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Microscopic Polyangiitis: more detail

Microscopic polyangiitis presenting with liver dysfunction preceding rapidly progressive necrotizing glomerulonephritis.(Case Report): An article from: Southern Medical Journal by Kohzo Takebayashi, Yoshimasa Aso, et all 2004-09-01
Microscopic polyangiitis in a pregnant woman. (Case Reports).: An article from: Southern Medical Journal by Ramazan Cetinkaya, Ali Riza Odabas, et all 2002-12-01

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Arthritis Research Campaign | Vasculitis
Disease such as microscopic polyangiitis, Wegener s granulomatosis and ChurgStrausssyndrome are In polyarteritis nodosa, microscopic polyangiitis,
http://www.arc.org.uk/newsviews/arctdy/107/vasc.htm

Extractions: south + southwest Professor David Scott, of the Norfolk and Norwich Hospital, explains the various diseases classed as vasculitis, and highlights ever-improving treatments. What it is Blood vessels carry blood and, therefore, oxygen to all organs and tissues in the body, so any part of the body can be involved in vasculitis. The consequences, therefore, depend on the site of the blood vessels involved, the size of the blood vessels involved and also the number of blood vessels involved. When small arteries are involved the inflammation often causes the artery to become blocked so the tissues supplied by that artery will die (i.e. become gangrenous). Surprisingly, when larger vessels are involved only part of the wall may become inflamed which can become weak and, because of the high pressure inside arteries, this weakness can cause the wall to expand forming an aneurysm (swelling) which can occasionally rupture with severe bleeding into the surrounding tissues. Who gets it and how it's diagnosed Vasculitis is rare. Around 5,00 people in the UK develop one of its various forms every year, including the more severe types such as polyarteritis nodosa, Wegener's granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis. These names are partly historical (relating to the doctors who first described the condition) and partly descriptive.
Arch Ophthalmol -- Abstract: Microscopic Polyangiitis With Ocular Involvement, M
microscopic polyangiitis is an exclusively smallvessel (arterioles, capillaries,or venules) vasculitis that primarily involves the kidney and often
http://archopht.ama-assn.org/cgi/content/abstract/114/3/346

Extractions: Vol. 114 No. 3, March 1996 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Caster JC Yee RW Contact me when this article is cited J. C. Caster, D. J. Shetlar, M. A. Pappolla and R. W. Yee Department of Ophthalmology, University of Texas Houston Health Science Center, USA. Microscopic polyangiitis is an exclusively small-vessel (arterioles, capillaries, or venules) vasculitis that primarily involves the kidney and often involves the lungs, skin, or nervous system. Characteristic features include focal segmental glomerulonephritis, nongranulomatous necrotizing vasculitis, and serum positive for perinuclear-staining antineutrophil
VASCULITIS
microscopic polyangiitis. Hypersensitivity vasculitis (Leukocytoclastic vasculitis) microscopic polyangiitis. Leukocytoclastic vasculitis
http://dermind.tripod.com/vasculitis.htm

Extractions: Search: Lycos Tripod Star Wars Share This Page Report Abuse Edit your Site ... Next VASCULITIS DERMATOLOGY LECTURE NOTES Debabrata Bandyopadhyay, Associate Head, Department of Dermatology, R.G.Kar Medical College Kolkata INDIA VASCULITIS Aetiology and pathogenesis Pathology Classification Clinical features ... Management T he vasculitides are a heterogeneous group of clinicopathological entities that share the common feature of vascular inflammation and injury. There is no universally acceptable classification of these group of disorders. While a number of underlying causes can be identified in some disorders, the aetiology is unknown in many. The pathogenetic mechanisms involved are mainly immunological, immune complex mediated tissue injury being the most commonly incriminated factor. Aetiology and pathogenesis While some forms of vasculitides may be ascribed to underlying factors like infections, malignancy, drug reactions or connective tissue disorders, the cause may remain undetermined in many vasculitic syndromes. Immunologic damage by immune-complex deposition or cell-mediated hypersensitivity is responsible in the majority of cases. The possible immunopathologic mechanism in the causation of vasculitis are . Deposition of circulating antigen-antibody complex or in -situ formation of immune complex within the vessel wall. This leads to complement activation and chemotactic attraction of neutrophils by complement components. Subsequent phagocytosis of such complexes with liberation of neutrophil granular products leads to vascular damage.
Progressive Obstructive Lung Disease Associated With Microscopic Polyangiitis --
airflow obstruction are unexpected features in patients with microscopicpolyangiitis. We report the case of a patient with microscopic polyangiitis and
http://ajrccm.atsjournals.org/cgi/content/abstract/155/2/739

