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Cowden Syndrome:     more detail

Cowden syndrome more common than suspected. (Genetic Cancer Syndrome).: An article from: Skin & Allergy News by Bruce Jancin, 2003-03-01 Cowden Syndrome - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-20 Cowden syndrome more common than suspected: linked to breast cancer risk. (Clinical Rounds).: An article from: Internal Medicine News by Bruce Jancin, 2003-04-01 Genetic cancer syndrome more common than suspected. (Cowden Syndrome).: An article from: Family Practice News by Bruce Jancin, 2003-03-01

lists with details

1. Cowden Syndrome
   A CHORUS notecard document about this syndrome.  
   http://chorus.rad.mcw.edu/doc/00100.html

2. Cowden Syndrome - Genetics Home Reference
   Where can I find additional information about cowden syndrome? What if Istill have specific questions about cowden syndrome?  
   http://www.ghr.nlm.nih.gov/ghr/disease/cowdensyndrome
   
   Extractions: Home What's New Browse Handbook ... Search Cowden syndrome On this page: Cowden syndrome is an inherited disorder characterized by multiple tumor-like growths (called hamartomas) and an increased risk of certain cancers. Almost everyone with this condition has hamartomas. These small, noncancerous growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but can also occur in the intestinal tract and other parts of the body. People with Cowden syndrome have an increased risk of developing several types of cancer, including cancers of the breast, thyroid, and uterus. Noncancerous breast and thyroid diseases are also common. Other signs and symptoms of Cowden syndrome can include an enlarged head; a rare, noncancerous brain tumor called Lhermitte-Duclos disease; and mental retardation. How common is Cowden syndrome?

3. EMedicine - Cowden Disease (Multiple Hamartoma Syndrome) Article
   Cowden Disease (Multiple Hamartoma Syndrome) Cowden disease (CD), also termed cowden syndrome and multiple hamartoma syndrome, is an autosomal  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. Cowden Syndrome - References - Genetics Home Reference
   Eng C. Will the real cowden syndrome please stand up revised diagnostic Kelly P. Hereditary breast cancer considering cowden syndrome a case study.  
   http://www.ghr.nlm.nih.gov/condition=cowdensyndrome/show/References
   
   Extractions: Home What's New Browse Handbook ... Search Cowden syndrome These sources were used to develop the Genetics Home Reference condition summary on Cowden syndrome. Last Comprehensive Review: October 2004 Published: September 6, 2005 Contact NLM Customer Service Lister Hill National Center for Biomedical Communications ... Selection Criteria for Web Links Indicates a page outside Genetics Home Reference.

5. Cowden Syndrome
   Identification of a PTEN mutation in a family with cowden syndrome and BannayanZonana syndrome. J Am Acad Dermatol 2001;44183-7  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. Cowden Syndrome - Genetics Home Reference
   What is cowden syndrome? cowden syndrome is an inherited disorder characterized by multiple tumorlike growths (called hamartomas) and an  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Cowden Syndrome
   cowden syndrome. multiple hamartoma syndrome . GItract hamartomas (incl.stomach and colon). breast Ca; thyroid Ca  
   http://chorus.rad.mcw.edu/to-go/00100.html

8. Cowden Syndrome
   a CHORUS notecard document about cowden syndrome  
   http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Cowden Syndrome
   cowden syndrome (CS) is a autosomal dominant inherited syndrome. The cutaneouspathology of Cowden s syndrome is characterized by multiple  
   http://www.thedoctorsdoctor.com/diseases/cowdensyndrome.htm
   
   Extractions: Background Cowden syndrome (CS) is a autosomal dominant inherited syndrome. These patients are characterized by multiple hamartomas occurring in the skin, breast, thyroid, gastrointestinal tract, endometrium, and brain. Patients do have an increased risk of experiencing malignant tumors with the most common ones are breast, endometrial, and thyroid cancer. OUTLINE Epidemiology Disease Associations Pathogenesis Laboratory/Radiologic/ ... Internet Links DISEASE ASSOCIATIONS CHARACTERIZATION Bannayan-Zonnana syndrome Some cases show overlap with macrocephaly, intestinal polyps, and lipomas, and mulitple trichilemmomas are found in both diseases Genetic basis of these two diseases is identical. INVERTED FOLLICULAR KERATOSES Multiple inverted follicular keratoses as a presenting sign of Cowden's syndrome: case report with human papillomavirus studies.

