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Sickle Cell Disease:     more books (100)

Sickle cell disease and trait: an increase in trabecular spacing, a case study.(Short Reports): An article from: Journal of Dental Hygiene by Marie Varley Gillis, Nathaniel M. West, 2004-03-22 Sickle cell disease: maintain the steady state: identifying common crises.(Children's Health): An article from: Family Practice News by Heidi Splete, 2004-05-15 Cephalosporin-resistant pneumococci and sickle cell disease.(RESEARCH): An article from: Emerging Infectious Diseases by Martha L. Miller, Caroline A. Obert, et all 2005-08-01 Sickle Cell Disease: Screening, Diagnosis, Management, and Counseling in Newborns and Infants Clinical (Guideline Number 6) by Sickle Cell Disease Guideline Panel, 1993-01-01 Acute chest syndrome in sickle cell disease.(PEDIATRIC/NEONATAL RESPIRATORY CARE): An article from: FOCUS: Journal for Respiratory Care & Sleep Medicine by Douglas Masini, 2009-05-01 Sickle Cell Disease: Basic Principles and Clinical Practice --1994 publication. by Robert P. Hebbel Stephen H. Embury, 1994-01-01 Sickle cell disease;: Transactions. Held on Jan. 20 and 21, 1972 (Thrombosis et diathesis haemorrhagica. Supplementum) Sickle Cell Disease and Thalassemias: New Trends in Therapies (Symposium) Sickle Cell Disease: A Handbook for the Layman. by Akin Isaacs-Sodeye, 1975 Pain experience in hospitalized adults with sickle cell disease.(CNE SERIES): An article from: MedSurg Nursing by Renee Granados, Eufemia Jacob, 2009-05-01 Central retinal vein occlusion in sickle cell disease.(Case Report): An article from: Southern Medical Journal by Syed Hasan, Mamoon Elbedawi, et all 2004-02-01 Management and Therapy of Sickle Cell Disease by Samuel and Other Editors Charache, 1985 Rhodotorula mucilaginosa catheter-related fungemia in a patient with sickle cell disease: case presentation and literature review.(Clinical report): An article from: Southern Medical Journal by Dionissios Neofytos, David Horn, et all 2007-02-01 Sickle cell disease related pain: Quick reference guide for clinicians : assessment and management by Barbara S Shapiro, 1994

lists with details

101. Sickle-cell Disease - Wikipedia, The Free Encyclopedia
     sicklecell anemia or anaemia (also sickle-cell disease) is a genetic disorder in which red blood cells may change shape under certain circumstances.  
     http://en.wikipedia.org/wiki/Sickle_cell_anemia
     
     Extractions: Sickle-shaped red blood cells Sickle-cell disease is a genetic disorder in which red blood cells may change shape under certain circumstances. This causes the cells to become stuck in capillaries which deprives the downstream tissues of oxygen and causes ischemia and infarction . The disease usually occurs in periodic painful attacks, eventually leading to damage of internal organs, stroke , or anemia , and usually resulting in decreased lifespan. It is common in people from countries with a high incidence of malaria , and especially in West Africa , or in descendents from those people. The disease was originally called sickle-cell anemia but this name has fallen out of favor in medical contexts because anemia is not the only symptom of the disease. edit Patients have baseline anemia that varies in severity, with hemoglobin levels of 7-9 mg/dl typical. Often white blood cell counts are elevated simply due to marrow hyperactivity. Reticulocyte counts are elevated, reflecting new red blood cells replacing the rapidly cleared older cells - red blood cell life span is markedly reduced in this disease.

102. Sickle Cell Anemia
     sickle cell anemia is an inherited disease in which the red blood cells, normally discshaped, become crescent shaped. As a result, they function abnormally  
     http://www.healthscout.com/ency/1/000527.html
     
     Extractions: Search HealthScout Web MEDLINE Special Offers TV Specials Chronic Pain Erectile Dysfunction GERD Diabetes ... High Tech Health Top Features Bipolar Disorder Resources Sleep Skin Cancer Migraines ... Diabetes Health Organizer Resources Healthscout News 3D Health Animations Health Videos Health Encyclopedia ... Drug Library Drug Information Drug Search Drug Interactions Image Database Pill Identifier Channels Home Today Women Men ... Drug Checker Medical Health Encyclopedia Injury Disease Nutrition Poison ... Prevention Definition: Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called "sickle cell pain crises." Causes, incidence, and risk factors: Sickle cell anemia is caused by an abnormal type of hemoglobin (oxygen carrying molecule) called hemoglobin S. It is inherited as an autosomal recessive trait that is, it occurs in someone who has inherited hemoglobin S from both parents. Someone who inherits hemoglobin S from one parent and normal hemoglobin (A) from the other parent will have sickle cell trait . Approximately 8% of African Americans have sickle cell trait. Someone who inherits hemoglobin S from one parent and another type of abnormal hemoglobin from the other parent will have another form of sickle cell disease, such as sickle cell-b

