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Schizencephaly: more detail

The Official Parent's Sourcebook on Schizencephaly: A Revised and Updated Directory for the Internet Age by ICON Health Publications, 2004-02-13
Schizencephaly: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Peter, MD Lin, 2005
The Official Parent's Sourcebook On Schizencephaly by Icon Health Publications, 2004

lists with details

Braintf22-Schizencephaly-Coronals
MRI features of schizencephaly. T2W Coronal T2W Coronal T2W Coronal.Click on the image to enlarge. To BrainTF22 schizencephaly.
http://www.mribhatia.com/braintf22/braintf22_coronal.html
Schizencephaly
Complete online version of The Encyclopaedia of Medical Imaging including textand images from The Encyclopaedia of Medical Imaging s eight book volumes
http://www.amershamhealth.com/medcyclopaedia/medical/Volume VI 1/SCHIZENCEPHALY.

Extractions: financial services our commitment our company Search Medcyclopaedia for: Search marked text (mark text before you click) Browse entry words starting with: A B C D ... amershamhealth.com Schizencephaly, a grey-matter-lined cleft that extends through the entire cerebral hemisphere from the ependymal surface of the lateral ventricle to the cerebral cortex. Two types of schizencephaly are recognized: a "closed-lip" schizencephaly in which the cleft walls are contiguous and an"open-lip" schizencephaly in which the walls are separated by wide subarachnoid spaces. The grey matter lining the cleft is usually polymicrogyric (see polymicrogyria ). The clefts can be unilateral or bilateral, symmetrical or asymmetrical and can appear anywhere in the brain. These lesions are believed to be due to in utero vascular injuries and their preferential location in the perisylvian areas follows the frontoparietal distribution of the middle cerebral artery. The clinical condition of patients relates to the amount and location of involved brain: patients with a narrow, unilateral cleft usually present with seizures and mild focal neurological deficits and they are otherwise developmentally normal; patients with bilateral clefts often have severe developmental delay with early intractable epilepsy and severe motor dysfunction. On imaging studies the key feature in the diagnosis of any type of schizencephaly is the presence of a ventricular dimple at the ependymal surface of the cleft. This can be the only CT feature in cases of closed or minimally open lip schizencephaly. On MR images the thickness of the transhemispheric cleft and the polymicrogyric aspect of the grey matter lining the cleft are better discernible (
Www.amershamhealth.com/medcyclopaedia/medical/Volu
Christopher A. Walsh LaboratoryYouve been told that your child has a condition called schizencephaly. This brochure gives you some general information about schizencephaly.
http://www.amershamhealth.com/medcyclopaedia/medical/Volume VII/SCHIZENCEPHALY.a

Extractions: financial services our commitment our company Search Medcyclopaedia for: Search marked text (mark text before you click) Browse entry words starting with: A B C D ... amershamhealth.com Schizencephaly, neuronal migration abnormality which occurs early in gestational life, possibly around the 7th to 8th week. It may be related to a vascular event. The resulting abnormality is a seam of grey matter extending from the pial surface of the brain down towards the ependyma of the lateral ventricle. This results in a grey matter lined cleft which can be described as open lipped, where there is a cerebrospinal fluid (CSF) track between the two sides, or closed lipped, where no CSF is identified. There is usually an associated abnormal contour of the lateral ventricle where the cleft meets the ventricular surface. In a large proportion of patients (70-80%) there will also be an absence of the septum pellucidum ( Fig.1 ). The abnormality is often found in the parietal lobe and can be bilateral ( Fig.2 ). The ventricular system may also be slightly dilated and the grey matter lining the cleft may be thickened. Children often present with seizures or developmental delay, but can have remarkably few symptoms. Also, see schizencephaly
Schizencephaly.html
TITLE Clinical manifestations of schizencephaly and its sonographic diagnosis ABSTRACT schizencephaly is defined as a cerebral malformation of the
http://www.indiana.edu/~pietsch/schizencephaly.html