10. Balanced Translocation Of 10q And 13q, Including The PTENGene, In
    Am J Med Genet. 80399402.CrossRefMedline Hanssen AMN, Fryns JP. 1995 cowden syndrome. J Med Genet. 32117-119.Abstract  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. High Incidence Of Breast And Endometrial Neoplasia Resembling
    High Incidence of Breast and Endometrial Neoplasia Resembling Human cowden syndrome in pten+/ Mice Vuk Stambolic1 , Ming-Sound Tsao  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. Virtual Children's Hospital: Cowden Syndrome: A Guide For Patients And Their Fam
    This booklet, from UI Hospitals and Clinics, supplements information provided bymembers of your health care team about cowden syndrome.  
    http://www.vh.org/pediatric/patient/cancercenter/cowden/
    
    Extractions: This material supplements information provided by physicians, nurses, genetic counselors, and other members of your health care team about Cowden syndrome. It does not replace regular medical care or discussions with your physician and health care team. If you see a an unfamiliar term, please consult the Glossary of Terms This information is written primarily for patients. See related Patient Textbooks about Cancer Center or Pediatrics See related Patient Topics Cancer Center CancerGeneral Cancers Digestive DiseasesGeneral ... Genetics or Pediatrics See related Provider Textbooks about or Pediatrics See related Provider Topics Cancers Digestive DiseasesGeneral Digestive System Genetics or Pediatrics Virtual Hospital Home Virtual Children's Hospital Home Site Map ... University of Iowa http://www.vh.org/pediatric/patient/cancercenter/cowden/index.html

13. Male Breast Cancer In Cowden Syndrome Patients With Germline PTEN
    Male breast cancer in cowden syndrome patients with germline PTEN mutations  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Virtual Children's Hospital: Cancer: Cowden Syndrome
    cowden syndrome is a poorly recognized and thus underdiagnosed Patientsdiagnosed with cowden syndrome do not necessarily have all the same features.  
    http://www.vh.org/pediatric/patient/cancercenter/cowden/whatisit.html
    
    Extractions: Last Revised: April 2002 Cowden syndrome is a poorly recognized and thus under-diagnosed condition characterized by multiple hamartomas and a risk of breast, thyroid, and uterine neoplasias (both benign and malignant). The most consistent features of CS, occurring in 99 percent of individuals with this clinical diagnosis, are found on the skin. These are small flesh-colored bumps on the skin involving a hair follicle (trichilemmomas) and small wart-like growths (papillomatous papules). Less commonly, CS is associated with a large head size (macrocephaly), benign fatty tumors (lipomas), and blood vessel changes (hemangiomas). The frequency of hamartomatous polyps of the small and large intestine is unknown, but is thought to occur in fewer than 40 percent of CS individuals. What is known is that CS hamartomatous polyps are rarely symptomatic. Please see Diagram 1. There is no clinical data that tells us when the features begin to appear in CS. However, we do know that more than 90 percent of individuals with CS have some features by the age of 20.

15. Male Breast Cancer In Cowden Syndrome Patients With Germline PTEN
    Male breast cancer in cowden syndrome patients with germline PTEN mutations  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. EMedicine - Cowden Disease (Multiple Hamartoma Syndrome) : Article By Charles Mi
    Cowden Disease (Multiple Hamartoma Syndrome) Cowden disease (CD), also termedcowden syndrome and multiple hamartoma syndrome, is an autosomal dominant  
    http://www.emedicine.com/DERM/topic86.htm
    
