sitosterolemia all of the coding exons of the http://dir.gigablast.com/Health/Conditions_and_Diseases/Nutrition_and_Metabolism
Extractions: This Article Full Text (PDF) Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Jenkins, D. J.A. Articles by Kendall, C. W.C. Journal of the American College of Nutrition, Vol. 18, No. 6, 559-562 (1999) Published by the American College of Nutrition David J.A. Jenkins, MD, PhD, DSc, FACN and Cyril W.C. Kendall, PhD In this issue of the journal, Williams and colleagues report the results of their study of nineteen two- to five-year old healthy children who received three grams of stanol in a margarine or five grams of wheat fiber in breakfast cereal for one month periods in a randomized crossover design [ ]. Stanol margarine reduced total cholesterol by 12.4% and LDL cholesterol by 15.5%
