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Cowden Syndrome:     more detail

Cowden syndrome more common than suspected. (Genetic Cancer Syndrome).: An article from: Skin & Allergy News by Bruce Jancin, 2003-03-01 Cowden Syndrome - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-20 Cowden syndrome more common than suspected: linked to breast cancer risk. (Clinical Rounds).: An article from: Internal Medicine News by Bruce Jancin, 2003-04-01 Genetic cancer syndrome more common than suspected. (Cowden Syndrome).: An article from: Family Practice News by Bruce Jancin, 2003-03-01

lists with details

21. Cowden Syndrome
    Detailed information on cowden syndrome, including causes of the disorder.  
    http://www.healthsystem.virginia.edu/uvahealth/adult_breast/cowden.cfm
    
    Extractions: [ Skip Navigation ] Topics All About Cancer Blood Disorders Bone Disorders Breast Health Cancer Cardiovascular Disease Dermatology Diabetes Digestive Disorders Endocrinology Environmental Medicine Eye Care Glossary Gynecological Health Infectious Diseases Kidney Disease Men's Health Mental Health Nervous System Disorders Non-Trauma Emergency Oral Health Orthopaedics Otolaryngology Pathology Pediatrics, General Health Prostate Health Radiology Respiratory Disorders Skin Cancer Surgical Care Urology Women's Health Search This Site The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous,tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s

22. Síndrome De Cowden (Cowden Syndrome)
    Translate this page El riesgo de cáncer del seno es mayor en el síndrome de Cowden, un trastornoautosómico dominante poco común que S­ndrome de Cowden (cowden syndrome)  
    http://www.healthsystem.virginia.edu/UVAHealth/adult_breast_sp/cowden.cfm
    
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23. Cowden Syndrome
    The risk for breast cancer is increased with cowden syndrome, a rare autosomal cowden syndrome is associated with the following characteristics  
    http://medicalcenter.osu.edu/patientcare/healthinformation/otherhealthtopics/Bre
    
    Extractions: increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation. It is also important to remember that the PTEN gene is not located on the sex chromosomes. Therefore, mutations can be inherited from the mother or the father's side of the family.

24. Cowden Syndrome - Mountain View Bay Area Sunnyvale Cupertino Palo Alto Standford
    cowden syndrome El Camino Hospital is located in the heart of Silicon Valleyat Mountain View, California ,serving Mountain View Bay Area Sunnyvale  
    http://www.elcaminohospital.org/11264.cfm
    
    Extractions: Back to Search The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

25. Sindrome De Cowden (Breast Health - Cowden Syndrome) - Mountain View Bay Area Su
    Sindrome de Cowden (Breast Health cowden syndrome) - El Camino Hospital islocated in the heart of Silicon Valley at Mountain View, California ,serving  
    http://www.elcaminohospital.org/14197.cfm
    
    Extractions: Back to Search Se pueden incluir caracteristicas adicionales como lesiones tiroideas no cancerosas, polipos intestinales hamartomatosos, lipomas (tumores adiposos benignos), fibromas, miomas uterinos y enfermedad fibroquistica del seno. Algunos individuos que han heredado una mutacion germinal PTEN jamas desarrollan cancer porque nunca se produce la segunda mutacion necesaria para destruir la funcion del gen e iniciar el proceso de formacion del tumor. Esto puede simular que el cancer saltea generaciones en una familia, cuando, en realidad, la mutacion esta presente. Sin embargo, las personas con una mutacion, sin tener en cuenta si desarrollan cancer o no, tienen un 50 por ciento de probabilidades de transmitir la mutacion a la generacion siguiente. Ademas, es importante recordar que el gen PTEN no se localiza en los cromosomas sexuales. Por lo tanto, las mutaciones se pueden heredar de parte de la familia materna o paterna.

26. PTEN Gene Of Cowden Syndrome Found In Autism
    Inherited gene mutations in the PTEN gene are seen in cowden syndrome, a poorlyrecognized disorder that increases a person’s risk of developing cancers of  
    http://www.rxpgnews.com/psychiatry/learning-disabilities/autism/article_1014.sht
    
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27. PTEN Gene Of Cowden Syndrome Found In Autism
    PTEN gene of cowden syndrome found in Autism By Ohio State University Apr 8,2005, 0136. A gene that is changed in many forms of cancer has also been found  
    http://www.rxpgnews.com/psychiatry/learning-disabilities/autism/printer_1014.sht
    
    Extractions: Inherited gene mutations in the PTEN gene are seen in Cowden syndrome, a poorly recognized disorder that increases a person’s risk of developing cancers of the breast, thyroid and uterus. PTEN mutations are also found in several non-inherited (i.e., spontaneous) cancers, including thyroid and endometrial cancers and some brain tumors.

