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Hyperhomocysteinemia: more detail

Hyperhomocysteinemia: Webster's Timeline History, 1992 - 2007 by Icon Group International, 2009-02-20
Hyperhomocysteinemia as a result of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism causes an increased risk of cerebrovascular disease: ... An article from: Original Internist by Robert A., Jr. Duca, 2010-09-01
Hyperhomocysteinemia in end stage renal disease: is treatment necessary? (Continuing Education).: An article from: Nephrology Nursing Journal by Jennifer Snavely, 2002-04-01

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Diffuse Plane Normolipemic Xanthomatosis Associated With Takayasu's Disease And
associated with Takayasu s disease and hyperhomocysteinemia A case report with hyperhomocysteinemia and DPNX is the only such report in literature.
http://www.ijdvl.com/article.asp?issn=0378-6323;year=2004;volume=70;issue=4;spag
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Research on familial hyperhomocysteinemia first suggested that elevated circulating levels of homocysteine (Hcy) were linked to atherosclerotic vascular
http://www.annclinlabsci.org/cgi/content/full/34/2/175

Extractions: This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Walker, E. Articles by Wright, G. L. To view this item, select one of the options below: Sign In User Name Sign in without cookies. Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 7 days for US$7.00 Pay for Admission - You may access all content in Annals of Clinical and Laboratory Science Online (from the computer you are currently using) for 7 days for US$25.00.
HNRCA : Hypercholesterolemia And Hyperhomocysteinemia Associated With Hypothyroi
hyperhomocysteinemia and hypercholesterolemia associated with hypothyroidism in the third US National Health and Nutrition Examination Survey.
http://hnrc.tufts.edu/publications/detail.php?id=108461
HNRCA : Hyperhomocysteinemia Associated With Poor Recall In An Nationally Repres
hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2001;7392733.
http://hnrc.tufts.edu/publications/detail.php?id=115256
Dr. Rose's Peripheral Brain--CAD RISK FACTORS
hyperhomocysteinemia. Severely increased levels in homocystinuria associated with accelerated atherosclerosis; Moderately increased concentrations of
http://faculty.washington.edu/momus/PB/cadriskf.htm

Extractions: CAD RISK FACTORS n.b. For purposes of guiding management of dyslipidemias, NCEP specifies a small list of risk factors as countingSee under " Dyslipidemias " for details. The NCEP recommends counting CAD risk factors among those in the "major" category below, though sedentary lifestyle and dyslipidemias in general aren't counted; HDL < 35 counts as a risk factor, though; Also, HDL > 59 counts as a "negative" risk factor, i.e. if it's there, you subtract 1 from the count of risk factors MAJOR (per JAMA 269:3015, 1993): Smoking Hypertension Dyslipidemias (high LDL, low HDL, high TC/HDL or LDL/HDL ratio) Diabetes Mellitus Unknown whether glycemic control affects risk Raises risk more for women than for men (NEJM 332:1758, 1995-rvw) Sedentary lifestyle OTHERS: High HDL (> 60mg/dl) is a "negative" risk factor per NCEP (see under " dyslipidemias ") Obesity Traditionally considered a weak but significant independent factor; may contribute secondarily through effects on glucose metabolism, BP, etc. 115,000 women enrolled in Nurses' Health study 30-55yo and free of CV disease or Ca at enrollment followed for 16y. In multivariate analysis (adjusted for age, tobacco consumption, menopausal status, use of OCP's and postmenopausal HRT, and parental h/o MI before age 60), the following results were obtained
Methylenetetrahydrofolate Reductase Polymorphism (C677T), Hyperhomocysteinemia,
hyperhomocysteinemia is associated with ischemic cardiovascular disease Therefore, ICD and VTE may cause hyperhomocysteinemia, rather than vice versa.
http://www.bloodjournal.org/cgi/content/abstract/104/10/3046

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approach to establish if hyperhomocysteinemia is a cause or simply an effect of the disease. Indeed, hyperhomocysteinemia is not a monogenic condition,
http://www.bloodjournal.org/cgi/content/full/105/8/3382-a

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Pulmonary Embolism in a Patient With Pernicious Anemia and Our report highlights the thrombotic risk of hyperhomocysteinemia secondary to We believe that the hyperhomocysteinemia associated with the PA may have
http://129.195.254.70/cgi-bin/HONselect?browse C18.452.648.066.480
Pulmonary Embolism In A Patient With Pernicious Anemia And Hyperhomocysteinemia
Our report highlights the thrombotic risk of hyperhomocysteinemia secondary to PA in a Key Words cobalamin hyperhomocysteinemia pernicious anemia
http://www.chestjournal.org/cgi/content/abstract/122/4/1487

