Hereditary Spastic Paraplegia An article about hereditary spastic paraplegia, also called familial spastic paralysis. http://healthlink.mcw.edu/article/921730935.html
Extractions: Subscribe now >> Hereditary spastic paraplegia (HSP), also called familial spastic paralysis, refers to a group of genetic disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. Symptoms of HSP may occur alone or, in more complicated forms of HSP, may occur in combination with a number of other neurological symptoms. Generally, the primary feature is severe, progressive, lower extremity spasticity. The spasticity sometimes occurs with abnormalities such as optic neuropathy, retinopathy (disease of the retina), dementia, ataxia (lack of muscle control), ichthyosis (a skin disorder causing dry, rough, scaly skin), mental retardation, and deafness. There is no specific treatment to prevent, slow, or reverse HSP's progressive disability. Treatment is symptomatic. The prognosis for individuals with HSP varies greatly. Some cases are seriously disabling while others are less disabling and are compatible with a productive and full life. The majority of individuals with HSP have a normal life expectancy.
SPF - Spastic Paraplegia Foundation Home Page Supports on the upper motor neuron disorders hereditary spastic paraplegia and primary lateral sclerosis. Information about these conditions, disability resources, newsletters, news, announcements, research and support. http://sp-foundation.org/
Extractions: E-News Bulletins: Aug.-Sept. June-July April-May Meet John K. Fink, MD, SPF Medical Advisor and Teepu Siddique, MD, top researchers of HSP and PLS. Also: programs on assistive technology and adaptive equipment and more. Details here The SPF is the only non-profit organization in the Americas dedicated to neurodegenerative disorders called Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia* (HSP). These diseases slowly attack one's ability to walk, causing levels of disability ranging from needing a cane to a wheelchair. In PLS, they generally also rob people of their ability to use their hands and arms, and even to speak. In very rare forms of HSP, they can cause mental retardation, dementia, epilepsy or other neurological problems. The Spastic Paraplegia Foundation is a 100% volunteer-managed and operated organization devoted to finding the causes and cures for these diseases and to providing critical information and support programs to people affected by them. We are enormously grateful to our
John K. Fink, M.D. Novel locus for autosomal dominant hereditary spastic paraplegia on chromosome 8q hereditary spastic paraplegia Advances in Genetic Research Neurology, http://www.med.umich.edu/geriatrics/research/directory/fink.htm
Extractions: Research Interests Our laboratory investigates nerve degeneration in the brain and spinal cord that occurs with age and with degenerative neurologic disorders. We use molecular genetic methods to genetically map and positionally clone genes responsible for degenerative neurologic diseases; study the functions of these genes; and to create animal models in which to study the pathophysiology and develop treatments for these conditions. Recently, for example, we demonstrated that SPG3A/atlastin gene mutations and SPG6/ NIPA1 gene mutations cause two forms of the inherited spinal cord disorder, hereditary spastic paraplegia. Animal models of HSP are in development through gene targeting of HSP genes. Recent Publications Zhao X, Alvarado, D, Rainier S, Lemons R, Hedera P, Weber C, Tukel T, Apakl M, Heiman-Patterson T, Ming L, Bui M, Fink JK. Mutations in a novel GTPase cause autosomal dominant hereditary spastic paraplegia. Nature Genetics, 2001;29:326-331.
NINDS Forwarding Page HSP information sheet compiled by the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/hereditarysp.htm
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Hereditary Spastic Paraplegia Home Page My laboratory is committed to finding the causes and developing treatments for hereditary spastic paraplegia. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Physical Medicine and Rehabilitation Disorders Of The Motor Unit Last Updated: August 4, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: HSP, hereditary spastic paraparesis, familial spastic paraparesis, Strumpell-Lorrain syndrome, Strumpell-Lorrain disease, pure hereditary spastic paraplegia, uncomplicated hereditary spastic paraplegia, complicated hereditary spastic paraplegia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Nam-Jong Paik, MD, PhD , Chief, Associate Professor of Rehabilitation Medicine, Rehabilitation Medicine, Seoul National University Bundang Hospital Coauthor(s): Jae-Young Lim, MD , Assistant Professor, Department of Rehabilitation Medicine, Division of Musculoskeletal Rehabilitation, Bundang Hospital, Seoul National University College of Medicine
The FSP Support Group - Home group that aims to provide assistance to those suffering from Familial Spastic Paraplegia (also known as hereditary spastic paraplegia or HSP). http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
SPF - Spastic Paraplegia Foundation Home Page dedicated to neurodegenerative disorders called Primary Lateral Sclerosis (PLS) and hereditary spastic paraplegia* (HSP). These diseases http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Extractions: Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs. Though the primary feature of HSP is severe, progressive, lower extremity spasticity, in more complicated forms it can be accompanied by other neurological symptoms. These include optic neuropathy, retinopathy (diseases of the retina), dementia, ataxia (lack of muscle control), icthyosis (a skin disorder resulting in dry, rough, scaly skin), mental retardation, peripheral neuropathy, and deafness. Diagnosis is primarily by neurological examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical centers.
GeneReviews Hereditary Spastic Paraplegia Overview In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Hereditary Spastic Paraplegia Article describes hereditary spastic paraplegia, its diagnosis, and treatment. http://rarediseases.about.com/cs/hs1/a/110103.htm
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Hereditary Spastic Paraplegia This group of neurological disorders causes progressive muscle weakness (paraplegia)and stiffness (spasticity). HSP is often misdiagnosed as Lou Gehrig s http://rarediseases.about.com/b/a/039604.htm
Extractions: zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Sign Up Now for the Rare / Orphan Diseases newsletter! Advertisement Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Muscular Dystrophy Autoimmune Kidney Disease Minamata Disease Charcot-Marie-Tooth Disease ... Meckel-Gruber Syndrome adunitCM(150,100,'x55') Topic Index Email to a Friend New York Times Company Hurricane Katrina About's Hurricane Blogs NY Times Coverage Where to Donate Exclusive: One Family's Story ... How to Explain to Kids Related Topics Multiple Sclerosis Parenting Special Needs Sleep Disorders Headlines Cystic Fibrosis Foundation helps Hurricane Katrina victims Robert J. Beall, Ph.D, President and CEO of the Cystic...
WE MOVE - Hereditary Spastic Paraplegia hereditary spastic paraplegia (HSP) is a group of genetic, degenerative disordersof the spinal cord characterized by progressive weakness (paraplegia) and http://www.wemove.org/hsp/
Extractions: E-mail: firstname.lastname@example.org Hereditary Spastic Paraplegia Information for Patients and Caregivers Table of Contents WE MOVE makes every effort to present medical information that is up-to-date and accurate. The material provided has undergone rigorous medical review. Information regarding the authors, editors, publisher, and medical reviewers of this material of the WE MOVE Web site is listed below. Medical science is constantly changing. Therefore, the authors, editors, and publisher do not warrant that the information in this text is complete, nor are they responsible for omissions or errors in the text or for the results of the use of this information. This information does not replace consultation with a physician. All medical procedures, drug doses, indications, and contraindications should be discussed with your personal physician. Writer: Joy B. Leffler, NASW, AMIA