Extractions: The following MEDLINE items were compiled by SilverPlatter and are presented with their permission. ( See SilverPlatter's Worldwide Library for bibliographic search information Click here for Schiz Kidz Buddies , a web-based support group devoted to children with Schizencephaly. Record 1 of 77 in MEDLINE EXPRESS (R) 2000/01-2000/06 TITLE: Persistent hyperplastic primary vitreous associated with septo-optic-pituitary dysplasia and schizencephaly. AUTHOR(S): Katsuya-Lauer-A; Balish-MJ; Palmer-EA ADDRESS OF AUTHOR: Casey Eye Institute, Oregon Health Sciences Center, Portland 97201-4197, USA. SOURCE (BIBLIOGRAPHIC CITATION): Arch-Ophthalmol. 2000 Apr; 118(4): 578-80 INTERNATIONAL STANDARD SERIAL NUMBER: 0003-9950 PUBLICATION YEAR: 2000 LANGUAGE OF ARTICLE: ENGLISH COUNTRY OF PUBLICATION: UNITED-STATES MINOR MESH HEADINGS: Adolescence-; Corticotropin-deficiency; Fundus-Oculi; Hydrocortisone-therapeutic-use; Hyperplasia-; Infant,-Newborn; Levothyroxine-therapeutic-use; Magnetic-Resonance-Imaging; Thyrotropin-deficiency; Vitreous-Body-blood-supply MAJOR MeSH HEADINGS: *Abnormalities,-Multiple-diagnosis; *Brain-abnormalities; *Eye-Abnormalities-diagnosis; *Optic-Nerve-abnormalities; *Pituitary-Gland,-Posterior-abnormalities; *Septum-Pellucidum-abnormalities; *Vitreous-Body-pathology
Fetal Schizencephaly: Pre- And Postnatal Imaging With A Review Of The Clinical M
schizencephaly is a rare malformation of the central nervous system. Prenatalultrasound (US) allows diagnosis of schizencephaly, although prenatal magnetic
http://radiographics.rsnajnls.org/cgi/content/abstract/25/3/647

Extractions: This Article Figures Only Full Text Full Text (PDF) ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Oh, K. Y. Articles by Byrne, J. L. B. Related Collections Magnetic Resonance Imaging RSNA Karen Y. Oh, MD Anne M. Kennedy, MD Antonio E. Frias, Jr, MD and Janice L. B. Byrne, MD From the Departments of Radiology (K.Y.O., A.M.K.) and Obstetrics and Gynecology (A.E.F., J.L.B.B.), University of Utah, 30 N 1900 E, SOM1A71, Salt Lake City, UT 84132. Presented as an education exhibit at the 2003 RSNA Scientific Assembly. Received May 13, 2004; revision requested June 8; revision received and accepted July 12. All authors have no financial relationships to disclose. Address correspondence to K.Y.O. (e-mail:
RadioGraphics -- Sign In Page
schizencephaly is a rare malformation of the central nervous system. Six casesof schizencephaly were evaluated at one institution; prenatal US was
http://radiographics.rsnajnls.org/cgi/content/full/25/3/647

Extractions: This Article Abstract Figures Only Full Text (PDF) ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Oh, K. Y. Articles by Byrne, J. L. B. Related Collections Magnetic Resonance Imaging
Schizencephaly
Online. E - mail list for persons with schizencephaly (a rare, developmentaldisorder characterized by
http://webcenter.health.webmd.netscape.com/hw/brain_nervous_system/shc29sch.asp

Extractions: The above information was "verified" as correct on the date at the end of each entry. Since American Self-Help Group Clearinghouse's database is extensive but staffing is limited and information for these organizations can change, it is not possible to keep every entry in American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information. For additional information on self-help groups, please visit the American Self-Help Group Clearinghouse web site at http://www.mentalhelp.net/selfhelp
A Genetic Basis For Schizencephaly
Lhx2 may play a role in schizencephaly, septooptic dysplasia, Septo-opticdysplasia, a disorder often associated with schizencephaly,
http://hcs.harvard.edu/~husn/BRAIN/vol8-spring2001/schiz.htm

