Extractions: Kleine-Levin Syndrome: A Report of Three Adolescent Female Patients M. Sadeghi MD Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran Abstract Kleine-Levin syndrome (KLS) is an uncommon psychiatric entity in children and adolescents which may present with non-specific and puzzling symptoms. Three cases of KLS in adolescent females are presented and clinical features and probable pathophysiological mechanisms discussed. Keywords Kleine-Levin syndrome Introduction K leine-Levin syndrome (KLS) is a relatively rare sleep disorder characterized by recurrent episodes of hypersomnia, hyperphagia, and mental and behavioral changes. Other features include apathy, irritability, confusion, sexual disinhibition, delusion, hallucination, disorientation memory impairment, incoherent speech and depression or agitation. In about 50% of cases, the syndrome has occurred following a specific factor such as thalamic infarction, Epstein Barr/herpes zoster infection, encephalitis
Kleine Levin Syndrome kleinelevin syndrome is a rare disorder characterized by the need for excessiveamounts of sleep (hypersomnolence), (ie, up to 22 hours a day); http://www.bchealthguide.org/kbase/nord/nord1068.htm
Extractions: It is possible that the main title of the report Kleine Levin Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Kleine-Levin syndrome is a rare disorder characterized by the need for excessive amounts of sleep (hypersomnolence), (i.e., up to 22 hours a day); excessive food intake (compulsive hyperphagia); and an abnormally uninhibited sexual drive. The disorder primarily affects adolescent males. When awake, affected individuals may exhibit irritability, lack of energy (lethargy), and/or lack of emotions (apathy). They may also appear confused (disoriented) and experience hallucinations. Symptoms of Kleine-Levin syndrome are cyclical. An affected individual may go for weeks or months without experiencing symptoms. When present, symptoms may persist for days to weeks. In some cases, the symptoms associated with Kleine-Levin syndrome eventually disappear with advancing age. However, episodes may recur later during life. The exact cause of Kleine-Levin syndrome is not known. However, researchers believe that in some cases, the disorder may be inherited as an autosomal dominant genetic trait. It is thought that symptoms of Kleine-Levin syndrome may be related to malfunction of the portion of the brain that helps to regulate functions such as sleep, appetite, and body temperature (hypothalamus).
BJSM -- Sign In Page kleinelevin syndrome (KLS) most often presents in adolescent males.1 It is The sleeping aviator aeromedical disposition of kleine-levin syndrome. http://bjsm.bmjjournals.com/cgi/content/full/39/2/e7
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Extractions: Hall of Fame The Kleine-Levin Syndrome Foundation, Inc. is very grateful to its supporters for their generosity. With their contributions we have been able to provide information and support to those suffering from KLS. The KLS Foundation plans to continue exchanging information with the public and the medical community to determine the cause of KLS and find a cure to this life-altering disorder. We extend a most sincere thank you to all of our contributors. Founders
Extractions: Kleine-Levin Syndrome Diaries The following is the diary of Jeff Sagel. FIRST EPISODE Sat., Jan.22, 1994 NOTE* Jeff grew 6" over the summer preceding his first episode and 1 1/2" from the time he was admitted until he went back to the hospital at the beginning of March. ** Jeff had chicken pox when he was 4 years old. Then he had shingles when he was 10 years old. ** Do either of these things have anything to do with this illness? Perhaps hormones or a chemical imbalance? Perhaps chicken pox virus manifesting itself in different form? ** This episode lasted 7 days. SECOND EPISODE Fri., Nov. 4, 1994 THIRD EPISODE Sun., Aug. 11, 1996 FOURTH EPISODE-Nov. 1996 Nov., 1996 Jeff saw Dr. Sherman at Childrens. We discussed the best way to take care of the remaining cavities. We decide that since the xylocaine seemed to bring on an episode, we shouldnt take that route for the rest because it would take so many trips and so many chances to go into sleep mode. So, we decide to do laughing gas and fill all the teeth at once and pull his wisdom teeth while he is out. Its set for Mon., Dec.16, 1996. Sun. Dec. 15, 1996 Jeff came home from work early (1:00 P.M.) and went straight to bed. I couldnt wake him at 6:00 for dinner. I tried again at 10:30 because hes not allowed to eat after midnight. but could not wake him. FIFTH EPISODE Tues., April 8, 1997
The Sleeping Princess kleinelevin syndrome is a rare disorder that causes cataplexy like sleep,excessive appetite and abnormal sex drive. It strikes mainly during the teen http://sleepdisorders.about.com/cs/sleepandchildren/a/princess.htm
Extractions: var zLb=14; var zIoa1 = new Array('Related Resources','What Is Hypersomnia?','http://sleepdisorders.about.com/cs/whatisnarcolepsy/a/hypersomnia.htm','Sleep and Children','http://sleepdisorders.about.com/cs/sleepandchildren/index.htm','All About Narcolepsy','http://sleepdisorders.about.com/cs/narcolepsy/'); var zIoa2 = new Array('Elsewhere on the Web','KLS World Organization','http://www.klsworld.com/','NINDS Kleine-Levin Syndrome Information Page','http://www.ninds.nih.gov/health_and_medical/disorders/kleine_levin.htm','Kleine Levin Syndrome','http://www.psychnet-uk.com/dsm_iv/kleine_levin_syndrome.htm'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a71' About Sleep Disorders Sleep and Children The Sleeping Princess Sleep Disorders Essentials Sleep Disorders - The Basics Try a Quiz ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Sign Up Now for the Sleep Disorders newsletter!
