MedlinePlus Medical Encyclopedia: Crigler-Najjar Syndrome criglernajjar syndrome is an inherited disorder in which bilirubin (a substance crigler-najjar syndrome is caused by an abnormal gene which fails to http://www.nlm.nih.gov/medlineplus/ency/article/001127.htm
Extractions: @import url(/medlineplus/images/advanced.css); Skip navigation Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Contents of this page: Liver anatomy Alternative names Return to top Glucuronyl transferase deficiency (type I Crigler-Najjar); Arias syndrome (type II Crigler-Najjar) Definition Return to top Crigler-Najjar syndrome is an inherited disorder in which bilirubin (a substance made by the liver) cannot be changed into its water-soluble form, bilirubin glucuronide. This causes jaundice (yellow discoloration of skin and eyes) and organ malfunctions. Causes, incidence, and risk factors Return to top Crigler-Najjar syndrome is caused by an abnormal gene which fails to produce a functional enzyme (bilirubin glucuronyltransferase) capable of converting bilirubin into a water-soluble and therefore, easily excreted form. As a result, bilirubin can build up in the body, which can damage the brain and other organs. The syndrome is inherited as an autosomal recessive trait. This means that the child must get the defective gene from both parents to develop the severe form of the condition. Parents who are carriers (with just one defective gene) have about half the enzyme activity of a normal adult.
? Crigler-Najjar Syndrome A medical encycopedia article on the topic crigler-najjar syndrome http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Gastroenterology Last Updated: August 26, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: CNS, Crigler-Najjar disease, Gilbert syndrome, Arias syndrome, congenital nonhemolytic jaundice, neonatal jaundice, inherited unconjugated hyperbilirubinemias, uridine diphosphate glycosyltransferase, UGT, kernicterus, bilirubin encephalopathy, plasma exchange transfusion AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Alessio Pigazzi, MD, PhD , Head, Minimally Invasive Surgery Program, Division of Surgery, Department of General Oncologic Surgery, City of Hope National Medical Center Coauthor(s): Stefano Ravalli, MD , Assistant Professor, Department of Medicine, Division of Cardiology, Columbia University College of Physicians and Surgeons Editor(s): Tushar Patel, MD
Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Gastroenterology Last Updated: January 21, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: constitutional hepatic dysfunction, constitutional hyperbilirubinemia, familial nonhemolytic jaundice, hereditary nonhemolytic bilirubinemia, low-grade chronic hyperbilirubinemia AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Sandeep Mukherjee, MD , Assistant Professor, Department of Internal Medicine, Section of Gastroenterology and Hepatology, University of Nebraska Medical Center Sandeep Mukherjee, MD, is a member of the following medical societies: American College of Gastroenterology American Society for Gastrointestinal Endoscopy American Society of Transplantation , and Royal College of Physicians and Surgeons of Canada Editor(s): Manoop S Bhutani, MD, FACG, FACP
Dr. Koop - Crigler-Najjar Syndrome criglernajjar syndrome. Injury Disease Nutrition Poison Symptoms Surgery Test Special Topic http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
EMedicine - Crigler-Najjar Syndrome Article By Alessio Pigazzi criglernajjar syndrome - crigler-najjar syndrome (CNS) is a rare disorder of bilirubin metabolism and has 2 distinct forms type 1 and type 2. Type http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
► Crigler-Najjar Syndrome A medical encycopedia article on the topic crigler-najjar syndrome. http://www.umm.edu/ency/article/001127.htm
Extractions: Toggle English Spanish Overview Symptoms Treatment Prevention Definition: Crigler-Najjar syndrome is an inherited disorder in which bilirubin (a substance made by the liver) cannot be changed into its water-soluble form, bilirubin glucuronide. This causes jaundice (yellow discoloration of skin and eyes) and organ malfunctions. Causes, incidence, and risk factors: Crigler-Najjar syndrome is caused by an abnormal gene which fails to produce a functional enzyme (bilirubin glucuronyltransferase) capable of converting bilirubin into a water-soluble and therefore, easily excreted form. As a result, bilirubin can build up in the body, which can damage the brain and other organs. The syndrome is inherited as an autosomal recessive trait. This means that the child must get the defective gene from both parents to develop the severe form of the condition. Parents who are carriers (with just one defective gene) have about half the normal enzyme activity of a normal adult. Infants who inherit the trait from both parents (this is called homozygous for the abnormal gene) develop severe jaundice (hyperbilirubinemia) beginning a few days after birth. If these infants are not treated, they may develop
