Entrez PubMed Cowden disease (CD) 158350, also known as multiple hamartoma syndrome, is amultisystemic cancer pr http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1
Extractions: This Article Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Hauser, H. Articles by Wettstein, P. H Hauser, B Ody, O Plojoux and P Wettstein The radiological findings in three cases of multiple hamartoma syndrome (MHS) (Cowden disease) are reported. MHS was associated with a widespread distribution of polyps of varied morphology along the gastrointestinal tract. There was an isolated case of bladder carcinoma, and the one woman studied had breast masses. In view of the nonspecific clinical findings in this disease, which may also suggest carcinoma, the importance of the
Penn State Faculty Research Expertise Database (FRED) Hamartoma Syndrome, Multiple Cowden s Disease, multiple hamartoma syndrome Disease, Cowden, Disease, Cowden s. Syndrome, Multiple Hamartoma http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D006223
Cowden Syndrome EPIDEMIOLOGY, CHARACTERIZATION. SYNONYMS, multiple hamartoma syndrome Multiple inverted follicular keratoses as a presenting sign of Cowden s syndrome http://www.thedoctorsdoctor.com/diseases/cowdensyndrome.htm
Extractions: Background Cowden syndrome (CS) is a autosomal dominant inherited syndrome. These patients are characterized by multiple hamartomas occurring in the skin, breast, thyroid, gastrointestinal tract, endometrium, and brain. Patients do have an increased risk of experiencing malignant tumors with the most common ones are breast, endometrial, and thyroid cancer. OUTLINE Epidemiology Disease Associations Pathogenesis Laboratory/Radiologic/ ... Internet Links DISEASE ASSOCIATIONS CHARACTERIZATION Bannayan-Zonnana syndrome Some cases show overlap with macrocephaly, intestinal polyps, and lipomas, and mulitple trichilemmomas are found in both diseases Genetic basis of these two diseases is identical. INVERTED FOLLICULAR KERATOSES Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: case report with human papillomavirus studies.
Extractions: References (6) View full size inline images Anesthesiology Volume 91(5) November 1999 p 1537 Omote, Keiichi M.D.*; Kawamata, Tomoyuki M.D.â ; Imaizumi, Hitoshi M.D.â¡; Namiki, Akiyoshi M.D., Ph.D§ *Assistant Professor, Department of Anesthesiology. â Instructor, Department of Anesthesiology. â¡Associate Professor, Department of Emergency Medicine. §Professor and Chairman, Department of Anesthesiology. Received from the Departments of Anesthesiology and Emergency Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan. Submitted for publication February 22, 1999. Accepted for publication June 22, 1999. Address reprint requests to Dr. Omote: Department of Anesthesiology, Sapporo Medical University School of Medicine, South-1, West-16, Chuoku, Sapporo, 060-8543, Japan. Address electronic mail to: komote@sapmed.ac.jp COWDEN'S disease, known also as multiple hamartoma syndrome, is a rare, predominantly inherited condition characterized by various ecto-, meso-, and endodermal benign and malignant tumors that may affect the skin; oropharyngeal, laryngeal, and gastrointestinal mucosa; thyroid; breast; and other organs.
The American Journal Of Dermatopathology - UserLogin multiple hamartoma syndrome. J Amer Acad Dermatol 1987;73426. Context Link Cowden s disease (multiple hamartoma and neoplasia syndrome). http://www.amjdermatopathology.com/pt/re/ajderm/fulltext.00000372-199808000-0001
The American Journal Of Dermatopathology - UserLogin multiple hamartoma syndrome. J Am Acad Dermatol 1987;173426. Medline Link ContextLink. 7. Pujol RM, Ravella A, Noguera X, de Moragas JM, http://www.amjdermatopathology.com/pt/re/ajderm/fulltext.00000372-199612000-0001
Log In Problems CS is a multiple hamartoma syndrome involving multiple organs. Cowden diseaseor multiple hamartoma syndrome cutaneous clue to internal malignancy. http://www.medscape.com/viewarticle/504044_print
Log In Problems Synonym multiple hamartoma syndrome See also Cowden Syndrome An autosomaldominant cancer syndrome characterized by a predisposition to early onset http://www.medscape.com/pages/sites/dnas/glossary/breastcancer
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Extractions: helpful? yes no Cowden disease: Cowden syndrome; Multiple Hamartoma syndrome Cowden disease (CD) is a rare inherited disorder of multiple hamartomas (non-cancerous tumour like growths) and an increased risk of a number of types of cancer . CD is named after the family of Rachel Cowden in whom the disorder was described in 1963. CD's mode of inheritance was identified in 1972 and the alternative name of Multiple Hamartoma syndrome was suggested. It is estimated that CD affects 1:300,000 individuals but is underdiagnosed. Both males and females are affected by CD. Onset is usually by the late 20s. CD is caused by mutations of the PTEN tumour suppressor gene on chromosome10. Features of CD may include: Hamartomas most commonly to be found on the skin and mucous membranes such as the lining of the mouth and nose but also in the intestines and other parts of the body; Non-cancerous tumours of the breast and thyroid;
Nature Publishing Group - 404 Page Cowden s syndrome, also known as multiple hamartoma syndrome, Cowden diseaseas multiple hamartoma syndromecutaneous clue to internal malignancy. http://www.nature.com/modpathol/journal/vaop/ncurrent/full/3800448a.html
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Neoplasms Cowden Disease (multiple hamartoma syndrome) C Miller eMedicine. Cowdens Syndromeand Bannayan-Riley-Ruvalcaba Syndrome Foundation http://www.mic.ki.se/Diseases/C04.html
Extractions: Diseases and Disorders Links pertaining to Neoplasms Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Adenoma Angiofibroma Arachnoid Cysts Arachnoid Cysts ... Uterine Neoplasms Neoplasms Cancer.gov including the PDQ database , a section on Cancer Treatment Information , a collection of Cancer Profilers (Treatment Decision Tools) , and a News Center - National Cancer Institute/NIH (US) OncoLink - Univ of Pennsylvania (US) MD Anderson Cancer Center including a set of Practice Guidelines - University of Texas (US) The Comprehensive Cancer Center at the University of Michigan (US) Medicine OnLine - UltiTech, Inc. The American Cancer Society , and Cancer Medicine 6th edition [full-text book online] Online Cancer Information and Support Electronic Groups [G Frydman] - ACOR Cancer Topic Pages at ASCO (US) What is your cancer risk?
