Extractions: Phospholipids are fats that contain phosphorus. Antiphospholipid (APL) antibodies are acquired antibodies to phospholipid-bound protein and prothrombin. These antibodies can prolong coagulation times. APL antibodies occur in about 5% of the population, including healthy persons and are common in people with lupus erythematosus (1030%) other connective tissue disorders, cancer, HIV, drug and possibly estrogen intake, pulmonary embolism, intravenous catheter thrombosis, or thrombosis in the liver, portal vein, kidney, or retina. A person with APL antibodies who has symptoms needs to take heparin for the acute event, then long-term warfarin. Some physicians prescribe steroids also. A person with APL antibodies who has lupus (lupus anticoagulant) and no symptoms and is having vascular reconstruction should take antiplatelet therapy such as aspirin preoperatively, heparin therapy during the operation, and warfarin postoperatively. Activated protein C cleaves (divides) and inactivates coagulation factors Va and VIIIa in the presence of protein S. This system allows blood to clot while maintaining fluidity. A genetic change in factor V, called
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Activated Protein C Resistance (APCR) Van Cott EM, Soderberg BL, Laposata M. activated protein c resistance, the factor V Leiden mutation, and a laboratory testing algorithm. http://www.labcorp.com/datasets/labcorp/html/chapter/mono/cf003300.htm
Extractions: Activated Protein C Resistance (APCR) Number CPT Related Information Factor V Leiden Mutation Analysis Synonyms APCR Specimen Plasma, frozen Volume 2 mL Minimum Volume 1 mL Container Blue-stopper (sodium citrate plasma) tube Collection Blood should be collected in a blue-stopper tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to completion to ensure a proper blood to anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times to ensure adequate mixing of the anticoagulant with the blood. A discard tube is not required prior to collection of coagulation samples. When noncitrate tubes are collected for other tests, collect sterile and nonadditive(red-stopper) tubes prior to citrate (blue-stopper) tubes. Any tube containing an alternate anticoagulant should be collected after the blue-stopper tube. Serum gel separator tubes and serum tubes with clot initiators should also be collected after the citrate tubes. Centrifuge and carefully remove the plasma without disturbing the cells using a plastic transfer pipette. Transfer the plasma into a LabCorp plastic purple tube with cap (LabCorp ID 9566589372). The specimen should be frozen immediately and maintained frozen until tested. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Extractions: Abbreviations used: APC, activated protein C; FV, factor V; FVa, activated factor V; FV:Q , factor V with glutamine (Q) at position 506 ; FV:R , factor V with arginine (R) at position 506; FXa, activated factor X; mAb, monoclonal antibody; HPC4, mAb against protein C; HPS54, mAb against protein S; HFV30, mAb against factor V; EGF, epidermal growth factor; PPACK, D -phenylalanyl- L -prolyl- L -arginine chloromethyl ketone; PEG, polyethylene glycol; APTT, activated partial thromboplastin time. * To whom correspondence should be addressed. Resistance to activated protein C (APC), which is the most prevalent pathogenetic risk factor of thrombosis, is linked to a single point-mutation in the factor V (FV) gene, which predicts replacement of Arg (R) at position 506 with a Gln (Q). This mutation modifies one of three APC-cleavage sites in the heavy chain of activated FV (FVa), suggesting that mutated FVa (FVa:Q ) is at least partially resistant to APC-mediated degradation. To elucidate the molecular mechanisms of APC-resistance and to investigate the functional properties of FV in APC resistance, FV:Q
Blackwell Synergy - Cookie Absent Mechanisms for acquired activated protein c resistance in cancer patients. G. SARIG, Y. MICHAELI*, N. LANIR, B. BRENNER and N. HAIM* http://www.blackwell-synergy.com/doi/abs/10.1111/j.1538-7836.2005.01168.x
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Extractions: Department of Dermatology, Royal South Hants Hospital, Southampton, UK. A 26-year-old woman with hereditary angineurotic oedema (HAE) presented at 22 weeks gestation with severe cutaneous necrosis similar to that seen in coumarin skin necrosis. Protein S deficiency secondary to HAE and pregnancy was postulated. Treatment with heparin, C1-inhibitor concentrates, systemic steroids and surgical debridement resulted in a successful outcome for both mother and child. Subsequent investigations revealed normal levels of protein C, antithrombin III, total protein S, free protein S but reduced function protein S activity with evidence of activated protein C resistance. Cutaneous necrosis has not been reported in associated with
Extractions: For Researchers For Librarians Authors: ; Reverter J-C. ; Font J. ; Espinosa G. ; Cervera R. ; Carmona F. ; Balasch J. ; Ingelmo M. ; Ordinas A. Source: Lupus , Volume 11, Number 11, 1 November 2002, pp. 730-735(6) Publisher: Hodder Arnold Journals View Table of Contents full text options Abstract: Antiphospholipid antibodies (aPL) may induce acquired activated protein C resistance (acquired APCR). The role of acquired APCR in patients with systemic lupus erythematosus (SLE) is not well known. To evaluate the prevalence of acquired APCR and its association with clinical manifestations we studied 103 consecutive SLE patients and 103 matched controls. APCR in the undiluted test and after dilution in factor V deficient plasma, factor V Leiden, protein C and S, lupus anticoagulant, and anti-cardiolipin, anti- vs P =0.007; and 33
Specialty Laboratories ::: We Help Doctors Help Patients Factor V Leiden and activated protein c resistance Comparison of functional testing for resistance to activated protein C and molecular biological http://www.specialtylabs.com/books/display.asp?id=1068
ACTIVATED PROTEIN C RESISTANCE V (APCRV), PLASMA activated protein c resistance V (APCRV), PLASMA Marquette General Health System Freeze specimen immediately at or = 40 degrees C, if possible. http://www.mgh.org/lab/CATALOG/TESTS/5096.HTM
ARUP Activated Protein C Resistance Certifications Internet Services Login. ARUP s User s Guide. 0030127 activated protein c resistance. Test Mnemonic APC RST. See APC Resistance Profile http://www.aruplab.com/guides/ug/tests/0030127activated_20protein_20c_20resistan
THE MERCK MANUAL OF GERIATRICS, Ch. 70, Hypercoagulability And activated protein c resistance increases the risk of venous thromboembolism activated protein c resistance is an important defect to be aware of when http://www.merck.com/mrkshared/mmg/sec9/ch70/ch70b.jsp
HighWire -- Browse Journals - Activated Protein C Resistance Journals focusing on activated protein c resistance (in order by highest focus). Radiology info free ISSUES Nephrology Dialysis Transplantation info http://highwire.stanford.edu/lists/topic_dir/608683/608684/613947/613948/614082/
Extractions: Sort by: Alphabet Frequency of articles in Activated Protein C Resistance Focus of journal on Activated Protein C Resistance What's this? Journals focusing on Activated Protein C Resistance (in order by highest focus) Radiology info free ISSUES Nephrology Dialysis Transplantation ... Thrombophilia Activated Protein C Resistance Home Adv. Search For Institutions For Publishers ... partners/suppliers
Turkish Journal Of Haematology Keywords activated protein c resistance, FV Leiden, Prevalence in healthy Activated protein C (APC) resistance has been found to be an important cause http://www.tjh.com.tr/text.php3?id=207
Activated Protein C Resistance Topic - Unified Search Environment most common cause of APC resistance. Synonyms and Source Vocabularies activated protein c resistance MSH/MH/D020016 LNC/CN/NOCODE MTHICD9/ET/289.81 http://www.use.hcn.com.au/portals/shared/subject.`Activated Protein C Resistance