Extractions: A Genetic Basis for Schizencephaly Lhx2 may play a role in Schizencephaly, septo-optic dysplasia, and Joubert Syndrome by Allen Ho is a LIM homeodomain gene expressed by proliferating cells in the developing cerebral cortex. Based on its expression pattern and similarities to knockout mice, was investigated as a candidate gene for the human disorder schizencephaly, a rare cortical malformation characterized by a full-thickness cleft within the cerebral hemispheres. Septo-optic dysplasia, a disorder often associated with schizencephaly, and Joubert Syndrome, a cerebellar disorder, were also investigated. The human genomic sequence was defined and PCR protocols were developed to amplify DNA samples from both blood and paraffin-embedded brain tissue. The human gene was sequenced in nine patients with one or more of these malformations, with no definite mutations found in the known functional domains sequenced so far. A heterozygous sequence alteration is reported involving a hydrophobic to hydrophilic amino acid change in a hydrophobic polyalanine stretch with unknown functional significance. Also, two other reported heterozygous sequence alterations are identified involving base changes not predicted to result in a change to the protein coding sequence.
Radiology, University Of Rochester Medical Center
Discussion schizencephaly is an uncommon congenital disorder of cerebral schizencephaly may be associated with other central system anomalies such as
http://www.urmc.rochester.edu/smd/Rad/neurocases/Neurocase58.htm

Extractions: and P-L Westesson MD, PhD, DDS Clinical Presentation An 11-month-old male presented with perinatal stroke and right-sided weakness. Radiological Findings: Axial T1-weighted MR image showed a cleft at the posterior aspect of right frontal lobe connecting the extra-axial fluid space with the right lateral ventricle ( Fig. 1A ). The cleft was lined by gray matter, which had a small gap in between opposing surfaces indicating an open lip schizencephaly ( Fig. 1B ). Right cerebral hemisphere was smaller than left hemisphere. Septum pellucidum was absent giving a boxlike configuration of ventricles. The right lateral ventricle was mildly dilated ( Fig. 2A
Schizencephaly : Genetic Disorders : Disorders And Diseases : Health And Fitness
http//www.schizencephaly.com. Dedicated to the family, friends, and caregiversof individuals with schizencephaly. FAQs, forum, and resources.
http://www.internet-web-directory.com/Health_and_Fitness/Disorders_and_Diseases/

Extractions: Skip to Content Login/Register Search the entire directory only this category Advanced Search Web Directory Health and Fitness Disorders and Diseases ... Genetic Disorders Schizencephaly http://www.schizencephaly.com Dedicated to the family, friends, and caregivers of individuals with Schizencephaly. FAQs, forum, and resources. More Details Review It Rate It Bookmark It Sponsor Links Love Romance Dating
Sumer's Radiology Site: Schizencephaly
schizencephaly. SKSethi, RS SolankI Ind J Radiol Imag 2004 1419596 schizencephalyschizencephaly is one of the migrational disorders of brain,
http://sumerdoc.blogspot.com/2004/09/schizencephaly.html

Extractions: Two types are recognized: type I, or closed lip schizencephaly, in which the cleft walls are in apposition, and type II, or open lip schizencephaly, in which the walls are separated. In either instance the cleft is lined by heterotopic gray matter. The clefts can be unilateral or bilateral, symmetric or asymmetric.[2] Bilateral clefts have a worse prognosis for development, with seizures present in the majority. Patients may present with hemiparesis (more likely in unilateral forms) or tetraparesis (more likely in bilateral forms). Mental retardation and seizures are other common presentations, being more severe in bilateral clefts.[3] CT scans of closed lip schizencephaly may show only a slight outpouching, or "nipple" at the ependymal surface of the cleft. The full thickness cleft or the pial-ependymal seam may be difficult to detect on CT scans. Open lip schizencephaly has a larger, more apparent gray matter lined CSF cleft. The majority of patients have bilateral clefts, most of them roughly symmetrical in location and more likely open (type II) than closed (type I) the presence of heterotopic gray matter is considered pathognomic for schizencephaly, distinguishing it from an acquired condition. [4]
Sumer's Radiology Site: IMAGE QUIZ
ANSWERCLOSED LIP schizencephaly WITH HETEROTOPIC GRAY MATTER schizencephaly isone of the migrational disorders of brain, which include lissencephaly,
http://sumerdoc.blogspot.com/2005/03/image-quiz.html