An. Bras. Dermatol. Vol.78 no.2; Abstract: S0365-05962003000200008 A case of Cowden s disease or multiple hamartoma syndrome is reported. The disorderis inherited Keywords multiple hamartoma syndrome; Mouth diseases. http://www.scielo.br/scielo.php?pid=S0365-05962003000200008&script=sci_abstract&
Virtual Children's Hospital: Cancer: Cowden Syndrome It is also known as multiple hamartoma syndrome. Other related, but not identical,clinical conditions include RuvalcabaMyhre syndrome, Riley-Smith http://www.vh.org/pediatric/patient/cancercenter/cowden/othernames.html
Extractions: Last Revised: April 2002 Other Names The use of different names can be confusing. The problem started when several different groups of physicians and researchers began describing collections of features they observed in their patients. Each group believed that they were describing a new condition. Because CS consists of various features that occur at different times or not at all, the names became even more confused. Simply put, different people will show different features even though they have the same genetic condition. That was enough to make researchers at the time believe they were describing different conditions. In fact, scientists did not realize that all these names were describing one condition until 1986 when it was proposed that Bannayan syndrome and Ruvalcaba-Myhre syndrome were one and the same. In 1996, the overlap of features in CS and Bannayan-Riley-Ruvalcaba syndrome was recognized and molecular evidence for this observation was reported in 1997 and 1999. Since then, many names have been added to the list of syndromes. Below are several names that you may encounter as well. Bannayan-Zonana syndrome Riley-Smith syndrome Ruvalcaba-Myhre syndrome
Virtual Hospital: Cancer Prevention: Definition Of Terms Cowden Syndrome Also known as multiple hamartoma syndrome. Affects primarilywomen, causes skin rashes, tiny wartlike bumps, thyroid disease, http://www.vh.org/adult/patient/cancercenter/prevention/preventionterms.html
Extractions: Last Revision Date: April 2001 3rd edition Agammaglobulinemia : An immunologic deficiency characterized by extremely low levels of all classes of gamma-globulin in the blood. It is associated with the increased risk of colorectal cancer. Ataxia-Telangiectasia : This inherited disorder affects many multiple systems in the body, including progressive degeneration of the cerebellum, a part of the brain, the appearance of spider veins, immunodeficiency that leads to recurrent respiratory infections, and a predisposition to cancer. It may include cancer of the brain, breast, leukemia, lymphoma, skin, stomach and uterus. Basal Cell Nevus Syndrome Bloom Syndrome : An inherited disorder characterized by short height, a sun-sensitive redness on the face, susceptibility to infections, and a tendency to develop several types of cancers, including breast, cervix, colon, esophagus, larynx, lung, skin, and tongue cancers, and leukemia and lymphoma. : A mutation prevents this gene from producing a tumor suppression protein which controls cell growth. This gene was discovered in 1995 and is linked to breast and pancreatic cancer, and possibly colon and prostate cancer.
USCAP 2002 Annual Meeting Colorectal polyps in Cowden s disease (multiple hamartoma syndrome). Am J SurgPathol 8763770, 1984. Eckardt VF, Kanzler G, Remmele W. Anal rectal http://www.uscap.org/siteâ¼/91st/case4.htm
Extractions: The solitary rectal ulcer syndrome, localized colitis cystica profunda, and inflammatory cloacogenic polyp are closely allied conditions that have been linked to bowel prolapse. Affected patients often demonstrate abnormal function of the anal and pelvic floor musculature during defecation that leads to rectal mucosal prolapse or even intussusception. The resulting trauma is thought to cause the clinical symptoms and the pathologic changes. The term solitary rectal ulcer syndrome is quite a misnomer because the ulcers are often multiple, there is preulcer polypoid phase, and similar lesions occur in the anal canal and sigmoid colon. Additionally, colitis cystica profunda and inflammatory cloacogenic polyp are also misnomers. Since all three conditions share a common histologic appearance, clinical presentation, clinical course, and pathogenesis, I prefer to consider them together under the heading mucosal prolapse syndromes. Clinical Presentation
