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Metachromatic Leukodystrophy: more detail

The Official Parent's Sourcebook on Metachromatic Leukodystrophy: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2002-09-11
Leukodystrophies: Adrenoleukodystrophy, Canavan Disease, Pelizaeus-Merzbacher Disease, Metachromatic Leukodystrophy, Krabbe Disease
Metachromatic leukodystrophy: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Igor, MD, PhD Medica, 2005

lists with details

AllRefer Health - Metachromatic Leukodystrophy (Arylsulfatase A Deficiency, MLD)
metachromatic leukodystrophy (Arylsulfatase A Deficiency, MLD) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence,
http://health.allrefer.com/health/metachromatic-leukodystrophy-info.html

Extractions: AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Alternate Names : Arylsulfatase A Deficiency, MLD Definition Metachromatic leukodystrophy is an inherited disease characterized by the absence of the enzyme arylsulfatase A, which causes a material called cerebroside sulfate to accumulate in cells. This is toxic to the cell, especially neurons (the cells of the nervous system) and causes the problems of the disease. MLD is a member of a class of diseases called lysosomal storage disorders. In these diseases, patients lack a protein needed to metabolize the food we eat.
EMedicine - Metachromatic Leukodystrophy Article By Theodore
metachromatic leukodystrophy metachromatic leukodystrophy (MLD) is part of a larger group of lysosomal storage diseases, some of which are
http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
AllRefer Health - Metachromatic Leukodystrophy Prevention (Arylsulfatase A Defic
metachromatic leukodystrophy (Arylsulfatase A Deficiency, MLD) information center covers Prevention.
http://health.allrefer.com/health/metachromatic-leukodystrophy-prevention.html

Extractions: AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia
BBC - H2g2 - Category Index Of Guide Entries
Medical Maggots. Mental Health. Metabolic Diseases. metachromatic leukodystrophy A Genetic Disease. Microbes - Good or Bad? Migraine.
http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Leukodystrophy, Metachromatic
metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic
http://my.webmd.com/hw/health_guide_atoz/nord212.asp

Extractions: Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of metachromatic leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness.
► Metachromatic Leukodystrophy
A medical encycopedia article on the topic metachromatic leukodystrophy.
http://www.umm.edu/ency/article/001205.htm

Extractions: Causes, incidence, and risk factors: Metachromatic leukodystrophy (MLD) is transmitted as an autosomal recessive trait. MLD has a wide range of symptoms. As with many other storage diseases, there are forms of early and delayed onset (late infant, juvenile and adult types). The most common (and the most severe form) is the late infant onset form, which has symptoms such as irritability decreased muscle tone muscle wasting , the loss of the ability to walk. Debility is progressive with blindness seizures , and partial paralysis . Death occurs usually before age 10.
OMIM - METACHROMATIC LEUKODYSTROPHY
http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=250100
Entrez PubMed
Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1
Metachromatic Leukodystrophy MLD Cure, Research, Genetics, Testing
metachromatic leukodystrophy diagnosis, research, cure, treatment (bone marrow, MSC, stem cell transplant), therapy, care, support, information,
http://www.mldfoundation.org/MLD101.html
MedlinePlus Medical Encyclopedia: Metachromatic Leukodystrophy
metachromatic leukodystrophy (MLD) is a genetic disorder that affects nerves metachromatic leukodystrophy is caused by a mutation in the gene that makes
http://www.nlm.nih.gov/medlineplus/ency/article/001205.htm

Extractions: @import url(/medlineplus/images/advanced.css); Skip navigation Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Contents of this page: Alternative names MLD; Arylsulfatase A deficiency Definition Return to top Metachromatic leukodystrophy (MLD) is a genetic disorder that affects nerves, muscles, and other organs. It gets progressively worse over time. MLD is usually caused by the lack of an important enzyme called arylsulfatase A. Because this enzyme is missing, chemicals called sulfatides accumulate in the nervous system, kidneys, gallbladder, and other organs. The sulfatides damage the nerves and organs where buildup occurs. In particular, it damages the myelin sheaths that surround nerve cells. There are three forms, based on when the symptoms begin: Late infantile symptoms usually begin by age 4. The symptoms include problems walking, loss of muscle control, and loss of mental functions. Juvenile symptoms begin between 4 and 6 years old. The child has trouble walking and loses developmental milestones. The first sign may be deteriorating school performance.
Treatment Of Metachromatic Leukodystrophy At Mayo Clinic
Read more about diagnosis of metachromatic leukodystrophy. Treatment Options. Treatment options for metachromatic leukodystrophy are very limited.
http://www.mayoclinic.org/metachromatic-leukodystrophy/

