Extractions: A n abnormally structured gene is the culprit in familial hemiplegic migraine, a rare inherited form of migraine. People with a similar neurological disorder, episodic ataxia type-2, have other alterations in the same gene, researchers found. The gene resides on chromosome 19, the organization and structure of which has long been studied by Lawrence Livermore National Laboratory's Human Genome Center. Three years ago, medical scientists at Leiden University in The Netherlands initiated a collaboration with the LLNL researchers to complete the physical mapping of the chromosome and clone the DNA of the gene for this form of migraine. Armed with the cloned DNA fragments and data from human patients studies, the Dutch researchers discovered the gene that regulates the transport of calcium into specific classes of brain cells. The researchers noted alterations in the DNA sequence in patients from the migraine families. These alterations result in the production of nonfunctional protein, which prevents calcium from being properly transported. The movement of calcium into brain cells regulates the release of neurotransmitters, which are critical elements in the network of communication among cells of the nervous system. While the type of Familial Hemiplegic Migraine associated with this gene is rare, many of its symptoms are similar to those of more common migraines. Scientists believe knowledge gained in studying this form of migraine will help understand the cause of other forms of the disorder.
Hemiplegic Migraine List of symptoms associated with hemiplegic migraine. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
ACHE Articles The inherited or familial form of hemiplegic migraine is a rare disorder found in In these families, hemiplegic migraine has an autosomal dominant http://www.achenet.org/articles/gardner.php
Extractions: Genes and Migraine By Kathy Gardner, MD Many migraineurs have other family members who also suffer with migraine headache. Mom used to have migraine headaches with her menstrual cycle, grandmother once had "sick" headaches, and brother has "sinus" headaches which are less severe but sound strangely similar to migraine if you ask questions about symptoms and triggers. For years scientists have argued whether disorders such as migraine that tend to run in families do so because of shared genes or the shared environment. People often assume that any disorder that occurs in several family members must be genetic. However, families tend to share similar diets, exposures and lifestyles, all of which might be involved in making someone susceptible to a specific disorder. A combination of genetic and environmental factors seems to be the best overall explanation for most common disorders, including migraine. Nevertheless, the fact that you occasionally find large families with many members suffering from migraine suggest a stronger genetic basis for those particular families. As it turns out, a definite inheritance pattern has been found in a few families who suffer with a severe form of migraine called hemiplegic migraine. Hemiplegic Migraine The inherited or "familial" form of hemiplegic migraine is a rare disorder found in families where two or more people suffer migraine-type headache associated with a "stroke-like" aura of weakness on one side of the body. Other neurologic symptoms can also occur and might include visual loss, difficulty with speech, confusion and numbness. In these families, hemiplegic migraine has an
National Headache Foundation Hemiplegic Migraine hemiplegic migraine. hemiplegic migraine is a very rare form of migraine that is considered to be one of the more severe types of migraine. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
What Is Hemiplegic Migraine? To understand hemiplegic migraine, we have to understand that Migraine attacksare episodic manifestations of a genetic neurological disease. http://headaches.about.com/od/migrainediseas1/a/hemiplegic_mig.htm
Extractions: var zLb=14; var zIoa1 = new Array('Suggested Reading','Anatomy of a Migraine','http://headaches.about.com/cs/headpain101/a/anatomy_mig.htm','Is Migraine a Progressive Brain Disease?','http://headaches.about.com/cs/management/a/brain_lesions.htm','Headaches and Migraine 101','http://headaches.about.com/od/headpain101/'); var zIoa2 = new Array('Elsewhere on the Web','International Headache Society','http://www.i-h-s.org','MAGNUM, the National Migraine Association','http://www.migraines.org','Help for Headaches and Migraine','http://www.helpforheadaches.com'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a58' About Headaches / Migraine Headaches / Migraine Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Sign Up Now for the Headaches / Migraine newsletter!
The Familial Hemiplegic Migraine Mutation R192Q Reduces The familial hemiplegic migraine mutation R192Q reduces Gprotein-mediated inhibition of P/Q-type (Ca. V http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
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National Headache Foundation: Hemiplegic Migraine hemiplegic migraine is a very rare form of migraine that is considered to be oneof the With hemiplegic migraine, there is often a familial occurrence. http://www.headaches.org/consumer/topicsheets/hemiplegic.html
Extractions: HEMIPLEGIC MIGRAINE Hemiplegic migraine is a very rare form of migraine that is considered to be one of the more severe types of migraine. The sufferer may develop some temporary motor paralysis on one side of the body. This may be accompanied by numbness or a pins-and-needles sensation. The neurological symptoms usually leave when the headache appears. With hemiplegic migraine, there is often a familial occurrence. In about 50% of these families, a chromosome defect may be found on chromosome 19 or on chromosome 1 and involves abnormal calcium channels. A physician should be consulted for this type of headache. You should not take triptans if you have this type of headache.
