Extractions: Verified by National Institutes of Health Clinical Center (CC) February 2, 2005 Sponsored by: National Human Genome Research Institute (NHGRI) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose This study will try to learn more about the genetic cause and symptoms of microphthalmia (small eyes) or anophthalmia (absence of one or both eyes). Patients with microphthalmia or anophthalmia with mental retardation may be eligible for this study. Patients' parents and siblings will also be included for genetic studies. Patients may participate in both the clinical and laboratory parts of the study or just the laboratory part, as described below: Laboratory The laboratory study consists of DNA analysis to determine the genetic cause of microphthalmia/anophthalmia. The DNA sample is obtained using one of the following methods: -Blood draw - for young children, a numbing cream is applied to the skin before the needlestick to decrease the pain
Portal Toolkit Invalid Site URL Congenital clinical anophthalmos. Newborn girl with bilateral congenital clinical Therapy for anophthalmos with enlarging conformers, and results. http://www.co-ophthalmology.com/pt/re/coophth/fulltext.00055735-200410000-00008.
NSW Health - ICD-9-CM 740-759 743.00 Clinical anophthalmos, unspecified Agenesis Congenital absence of eyeanophthalmos NOS 743.03 Cystic eyeball, congenital 743.06 Cryptophthalmos http://www.health.nsw.gov.au/public-health/icd/740-759.htm
Oculoplastic Surgery - Reconstructive Surgery - VisionChannel A child born without an eyeball (congenital anophthalmos) usually has a small eye Cosmetic procedures for children with congenital anophthalmos are http://www.visionchannel.net/oculoplasticsurgery/reconstructive.shtml
Extractions: Reconstructive Surgery Surgical removal of skin cancer of the eyelid is standard therapy. Depending on the size, depth, and location of the lesion, this can cause substantial loss of eyelid skin that may affect its function and appearance. Surgeons attempt to preserve as much skin as possible and minimize scarring, while making sure that all of the cancer cells are removed. Mohs technique, (link) or frozen section control, for example, enables the surgeon to excise the tumor while leaving more healthy tissue intact. Some very small tumors may heal on their own, through a process called granulation A large tumor may require reconstructive surgery. Two methods used are
The EyePathologist Disease - A anophthalmos X-linked - Klintworth, Gordon K. anophthalmos with associatedanomalies - Klintworth, Gordon K. Anterior ischemic optic neuropathy http://www.eyepathologist.com/List.asp
Extractions: To see an alphabetized list of diseases illustrated and described in the EyePathologist database click the appropriate initial letter. You must Register to view the entire EyePathologist program, which includes sections on Anatomy and Pathology as well as an interactive Glossary of over 5,000 terms. A B C D E ... Z Aarskog syndrome - Klintworth, Gordon K.
EUROCAT anophthalmos/micropthalmos, , 7430, 7431, Q110, Q111, Q112. anophthalmos,Unilateral or bilateral absence of the eye tissue. 7430, Q110, Q111 http://www.biomedicalweb.biz/eurocat/appendices.cgi
Extractions: Anomaly Description Of Anomaly Comments Nervous system Nervous system anomalies include neural tube defects, hydrocephaly, microcephaly and other anomalies of the brain, spinal cord and nervous system Neural Tube Defects Neural tube defects include anencephaly, encephalocele, spina bifida and iniencephacy Anencephalus and similar Absence or deficience of a major portion of the cranial vault, the covering skin and the brain tissue. (incompatible with life) Encephalocele Herniation of the brain and/or meninges through a defect in the skull exclude if associated with anencephalus Spina Bifida Midline defect of the osseous spine ususally affecting the posterior arches resulting in a herniation or exposure of the spinal cord and/or meninges exclude if associated with anencephalus, or encephalocele