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Krabbe Disease:     more detail

Krabbe's Disease: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References by Icon Health Publications, 2004-10-08 Krabbe disease: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Amie, MS Stanley, Rosalyn, MD Carson-DeWitt, 2005 Krabbe Disease - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-18 Krabbe disease: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Amie, MS Stanley, 2005 Leukodystrophies: Adrenoleukodystrophy, Canavan Disease, Pelizaeus-Merzbacher Disease, Metachromatic Leukodystrophy, Krabbe Disease Neurology, lectures for medical students and general practitioners by Knud H Krabbe, 1941 Urolithiasis in dogs and cats by Agnete Krabbe, 1949

lists with details

41. Krabbe Disease Definition - Medical Dictionary Definitions Of Popular Medical Te
    Online Medical Dictionary and glossary with medical definitions.  
    http://www.medterms.com/script/main/art.asp?articlekey=21076

42. Krabbe Disease
    krabbe disease. Synonym(s) Globoid Cell Leukodystrophy. What is krabbe disease?krabbe disease is a rare, degenerative disorder of the central and  
    http://www.clevelandclinic.org/health/health-info/docs/1200/1293.asp?index=6039&

43. Show-documents.asp
    krabbe disease (Globoid Cell Leukodystrophy) Written Information. Care Treatment. krabbe disease New Search Contact Us Disclaimer Send This Link  
    http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=1315

44. Article: NINDS Krabbe Disease Information Page: NINDS - WrongDiagnosis.com
    Medical article NINDS krabbe disease Information Page NINDS including all symptom,diagnosis, misdiagnosis, treatment and prevention information.  
    http://www.wrongdiagnosis.com/artic/ninds_krabbe_disease_information_page_ninds.
    
    Extractions: Krabbé disease is a rare, degenerative disorder of the central and peripheral nervous systems. It is one of a group of genetic disorders called the leukodystrophies that affect the growth of the myelin sheath, the fatty covering-which acts as an insulator-on nerve fibers in the brain. Symptoms vary in prevalence and severity among patients and may include loss of previously attained developmental skills, unexplained fevers, irritability, myoclonic seizures (sudden, shock-like contractions of the limbs), blindness, spasticity (stiffness of the limbs), and paralysis. Prolonged weight loss may occur also. Onset of the disorder generally occurs at 3 to 6 months of age, but juvenile and even adult-onset patients are known. Is there any treatment?

45. Introduction: Krabbé Disease - WrongDiagnosis.com
    Introduction to Krabbé Disease as a medical condition including symptoms, diagnosis, 1. excerpt from NINDS krabbe disease Information Page NINDS  
    http://www.wrongdiagnosis.com/k/krabbe_disease/intro.htm
    
    Extractions: Krabbé Disease: Krabbé disease is a rare, degenerative disorder of the central and peripheral nervous systems. It is one of a group of genetic disorders called the leukodystrophies that affect the growth of the myelin sheath, the fatty covering-which acts as an insulator-on nerve fibers in the brain. Researching symptoms of Krabbé Disease: Further information about the symptoms of Krabbé Disease is available including a list of symptoms of Krabbé Disease , or alternatively return to research other symptoms in the symptom center Treatments for Krabbé Disease: Various information is available about treatments available for Krabbé Disease , or research treatments for other diseases.

46. AllRefer Health - Krabbe Disease Treatment (Galactosylcereamidase Deficiency, Ga
    krabbe disease (Galactosylcereamidase Deficiency, GalactosylcerebrosidaseDeficiency, Globoid Cell Leukodystrophy) information center covers Treatment.  
    http://health.allrefer.com/health/krabbe-disease-treatment.html
    
    Extractions: AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Alternate Names : Galactosylcereamidase Deficiency, Galactosylcerebrosidase Deficiency, Globoid Cell Leukodystrophy Krabbe Disease Treatment There is no specific treatment for Krabbe disease. Bone marrow transplantation (with its own risks) has been attempted in early stages of the disease. It is too early to know if the new bone marrow can fully restore the brain to health in the small number of patients who have had this treatment. In the future there may be 'enzyme replacement therapy,' but it is in the early stages of development as of 2003. Prevention by prenatal or genetic testing is available.

47. AllRefer Health - Krabbe Disease Prevention (Galactosylcereamidase Deficiency, G
    krabbe disease (Galactosylcereamidase Deficiency, GalactosylcerebrosidaseDeficiency, Globoid Cell Leukodystrophy) information center covers Prevention.  
    http://health.allrefer.com/health/krabbe-disease-prevention.html
    
    Extractions: AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Alternate Names : Galactosylcereamidase Deficiency, Galactosylcerebrosidase Deficiency, Globoid Cell Leukodystrophy Krabbe Disease Prevention Genetic counseling is recommended for prospective parents with a family history of Krabbe disease. Whether you are a carrier for the disease can be determined by testing your white blood cells or skin cells for decreased galactocerebroside beta-galactosidase levels. Prenatal diagnosis is possible by measuring galactocerebroside beta-galactosidase levels in cultured amniotic fluid cells or from cultured chorionic villi cells.