Extractions: HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Brugiere, O. Articles by Fournier, M. Am. J. Respir. Crit. Care Med., Vol 155, No. 2, 02 1997, 739-742. O Brugiere, O Raffy, C Sleiman, O Groussard, E Rothchild, F Mellot, G Jebrak, H Mal, C Roue, R Pariente and M Fournier Service de Pneumologie et Reanimation Medicale, Hopital Beaujon, Clichy, France. Small airway involvement and progressive severe airflow obstruction are unexpected features in patients with microscopic polyangiitis. We report the case of a patient with microscopic polyangiitis and circulating anti-neutrophil cytoplasmic antibodies (ANCA), who developed pulmonary hyperinflation and airflow obstruction over a 7-yr period. Systemic
Neurology -- Sign In Page
Conversely, microscopic polyangiitis (MPA) is a systemic disorder characterizedby necrotizing vasculitis with few or no immune deposits, affecting small
http://www.neurology.org/cgi/content/full/63/9/1722

Extractions: This Article Abstract Figures Only Full Text (PDF) ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Furukawa, Y. Articles by Yamada, M. Related Collections All Immunology
Postgraduate Medicine: Symposium: Rheumatologic Diseases
microscopic polyangiitis lacks the immune complex deposition in the blood vessels Treatment of microscopic polyangiitis is the same as that of Wegener s
http://www.postgradmed.com/issues/1998/02_98/bush.htm

Extractions: Thomas M. Bush, MD VOL 103 / NO 2 / FEBRUARY 1998 / POSTGRADUATE MEDICINE This page is best viewed with a browser that supports tables This is the first of five articles on rheumatologic diseases Preview : Systemic vasculitis can be difficult to recognize because of the many types of the disease and the conditions that can mimic it. However, early identification and initiation of treatment (often empirical) are important to avoid severe morbidity. In this symposium article, Dr Bush clearly describes the most common types of vasculitis according to current nomenclature based on the size of affected vessels. Illustrations of common signs of the various types of vasculitis are also included. S ystemic vasculitides are characterized by aberrant immune responses that result in inflammation and necrosis of blood vessels. The immune dysfunction may be triggered by infection, autoimmune disease, or exposure to a drug; often the cause is unknown. The categorization of vasculitis by the size of the involved blood vessels is a useful guide to diagnosis and therapy(1-3) (table 1). The most recent nomenclature for vasculitis was developed by a multispecialty panel at the Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitis (3). This article presents a review of the chief types of vasculitis with an emphasis on important diagnostic features. Table 1. Classification of systemic vasculitis
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microscopic polyangiitis Associated with Diffuse Panbronchiolitis Microscopicpolyangiitis with MPOANCA is considered to be frequently associated with
http://www.naika.or.jp/im2/43/04/15c.aspx

