Extractions: Vol. 98 No. 6, June 1980 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Eshaghian J Cancilla PA Contact me when this article is cited J. Eshaghian, R. L. Anderson, T. A. Weingeist, M. N. Hart and P. A. Cancilla Orbicularis oculi muscle biopsies were performed in 38 patients (ten with chronic progressive external ophthalmoplegia and 28 controls) to determine whether ragged red fibers were present and, if so, whether they were specific to progressive external ophthalmoplegia. To our knowledge, the orbicularis muscle has not been previously studied in this regard. Ragged
Extractions: Vol. 118 No. 10, October 2000 Featured Link E-mail Alerts Clinicopathologic Report Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Carta A Zeviani M Articles that cite this article ISI Web of Science (4) ... Contact me when this article is cited Topic Collections Ophthalmology, Other Topic Collection Alerts
Kearns Sayre Syndrome chronic progressive external ophthalmoplegia and Myopathy; CPEO with Myopathy;CPEO with RaggedRed Fibers; KSS; Mitochondrial Cytopathy, Kearn-Sayre Type http://my.webmd.com/hw/raising_a_family/nord367.asp
Entrez PubMed chronic progressive external ophthalmoplegia a correlative study of quantitativemolecular data and histochemical and biochemical profile. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9
Entrez PubMed chronic progressive external ophthalmoplegia a correlative study of mitochondrialDNA deletions and their phenotypic expression in muscle biopsies. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9
Extractions: A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422) Synonyms and Source Vocabularies:
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Extractions: Leu(UUR) a case of chronic progressive external ophthalmoplesia with a heteroplasmic A-to-G transition at nt.3243 in the tRNA Leu(UUR) Yoshiko Aoki, Yasuhiro Nishida, Toyotaka Murata, Makiko Kimura, Masahiko Terada We report on a 35 year-old female with chronic progressive external ophthalmoplegia. She had bilateral blepharoptosis, total ophthalmoplegia and muscle weakness of the bilateral proximal groups of the upper extremities and facial muscles. She did not exhibit either endocrinological disorder or hearing loss nor was there any family history. Pathological findings of the limb skeletal muscle showed ragged red fibers and cytochrome c oxidase-negative fibers. Mitochondrial DNA analysis revealed a mutation at the heteroplasmic A-to-G transition at nt.3243 in the RNA (LeuUUR) . During clinical examinations, there were no signs of encephalopathy or stroke-like episodes normally seen in cases of MELAS. keyword : CPEO, mtDNA3243 tRNA (LeuUUR) mutation, MELAS
Accessing Article chronic progressive external ophthalmoplegia (CPEO) is a mitochondrial myopathycharacterised by ophthalmoplegia and ptosis. http://www.nature.com/eye/journal/vaop/ncurrent/full/6701924a.html
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Accessing Article We studied 25 patients with chronic progressive external ophthalmoplegia. In eachcase muscle biopsies were consistent with mitochondrial myopathy. http://www.nature.com/eye/journal/v19/n3/full/6701488a.html
Extractions: Most users gain access to full text articles through a site license. This is available to institutional customers only. For further information visit the Librarian Gateway. Full-text articles are also available through a number of other options: I want to purchase this article Select this option to view this article immediately and access it for seven days. I am already a personal subscriber to Eye Personal subscribers to Eye can view this article. To do this you need to associate your subscription with your registration via the My Account page. If you already have an active online subscription, log in via the login box in the top right-hand corner of this page.
Mental Diseases (KearnsSayre Disease , chronic progressive external ophthalmoplegia and Myopathy ,Mitochondrial Cytopathy, Kearn-Sayre Type , CPEO with Ragged-Red Fibers http://www.thirdaid.com/index/qfm/fuseaction/registrationStep3/catalog_id/10521/
Ophthalmic Hyperguide. Oculoplastics: Ophthalmoplegia Plus Syndromes chronic progressive external ophthalmoplegia may also occur in isolation of anyother system involvement. To correctly diagnose the underlying disorder in a http://www.ophthalmic.hyperguides.com/tutorials/oculoplastics/ophthalmoplegia_pl
Extractions: Ophthalmoplegia Plus Syndromes Janet Rucker, MD Neurologic, ophthalmologic, and systemic disorders with common chronic progressive external ophthalmoplegia (CPEO) have been identified. Chronic progressive external ophthalmoplegia may also occur in isolation of any other system involvement. To correctly diagnose the underlying disorder in a patient with CPEO, a baseline understanding of the common disorders and pathways to diagnosis is necessary. The term ophthalmoplegia plus was coined by David Drachman, MD, in 1968 and refers to disorders with abnormalities, often neurologic, in addition to CPEO. Knowledge of these disorders has increased significantly since then; however, overlap between clinical phenotypes and genetic defects for the most common causes of CPEO remains. Chronic progressive external ophthalmoplegia should be considered a sign of disease, rather than a disease. In addition to slowly progressive, bilateral, typically symmetric ocular immobility, bilateral ptosis is often present ( Slide 1 ). Mitochondrial myopathy is the most common cause of CPEO, but CPEO may be a component of other disorders that should be considered in the differential diagnosis (Table 1).