Hydrocephaly Dilation of ventricular system, not due to primary atrophy of the brain, with or without enlargement of the skull 7423, excl 74232 exclude hydranencephaly, or association with NTDs Microcephaly Reduction in the size of the brain with a skull circumference less than three standard deviations below the mean for gestation or age and reduced growth during first year of life exclude association with NTDs Arhinencephaly/holoprosencephaly Absence of the first cranial (olfactory) nerve tract. There is a spectrum of anomalies from a normal brain, except for the first cranial nerve tract, to a single ventricle (holoprosencephaly)
Araceli Busby EUROCAT.ulst.ac.uk/pdf/CaptureRecapture.pdf; Busby A, Dolk H, Armstrong BGanophthalmos/microphthalmos in England temporal variation and the association http://www.lshtm.ac.uk/pehru/staff/abusby.html
Extractions: Contact People Sitemap A-Z ... Departments You are here: Home Departments PHP PEHRU ... Staff Title: Research Fellow Disciplines: Epidemiology. Research areas: Perinatal health, Reproductive health, Environment. Other keywords: congenital anomalies. Room: 40A Keppel Street Telephone: Fax: Email: a.busby@lshtm.ac.uk Carolyn Stephens, Rupert Hough, Araceli Busby. (March 2004). Assessing the health risk and impact associated with living on the Thames View Estate. A rapid literature review of methods. Report for Barking and Dagenham PCT. www.barkinghaveringhealth.nhs.uk/pdfs/tvriskassess.pdf Lenore Abramsky, Nicola Armstrong, Araceli Busby, Helen Dolk and a EUROCAT Working Group. Prevention of Neural Tube Defects by Periconceptional Folic Acid Supplementation in Europe. EUROCAT Special Report, May 2003. http://www.EUROCAT.ulst.ac.uk/pubdata/folic%20acid.html Armstrong B, Busby A, Dolk H. Using capture recapture methods to ascertain completeness of a register: case study and methodological considerations. EUROCAT Special Report, November 2003. http://www.EUROCAT.ulst.ac.uk/pdf/Capture-Recapture.pdf
MEANWHILE BACK IN IRAQ AND VIETNAM I have not seen any reports on anophthalmos cases (babies born without eyes)associated with these compounds, but this data may well be in company files. http://www.firethistime.org/meanwhileiniraq.htm
Extractions: "The Security Council began to streamline its vetting procedures in March 2000, when the total value of blocked contracts stood at about 1.7 billion dollars. In his letter, Sevan said a total of 1,854 contracts were now on hold, worth a total 4.956 billion dollars. They included orders for 4.28 billion dollars worth of humanitarian supplies and for 676 million dollars worth of oil industry equipment." - from 'UN alarmed by contract blocking of Iraq oil-for-food programme,' reported by Agence France Press, 9th January 2002 "In 30 years in Washington I've never seen anything quite like it. They're being treated like enemies because of a policy disagreement." - Richard Perle, US Defense Policy Board Chairman and reiterated by former CIA Director James Woolsey, quoted in the Wall Street Journal, 10th January 2002 Perle was describing the US State Deptartment decision to suspend funding to the INC citing financial irregularities. The INC (Iraqi National Congress - in opposition to Saddam Hussein) had been pledged $97 million and were given a January 15th 2002 deadline to produce accounts. The State Department announcement came 10 days ahead of schedule. The INC informed them that undercover sources in Iraq would be compromised by full disclosure.
Publications - Childhood Eye Diseases variation in blindness in children due to microphthalmos, anophthalmos andcoloboma. and pedigrees in children with anophthalmos in southern India. http://www.iceh.org.uk/res_pu03.asp
Extractions: (include unspecified) nr N.A. Anotia nr N.A. Microtia nr N.A. Transposition of great vessels nr N.A. Tetralogy of Fallot nr N.A. Hypoplastic left heart syndrome nr N.A. Coarctation of aorta nr N.A. Choanal atresia, bilateral nr N.A. Cleft palate without cleft lip nr N.A. Cleft lip with or without cleft palate nr N.A.