28. Genetics & Cancer - Cowden Syndrome
    cowden syndrome is a rare autosomal dominant disorder that is also associated with a cowden syndrome is associated with the following characteristics  
    http://ymghealthinfo.org/content.asp?pageid=P07171

29. Cancer Center
    Health Information, Genetics Cancer cowden syndrome cowden syndrome isassociated with the following characteristics  
    http://www.rush.edu/rumc/page-1098987397359.html
    
    Extractions: Hematology/Oncology Trials The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

30. Frankford Hospitals - Cowden Syndrome
    Detailed information on cowden syndrome, including causes of the disorder.A consumer web site for Frankford Hospitals, a community hospital system in  
    http://www.frankfordhospitals.org/healthinfo/adult/breast/cowden.html
    
    Extractions: Topic Home Page Topic Index The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

31. Kprones CowdenID10018
    Cowden s disease a possible new syndrome with multiple system involvement. The cowden syndrome a clinical and genetic study in 21 patients.  
    http://www.infobiogen.fr/services/chromcancer/Kprones/CowdenID10018.html
    
    Extractions: Home Genes Leukemias Solid Tumours ... NA Identity Other names Multiple hamartoma syndrome Inheritance autosomal dominant; high penetrance (close to 100% by the age of 30 yrs); highly variable expressivity (between and within families) Clinics Phenotype and clinics clinical manifestations usually occur during the 2nd and 3rd decade; they are dystrophic, hamartomatous or tumoral lesions including the following to variable extend: Overlapping syndromes Bannayan-Riley-Ruvalcaba syndrome including precocious stigmata of Cowden disease (macrocephaly, lipomas, genital pigmented macules, hamartomatous intestinal tract polyps) is considered as a pediatric form of Cowden disease Lhermitte Duclos syndrome or dysplastic gangliocytoma of the cerebelum is a rare and complex hamartomatous condition of the cerebellum which can occur alone but also in association with Cowden disease juvenile polyposis and Peutz Jeghers syndrome : Cowden disease, by its intestinal tract lesions can be linked to the scope of hereditary hamartomatous polyposis; molecular diagnosis can be useful in distinguishing juvenile polyposis, Peutz Jeghers syndrome or Cowden disease/Bannayan

32. Will The Real Cowden Syndrome Please Stand Up: Revised Diagnostic Criteria -- En
    cowden syndrome (CS, MIM 158350) is an autosomal dominant disorder with agerelated penetrance characterised by multiple hamartomas and a high risk of  
    http://jmg.bmjjournals.com/cgi/content/extract/37/11/828
    
    Extractions: Vol Page [Advanced] This Article Full Text Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Eng, C. Related Collections Other Oncology Genetics J Med Genet 828-830 ( November ) Charis Eng Clinical Cancer Genetics and Human Cancer Genetics Programs, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 420 W 12th Avenue (Suite 690 MRF), Columbus, OH 43210, USA; CRC Human Cancer Genetics Research Group, University of Cambridge, Cambridge, UK

33. Male Breast Cancer In Cowden Syndrome Patients With Germline PTEN Mutations -- F
    cowden syndrome (CS) is an autosomal dominant cancer susceptibility syndrome The cowden syndrome a clinical and genetic study in 21 patients.  
    http://jmg.bmjjournals.com/cgi/content/full/38/3/159
    
    Extractions: Vol Page [Advanced] This Article Abstract Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Fackenthal, J. D Articles by Olopade, O. I Related Collections Cancer:other Genetics J Med Genet 159-164 ( March ) James D Fackenthal a , Deborah J Marsh b , Anne-Louise Richardson b , Shelly A Cummings a , Charis Eng c , Bruce G Robinson b , Olufunmilayo I Olopade a a Center for Clinical Cancer Genetics, Department of Medicine, University of Chicago Medical Center, Chicago, IL 60637, USA, b Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, Sydney NSW 2065, and Department of Medicine, University of Sydney, NSW 2006, Australia, c Clinical Cancer Genetics and Human Cancer Genetics Program, Comprehensive Cancer Center, and Division of Human Genetics, Department of Internal Medicine, The Ohio State University, 690C Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43201 USA, and CRC Human Cancer Genetics Research Group, University of Cambridge, UK

34. Cowden Syndrome - Definition From Biology-Online.org
    Definition and other additional information on cowden syndrome from BiologyOnline.orgdictionary.  
    http://www.biology-online.org/dictionary/cowden_syndrome

35. Germline Mutations Of The PTEN Gene In Cowden Disease, An Inherited Breast And T
    cowden syndrome and LhermitteDuclos disease in a family a single genetic The cowden syndrome a clinical and genetic study in 21 patients, dm. Clin.  
    http://www.nature.com/ng/journal/v16/n1/abs/ng0597-64.html
    