103. Sickle Cell Sufferers Living Longer, Dying Less
     University of Texas Southwestern Medical Center at Dallas.  
     http://www8.utsouthwestern.edu/utsw/cda/dept37389/files/158834.html
     
     Extractions: from their disease Latest News More Medical News Video News Releases En Espanol ... Publications Staff DALLAS - March 25, 2004 - Children with sickle cell disease - an inherited red blood-cell disorder - are living longer, dying less often from their disease and contracting fewer fatal infections than ever before, researchers at UT Southwestern Medical Center at Dallas report. Their study, which will appear in the June edition of the scientific journal Blood In one of the largest published sickle cell studies to date, UT Southwestern researchers, including Dr. Charles Quinn (left), assistant professor of pediatrics and Dr. Zora Rogers, associate professor of pediatrics, discovered that children with sickle cell disease today have a 12 percent increase of survival at 18 years of age from comparable statistics of 30 years ago. Thirty years ago, only half of children with sickle cell disease were expected to reach adulthood. This new study showed that patients with sickle cell anemia, the severest and most common form of the disease, had a survival rate of 85.6 percent at 18 years old, and patients with milder forms of sickle cell disease had a survival rate of 97.4 percent at 18. Also, 11.5 percent of patients with sickle cell anemia had a stroke by 18 years old. Although this rate remains constant, fewer children are dying as a result of the stroke, researchers said.

104. MedlinePlus Medical Encyclopedia: Sickle Cell Anemia
     Takes a look at this disorder with a definition, causes, incidence and risk factors.  
     http://www.nlm.nih.gov/medlineplus/ency/article/000527.htm
     
     Extractions: @import url(/medlineplus/images/advanced.css); Skip navigation Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Contents of this page: Red blood cells, sickle cell Red blood cells, normal Red blood cells, multiple sickle cells Red blood cells, sickle cells ... Blood cells Alternative names Return to top Anemia - sickle cell; Hemoglobin SS disease (Hb SS); Sickle cell disease Definition Return to top Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called "sickle cell pain crises." Causes, incidence, and risk factors Return to top Sickle cell anemia is caused by an abnormal type of hemoglobin called hemoglobin S. Hemoglobin is a protein inside red blood cells that carries oxygen. Hemoglobin S, however, reduces the amount of oxygen inside the cells, distoring their shape. The fragile, sickle-shaped cells deliver less oxygen to the body's tissues, and can break into pieces that disrupt blood flow. Sickle cell anemia is inherited as an autosomal recessive trait , which means it occurs in someone who has inherited hemoglobin S from both parents. Sickle cell disease is much more common in certain ethnic groups, affecting approximately one out of every 500 African Americans. Someone who inherits hemoglobin S from one parent and normal hemoglobin (A) from the other parent will have

105. Human Gene Testing - Summary
     Article by Drs. Stuart Orkin and Gary Felsenfeld describing how basic research led to genetic testing, including how the discoveries of DNA, restriction enzymes, cloning, PCR (polymerase chain reaction) make tests for diseases like sicklecell anemia and breast cancer possible.  
     http://www.beyonddiscovery.org/content/view.article.asp?a=239

106. Sickle Cell Anemia
     sickle cell anemia occurs when a person inherits two abnormal genes that cause their red blood cells to change shape. Find out more about what sickle cell  
     http://kidshealth.org/teen/diseases_conditions/blood/sickle_cell_anemia.html
     
     Extractions: Sickle cell anemia is a hereditary disorder that mostly affects people of African ancestry, but also occurs in other ethnic groups, including people who are of Mediterranean and Middle Eastern descent. More than 70,000 Americans have sickle cell anemia. And about 2 million Americans - and one in 12 African Americans - have sickle cell trait (this means they carry one gene for the disease, but do not have the disease itself). Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape. Instead of being flexible and round, these cells are more rigid and curved in the shape of the farm tool known as a sickle - that's where the disease gets its name. The shape is similar to a crescent moon. What Is Sickle Cell Anemia? Sickle cell anemia is a blood disorder that affects hemoglobin (pronounced: hee -muh-glow-bin), a protein found in red blood cells that helps carry oxygen throughout the body. Red blood cells with normal hemoglobin ( HbA ) move easily through the bloodstream, delivering oxygen to all of the cells of the body. Normal red blood cells are shaped like doughnuts with the centers partially scooped out and are soft and flexible.