Crigler-Najjar Syndrome (www.whonamedit.com) criglernajjar syndrome A familial form of congenital hyperbilirubinemia associated with severe disorders of the central nervous system and http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
► Crigler-Najjar Syndrome A medical encycopedia article on the topic crigler-najjar syndrome. http://www.umm.edu/ency/article/001127sym.htm
Crigler-Najjar Syndrome Article describes criglernajjar syndrome, its symptoms, diagnosis, and treatment. http://rarediseases.about.com/od/rarediseasesc/a/021305.htm
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CRIGLER-NAJJAR SYNDROME criglernajjar syndrome - A rare genetic defect (autosomal recessive) where there is the inability to form bilirubin glucuronide due to the http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Crigler-Najjar Syndrome criglernajjar syndrome is an inherited disorder of bilirubin metabolism.Prompt recognition of the syndrome in infancy and treatment of the excess http://rarediseases.about.com/b/a/146277.htm
Extractions: zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Sign Up Now for the Rare / Orphan Diseases newsletter! Display Latest Headlines Read Archives powered by Movable Type Advertisement Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Muscular Dystrophy Autoimmune Kidney Disease Minamata Disease Charcot-Marie-Tooth Disease ... Meckel-Gruber Syndrome adunitCM(150,100,'x55') Topic Index Email to a Friend
Crigler-Najjar3bis Mutations in criglernajjar syndrome patients. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Crigler-Najjar Syndrome (www.whonamedit.com) criglernajjar syndrome A familial form of congenital hyperbilirubinemia associatedwith severe disorders of the central nervous system and resembling http://www.whonamedit.com/synd.cfm/86.html
Extractions: This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. A familial form of congenital hyperbilirubinemia associated with severe disorders of the central nervous system and resembling kernicterus (degeneration of the basal ganglia). Other symptoms include jaundice of the skin, sclera, and mucous membrane. The syndrome is caused by an enzyme deficiency in the liver and faulty bilirubin conjugation. Both sexes affected. Presents with severe jaundice in the first few days after birth. Inheritance is autosomal dominant with incomplete penetration and varied expressivity. A deficiency of glucuronide formation was demonstrated by Irwin Monroe Arias in an anicteric father of two jaundiced children with a defect of hepatic glucuronyl transferase activity. This is sometimes referred to as Crigler-Najjar, type II. In Type I (above) death from kernicterus usually occurs within 15 months after birth. In Type II, which has been called AriasÂ’ syndrome, the patient may survive to young adult life.
Crigler-Najjar Information and useful links on criglernajjar syndrome http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
John Fielding Crigler (www.whonamedit.com) Crigler American paediatrician, born September 11, 1919, Charlotte, NorthCarolina. Associated with criglernajjar syndrome,Najjar-Crigler icterus. http://www.whonamedit.com/doctor.cfm/69.html
Extractions: This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor.
CLF Gilbert's Syndrome CLF Regional Offices. Gilbert's Syndrome What is Gilbert's Syndrome? Gilbert's Syndrome is a fairly common, mild liver disorder. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126
Crigler-Najjar Syndrome criglernajjar syndrome Web Pages - Welcome to the crigler-najjar syndrome Web Advertisement crigler-najjar syndrome - A rare genetic defect (autosomal http://www.health-nexus.com/crigler-najjar_syndrome1.htm
Extractions: The #1 Health information site Health-Nexus.Net Health-Nexus.Org Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Crigler-Najjar Syndrome MEDLINEplus Medical Encyclopedia: Crigler-Najjar syndrome Crigler-Najjar syndrome. ... Causes and risks Return to top. Crigler-Najjar syndrome is inherited as an autosomal recessive trait. Parents ...