Extractions: (include unspecified) nr N.A. Anotia nr N.A. Microtia nr N.A. Transposition of great vessels nr N.A. Tetralogy of Fallot nr N.A. Hypoplastic left heart syndrome nr N.A. Coarctation of aorta nr N.A. Choanal atresia, bilateral nr N.A. Cleft palate without cleft lip nr N.A. Cleft lip with or without cleft palate nr N.A.
Extractions: It is possible that the main title of the report Lenz Microphthalmia Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Lenz Microphthalmia syndrome is an extremely rare inherited disorder characterized by abnormal smallness of one or both eyes (unilateral or bilateral microphthalmos) and/or droopy eyelids (blepharoptosis), resulting in visual impairment. In rare cases, affected infants may exhibit complete absence of the eyes (anophthalmia). Most affected infants also exhibit developmental delay and mental retardation, ranging from mild to severe. Additional physical abnormalities are often associated with this disorder such as an unusually small head (microcephaly) and/or malformations of the teeth, ears, and/or fingers and/or toes (digits). The range and severity of findings may vary from case to case. Lenz microphthalmia syndrome, which is inherited as an X-linked recessive genetic trait, is fully expressed in males only. However, females who carry one copy of the disease gene (heterozygotes) may exhibit some of the symptoms associated with the disorder, such as an abnormally small head (microcephaly), short stature, and/or malformations of the fingers and/or toes.
GeneCard For ANOP1 anophthalmos 1 (with mental retardation, without limb anomalies or dental orurogenital abnormalities) Symbol approved by the HUGO Gene Nomenclature http://www.genecards.org/cgi-bin/carddisp?ANOP1
Adbusters : "A Culture Of Life" In babies born in Iraq in 2002, the incidence of anophthalmos was 250000 times .. . the natural occurrence. The White House s dodging and weaving to duck http://adbusters.org/blogs/A_Culture_of_Life.html
Extractions: A nation that has already suffered 20 years of warfare will suffer once again. Armies on both sides will take new casualties. And the war will go on. So said US president Lyndon Johnson in March 1968 of the war in Vietnam. History would prove him supremely correct. By the time it was over, Americas longest-running military engagement90 months of bloody guerilla warfarewould kill 58,000 Americans and 1.5 million Vietnamese. But for some 4 million more Vietnamese citizensthose exposed to the toxic herbicide Agent Orangethe war is still being fought today. Used by the United States to kill the thick foliage that hid enemy troops, Agent Orange contains the most dangerous form of dioxin, TCDD. US planes sprayed 11 million gallons of it between 1962 and 1971, dispersing what has been called the most toxic molecule on earth throughout a country Johnson aimed to make free of any outside domination or interference. Ever since, US veterans and Vietnamese citizens have suffered a horrifying array of health problems linked to Agent Orange, from miscarriages to severe birth defects in their offspring, cancer to diabetes. But, while the US government and Agent Oranges manufacturers have agreed to compensate US veterans for suffering caused by exposure to the herbicide, no such justice has been found for Vietnams victims.
UNSW Embryology-OMIM Syndactyly List *309800 MICROPHTHALMIA OR anophthalmos, WITH ASSOCIATED ANOMALIES; MAA *309801MICROPHTHALMIA WITH LINEAR SKIN DEFECTS; MLS 122920 CRANIOFRONTAL DYSPLASIA http://embryology.med.unsw.edu.au/OMIMfind/skmus/OMIM-syndactyly_list.htm
Extractions: MUSCULOSKELETAL DEVELOPMENT Embryology Home Page Select Entries from OMIM Online Mendelian Inheritance in Man (Internet Link) This page is for computers without external internet access. Internet access computers can see the full description of the abnormality from the links below. Back to UNSW Embryology-Musculoskeletal Notes 169 entries found, searching for " syndactyly SYNDACTYLY, TYPE III
Information Center For Rare Diseases And Orphan Drugs anophthalmos anophthalmos clinical anophthalmos with limb anomalies anorectalanomalies anotia anotia facial palsy cardiac defect http://www.raredis.org/modules/sections/index.php?op=printpage&artid=25