107. Do You Know About Sickle Cell Anemia?
     sickle cell anemia gets its name because a person s red blood cells turn from a doughnut shape into a curved sickle shape. What s a sickle look like?  
     http://kidshealth.org/kid/health_problems/blood/sickle_cell.html
     
     Extractions: Have you ever seen a sickle? It's a farm tool with a curved, sharp edge for cutting wheat. Sickle cell anemia (say: sih -kul sell uh- nee -mee-uh) is a disease of the blood. It gets its name because a person's red blood cells are shaped like sickles, or crescent moons, instead of their usual round, flat shape. Round and flat is the healthiest shape for red blood cells because they can move easily through the body. Red blood cells carry oxygen around your body. And every part of your body needs oxygen to work properly. Red blood cells are made inside the bones in the soft, spongy area called the bone marrow (say: mar -o). Every time you take a breath, you breathe in oxygen. And your red blood cells carry oxygen to every cell in your body. Any time a person's body doesn't have enough red blood cells, it's called anemia. When the cause is the sickle shape of the red blood cells, it's called sickle cell anemia. When red blood cells are shaped like sickles or moons, they can get stuck and die, especially inside smaller blood vessels. This keeps blood from flowing properly in the body and it also causes a lot of pain. Important organs like the brain, heart, and kidneys need constant blood flow to work properly. A person's body knows that the sickle cells aren't good, so it attacks and destroys them. But the body can't make new blood cells fast enough to replace the old ones.

108. Welcome To The American Sickle Cell Anemia Association
     The American sickle cell Anemia Association of Cleveland Ohio.  
     http://www.ascaa.org/
     
     Extractions: Updated 06/25/05 *Information relayed on this site is collective, and has been accumulated over time from various factual sources, medical journals and general entities about sickle cell anemia and its disease variants. For specific printed matter, useful for citing text information, please contact us and we will forward printed matter to you. The materials on www.ascaa.org Please note that while ASCAA makes a conscientious attempt to make certain that information on our site is current and accurate, any errors or exclusions are not the liability of ASCAA. All information on our Message Board is subject to public response, therefore, while we will make our best effort to display accurate information, it is not the liability of ASCAA if any misinformation is submitted through the public message board (direct request, should be sent to ASCAA via email, mail or phone.)

109. Welcome To The American Sickle Cell Anemia Association
     Future of sickle cell treatment. Scientists have learned a great deal about sickle cell anemia during the past 30 years what causes it, how it affects  
     http://www.ascaa.org/ftreat.htm
     
     Extractions: Scientists have learned a great deal about sickle cell anemia during the past 30 years - what causes it, how it affects the patient, and how to treat some of the complications. They also have begun to have success in developing drugs that will prevent the symptoms of sickle cell anemia and procedures that should ultimately provide a cure. Some researchers are focusing on identifying drugs that will increase the level of fetal hemoglobin in the blood. Fetal hemoglobin is a form of hemoglobin that all humans produce before birth, but most stop making shortly after birth. Most humans have little fetal hemoglobin left in their bloodstream by the time they reach the age of 6 months. However, some people with sickle cell anemia continue to produce large amounts of fetal hemoglobin after birth, and studies have shown that these people have less severe cases of the disease. Fetal hemoglobin seems to prevent sick- ling of red cells, and cells containing fetal hemoglobin tend to survive longer in the bloodstream. Hydroxyurea appears to work primarily by stimulating production of fetal hemoglobin. There is some evidence that administering hydroxyurea with erythropoietin, a genetically engineered hormone that stimulates red cell production, may make hydroxyurea work better. This combination approach offers the possibility that lower doses of hydroxyurea can be used to achieve the needed level of fetal hemoglobin. However, both of these drugs may produce serious side effects, so researchers continue to search for safer agents that are just as effective.

