Home criglernajjar syndrome is caused by a liver enzyme deficiency. Crigler-NajjarSyndrome (CNS) is an inherited metabolic disorder caused by a liver enzyme http://www.criglernajjar.com/
Extractions: Our Site Last Updated June 29, 2003 Crigler-Najjar Syndrome is caused by a liver enzyme deficiency Crigler-Najjar Syndrome (CNS) is an inherited metabolic disorder caused by a liver enzyme deficiency which prevents the usual metabolic breakdown of bilirubin; a normal by-product in our bodys disposal of worn-out red blood cells. Children with CNS are unable to eliminate bilirubin from their bodies and therefore must undergo daily 12-hour exposure to special blue lights, just to survive. Without daily treatments, a child would suffer brain damage, muscle and nerve damage and death due to bilirubin toxicity. A Rare Orphan Disease Crigler-Najjar is a very rare disease. There are less than 50 known cases in the USA, and less than 200 worldwide. It is named after Dr. Crigler and Dr. Najjar who discovered the disease. Dr. John F. Crigler is a Special Medical Two-year-old Melanie has to sleep under intense blue lights to help combat the disease Crigler-Najjar Syndrome Advisor to the CNA. The Crigler-Najjar Association Providing Support and Helping Others Our group represents approximately 30 families in the U.S.A. who have family members affected by Crigler-Najjar syndrome. Started in 2002 with a handful of Crigler-Najjar families, our group has grown and expanded to represent all families who are interested in providing support, information and helping others who are less fortunate that may not have the ability to pay for expensive phototherapy lights and medications required just to live.
Extractions: Advanced Search Or click the first letter of a drug name: A B C D ... Z Injury Disease Nutrition Poison ... Liver anatomy Crigler-Najjar syndrome is an inherited disorder in which bilirubin (a substance made by the liver) cannot be changed into its water-soluble form, bilirubin glucuronide. This causes jaundice (yellow discoloration of skin and eyes) and organ malfunctions. Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar) Crigler-Najjar syndrome is caused by an abnormal gene which fails to produce a functional enzyme (bilirubin glucuronyltransferase) capable of converting bilirubin into a water-soluble and therefore, easily excreted form. As a result, bilirubin can build up in the body, which can damage the brain and other organs.
Crigler-Najjar Syndrome criglernajjar syndrome Type II, Arias syndrome, is an autosomal dominantform; one parent will have elevated bilirubin. Kernicterus has been reported http://www.5mcc.com/Assets/SUMMARY/TP0237.html
Extractions: UDP glucuronyl transferase deficiency Crigler-Najjar syndrome: Definition(s) via UMLS Code translations and terms via UMLS Crigler-Najjar syndrome: specific web sites Send Crigler-Najjar syndrome to medical search engines (JavaScript enabled browsers only.) If your browser has no JavaScript you can still use these:
Crigler-Najjar3bis Clinical description of the criglernajjar syndrome from the Online Mendelian Laboratories specialized in the diagnosis of Crigler -Najjar syndrome http://it.geocities.com/criglernajjar/trebis.htm
