Extractions: Background. Transplant coronary artery disease (TCAD) is a major cause of morbidity and mortality among heart transplant recipients. A variety of immunologic and nonimmunologic mechanisms are involved in the pathogenesis of the disease. Hyperhomocysteinemia has been recognized as an important risk factor for atherosclerotic vascular disease. The purpose of this article is to evaluate the prevalence of hyperhomocysteinemia in heart transplant recipients but more specifically to assess the published literature regarding the association between hyperhomocysteinemia and TCAD. Methods. A MEDLINE search using the key words hyperhomocysteinemia, transplant coronary artery disease, and heart transplant was performed. Results. Hyperhomocysteinemia has been commonly found among heart transplant recipients (average prevalence 51% to 76%). Worsening renal function and impaired vitamin metabolism seem to be the major causes of hyperhomocysteinemia in this particular population. TCAD has been found to be more prevalent and severe among patients with higher serum homocysteine levels. Vitamin supplementation is safe and effective in reducing serum homocysteine among heart transplant recipients. Conclusion. A large, long-term, double-blind, placebo-controlled prospective trial aimed at assessing the clinical significance of homocysteine-lowering therapy on the natural history of TCAD seems warranted.
Transplantation - UserLogin hyperhomocysteinemia and transplant coronary artery disease hyperhomocysteinemia has been recognized as an important risk factor for atherosclerotic http://www.transplantjournal.com/pt/re/transplantation/fulltext.00007890-2002112
Internet Scientific Publications, LLC. We present a patient with megaloblastic anemia and hyperhomocysteinemia due to vitamin Sodium valproate may lead to anemia and hyperhomocysteinemia by http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol3n1/valproa
CTF Structured Abstract: Hyperhomocysteinemia The prevalence of hyperhomocysteinemia in the general population is between 5 and 10%, based on a threshold set at the 90th or 95th percentile http://www.ctfphc.org/Abstracts_printable/Homocyst_abs.html
Extractions: Please note: In 2003, the CTF updated its Grades of Recommendations to include an "I Recommendation" for situations where insufficient evidence exists to allow a recommendation to be made. (Formerly, these situations were captured under a "C Recommendation".) This change is not retroactive, and all "C Recommendations" made prior to 2003 have not been reevaluated in light of the new "I" recommendation grade. For a discussion of these recommendation grades, please link to the 2003 article in the Canadian Medical Association Journal here Prepared by Gillian L. Booth, MD, Departments of Medicine, Clinical Epidemiology and Health Care Research Program, University of Toronto, Elaine E. L. Wang, MD, Departments of Pediatrics, Clinical Epidemiology and Health Care Research Program, University of Toronto Objective
CTF Selected References: Hyperhomocysteinemia Metaanalysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. hyperhomocysteinemia is associated with an increased risk of http://www.ctfphc.org/References/Homocyst_bib.html
Extractions: Prepared by Gillian L. Booth, MD, Departments of Medicine, Clinical Epidemiology and Health Care Research Program, University of Toronto, Elaine E. L. Wang, MD, Departments of Pediatrics, Clinical Epidemiology and Health Care Research Program, University of Toronto These recommendations were finalized by the Task Force in July 1999 Statistics Canada. Causes of death, 1995 (Catalogue 84-208-XPB). 1997. Ottawa, Minister of Industry. Brophy JM. The epidemiology of acute myocardial infarction and ischemic heart disease in Canada. data from 1976 to 1991. Can J Cardiol 1997;13:474-478. Skovby F. Inborn errors of metabolism causing homocysteinemia and related vascular involvement. Haemostasis 1989;19(suppl 1):4-9. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, Andria G, Boers GHJ, Bromberg IL, Cerone R, Fowler B, Gröbe H, Schmidt H, Schweitzer L. The natural history of homocystinuria due to cystathione-synthase deficiency. Am J Hum Genet 1985;37:1-31. Moghadasian MH, McManus BM, Frohlich JJ. Homocyst(e)ine and coronary artery disease. Clinical evidence and genetic and metabolic background. Arch Intern Med 1997;157:2299-2308.