Extractions: Microscopic Polyangiitis Associated with Diffuse Panbronchiolitis Jangchul Park, Shogo Banno, Yoshiki Sugiura, Kosho Yoshikawa*, Taio Naniwa, Kaori Wakita, Yoshihito Hayami, Shigeki Sato and Ryuzo Ueda There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis. (Internal Medicine 43: 331â335, 2004)
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and PANCA staining in microscopic polyangiitis (but also in Wegener sgranulomatosis which may be a renal-limited form of microscopic polyangiitis.
http://ppv.ovid.com/pt/re/adch/fulltext.00000740-199709000-00023.htm
Hospital Practice: Management Of Rapidly Progressive Glomerulonephritis
AntiMPO is associated with what we now call microscopic polyangiitis. Once the serologic diagnosis of microscopic polyangiitis has been established,
http://www.hosppract.com/issues/2000/02/dmmglas.htm

Extractions: Serologic studies now permit early and easy identification of renal vasculitis, and current treatment regimens boast short-term survival rates of greater than 85%. Still, achieving an optimal outcome requires that the diagnostic process be set in motion promptly, before the disease causes irreversible renal damage. Dr. Glassock is Professor Emeritus, Department of Medicine, University of California, Los Angeles, UCLA School of Medicine. Dr. Henrich is Chairman, Department of Medicine, University of Maryland Hospital, Baltimore. A 58-year-old man, an international business consultant, presented to his primary care physician complaining of fever, cough, and weight loss. The patient reported that he had been healthy until about a month earlier, when a low-grade fever developed along with a cough productive of whitish sputum that was occasionally streaked with blood. His weight had dropped by about 6.8 kg, and he felt weak and tired. Ten years ago, he had received a blood transfusion in a foreign country after an automobile accident that had resulted in a fractured leg and a lung contusion. The patient smoked two packs of cigarettes a day and drank alcohol moderately. There was no family history of cancer, tuberculosis, or kidney disease.
LU:research - Lund University Institutional Archive
special reference to Wegener´s granulomatosis and microscopic polyangiitis or microscopic polyangiitis with renal involvement, KerstinW A Westman,
http://lu-research.lub.lu.se/php/gateway.php?who=lr&method=getfile&file=archive/
NEJM -- Sign In
Does the patient have polyarteritis nodosa or microscopic polyangiitis? Severe systemic microscopic polyangiitis would be unusual without involvement of
http://content.nejm.org/cgi/content/full/338/14/994

Extractions: SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. Log in via Athens. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.
Microscopic Polyangiitis: First Report Of A Case With Onset During Pregnancy --
Hypersensitivity vasculitis (microscopic polyangiitis) in pregnancy with transmissionto microscopic polyangiitis in a pregnant woman. South Med J 2002;
http://ndt.oxfordjournals.org/cgi/content/full/19/1/234

Extractions: This Article Extract FREE Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Download to citation manager Search for citing articles in: Case Report Kate L. Milne Katharine P. Stanley Rosemary C. Temple Tim H. Barker and Calum N. Ross Department of Renal Medicine, Department of Obstetrics and Gynaecology, Department of Diabetes and Endocrinology and Department of Histopathology, Norfolk and Norwich University Health Care Trust, Norwich, UK Correspondence and offprint requests to : Kate Milne, Department of Renal Medicine, Norfolk and Norwich University Health Care Trust, Norwich, Norfolk, UK. Email:
BioMed Central | Abstract | Historical Perspective Of Vasculitis: Polyarteritis
Historical Perspective of Vasculitis Polyarteritis Nodosa and MicroscopicPolyangiitis Eric L Matteson MD, MPH Division of Rheumatology, 200 1st Street SE,
http://www.biomedcentral.com/1523-3774/4/67/abstract

Extractions: The original and early case reports of vasculitis provide a historical context and foundation for understanding current concepts of these diseases. These early case reports are valuable as reference points for the current efforts in diagnosing, treating, and classifying vasculitis. In addition, they emphasize the importance of careful clinical observation in these efforts and the essential nature of medical science. Polyarteritis nodosa was the first noninfectious vasculitis to be described and studied in detail. Research on this group of vasculitides has been the cornerstone for understanding the pathophysiology of other forms of idiopathic vasculitis. Historically, most forms of vasculitis described subsequently have been characterized and classified on the basis of features similar to or distinct from polyarteritis.

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