48. The DRM WebWatcher: Krabbes Disease
    bullet krabbe disease Technical information from Online Mendelian Inheritance in The pages include information about krabbe disease, a message board,  
    http://www.disabilityresources.org/KRABBES.html

49. Short Description Of Cell Lines. Pathology: Krabbe Disease *245200
    Pathology krabbe disease *245200 OMIM record. By selecting the cell line name,you will receive the detailed description of the cell line  
    http://www.biotech.ist.unige.it/cldb/pat105.html

50. IRSC - Rare Disorders, Krabbe Disease
    The Internet Resources for Special Children (IRSC) Global disABILITY resourceis dedicated to communicating information relating to the needs of children  
    http://www.irsc.org:8080/irsc/irscmain.nsf/sub?readform&cat=Rare Disorders&subca

51. IRSC - Rare Disorders, Krabbe Disease
    The Internet Resources for Special Children (IRSC) Global disABILITY resourceis dedicated to communicating information relating to the needs of children  
    http://www.irsc.org:8080/irsc/irscmain.nsf/sub?readform&cat=Rare Disorders&subca

52. KRABBE DISEASE: Contact A Family - For Families With Disabled Children: Informat
    Contact a Family is a UK charity for families with disabled children. We offerinformation on specific conditions and rare disorders.  
    http://www.cafamily.org.uk/Direct/k24.html
    
    Extractions: helpful? yes no Krabbe disease is a rare genetic, degenerative disorder of the nervous system. It is one of a group of genetic disorders called the leukodystrophies. The term leukodystrophy comes from the Greek words, 'leuko' meaning white, and referring to the 'white matter' of the nervous system. This is a fatty cover which acts as an insulator around nerve fibres of the brain. The word 'dystrophy' means imperfect growth or development. In Krabbe disease the growth of the white matter (otherwise known as myelin sheath) is affected. Each nerve in the body is surrounded by myelin sheath. This transmits the electrical impulses to every other nerve in the body. Myelin sheath is a made up of a number of chemicals and Krabbe disease is caused by reduced activity of an enzyme known as galactocerebrosidease (GALC). This enzyme is coded for by a gene on chromosome 14. In addition to the infantile form of Krabbe disease, there are also juvenile and adult forms. Although older infants and juveniles with the disorder regress at an unpredictable rate, all will become severely incapacitated. Some adolescents and adults have symptoms confined to weakness, without intellectual deterioration, others become bedridden and continue to deteriorate mentally and physically. Adults may present with loss in manual dexterity, burning paraesthesia (numbness or tingling) in extremities, weakness and dementia. It is nearly impossible to predict the life expectancy of a newly diagnosed older infantile, juvenile, adolescent or adult patient.

53. Partners Leukodystrophy Service At MGH
    1983), mimics the krabbe disease phenotype. These mice develop normally until 22days then twitch their heads, develop paralysis and die at around day 45  
    http://fisher.mgh.harvard.edu/leuko/globoid.html
    
    Extractions: Treatment It is rare. There is significant clustering of the disease among the Druze community in Israel. 90% of patients present, before 6 months of age, with central and peripheral nervous system disease. These infants develop fevers, myoclonic seizures, blindness, spasticity and paralysis and usually die before their second birthday. The remaining 10% can develop disease at any age, with adults sometimes presenting with a painful peripheral neuropathy. Return to top Testing The disease has a radiologically characteristic pattern: The diagnosis is made by assaying the activity of galctosylcerebrosidase. Pathology Krabbe is pathologically characterized by oligodendroglial apoptosis, severe gliosis and large, multinucleated (globoid) cells which arise from microglia (Suzuki and Tanaka 1976). Return to top Characterized by the accumulation of psychosin (glactosphingosine), which is the substrate for galactocerebroside beta-galactosidase, the enzyme whose activity is deficient in this disorder.

54. Indian Pediatrics - Editorial
    Conclusion krabbe disease should be considered in the differential diagnosis TABLE 1–Clinical Features and Investigations in Infantile krabbe disease.  
    http://www.indianpediatrics.net/sept2000/sept-939-946.htm
    
    Extractions: Revision accepted: April 13, 2000. Objective: To study clinical features and investigations of children with Krabbe Disease (KD). Design: Retrospective. Setting: Genetic Clinic of a tertiary care teaching hospital. Methods: Hospital records of patients with enzymatically confirmed KD were analyzed with respect to their clinical features and investigations including neuroimaging (CT-scan and/or MRI). Galactocerebrosidase (GALC) activity was estimated photometrically in the peripheral blood leukocytes. Results: Nine children (age ranging from 2½ months to 8 years) were studied, of which 5 had the classical infantile disease, 3 had late infantile form and one was diagnosed as juvenile KD. GALC levels in peripheral blood leukocytes were low or absent in all. Most of the children with infantile disease presented with neurodegeneration, seizures or fever. Optic atrophy was uncommon in our series (present only in a single case). Majority of the cases had elevated cerebrospinal fluid (CSF) protein levels and peripheral neuropathy on nerve conduction (NC) studies. Findings typical of KD were noted in 7 patients who underwent magnetic resonance imaging (MRI). The sole patient with juvenile disease presented with developmental delay and progressive spastic quadriparesis.