Extractions: SYNDROME Please refer to the following link: Crigler-Najjar Web pages Other useful links: OMIN Clinical description of the Crigler-Najjar syndrome from the Online Mendelian Inheritance in Man database. NORD Clinical description of the Crigler-Najjar syndrome from the National Organization for Rare Disorders, Inc. database. Dr. Namita Roy-Chowdhury Home page of Dr. N. Roy-Chowdhury at the Albert Einstein College of Medicine of Yeshiva University, Bronx, NY. The Human Gene Mutation Database Mutations in Crigler-Najjar syndrome patients. B-UDPGT Human UDP-glucuronosyltransferase from the OMIN database. Online Medical Dictionary Medical dictionary from the CancerWeb. Yahoo.health Clinical description of the Crigler-Najjar syndrome from the database of Adam.com. Yahoo.health. Glossary of Genetic Terms Glossary of genetic term from the NIH site. Cholestyramine Information on cholestyramine frome On Health web site. Download Acrobat file data sheet of Questran. More Liver Links Foundations: American Liver Foundation Children's Liver Disease Foundation Children's Liver Alliance Inc. (Australia) Center for Liver Disease and Transplantation ... Italian Crigler-Najjar Association CI AMI (Onlus)
Crigler-Najjar3news News about criglernajjar syndrome from the following sources Crigler-NajjarSyndrome type I is a rare congenital disease with high mortality and http://it.geocities.com/criglernajjar/trenews.htm
CRIGLER-NAJJAR SYNDROME Dr. Koop crigler-najjar syndromecrigler-najjar syndrome, Jul 29, 2005 Genetic counseling is recommended forprospective parents with a family history of crigler-najjar syndrome. http://www.medhelp.org/glossary/new/GLS_1354.HTM
Extractions: AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Crigler-Najjar Syndrome Alternate Names : Arias Syndrome (Type II Crigler-Najjar), Glucuronyl Transferase Deficiency (Type I Crigler-Najjar) Definition Crigler-Najjar syndrome is an inherited disorder in which bilirubin (a substance made by the liver) cannot be changed into its water-soluble form, bilirubin glucuronide. This causes jaundice (yellow discoloration of skin and eyes) and organ malfunctions.
Extractions: AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia
Home Support site for parents and patients with criglernajjar syndrome Type 1 and Type 2. For physicians and researchers learn about essential treatment to avoid brain damage due to excessive bilirubin concentrations. http://criglernajjar.com
Extractions: Our Site Last Updated June 29, 2003 Crigler-Najjar Syndrome is caused by a liver enzyme deficiency Crigler-Najjar Syndrome (CNS) is an inherited metabolic disorder caused by a liver enzyme deficiency which prevents the usual metabolic breakdown of bilirubin; a normal by-product in our bodys disposal of worn-out red blood cells. Children with CNS are unable to eliminate bilirubin from their bodies and therefore must undergo daily 12-hour exposure to special blue lights, just to survive. Without daily treatments, a child would suffer brain damage, muscle and nerve damage and death due to bilirubin toxicity. A Rare Orphan Disease Crigler-Najjar is a very rare disease. There are less than 50 known cases in the USA, and less than 200 worldwide. It is named after Dr. Crigler and Dr. Najjar who discovered the disease. Dr. John F. Crigler is a Special Medical Two-year-old Melanie has to sleep under intense blue lights to help combat the disease Crigler-Najjar Syndrome Advisor to the CNA. The Crigler-Najjar Association Providing Support and Helping Others Our group represents approximately 30 families in the U.S.A. who have family members affected by Crigler-Najjar syndrome. Started in 2002 with a handful of Crigler-Najjar families, our group has grown and expanded to represent all families who are interested in providing support, information and helping others who are less fortunate that may not have the ability to pay for expensive phototherapy lights and medications required just to live.