    Extractions: (advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Dermatology Internal Medicine Last Updated: June 2, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: multiple hamartoma syndrome, Cowden syndrome PTEN (phosphatase and tensin homolog) hamartoma tumor syndrome AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Charles Miller, MD , Dermatologist, Department of Dermatology, Southern California Kaiser Permanente Charles Miller, MD, is a member of the following medical societies: American Academy of Dermatology Editor(s): Craig A Elmets, MD , Director of Dermatology, Departments of Dermatology, Professor, Pathology, Environmental Health Sciences, The Kirklin Clinic, University of Alabama at Birmingham; Richard Vinson, MD

17. Genetics Cancer - Cowden Syndrome Health Information
    cowden syndrome. The risk for breast cancer is increased with cowden syndrome, a rare autosomal dominant disorder that is also associated with a  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. EMedicine - Trichilemmoma : Article Excerpt By: William P Baugh, MD
    cowden syndrome is a rare autosomal dominant condition characterized by Because of this, cowden syndrome is also known as multiple hamartoma syndrome.  
    http://www.emedicine.com/derm/byname/trichilemmoma.htm
    
    Extractions: (advertisement) Synonyms, Key Words, and Related Terms: tricholemmoma, benign neoplasms of the follicular epithelium, Cowden syndrome, Cowden’s syndrome, Cowden disease, Cowden’s disease, multiple hamartomas, multiple hamartoma syndrome, nevus sebaceous of Jadassohn Background: In 1962, Headington and French first described trichilemmoma as a benign neoplasm with differentiation toward pilosebaceous follicular epithelium. Subtle clinical and distinctive histologic features may characterize these superficial cutaneous tumors. Their significance resides in the association with Cowden disease and the need to differentiate trichilemmomas from other more aggressive cutaneous tumors. Clinically, trichilemmomas present as smooth, asymptomatic papules or verrucoid growths. They may occur as a solitary lesion or as multiple lesions, and they are usually found on the face (see Image 1 ). These lesions often mimic a basal cell carcinoma or a wart. Trichilemmoma should be considered in the differential diagnosis of any indistinct facial papule. Differentiation from a basal cell carcinoma or a trichilemmal carcinoma is needed for appropriate patient management. Trichilemmomas are often reported in association with a nevus sebaceous of Jadassohn. When many trichilemmomas are present, Cowden disease (multiple hamartoma syndrome) should be suspected. The diagnosis of trichilemmoma is usually obtained by microscopic examination, revealing distinct histologic features.

19. Phenotypic Findings Of Cowden Syndrome And Bannayan-Zonana
    Your browser does not support frames. Click here to view the unframed reprint.  
    http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Cowdens Syndrome
    cowden syndrome is an inhereted genetic disease. Currently, about 80% of thecowden syndrome patients have a mutation that can be found in the test.  
    http://groups.msn.com/cowdenssyndrome/cowdensyndrome.msnw
    
    Extractions: var nEditorialCatId = 102; MSN Home My MSN Hotmail Shopping ... Money Web Search: document.write(' Groups Groups Home My Groups Language ... Help Cowdens Syndrome cowdenssyndrome@groups.msn.com What's New Join Now Welcome general messages ... Tools Cowden syndrome is an inhereted genetic disease. If you have it your child has a 50% chance of having it. If your parent had it you also have a 50% chance of having it. It is caused by a mutation of the Pten gene. It is inhereted equally by both sexes, although the childhood version of the disease tends to be more common in males. The Pten gene is a cell regulator gene. This means it is one of our genes that helps control cell growth. We get two copies of this gene from our parents,and if one is damaged it is harder for the body to control cell growth. Due to this problem people who have the damaged gene and have cowdens syndrome or BRRS,which is the childhood version of the disease tend to easily grow various things on their body. The most common growth in the adult and childhood version of the disease is a hamartoma. Genetics people have recently renamed both diseases to "The Pten Hamartoma Tumor Syndrome". A hamartoma is basically an overgrowth of the same tissue on where its located. A lung hamartoma is lung tissue, a breast hamartoma is breast tissue. In Cowdens Syndrome the most known risks for these hamartomas to turn cancerous are in the breast.

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