Extractions: This Article Full Text Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles PubMed PubMed Citation Articles by Caldera, A. Articles by Eiger, G. Chest. American College of Chest Physicians Angel Caldera, MD Jorge Mora, MD Morris Kotler, MD and Glenn Eiger, MD From the Department of Medicine (Drs. Caldera and Mora), and the Divisions of Cardiology (Dr. Kotler) and Pulmonary and Critical Care Medicine (Dr. Eiger), Albert Einstein Medical Center, Philadelphia, PA. Correspondence to: Angel Caldera, MD, Department of Medicine, Albert Einstein Medical Center, 5401 Old York Rd, Philadelphia, PA 19141; e-mail: We report the case of a 60-year-old woman with a history of ataxia who sought evaluation after a syncopal episode. A diagnostic
Hyperhomocysteinemia, Low Folate And Vitamin B12 Concentrations, And Methylene T
hyperhomocysteinemia, Low Folate and Vitamin B12 Concentrations, and Methylene The estimated risk of CVT associated with hyperhomocysteinemia,
http://stroke.ahajournals.org/cgi/content/abstract/35/8/1790

Extractions: 01.STR.0000132570.24618.78v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Cantu, C. Articles by Barinagarrementeria, F. Related Collections Clinical genetics
Revista De Nutrição -
Translate this page The treatment of hyperhomocysteinemia consists on supplementation of the vitamins This study reviews the hyperhomocysteinemia etiology on chronic renal
http://www.scielo.br/scielo.php?pid=S1415-52732005000200008&script=sci_arttext&t
Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Hyperhomoc
Acute methionine loadinduced hyperhomocysteinemia enhances To determine the true thrombogenicity of moderate hyperhomocysteinemia and better We conclude that moderate hyperhomocysteinemia plays a role in the
http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Hyperhomocysteinemia
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hyperhomocysteinemia, defined as an elevated concentration of hyperhomocysteinemia was defined as a fasting homocysteine concentration and/or an
http://www.jcircadianrhythms.com/pubmed/9665374

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Methylenetetrahydrofolate Reductase (MTHFR) Thermolabile Variant
hyperhomocysteinemia, C677T and A1298C Mutations; MTHFR In patients with hyperhomocysteinemia, followup testing for the MTHFR mutation might be
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/mg003500.htm

Extractions: Methylenetetrahydrofolate Reductase (MTHFR) Thermolabile Variant, DNA Analysis Number CPT Related Information Factor II (Prothrombin), DNA Analysis Factor V Leiden Mutation Analysis Thrombotic Risk Profile, DNA Synonyms Hyperhomocysteinemia, C677T and A1298C Mutations; MTHFR Specimen Whole blood, buccal swab (The buccal swab collection kit contains instructions for the use of a buccal swab.) Volume 7 mL whole blood (EDTA) or buccal swab kit Minimum Volume 3 mL whole blood (EDTA) or two buccal swabs Container Lavender-stopper (EDTA) or yellow-stopper (ACD) tube, LabCorp buccal swab kit Storage Instructions Maintain specimen at room temperature or refrigerate. Causes for Rejection Frozen specimen; hemolyzed; quantity not sufficient for analysis; improper container; one buccal swab Use Follow-up evaluation in individuals with hyperhomocysteinemia; evaluation of patients with venous thrombosis Limitations This assay detects only the C677T and A1298C mutations in the MTHFR gene. The diagnosis of hyperhomocysteinemia can not rely on DNA testing alone but should take into consideration clinical findings and other studies, such as serum homocysteine levels. Methodology Polymerase chain reaction (PCR) and restriction enzyme analysis Additional Information Hyperhomocysteinemia has been found in women who have experienced two or more early pregnancy losses, placental infarction and fetal growth retardation, but MTHFR mutation as a cause for early pregnancy loss is still controversial. Homozygosity for C677T has been shown to have a 2 to 3-fold increased risk for neural tube defects (NTDs) such as anencephaly and spina bifida, and compound heterozygosity for C677T and A1298C may also be a risk factor for NTDs. Dietary folic acid supplementation before the fourth week of gestation is well documented in reducing the recurrence risk for open neural tube defects by approximately 75%. It may act by normalizing homocysteine levels.
Folate And Cobalamin Deficiencies And Hyperhomocysteinemia In Bangladesh -- Gamb
Results The prevalence of hyperhomocysteinemia (men 11.4 µmol/L; women 10.4 µmol/L) was markedly (P 0.0001) greater among men (63%; ± SD 15.3 ± 9.5
http://www.ajcn.org/cgi/content/abstract/81/6/1372