110. EMedicine - Anemia, Sickle Cell : Article By Ali Taher, MD
     Anemia, sickle cell sickle cell anemia is a common reason patients of African descent seek emergency medical care. Although knowledge of the  
     http://www.emedicine.com/emerg/topic26.htm
     
     Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Emergency Medicine Hematology And Oncology Last Updated: January 5, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: crescent cell anemia sickle cell disease , autosomal recessive genetic disease, hemoglobin S HbS sickle cell anemia vasoocclusive crisis ... avascular necrosis , hand and foot syndrome, dactylitis, isosthenuria , acute chest syndrome, hypertransfusion programs, hematologic crises aplastic crisis Parvovirus B 19 infection infectious crises ... syncope AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography

111. New Hope For People With Sickle Cell Anemia (FDA Consumer Reprint)
     A recent clinical trial found that the drug Hydrea (hydroxyurea) significantly reduced painful episodes in adults with a severe form of sickle cell anemia.  
     http://www.fda.gov/fdac/features/496_sick.html
     
     Extractions: This article originally appeared in the May 1996 FDA Consumer and contains revisions made in December 1997 and February 1999. The article is no longer being updated. New Hope for People with Sickle Cell Anemia by Eleanor Mayfield In tropical regions of the world where the parasite-borne disease malaria is prevalent, people with a single copy of a particular genetic mutation have a survival advantage. Over time, people from these regions have migrated, had children, and in some cases married each other. Some of their children inherit two copies of the mutation. While inheriting one copy of the mutation confers a benefit, inheriting two copies is a tragedy. Children born with two copies of the genetic mutation have sickle cell anemia, a painful disease that affects the red blood cells and is curable only in rare instances. In February 1998, the Food and Drug Administration approved the drug Droxia (hydroxyurea) for reducing painful episodes in adults with a severe form of sickle cell anemia. The drug doesn't cure the disease. Hydroxyurea also is approved under the name Hydrea for treating certain cancers. Genetic Defect Changes Cell Shape The genetic defect that causes sickle cell anemia affects hemoglobin, a component of red blood cells. Hemoglobin's job is to carry oxygen to all the cells and tissues of the body. Red blood cells that contain normal hemoglobin (such as the one pictured top right) are soft and round. Their soft texture enables them to squeeze through the body's small blood vessels.

112. Sickle Cell Anemia - DrGreene.com
     Read an article discussing a genetic condition which destroys blood cells leading to anemia.  
     http://www.drgreene.com/21_1186.html
     
     Extractions: QUICK SEARCH A - Z Guide ADHD Allergy Care Guide Allergies Asthma Care Guide Asthma Bedwetting Breastfeeding Childhood Obesity Diabetes Care Guide Ear Infections Environmental Health Genetics Infectious Diseases Medical Treatment Mental Health Multimedia Library Potty Training Rashes Safety Sleep About DrGreene.com Archives About Us Context Reviews Awards Readers Comments Press Room Partners and Supporters Children's Health Topic Centers Contact Us Professional Resources Dr. Greene's Welcome Analytical Chemistry Business: Healthcare Cardiology Clinical Pharmacology Clinical Trials Mgmt Cosmetic Surgery Dermatology Diabetes Drug Discovery Emergency Medicine Endocrinology Family Practice Gastroenterology Geriatrics HIV/AIDS Infectious Disease Internal Medicine Managed Care Neurology Nursing Ob/Gyn Oncology Ophthalmology Orthopedics Pediatrics Pharma Marketing Pharma Sales Pharma Science/Tech Pharmacy Psychiatry Pulmonology Radiology Residents / Students Rheumatology Surgery Urology Pediatric Information A-Z Guide Allergy Care Guide Asthma Care Guide Diabetes Care Guide Discussion Boards Dr. Greene´s Chats

113. Sickle Cell Anemia, Cincinnati Children's Hospital Medical Center
     Cincinnati Children s Hospital Medical Center treats sickle cell anemia an inherited disorder of the hemoglobin in red cells.  
     http://www.cincinnatichildrens.org/health/info/blood/diagnose/sickle-cell-anemia
     
     Extractions: Sickle Cell Anemia is an inherited disorder of hemoglobin, the chemical substance which gives red blood cells their red color and carries oxygen to the tissues. In sickle cell anemia the abnormal hemoglobin (Hgb SS) makes the red cells rigid and distorted from the usual round shape into sickle shapes. At times, these stiff, crescent-shaped sickled red blood cells can plug up small blood vessels and decrease blood flow to various parts of the body. This leads to anemia and to periodic painful episodes. A painful episode can sometimes be referred to as a "crisis" we prefer not to use this unduly frightening word. This genetic disorder is a result of both parents passing a sickle gene to their child. The parents are said to be carriers or to have sickle trait. Sickle trait is not a disease by itself. Pain is the hallmark of sickle cell disease. Because of the nature of the disease, signs and symptoms may vary in frequency and severity. This disease can effect every major organ in the body (lungs, liver, kidneys, spleen, heart, brain, intestines, bones, etc.). Symptoms such as painful swelling of the hands and/or feet (Dactylitis) can be seen as early as 4 months of age. Sometimes more serious complications develop, such as, strokes, difficulty breathing, or orthopedic problems.