55. Newborn Screening For Krabbe Disease Petition
    Newborn Screening For krabbe disease Petition, hosted at PetitionOnline.com.  
    http://www.petitiononline.com/3018/petition.html
    
    Extractions: The Newborn Screening For Krabbe Disease Petition to U.S. Congress and Mississippi Senate was created by and written by Randy Tuggle www.PetitionOnline.com as a public service. There is no endorsement of this petition, express or implied, by Artifice, Inc. or our sponsors. For technical support please use our simple Petition Help form. Send this to a friend Send Petition to a Friend Petition FAQ Start a Petition ... Search http://www.PetitionOnline.com/3018/petition.html

56. Add Krabbe Disease To Newborn Screening Petition
    Add krabbe disease to newborn screening Petition, hosted at PetitionOnline.com.  
    http://www.petitiononline.com/krabbe/petition.html
    
    Extractions: Krabbe disease (globoid cell leukodystroy) is a terminal disease with a life expencancy of 8-16 months, with 80% being babies most children do not make it to 2 years. There is a treatment now for Krabbe disease and this treatment has been successful in several Krabbe babies, this treatment gives our children hope for a future. However, only if diagnosed prior to symptoms can this treatment be successful. We must test our babies at birth so no other babies will have to die from Krabbe disease.

57. Krabbe's Disease
    krabbe disease This one is odd. We have seen such a wide spectrum of cases with In the case of krabbe disease, the defect is even more damaging than an  
    http://www.pediatric-orthopedics.com/Topics/Muscle_Neuro/Diseases/KRABBE_DISEASE
    
    Extractions: Krabbe Disease Krabbe Disease This one is odd. We have seen such a wide spectrum of cases with this diagnosis that one wonders if the details are as worked out as the literature would have you believe. The defect is in galactos yl ceramid ase I, an enzyme which removes the sugar called galactose from galactosyl sphingosine . Look at the Lipids and Membranes sections to get a feel for how utterly basic to cell membrane function these substances are. The differing tweaks of similar phospholipids - tall oil molecules wearing a water seeking cap. In the case of Krabbe Disease, the defect is even more damaging than an absence of one of many variations on a membrane oil. The defect disallows a specific substance (called by many names including psychosine ) to build up. That substance is cell toxic and causes cells to die. Irritability, sustained muscle tone in the first year of life are typical. But there are late diagnoses as well. Fevers without apparent cause are also seen. We have seen children with the diagnostic enzyme defect who are relatively well save for some 'heel cord' contracture similar to mild spastic diplegia. Perhaps there are mixes or percentage of involved cell population issues. The general experience is usually far more serious.

58. Krabbe Disease: Neurophysiologic Studies And MRI Correlations -- Husain Et Al. 6
    Background krabbe disease (KD) is a rare hereditary leukodystrophy affecting Conclusions Children with early infantile krabbe disease and lateonset  
    http://www.neurology.org/cgi/content/abstract/63/4/617
    
    Extractions: This Article Full Text Full Text (PDF) Take the CME quiz ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Husain, A. M. Articles by Aldosari, M. Related Collections MRI American Academy of Neurology Aatif M. Husain, MD Maha Altuwaijri, MA and Mohammed Aldosari, MD From the Departments of Medicine (Neurology) (Dr. Husain) and Pediatrics (Pediatric Neurology) (Dr. Aldosari), Duke University, and Neurodiagnostic Center (Dr. Husain), Veterans Affairs Medical Center, Durham, and School of Pharmacy (M. Altuwaijri), Campbell University, Buies Creek, NC. Address correspondence and reprint requests to Dr. A.M. Husain, Duke University Medical Center, 202 Bell Bldg., Box 3678, Durham, NC 27710; e-mail: Background: Krabbe disease (KD) is a rare hereditary leukodystrophy affecting children mostly in the first 6 months of life; later

59. Neurology -- Sign In Page
    Krabbe’s disease or globoidcell leukodystrophy is an autosomal recessive Localization of the krabbe disease gene (GALC) on chromosome 14 by multipoint  
    http://www.neurology.org/cgi/content/full/54/12/2348
    
    Extractions: This Article Figures Only Full Text (PDF) Correspondence: ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Bernal, O. G. Articles by Lenn, N. To view this item, select one of the options below: Sign In User Name Sign in without cookies.

60. Krabbe
    1Up Health krabbe disease or Globoid Cell Leukodystrophy Info - Details thecauses, signs, National Center for Biotechnology Info - Krabbe s Disease  
    http://www.health-nexus.com/krabbe1.htm
    
    Extractions: The #1 Health information site Health-Nexus.Net Health-Nexus.Org Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Krabbe Hunter's Hope.org

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