Kleine-Levin Syndrome - General Practice Notebook kleinelevin syndrome is characterised by episodes of somnolence and increasedappetite, often lasting for days or weeks and with long intervals between http://www.gpnotebook.co.uk/cache/-456130552.htm
Extractions: Kleine-Levin syndrome Kleine-Levin syndrome is characterised by episodes of somnolence and increased appetite, often lasting for days or weeks and with long intervals between them. In this syndrome patients can always be roused from the day-time sleep. However they are often irritable on waking and occasionally aggressive. Some patients are muddled and experience depression, disorientation and hallucinations. The combination of sleep disturbance and appetite disorder have pointed to a possible hypothalamic disorder. However there is no convincing evidence for this aetiology.
Arquivos De Neuro-Psiquiatria - ABSTRACT kleine-levin syndrome is characterized by periodic hypersomnia, We describe a typical case of kleine-levin syndrome associated with apparent http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2000000300021
Arquivos De Neuro-Psiquiatria - ABSTRACT A case of kleine-levin syndrome, with chronic severe periodic hypersomniais Multiple Sleep Latency Test findings in kleine-levin syndrome. http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1998000400021
Kleine-Levin Syndrome A Unique Cause Of Fatigue In An Athlete A classical case of a rare disorder characterized by hypersomnolence and hyperphagia.The subject is a male adolescent athlete. http://www.psychiatrysource.com/psychsource/Case_Studies/Child/Adolescent/articl
Kleine-Levin Syndrome kleinelevin syndrome - Provides information and support for those people whohave KLS or kleine-levin syndrome is a rare disorder characterized by the http://www.health-nexus.com/kleine-levin_syndrome.htm
Extractions: The #1 Health information site Health-Nexus.Net Health-Nexus.Org Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Kleine-Levin Syndrome NORD - National Organization for Rare Disorders, Inc.
Extractions: Vol. 39 No. 1, January 1982 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Carpenter S Ochs R Articles that cite this article Contact me when this article is cited S. Carpenter, R. Yassa and R. Ochs A patient with Kleine-Levin syndrome, typical except that onset was at 39 years of age, died during a symptomatic period. Autopsy disclosed recent and old lesions in the medial thalamus involving intralaminar, medial, and some dorsal nuclei as well as the pulvinar. Despite massive microglial infiltration, there was minimal neuronal loss. The hypothalamus was not involved. The findings suggest a viral cause for Kleine-Levin syndrome.
Extractions: Vol. 59 No. 12, December 2002 Featured Link E-mail Alerts Observation Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Katz JD Ropper AH Articles that cite this article ISI Web of Science (2) ... Contact me when this article is cited Topic Collections Neurology, Other Topic Collection Alerts
Kleine-Levin Syndrome - Talk Medical Humanfriendly medical definition of kleine-levin syndrome. http://www.talkmedical.com/medical-dictionary/8024/Kleine-Levin-Syndrome
Extractions: Tell a friend Kleine-Levin syndrome: A rare condition characterized by excessive need for sleep, food, and sexual disinhibition. Most people with Kleine-Levin syndrome are adolescent males. When awake, they may be confused, irritable, and lethargic, and some have hallucinations. The cause is unknown, although current theory holds that Kleine- Levin syndrome is caused by an inherited autosomal dominant trait that affects the hypothalamus gland. Most cases resolve over time without treatment. Print this page About Talk Medical Help Contact Us ... Terms and Conditions
Clinical Case Studies -- Sign In Page kleinelevin syndrome is a rare disorder characterized by alternating periods of The kleine-levin syndrome Case report and review of the literature. http://ccs.sagepub.com/cgi/content/refs/2/1/70
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Extractions: This Article Full Text (PDF) References Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Reprints and Permissions Joseph F. Kulas Jean E. Dumas Douglas M. Dollison Purdue University Kleine-Levin syndrome is a rare disorder characterized by alternating periods of exceedingly prolonged sleep and disordered waking and normal sleep and alert waking. Wakeful periods during an episode are usually marked by social withdrawal and accompanied by a variety of maladaptive behaviors, including hallucinations, delusions, sexual disinhibition, severe anxiety, depression, memory impairment, and increased appetite. Due to the rarity and complexity of the disorder, Kleine-Levin can be easily misdiagnosed.
Penn State Faculty Research Expertise Database (FRED) , A rare condition characterized by recurrenthypersomnias Kleine Levin Critchley Syndrome, Kleine Levin Syndromekleinelevin syndrome. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D017593