Extractions: Home German Journal of Psychiatry ISSN 1433-1055 Moderate hyperhomocysteinemia and neuropsychiatric symptoms in manganese-induced parkinsonism Stefan Bleich, Detlef Degner, Borwin Bandelow, Antje Riegel , Juan M. Maler, Eckart Rüther, and Johannes Kornhuber Department of Psychiatry Department of Neuroradiology Georg-August University of Göttingen, Germany Corresponding author: Stefan Bleich, M.D, Department of Psychiatry, Georg-August University of Göttingen, von-Siebold-Str. 5, D-37075 Göttingen, Germany; e-mail stefan.bleich@t-online.de Abstract Manganese intoxication is a well-known cause of parkinsonism and dementia. Here we present the case of an 80-year-old patient with proven manganese poisoning. We observed no long-term progression of the manganese-induced parkinsonian syndrome. The blood manganese concentration is now reduced to below the normal range (4.8 m g/l), but the manganese concentration in scalp hair (2.79 m g/g) has kept on increasing. Strikingly, even though we found normal cobalamin and even elevated serum folate levels, we observed a moderate hyperhomocysteinemia in two independent samples. We did not find any common known risk factors for this moderate hyperhomocysteinemia The possible role of hyperhomocysteinemia in manganese-induced parkinsonism is discussed (German J Psychiatry 2000;3:14-20) Key words: manganese, homocysteine, parkinsonism
Journal Of The American College Of Nutrition -- Sign In Page Results hyperhomocysteinemia was found in 32 cases and in 4 controls. hyperhomocysteinemia is also suggested to be a risk factor of atherosclerosis http://www.jacn.org/cgi/content/full/23/5/386
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Extractions: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Steegers-Theunissen, R. P. Articles by Steegers, E. A. Related Collections Basic Science Pathology Carola A. Van Iersel, MSc Petronella G. Peer, PhD Willianne L. Nelen, PhD and Eric A. Steegers, PhD From the Departments of *Obstetrics and Gynecology, and Epidemiology and Biostatistics, University Medical Center Nijmegen, Nijmegen; and Departments of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, the Netherlands OBJECTIVE: To assess associations between vitamin-dependent homocysteine metabolism and vascular-related pregnancy complications by considering interval between delivery and postpartum investigation and maternal age.
Extractions: Vol. 158 No. 19, October 26, 1998 Featured Link E-mail Alerts Original Investigation Article Options Full text PDF Send to a Friend Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Ray JG Articles that cite this article ISI Web of Science (97) Contact me when this article is cited Topic Collections Evidence-Based Medicine Venous Thromboembolism Topic Collection Alerts
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Disclaimer - Electronic Collection The prevalence of hyperhomocysteinemia in the general population is between Definitive guidelines for the management of hyperhomocysteinemia await the http://collection.nlc-bnc.ca/100/201/300/cdn_medical_association/cmaj/vol-163/is
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Extractions: Hyperhomocysteinemia (H-Hcy) may be an independent risk factor for atherosclerotic vascular disease. The purpose of this study was to evaluate whether hyperhomocysteinemia may induce direct vascular changes. Wild-type (+/+) and heterozygous (+/-) methylenetetrahydrofolate reductase (Mthfr) knockout mice, a model of mild H-Hcy, were divided in four groups for a 2-week treatment: wild-type with vehicle infusion (+/+ sham), wild-type with angiotensin (Ang) II infusion (400 ng/Kg/min s.c.), Mthfr +/- sham and Mthfr +/- with Ang II. Second-order branches of mesenteric arteries (lumen diameter 0.05). In Mthfr +/- mice Ang II induced hypertrophic remodeling with increased M/L ratio (7.2 ± 0.2 vs 6.3 ± 0.3 %, p
ROLE OF HYPERHOMOCYSTEINEMIA IN THE DEVELOPMENT OF ATHEROSCLEROSIS hyperhomocysteinemia is a strong and independent risk factor for cardiovascular disease. Our results indicate that hyperhomocysteinemia accelerates http://www.ccs.ca/society/congress2002/abstracts/abs/a153.htm
Extractions: Remember Me Forgot your password? Create a guest account BECOME A MEMBER Journal of Clinical Oncology Journal of Oncology Practice The ASCO Foundation People Living With Cancer BECOME A SPONSOR The remember me feature is an automatic login process which creates a cookie on the hard drive of your computer containing your username and password, thereby avoiding the need to enter them upon subsequent visits to asco.org. DO NOT select this option if you share this computer with others since personal or member only information will be accessible by other users. For addition information please review our . Click OK to keep the Remember Me option, or click Cancel to remove it. When you are done, click the LOGIN button to continue with the login Process . Home Abstracts Browse by Meeting Meeting: 2004 ASCO Annual Meeting Printer Friendly Bookmark Category: Health Services Research SubCategory: Health Services Research Hyperhomocysteinemia in cancer patients with thrombosis is independent of methylene tetrahydrofolate reductase gene mutation.