Arch Neurol Abstract Expanding The Phenotypic Spectrum Of The of 5 Families With Familial hemiplegic migraine E. E. Kors, MD ; J. Haan, PhD ; N. J. Giffin, MD ; L. Pazdera, MD ; C. SchnittgerA http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Headaches Types | Migraine hemiplegic migraine If you suffer from this rare but severe type of migraine The hemiplegic migraine often begins with temporary motor paralysis and/or http://www.headaches.org/consumer/educationalmodules/completeguide/migraine2.htm
Extractions: Symptoms There are several types of migraine, all share basic features, and each person will suffer this headache in a unique way. Generally, however, migraine often begins as a dull ache and then develops into a constant, throbbing and pulsating pain that you may feel at the temples, as well as the front or back of one side of the head. The pain is usually accompanied by nausea and vomiting, and sensitivity to light and noise. The two most prevalent types of migraine are migraine with aura (formerly referred to as classic migraine) and migraine without aura (formerly referred to as common migraine). As we have said, migraine is a vascular headache, which means the headache is associated with changes in the size of the arteries inside and around the skull. During the pre-headache phase, blood vessels constrict; when vascular dilation occurs, the migraine begins. The blood vessels are thought to become inflamed as well as swollen, and it is believed that migraine pain is caused by this inflammation, as well as by the pressure on the swollen walls of the blood vessels. Most migraine sufferers experience two to four headaches per month; but, some people can get one every few days, and others may only have one or two a year. Most migraine headaches last at least four hours, although very severe ones can last up to a week. Headaches may begin at any time of the day or night; and while a sufferer may wake up with one, a migraine will rarely awaken a person from sleep.
Arch Neurol Abstract Phenotypes Of Spinocerebellar Ataxia Type Phenotypes of Spinocerebellar Ataxia Type 6 and Familial hemiplegic migraine Caused by a Unique CACNA1A Missense Mutation in Patients From a http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
GeneReviews: Familial Hemiplegic Migraine Your browser does not support HTML frames so you must view Familial HemiplegicMigraine in a slightly less readable form. Please follow this link to do so. http://www.geneclinics.org/profiles/fhm/
A New CACNA1A Gene Mutation In Acetazolamide-responsive Familial A new CACNA1A gene mutation in acetazolamideresponsive familial hemiplegic migraine and ataxia S. Battistini, MD, PhD , S. Stenirri, PhD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Extractions: Editorial by Hoffman, E. P. ... PubMed Citation ABSTRACT Background Familial hemiplegic migraine, an autosomal dominant disorder characterized by attacks of transient hemiparesis followed by a migraine headache, is divided into pure familial hemiplegic migraine (affecting 80 percent of families) and familial hemiplegic migraine with permanent cerebellar signs (affecting 20 percent of families). Mutations in which encodes a neuronal calcium channel, are present in 50 percent of families with hemiplegic migraine, including all those with cerebellar signs. We studied the various clinical manifestations associated with mutations in in 28 families with hemiplegic migraine with and without cerebellar signs.
News - TopAbstracts In Migraine 07/07/2005 Hemeplegic Migraine with Leptomeningeal Angiomatosis. Subacute Glaucoma Masquerading as Migraine. Familial hemiplegic migraine Cases archive http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
NEJM -- Sign In Editorial from The New England Journal of Medicine hemiplegic migraine Downstream of a SingleBase Change. http://content.nejm.org/cgi/content/full/345/1/57
Extractions: SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. Log in via Athens. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.
Significant Linkage To Migraine With Aura On Chromosome 11q24 Migraine with aura (MA) is a prevalent neurological condition with strong evidence for a genetic basis. Familial hemiplegic migraine, a rare http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Hemiplegic Migraine - General Practice Notebook hemiplegic migraine is a term used to describe the migraine syndrome that isassociated with a weakness or sensory loss of the limbs on one side of the body http://www.gpnotebook.co.uk/cache/1154482184.htm
Extractions: hemiplegic migraine Hemiplegic migraine is a term used to describe the migraine syndrome that is associated with a weakness or sensory loss of the limbs on one side of the body. The headache usually precedes the weakness by a day or more. The limbs gradually return to normal over several days. Often there is a family history of this type of migraine, usually with an autosomal dominant inheritance. It is always necessary to exclude another possible underlying cause for the hemiplegia such as an angioma. It is a rare form of migraine.