Extractions: Two types are recognized: type I, or closed lip schizencephaly, in which the cleft walls are in apposition, and type II, or open lip schizencephaly, in which the walls are separated. In either instance the cleft is lined by heterotopic gray matter. The clefts can be unilateral or bilateral, symmetric or asymmetric. Bilateral clefts have a worse prognosis for development, with seizures present in the majority. Patients may present with hemiparesis (more likely in unilateral forms) or tetraparesis (more likely in bilateral forms). Mental retardation and seizures are other common presentations, being more severe in bilateral clefts.
Cephalic Disorder: Information From Answers.com
schizencephaly is a form of porencephaly. Individuals with clefts in both hemispheres, Patients with schizencephaly may also have varying degrees of
http://www.answers.com/topic/cephalic-disorder

Extractions: showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping cephalic disorder Wikipedia cephalic disorder Cephalic disorders are congenital conditions that stem from damage to, or abnormal development of, the budding nervous system . Cephalic is a term that means " head " or "head end of the body." Congenital means the disorder is present at, and usually before, birth Cephalic disorders are not necessarily caused by a single factor, but may be influenced by hereditary or genetic conditions, nutritional deficiencies, or by environmental exposures during pregnancy , such as medication taken by the mother, maternal infection, or exposure to radiation (such disorders are more common in areas of the former Soviet Union affected by nuclear waste disposal problems, such as the area around the Mayak plant in Chelyabinsk Russia .) Some cephalic disorders occur when the cranial sutures (the fibrous joints that connect the bones of the skull ) join prematurely. Most cephalic disorders are caused by a disturbance that occurs very early in the development of the
Open And Minimally Open Lips Schizencephaly. Srikanth SG, Jayakumar PN, Vasudev
Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India.
http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2000;volume=48;iss
Schizencephaly Associated With Bipolar Affective Disorder. Relan P, Chaturvedi S
Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India.
http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2002;volume=50;iss
Schizencephaly - St. Joseph Mercy, Ann Arbor Michigan
schizencephaly St. Joseph Mercy Health System Hospitals serving Ann Arbor, SEMichigan, Washtenaw County, Livingston County, Wayne County, Oakland County,
http://www.sjmercyhealth.org/15417.cfm

Extractions: @import url(default.css); Online Health Information Back to Health Library Print This Page Email to a Friend Schiz Kidz Buddies This information is provided as a resource and does not constitute an endorsement for any group. It is the responsibility of the reader to decide whether a group is appropriate for his/her needs. For evidence-based information on diseases, conditions, symptoms, treatment and wellness issues, continue searching this site. Online. The above information was "verified" as correct on the date at the end of each entry. Since American Self-Help Group Clearinghouse's database is extensive but staffing is limited and information for these organizations can change, it is not possible to keep every entry in American Self-Help Group Clearinghouse database completely current and accurate. Please check with the organizations listed for the most current information. For additional information on self-help groups, please visit the American Self-Help Group Clearinghouse web site at http://www.mentalhelp.net/selfhelp
Disabilityexchange.org - Taxonomy
schizencephaly. print Print this Page. What is schizencephaly? schizencephaly isan extremely rare developmental disorder characterized by abnormal slits,
http://www.disabilityexchange.org/taxonomy/index.php?fid=3&path=3_433
Dorlands Medical Dictionary
schizencephaly (schiz·en·ceph·a·ly) (skiz²schwansef¢schwa-le) schiz- + Gr.enkephalos brain schizencephalic porencephaly.
http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS
Schizencephaly
Dizygotic Twins with schizencephaly and Focal Cortical Dysplasia Location ofthe Primary Motor Cortex in schizencephaly Location of the Primary Motor
http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=266
Schizencephaly
schizencephaly. Bilateral open lip schizencephaly Bilateral open lipschizencephaly Closed lip schizencephaly Pediatric Radiology Faculty of
http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?offset=15&cat3=26

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