Extractions: at Mayo Clinic (Synonyms: arylsulfatase A deficiency, white matter diseases) Metachromatic leukodystrophy (MLD) is a genetically inherited disorder, passed on from parents to their biological child, in which the brain and nervous system progressively deteriorate, the person loses brain and body functions and eventually dies. Mayo Clinic has experience in diagnosing and caring for patients with MLD, treating more than 150 such patients each year (the vast majority in Rochester). Treatment programs are tailored to each individual and take into account the needs of the patient and family, while providing state-of-the-art care and access to new developments and appropriate clinical trials. The patient will first have a complete physical examination, along with a detailed history of symptoms and family inherited disorders, including metachromatic leukodystrophy. Various tests may be required to aid in an accurate diagnosis. Read more about diagnosis of metachromatic leukodystrophy Treatment options for metachromatic leukodystrophy are very limited. Bone marrow transplantation, when performed early in the course of the disease, has been used effectively on appropriate patients, but also poses some risk. Gene therapy research may eventually lead to a cure or treatment to slow the progression of MLD disease. Genetic testing and genetic counseling are strongly recommended for adults with a family history of MLD. Read more about
Symptoms Of Metachromatic Leukodystrophy
The symptoms of metachromatic leukodystrophy vary, depending on the age they develop and in Because metachromatic leukodystrophy is relatively rare,
http://www.mayoclinic.org/metachromatic-leukodystrophy/symptoms.html

Extractions: Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Metachromatic Leukodystrophy Metachromatic Leukodystrophy Overview Diagnosis Symptoms of MLD Treatment Options ... Medical Services The symptoms of metachromatic leukodystrophy vary, depending on the age they develop and in degree of severity. Because metachromatic leukodystrophy is relatively rare, and the symptoms mimic other diseases, patients with MLD may be misdiagnosed. Children may be diagnosed with crebral palsy, deterioration in learning skills or behavioral disturbances. For people with late juvenile or adult MLD, early symptoms may mimic mental illness or psychiatric disorders. There are four forms of MLD. The forms and their symptoms are: Late infantile This is the most common form of metachromatic leukodystrophy. Symptoms appear at age 4 or younger and may include: Loss of motor development milestones, such as losing the ability to walk or stand up Problems walking (gait disturbances) Behavioral changes, such as increased irritability or decreased attention span
Metachromatic Leukodystrophy Medical Information
metachromatic leukodystrophy Information from Drugs.com.
http://www.drugs.com/enc/metachromatic_leukodystrophy.html

Extractions: Advanced Search Or click the first letter of a drug name: A B C D ... Z Injury Disease Nutrition Poison ... Z Metachromatic leukodystrophy (MLD) is a genetic disorder that affects nerves, muscles, and other organs. It gets progressively worse over time. MLD is usually caused by the lack of an important enzyme called arylsulfatase A. Because this enzyme is missing, chemicals called sulfatides accumulate in the nervous system, kidneys, gallbladder, and other organs. The sulfatides damage the nerves and organs where buildup occurs. In particular, it damages the myelin sheaths that surround nerve cells. There are three forms, based on when the symptoms begin:
Metachromatic Leukodystrophy (Sulfatidosis) NeuroLearn NeuroHelp
Summary Sulfatidosis (metachromatic leukodystrophy) is a systemic disease metachromatic leukodystrophy is due to deficiency of cerebroside sulfatase.
http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNF5IE01.htm