Extractions: This Article Full Text Full Text (PDF) Purchase Article ... Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Request Permissions PubMed PubMed Citation Articles by Gamble, M. V Articles by Graziano, J. H American Journal of Clinical Nutrition, Vol. 81, No. 6, 1372-1377, June 2005 American Society for Clinical Nutrition Mary V Gamble Habibul Ahsan Xinhua Liu Pam Factor-Litvak Vesna Ilievski Vesna Slavkovich Faruque Parvez and Joseph H Graziano From the Departments of Environmental Health Sciences (MVG, VI, VS, FP, and JHG), Epidemiology (HA and PF-L), and Biostatistics (XL), Mailman School of Public Health, and the Department of Pharmacology, College of Physicians and Surgeons (JHG), Columbia University, New York, NY, and the New York State Psychiatric Institute, New York, NY (XL) Background: Indian Asian men residing in the United Kingdom have a higher prevalence of hyperhomocysteinemia than do their European counterparts. This has been largely attributed to dietary
High Prevalence Of Hyperhomocysteinemia Related To Folate Deficiency And The 677
Background Moderate hyperhomocysteinemia is a risk for neural tube defect Conclusion A high prevalence of hyperhomocysteinemia in coastal West Africa
http://www.ajcn.org/cgi/content/abstract/79/4/619

Extractions: This Article Full Text Full Text (PDF) Purchase Article ... Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Request Permissions PubMed PubMed Citation Articles by Amouzou, E. K American Journal of Clinical Nutrition, Vol. 79, No. 4, 619-624, April 2004 American Society for Clinical Nutrition Emile K Amouzou Charles E Adjalla Christian Villaume Ambaliou Sanni and Background: Moderate hyperhomocysteinemia is a risk for neural tube defect and neurodegenerative and vascular diseases and has nutritional, metabolic, and genetic determinants. Its prevalence in sub-Saharan Africa remains unknown. Objective: Our goal was to evaluate the prevalence of hyperhomocysteinemia and the influence of nutritional, metabolic, and genetic determinants
Hyperhomocysteinemia Induces Hepatic Cholesterol Biosynthesis And Lipid Accumula
hyperhomocysteinemia is an independent risk factor for cardiovascular disorders. hyperhomocysteinemia was induced in SpragueDawley rats by feeding a
http://ajpendo.physiology.org/cgi/content/abstract/288/5/E1002

Extractions: Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Download to citation manager PubMed PubMed Citation Articles by Woo, C. W. H. Articles by O, K. Connie W. H. Woo, Yaw L. Siow, Grant N. Pierce, Patrick C. Choy, Gerald Y. Minuk, David Mymin, and Karmin O Departments of Physiology and Animal Science, National Centre for Agri-Food Research in Medicine, St. Boniface Hospital Research Centre, Centre for Research and Treatment of Atherosclerosis, Faculty of Medicine, and
Chlamydia Pneumoniae Seropositivity And Hyperhomocysteinemia Are Linked In Patie
Concurrently, epidemiologic evidence suggests that hyperhomocysteinemia is Both C. pneumoniae infection and hyperhomocysteinemia have been assumed to
http://www.clinchem.org/cgi/content/full/47/7/1304

Extractions: This Article Extract Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Cited by other online articles Search for citing articles in: ISI Web of Science (11) PubMed PubMed Citation Articles by Wiesli, P. Articles by Schulthess, G. Related Collections Lipids, Lipoproteins, and Cardiovascular Risk Factors Clinical Chemistry. Peter Wiesli Friedrich E. Maly Alfredo Meniconi Wolfgang Czerwenka Ulrich Hoffmann Wilhelm Vetter and Georg Schulthess a
Selective Screening For Hyperhomocysteinemia In Pediatric Patients -- Vilaseca E
hyperhomocysteinemia is a common condition with genetic and environmental Testing for hyperhomocysteinemia in children may be useful for investigation
http://www.clinchem.org/cgi/content/extract/44/3/662
Diabetes Forum : Complication_Causes Of Hyperhomocyst(e)inemia
Mellitus Complication Homocysteine AVD Mellitus Free Radicals Nerphropathological changes Oxidation Cause of hyperhomocysteinemia
http://www.diabetesforum.net/eng_comp_causehyper .htm

Extractions: Elevations in homocyst(e)ine are typically caused either by genetic defects in the enzymes involve in homocysteine metabolism or by nutritional deficiencies in vitamin co-factors. Thus, reduction in activity of MS, MTHFR, or CbS, or decreased availability of their co-factors, vitamin B12, folic acid or vitamin B6 respectively, can cause hyperhomocyst(e)inemia. Defects of betaine homocysteine methylene transferase have not been described in literature. Homocyst(e)ine levels are higher in men than in women, both fasting and post methionine loading, and usually higher in postmenopausal rather than premenopausal women. Homocyst(e)ine also rises with age even when allowance is made for age-related increase in creatinine and decreasing vitamin levels. The rise may be related to age induced reduction in the function of MS or CbS. Other conditions that may be associated with hyperhomocyst(e)inemia are hypothyroidism, impaired kidney function, systemic lupus erythematosus and certain medications, e.g., nicotinic acid, nitrous oxide exposure, theophylline, methotrexate, and L-dopa.

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