The EyePathologist Disease - O olivopontocerebellar atrophy type IV Klintworth, Gordon K. Olivopontocerebellaratrophy with retinal degeneration - Klintworth, Gordon K. http://www.eyepathologist.com/LIST.ASP?Title=O
Extractions: Alternative names OPCA; Olivopontocerebellar degeneration Definition Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Causes, incidence, and risk factors The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. This condition can be inherited or affect people without a known family history (sporadic form). Symptoms tend to start sooner in people with the familial form. This disease is slightly more common in men than in women. Symptoms Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include: Signs and tests A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition.
Multiple System Atrophy 2) Synonyms ShyDrager syndrome, olivopontocerebellar atrophy, striatonigraldegeneration 3 . Course Orthostatic hypotension and symptoms of autonomic http://www.alzheimer-adna.com/Gb/Diseases/MSA.html
Extractions: Orthostatic hypotension and symptoms of autonomic failure such as constipation, impotence in men, and urinary incontinence usually predominate early in the course of the disease. Constipation may be unrelenting and hard to manage. Shy-Drager syndrome may be difficult to diagnose in the early stages. For the majority of patients, blood pressure is low when the patients stand up and high when the patients lie down. Other symptoms that may develop include impaired speech, difficulties with breathing and swallowing, and inability to sweat.
MDVU Resource Library - Multiple System Atrophy ShyDrager syndrome, striatonigral degeneration, and olivopontocerebellaratrophy. while olivopontocerebellar atrophy principally affects balance, http://www.mdvu.org/library/disease/msa/
Extractions: Resource Library Movement Disorders Latest Multiple System Atrophy News from E-MOVE Resource Library Multiple System Atrophy Description Multiple system atrophy (MSA) is a neurodegenerative disease marked by a combination of symptoms affecting movement, blood pressure, and other body functions; hence the label "multiple system" atrophy. The cause of MSA is unknown. Various Forms of MSA Symptoms of MSA vary in distribution, onset and severity from person to person. Because of this, three different diseases were initially described to encompass this range of symptoms: Shy-Drager syndrome, striatonigral degeneration, and olivopontocerebellar atrophy. In Shy-Drager syndrome, the most prominent symptoms are those involving the autonomic system, the body system that regulates blood pressure, urinary function, and other functions not involving conscious control. Striatonigral degeneration causes parkinsonian symptoms such as slowed movements and rigidity, while olivopontocerebellar atrophy principally affects balance, coordination, and speech.
Ataxia olivopontocerebellar atrophy (OPCA) is characterized by loss of nerve cells olivopontocerebellar atrophy I (Menzel type OPCA) usually begins in the http://www.alaska.net/~mnewell/html/ataxia.html
Extractions: National Ataxia Foundation (NAF) (For people who have ataxia as a symptom of other medical conditions such as head injury, stroke, MS, or alcoholism, we recommend that you contact the organization related to your specific condition for the most up-to-date information. We will be happy to provide you with appropriate addresses and telephone numbers if needed.) What does NAF do?
Extractions: This monograph clearly illustrates the limitations associated with the genetic screening and diagnosis of this rare and often fatal disease in infants. The report elaborates the subtle differences in clinical presentation and genetic screening for Werdnig-Hoffman Disease vis a vis Olivopontocerebellar Atrophy. The case example provides evidence sufficient to caution geneticists not to confuse the two syndromes when rendering genetic counselling to families.
Extractions: Extracted from IndMED Pal PK; Rao SL; Jamuna N; Taly AB; Nagaraja D; Jayakumar PN; Shobini L Rao Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore - 560 029, India. Olivopontocerebellar atrophy and early onset cerebellar ataxia with retained tendon reflexes: a neuropsychological evaluation. NIMHANS J. 1995 July; 13(2): 101-9 KEYWORDS: Olivopontocerebellar Atrophy/PP; Cerebellar Ataxia/PP; Reflex, Stretch; Neuropsychological Tests; Neuropsychology; Psychological Tests; Tomography, X-Ray Computed; Age of Onset; Cognition; Cognition Disorders; Human; Male; Female; Adolescence; Adult; Middle Age Record Identifier: NM000495
Extractions: Vol. 106 No. 6, June 1988 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Traboulsi EI Moser H Contact me when this article is cited E. I. Traboulsi, I. H. Maumenee, W. R. Green, M. L. Freimer and H. Moser Eye Pathology Laboratory, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21205. The ocular histopathologic and electron microscopic findings were determined in eyes obtained at autopsy from twins with dominant olivopontocerebellar atrophy (OPCA) and retinal degeneration (OPCA type III). On light microscopy, a retinal degeneration that involved primarily
Neuroguide.com - Human Neurological Diseases olivopontocerebellar atrophy. * olivopontocerebellar atrophy Information (NINDS).Acid Maltase Deficiency, Acquired Epileptiform Aphasia, Acute Disseminated http://www.neuroguide.com/cgi-bin/pdistoc.pl?file=OlivopontocerebellarAtrophy
Entrez PubMed We report two sisters with congenital olivopontocerebellar atrophy, includingimmunohistochemical studies of autopsy brain tissue. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9
Entrez PubMed Xlinked olivopontocerebellar atrophy. Lutz R, Bodensteiner J, Schaefer B, Gay C.Department of Pediatrics, Oklahoma University College of Medicine. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2
Extractions: This Article Figures Only Full Text Full Text (PDF) ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Gilman, S. Articles by An, H. Neurology Articles S. Gilman, MD R. Little, PhD J. Johanns, MS M. Heumann, BA K. J. Kluin, MS L. Junck, MD R. A. Koeppe, PhD and H. An, MS From the Department of Neurology (Drs. Gilman and Junck, M. Heumann, and K.J. Kluin), Department of Biostatistics (Dr. Little, J. Johanns, and H. An), Department of Physical Medicine and Rehabilitation (K.J. Kluin), and Division of Nuclear Medicine, Department of Internal Medicine (Dr. Koeppe), University of Michigan, Ann Arbor, Michigan. Address correspondence and reprint requests to Dr. Sid Gilman, Department of Neurology, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0316
Extractions: Submit a response Alert me when this article is cited Alert me when Correspondence are posted ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Whitehouse, P. J. Articles by Kanazawa, I. PJ Whitehouse, O Muramoto, JC Troncoso and I Kanazawa We used in vitro receptor autoradiography to study four cases of olivopontocerebellar atrophy (OPCA) and three age- and postmortem delay- matched controls. In OPCA, benzodiazepine receptors were unchanged in cerebellar cortex but increased in the dentate nucleus, perhaps related to loss of Purkinje cell or brainstem afferents. Muscimol binding was reduced primarily in the granule cell layer. The density of muscarinic cholinergic
Extractions: This Article Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Savoiardo, M. Articles by Petrillo, R. M Savoiardo, L Strada, F Girotti, RA Zimmerman, M Grisoli, D Testa and R Petrillo Department of Neuroradiology, Istituto Nazionale Neurologico C. Besta, Milan, Italy. Clinical diagnosis of olivopontocerebellar atrophy (OPCA) must be confirmed by radiologic demonstration of atrophy in an appropriate distribution. OPCA may be associated with degeneration of other systems in multisystem atrophy (MSA). The authors report 23 cases of OPCA, eight of which were associated
RDInfo - Research And Development Information Details Of The Award Research Seed Money Grants for olivopontocerebellar atrophy (OPCA) and CloselyRelated Diseases Details (Hits 672) Last updated 14 April 2005 http://www.rdinfo.org.uk/Queries/ListGrantDetails.asp?GrantID=5476