Ophthalmic Hyperguide. Section: Oculoplastics chronic progressive external ophthalmoplegia is a disorder resulting from a defectin the mitochondrial function in which the extraocular and periocular http://www.ophthalmic.hyperguides.com/tutorials/oculoplastics/ptosis/tutorial.as
Extractions: SLIDE 1 Over the years, many classifications of ptosis have been developed. However, recently with refinements in the diagnosis of ptosis, along with improved anatomic evaluation and study of the pathophysiology of certain types of ptosis, a better understanding of ptosis has developed. Ptosis may be classified into congenital and acquired types. Congenital ptosis is a developmental dystrophy of the levator muscle of an unknown cause ( Slide 1 SLIDE 2 The condition is usually sporadic, but it may be hereditary. Congenital ptosis may be simple with the defect isolated to only the levator muscle or with superior rectus muscle weakness. Congenital ptosis also includes blepharophimosis syndrome, which is hereditary and which, in addition to ptosis, may include varying degrees of telecanthus, epicanthus inverses, phimosis, and ectropion of the lower eyelids. Congenital ptosis also includes the Marcus Gunn jaw winking syndrome, which is caused by abnormal levator innervation rather than a striated muscle fiber deficiency. Acquired ptosis is best classified by Beard ; however, other authors have added subclassifications, including aponeurotic, neurogenic, myogenic, mechanical, traumatic, and pseudoptosis.
British Library Direct: Order Details Order from the British Library chronic progressive external ophthalmoplegia,mitochondrial encephalomyopathies, and ocular motor disorders Japanese http://direct.bl.uk/research/50/33/RN140445083.html
Extractions: This is an article from British Library Direct, a new service that allows you to search across 20,000 journals for free and order full text using your credit card. Article details Article title Chronic progressive external ophthalmoplegia, mitochondrial encephalomyopathies, and ocular motor disorders Author Kase, M. Journal title JAPANESE JOURNAL OF CLINICAL OPHTHALMOLOGY Bibliographic details 2003, VOL 57; PART 9, pages 1407-1419 Publisher IJAKU SHOIS LTD Country of publication Japan ISBN ISSN Language Original Pricing To buy the full text of this article you pay:
Extractions: Clin Cardiol. 1997 Mar; 20(3): 239-243. The cardiac function in five patients with chronic progressive external ophthalmoplegia (CPEO) was evaluated. Carotid pulse recording and echocardiography showed a left ventricular systolic dysfunction in two patients. One of these patients died of congestive heart failure 2 months after the study. The Doppler pattern of left ventricular filling in the three remaining patients showed left ventricular diastolic dysfunction. Although the cardiac involvement of patients with CPEO is generally considered to be limited to the cardiac conduction system, left ventricular dysfunction should receive more attention in the management of patients with CPEO.
Muscular Dystrophy Campaign that most of these patients have either oculopharyngeal muscular dystrophy (OPMD)or mitochondrial chronic progressive external ophthalmoplegia (CPEO). http://www.muscular-dystrophy.org/information_resources/factsheets/medical_condi
Extractions: It has been recognised for many years that some patients with muscle disease have particular problems with the muscles around the eyes, although other parts of the body can also be involved. Whilst research is continuing, it appears that most of these patients have either oculopharyngeal muscular dystrophy (OPMD) or mitochondrial chronic progressive external ophthalmoplegia (CPEO). The main features of these disorders are discussed below. Some of the symptoms and signs are common to both disorders. You can download this factsheet as a Word document: Ocular Myopathies factsheet Muscular dystrophy is a term used to describe a number of conditions in which there is progressive muscle weakness, caused by the patient having a faulty gene. In OPMD the weakness mainly affects the ocular (eye) and pharyngeal (throat) muscles.
1 In a patient with chronic progressive external ophthalmoplegia and bilateralptosis obscuring the visual axis. Would you perform levator resection or brow http://www.mrcophth.com/vivaquestions/viva1/3.html