Extractions: Metachromatic Leukodystrophy (Sulfatidosis) NeuroLearn NeuroHelp Metabolic Lysosomal storage disorders, classification ... Gross Pathology BACKGROUND AND CLINICAL INFORMATION Head Summary: Sulfatidosis (metachromatic leukodystrophy) is a systemic disease that affects the CNS, PNS, and other organs. There are two common clinical subtypes and two rare clinical subtypes. Biochemically, it is characterized by abnormal catabolism of cerebroside sulfate resulted from deficiency of cerebrosulphatase and lead to accumulation ofcerebroside sulfate. The clinical test tests for arysulfatase A activity and pseudodeficiency can occur. Histologically characterized by demyelination and dysmyelination with accumulation of metachromatic inclusion bodies, presumably derivatives of cerebroside sulfate. Rare cases due to deficiency of saponin B, a co-factor necessary for cerebrosulphatase activity, can occur. Biochemistry: Cerebroside sulfate requires both cerebrosulphatase and saposin B, a co-factor, for its catabolism. The catabolism of sulfatide, a sphingolipid that is normal consistuent of myelin and cellular membranes, is defective in this disease. Metachromatic leukodystrophy is due to deficiency of cerebroside sulfatase. Sulfatide is stored in the lysosomes of oligodendrocytes and Schwann cells and also in many somatic tissues. No clinical manifestation is apparent when arylsulfatase is 10% or higher of normal level. Diagnostic test: In addition to the arylsulfatase, A deficiency, there is a loss of activity of arylsulfatases B and C, and other sulfatases involved in mucopolysaccharide degradation. Prenatal diagnosis can be made by enzymatic assay in aminocytes or chorionic villi. Pseudodeficiency may raise a difficult problem for prenatal diagnosis.
Leukodystrophy, Metachromatic
metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain
http://www.bchealthguide.org/kbase/nord/nord212.htm

Extractions: It is possible that the main title of the report Leukodystrophy, Metachromatic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of metachromatic leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness.
[ What Is MLD ] - Bethanys Hope - MLD Research
metachromatic leukodystrophy (MLD), the most common form of Leukodystrophy, Symptoms of metachromatic leukodystrophy may include convulsions, seizures,
http://www.bethanyshope.org/mld.html

Extractions: Metachromatic Leukodystrophy Metachromatic Leukodystrophy (MLD), the most common form of Leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (Leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of Metachromatic Leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness.
Partners Leukodystrophy Service At MGH
After XALD, metachromatic leukodystrophy (MLD) is the most frequently observed leukodystrophy. It is a progressive disorder, transmitted by autosomal
http://fisher.mgh.harvard.edu/leuko/metochromatic.html

Extractions: Future and ongoing studies After X-ALD, Metachromatic leukodystrophy (MLD) is the most frequently observed leukodystrophy. It is a progressive disorder, transmitted by autosomal recessive inheritance. Epidemiology After X-ALD, Metachromatic leukodystrophy (MLD) is the most frequently observed leukodystrophy. One in 40,000 births are affected. Return to top MLD manifests in a late infantile, juvenile and adult form. A progressive dementia is the primary manifestation of the disease. Peripheral neuropathy is a prominent disease manifestation in the late infantile and juvenile forms. Patients with the adult form of MLD may initially present with psychiatric disease or, more rarely, isolated peripheral neuropathy. Unlike X-ALD, MLD demonstrates a close genotype to phenotype correlation with only one form of the disease developing in a particular family. Clinical Subtypes Return to top MRI of brain shows a frontal predominant confluent white matter lesion with preferential thinning of the rostral corpus callosum (Faerber, Melvin et al. 1999).
Blackwell Synergy - Cookie Absent
metachromatic leukodystrophy is associated with impaired myelination caused by There has been only one report of metachromatic leukodystrophy studied by
http://www.blackwell-synergy.com/doi/abs/10.1034/j.1600-0455.2003.00094.x

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Metachromatic Leukodystrophy Of The Brain
metachromatic leukodystrophy of Brain From the Virtual Pathology Museum, Department of Pathology, University of Connecticut Health Center.
http://radiology.uchc.edu/eAtlas/CNS/1723.htm
Metachromatic Leukodystrophy
metachromatic leukodystrophy metachromatic leukodystrophy (MLD) is transmitted as an autosomal recessive trait, which means that a person must inherit
http://www.lifespan.org/ADAM/English/HIE/001205.htm

Extractions: Other ways to give Injury Disease Nutrition Poison ... Prevention Metachromatic leukodystrophy is an inherited disease characterized by the absence of the enzyme arylsulfatase A, which causes a material called cerebroside sulfate to accumulate in cells. This is toxic to the cell, especially neurons (the cells of the nervous system) and causes the problems of the disease. MLD is a member of a class of diseases called lysosomal storage disorders. In these diseases, patients lack a protein needed to metabolize the food we eat. MLD; Arylsulfatase A deficiency Metachromatic leukodystrophy (MLD) is transmitted as an autosomal recessive trait, which means that a person must inherit the defective gene from both parents to be affected. MLD has a wide range of symptoms. As with many other storage diseases, there are forms of early and delayed onset (late infant, juvenile, and adult types). The most common and most severe form is the late infant onset form, which has symptoms such as

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