Crigler-Najjar Syndrome criglernajjar syndrome is caused by a disorder in the metabolism of bilirubin,the chemical that causes jaundice. http://digestive-disorders.health-cares.net/crigler-najjar-syndrome.php
UpToDate Crigler-Najjar Syndrome CLASSIFICATION criglernajjar syndrome, also referred to as congenital TYPE I DISEASE crigler-najjar syndrome type I was described by Crigler and http://patients.uptodate.com/topic.asp?file=hep_dis/12983
Crigler-Najjar Syndrome Treatment Options At Mayo Clinic (type I CriglerNajjar); Arias syndrome (type II Crigler-Najjar). Crigler-Najjarsyndrome (CNS) is a rare genetic condition in which the liver cannot http://www.mayoclinic.org/genetic-liver-diseases/crigler-najjar.html
Extractions: Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Genetic Liver Diseases Genetic Liver Diseases Overview Treatment Options Treatment in Jacksonville Treatment in Rochester ... Medical Services Synonyms: Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar) Crigler-Najjar syndrome (CNS) is a rare genetic condition in which the liver cannot process bilirubin (a pigment produced when the liver processes waste products). This extremely rare syndrome is usually diagnosed by jaundice testing shortly after birth. Factors which lead to a suspicion of the disease are a family history of Crigler-Najjar syndrome and jaundice (yellow skin or eyes) that persists beyond two weeks without an obvious cause. The condition is marked by confusion and changes in thinking, resulting from the effects of excess bilirubin in the brain. Besides bilirubin tests, other diagnostics may include enzyme assays (another blood test) or liver biopsies. Children with CNS are unable to eliminate bilirubin from their bodies. Blood transfusions are used to eliminate excess bilirubin. Long-term treatment for this condition is phototherapy in which patients lay under lights for as many as 12 hours per day to break down the bilirubin. Without daily treatments, CNS patients may suffer brain damage, muscle and nerve damage or death due to bilirubin toxicity. Oral calcium phosphate may be used in conjunction with phototherapy. In school-age children, phototherapy may increase to approximately 15 hours a day, which interferes considerably with daily life. In these circumstances, liver transplantation either whole liver replacement or partial liver transplantation is the treatment of choice. A variant of the condition (type 2) is less serious and responds to drugs such as phenobarbitone.
Crigler-Najjar Syndrome - Patient UK criglernajjar syndrome - Patient UK. A directory of UK health, disease, illnessand related medical websites that provide patient information. http://www.patient.co.uk/showdoc/40001363/
Extractions: PatientPlus articles are written for doctors and so the language can be technical. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people. Two syndromes of severe unconjugated hyperbilirubinaemia: Defect in the gene encoding for UDP-glucuronyl transferase responsible for conjugating bilirubin. Epidemiology
Extractions: Ira J. Fox, M.D., Jayanta Roy Chowdhury, M.D., Stuart S. Kaufman, M.D., Timothy C. Goertzen, M.D., Namita Roy Chowdhury, Ph.D., Phyllis I. Warkentin, M.D., Kenneth Dorko, B.S., Bernhard V. Sauter, M.D., and Stephen C. Strom, Ph.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Editorial by Lake, J. R. ... PubMed Citation disorder characterized by severe unconjugated hyperbilirubinemia beginning at birth. The syndrome results from an absence of hepatic uridine diphosphoglucuronate (UDP) glucuronosyltransferase activity, which is essential for the conjugation and excretion of bilirubin. Because of the accumulation of unconjugated bilirubin in plasma, patients are at risk for kernicterus. Although phototherapy successfully reduces serum bilirubin levels, patients are again at risk for kernicterus around the time of puberty, when phototherapy
NEJM -- Sign In Original Article from The New England Journal of Medicine Treatment of thecriglernajjar syndrome Type I with Hepatocyte Transplantation. http://content.nejm.org/cgi/content/full/338/20/1422
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Extractions: Text Size A A A Front Page ... Genetic Disorders : Crigler-Najjar Syndrome Mayo Clinic Develops New Coma Measurement System (September 8, 2005) full story Nitric Oxide Could Extend Fertility (September 8, 2005) Biochemistry , an American Chemical Society journal. full story Flipped, Expelled, Copied, And Shrunk: Researchers Document Dramatic Genome Alterations During Primate Evolution (September 6, 2005) Genome Research presents a series of studies that provide insight into the evolution and variation of primate genomes. The issue will appear online and in print on September 1, concomitant with the publication of the chimpanzee genome sequence in the journal Nature full story Discovery Will Aid Identification Of Misregulated Genes In Rett Syndrome (September 4, 2005) Molecular Cell that the "Rett Syndrome protein", MeCP2, only binds to genes with a specific sequence of nucleotide bases. This knowledge will aid in the identification of the genes that are regulated by the gene MECP2. This work was supported, in part, by the Rett Syndrome Research Foundation (RSRF).