    Extractions: @import "/ng/style.css"; NATURE.COM NEWS@NATURE.COM NATUREJOBS NATUREEVENTS ... Help E-MAIL: PASSWORD: Save password Forgotten password? SEARCH JOURNAL Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Cell Biology Nature Medicine Nature Reviews Genetics ... Browse all publications Letter Nature Genetics doi:10.1038/ng0597-64 Danny Liaw , Debbie J. Marsh , Jing Li , Patricia L. M. Dahia , Steven I. Wang , Zimu Zheng , Shikha Bose , Katherine M. Call , Hui C. Tsou , Monica Peacoke , Charis Eng Departments of Pathology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10032, USA. Departments of Medicine, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10032, USA. Departments of Dematology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, New York 10032, USA. . Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, D920C, Boston, Massachusetts 02115, USA.

36. Greenville Hospital System
    Genetics Cancer cowden syndrome, Printable View cowden syndrome isassociated with the following characteristics  
    http://www.ghs.org/frame.php?pageid=P07171

37. Resources For Genetic Counselors - Cowden Syndrome
    B. Part of PTEN hamartoma tumor syndrome (PHTS). 1. Includes cowden syndrome,BannayanRiley-Ruvalcaba, Proteus syndrome, and Proteus-like syndrome  
    http://www.genesoc.com/counseling2/article51.html

38. Southeast Missouri Hospital - Cowden Syndrome
    cowden syndrome. The risk for breast cancer is increased with cowden syndrome,a rare autosomal dominant disorder that is also associated with a number of  
    http://www.southeastmissourihospital.com/cancerresource/cowden.htm
    
    Extractions: The risk for breast cancer is increased with Cowden syndrome, a rare autosomal dominant disorder that is also associated with a number of specific noncancerous features. Cowden syndrome is associated with the following characteristics: multiple hamartomatous lesions (benign, or noncancerous, tumors of normal organ tissue) of the skin and other organs, usually present by the late 20s increased risk of endometrial cancer Additional features can include noncancerous thyroid lesions, hamartomatous intestinal polyps, lipomas (benign fatty tumors), fibromas, uterine fibroids, and fibrocystic disease of the breast. Cowden syndrome is caused by mutations in a gene on chromosome 10 known as PTEN. About 80 percent of people whose symptoms meet the criteria for a diagnosis of Cowden syndrome will have a PTEN mutation. Mutations in PTEN confer a 25 percent to 50 percent lifetime risk for breast cancer, about a 10 percent risk of thyroid cancer, and potentially up to a 5 percent to 10 percent risk of endometrial cancer, although this risk is still being evaluated. Some individuals who have inherited a germline PTEN mutation never develop cancer because they never get the second mutation necessary to knock out the function of the gene and start the process of tumor formation. This can make the cancer appear to skip generations in a family, when, in reality, the mutation is present. Persons with a mutation, regardless of whether they develop cancer, however, have a 50/50 chance to pass the mutation on to the next generation.

39. Genetics Of PTEN In Cowden Syndrome And Sporadic Breast Cancer - Storming Media
    Germline mutations in PTEN on 10q23.3 cause 80% of classic cowden syndrome (CS)and SO of BannayanRiley-Ruvalcaba syndrome (CS) as well as up to 20% of  
    http://www.stormingmedia.us/30/3038/A303893.html
    
    Extractions: Limitations: APPROVED FOR PUBLIC RELEASE Description: Final rept. 1 Oct 1998-30 Sep 2001 Pages: Report Date: OCT 2001 Report number: Keywords relating to this report: BREAST CANCER CHROMOSOMES DIAGNOSIS(GENERAL) EMBRYOLOGY ... VACCINES Printed Format - $25.95 Adobe PDF - $8.95 Please check the box for the format you wish to order. Shipping Terms

40. Genetics Of PTEN In Cowden Syndrome And Sporadic Breast Cancer - Storming Media
    cowden syndrome (CS) is an autosomal dominant disorder characterized by multiplehamartomas and a high risk of breast, thyroid and other cancers.  
    http://www.stormingmedia.us/44/4483/A448383.html
    
    Extractions: Limitations: APPROVED FOR PUBLIC RELEASE Description: Annual rept. 1 Oct 1998-30 Sep 1999 Pages: Report Date: OCT 1999 Report number: Keywords relating to this report: BREAST CANCER CHROMOSOMES GENES GENETICS ... THYROID GLAND Printed Format - $25.95 Adobe PDF - $8.95 Please check the box for the format you wish to order. Shipping Terms

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