114. Sickle Cell Anemia
     sickle cell anemia national and international resources, clinics with genetic counselors and geneticists.  
     http://www.kumc.edu/gec/support/sickle_c.html
     
     Extractions: E-mail: ashc@cybernex.net What is Sickle Cell Disease? Education materials on Alpha Thalassemia, Beta Thalassemia, Hemoglobin C Trait (AC), Sickle Cell Trait (AS), Hemoglobin E Trait (AE) Map of United States with links to state organizations Uriel Owens Chapter SCDAA, PO BOX 171371, 650 Minnesota Ave., 2nd Floor, Kansas City, KS 66117, 913.621.1713, owens@sicklecellkck.org Sickle Cell Disease Association of Piedmont , NC Sickle Cell Anemia Research Foundation (SCARF), 2625 Third Street, P.O. Box 206, Alexandria, Louisiana 71309, 877.722.7370, e-mail: scarf@sicklecelldisease.org Regional Organizations, Clinics, Groups

115. InteliHealth: Sickle Cell Anemia
     InteliHealth Featuring Harvard Medical School s consumer health information. For more than 550 diseases and conditions, learn What Is It?, Symptoms,  
     http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9453.html
     
     Extractions: Sickle Cell Anemia What Is It? Symptoms Diagnosis Expected Duration ... Additional Info What Is It? Sickle cell anemia is most common in people whose ancestors came from parts of Africa, Saudi Arabia, India and the Mediterranean region. To have a fully developed case of sickle cell anemia, one gene for the illness must be inherited from both parents. When a person inherits only one sickle cell gene from one parent, that person is said to have sickle cell "trait" rather than sickle cell anemia. People with sickle cell trait usually have no symptoms of sickle cell anemia, but they can pass the gene for sickle cell hemoglobin to their children. Health experts estimate that approximately 2 million people in the United States currently carry the sickle cell trait, while another 72,000 have full-blown sickle cell anemia. Right now, about one of every 500 African-American children, and one of every 1,100 to 1,400 Hispanic-American children, are born with sickle cell anemia.

116. Hardin MD : Sickle Cell Anemia
     From the University of Iowa, the *best* lists of Internet sources in sickle cell Anemia.  
     http://www.lib.uiowa.edu/hardin/md/sicklecellanemia.html

117. Sickle Cell Anemia: Definition And Much More From Answers.com
     sickle cell anemia n. A chronic, usually fatal anemia marked by sickleshaped red blood cells, occurring almost exclusively in Black people of Africa.  
     http://www.answers.com/topic/sickle-cell-anemia
     
     Extractions: n. A chronic, usually fatal anemia marked by sickle-shaped red blood cells, occurring almost exclusively in Black people of Africa or of African descent, and characterized by episodic pain in the joints, fever, leg ulcers, and jaundice. The disease occurs in individuals who are homozygous for a mutant hemoglobin gene. Also called sickle cell disease n. A chronic, usually fatal inherited form of anemia marked by crescent-shaped red blood cells, occurring almost exclusively in Blacks, and characterized by fever, leg ulcers, jaundice, and episodic pain in the joints. Also called crescent cell anemia drepanocytic anemia drepanocytosis meniscocytosis sickle cell disease sickle cell syndrome WordNet Note: click on a word meaning below to see its connections and related words.

118. Hematopathology
     This is sickle cell anemia in sickle cell crisis. Persons with sickle cell trait (Hemoglobin AS) are much less likely to have this happen.  
     http://www-medlib.med.utah.edu/WebPath/HEMEHTML/HEME015.html
     
     Extractions: This is sickle cell anemia in sickle cell crisis. The abnormal hemoglobin SS is prone to crystallization when oxygen tension is low, and the RBC's change shape to long, thin sickle forms that sludge in capillaries, further decreasing blood flow and oxygen tension. Persons with sickle cell trait (Hemoglobin AS) are much less likely to have this happen.

119. Sickle Cell Anemia - Vitacost
     Anemia is a deficiency of the oxygencarrying capacity of red blood cells. sickle cell anemia is an inherited chronic anemia in which the red blood cells  
     http://www.vitacost.com/science/hn/Concern/Sickle_Cell_Anemia.htm

120. MRC Jamaica
     MRC Jamaica. The sickle cell Unit is now a research centre within the Tropical Medicine Research Institute of the University of the West Indies.  
     http://mrcjamaica.nimr.mrc.ac.uk/

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