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         Waardenburg Syndrome:     more detail
  1. Waardenburg Syndrome (Gentics and Communication Disorders Series) by Alice Kahn, 2006-07-25
  2. Light-eyed Negroes and the Klein-Waardenburg Syndrome by Jenni Soussi-Tsafrir, 1974-03
  3. The Official Patient's Sourcebook on Waardenburg Syndrome: A Revised and Updated Directory for the Internet Age by ICON Health Publications, 2006-12-05
  4. Waardenburg Syndrome - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers by Philip M. Parker, 2007-07-19
  5. Waardenburg syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Scott, MS Polzin, 2005
  6. Waardenburg Syndrome by AliceKahn, 2006-01-01
  7. Vestibular function and additional findings in Waardenburg's syndrome (Acta Oto-Laryngologica/Supplementum) by Richard E Marcus, 1968
  8. Hereditary deafness in the cat: Free amino acid and sugar content in the perilymph by Hans H Elverland, 1977

21. Waardenburg Syndrome
waardenburg syndrome Genetic Information and Resources.
http://www.kumc.edu/gec/support/waardenb.html
Waardenburg Syndrome
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22. Waardenburg Syndrome - Genetics Home Reference
Where can I find additional information about waardenburg syndrome? What other names do people use for waardenburg syndrome? What if I still have specific
http://ghr.nlm.nih.gov/condition=waardenburgsyndrome
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What is Waardenburg syndrome?
Waardenburg syndrome is a group of genetic conditions characterized by hearing loss and changes in coloring (pigmentation) of the hair, skin, and eyes. The hearing loss can occur in one or both ears. People with Waardenburg syndrome often have very pale blue eyes or different colored eyes (such as one blue eye and one brown eye). There may also be segments of two different colors in the same eye. Distinctive hair coloring (such as a patch of white hair or hair that prematurely turns gray) is another common sign of the condition. The features of Waardenburg syndrome vary among affected individuals, even among people in the same family. There are four known types of Waardenburg syndrome. The types are distinguished by their physical characteristics and sometimes by their genetic cause. Types I and II have very similar features, except people with type I almost always have eyes that appear widely spaced because the tear ducts are spread outward. People with type II do not have the appearance of widely spaced eyes. Type III (sometimes called Klein-Waardenburg syndrome) includes abnormalities of the upper limbs in addition to hearing loss and changes in pigmentation. Type IV (also known as Waardenburg-Shah syndrome) has signs and symptoms of both Waardenburg syndrome and Hirschsprung disease (a disorder that can lead to blockage of the large intestine).

23. Waardenburg Syndrome - OMIM - Genetic Disorder Catalog - Genetics Home Reference
OMIM waardenburg syndrome, type I This link leads to a site outside Genetics OMIM waardenburg syndrome type IV (WaardenburgShah syndrome) This link
http://ghr.nlm.nih.gov/condition=waardenburgsyndrome/show/OMIM
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OMIM - Genetic disorder catalog
These resources supplement the information in the Genetics Home Reference condition summary on Waardenburg syndrome. Last Comprehensive Review: October 2004 Published: September 6, 2005 Contact NLM Customer Service Lister Hill National Center for Biomedical Communications ... Selection Criteria for Web Links Indicates a page outside Genetics Home Reference.

24. AllRefer Health - Waardenburg Syndrome
waardenburg syndrome information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, tests, support groups,
http://health.allrefer.com/health/waardenberg-syndrome-info.html

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Definition Waardenburg syndrome is a group of hereditary conditions characterized by deafness and partial albinism (pale skin, hair and eye color).
Broad Nasal Bridge
Sense of Hearing Waardenburg syndrome is inherited as an autosomal dominant trait; only one parent has to pass on the gene for a child to be affected. There are four types of this syndrome. (Type 3 is known as Klein-Waardenburg syndrome; Type 4 is Waardenburg-Shah syndrome.) The multiple types of this syndrome result from mutations occurring in different genes. All types share two dominant features: hearing loss and partial albinism. The albinism is incomplete and may appear as a white forelock in an otherwise dark head of hair, very pale light-blue eyes, or two

25. AllRefer Health - Waardenburg Syndrome Information
waardenburg syndrome information center covers definition, Overview, Causes, Risk Factors, Symptoms Signs, Diagnosis Tests, Treatment,
http://health.allrefer.com/health/waardenberg-syndrome.html

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Waardenburg Syndrome
Definition Waardenburg syndrome is a group of hereditary conditions characterized by deafness and partial albinism (pale skin, hair and eye color).
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26. Waardenburg Syndrome
waardenburg syndrome (WS) is an inherited disorder often characterized by varying One commonly observed characteristic of waardenburg syndrome is two
http://www.drlera.com/waardenburg_syndrome.htm
Waardenburg Syndrome Waardenburg syndrome (WS) is an inherited disorder often characterized by varying degrees of hearing loss and changes in skin and hair pigmentation. The syndrome got its name from a Dutch eye doctor named Petrus Johannes Waardenburg who first noticed that people with differently colored eyes often had a hearing impairment. He went on to study over a thousand individuals in deaf families and found that some of them had certain physical characteristics in common.
One commonly observed characteristic of Waardenburg syndrome is two differently colored eyes. One eye is usually brown and the other blue. Sometimes, one eye has two different colors. Other individuals with Waardenburg syndrome may have unusually brilliant blue eyes.
People with WS may also have distinctive hair coloring, such as a patch of white hair or premature gray hair as early as age 12. Other possible physical features include a wide space between the inner corners of eyes called a broad nasal root. In addition persons with WS may have low frontal hairline and their eyebrows may connect. The levels of hearing loss associated with the syndrome can vary from moderate to profound.
Individuals with Waardenburg syndrome may have some or all of the traits of the syndrome. For example, a person with WS may have a white forelock, a patch of white hair near the forehead and no hearing impairment. Others may have white patches of skin and severe hearing impairment. The severity of the hearing impairment varies among individuals with WS as do changes in the skin and hair.

27. Klein-Waardenburg Syndrome (www.whonamedit.com)
Kleinwaardenburg syndrome A hereditary congenital defect involving pigmentation, lateral displacement of the medial canthi and lacrimal points,
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Klein-Waardenburg syndrome Also known as: Klein’s syndrome Mende's syndrome II van der Hoeve-Halbertsma-Waardenburg syndrome Van der Hoeve-Halbertsma-Gualdi syndrome van der Hoeve-Waardenburg-Klein syndrome Vogt’s syndrome (Cécile Vogt) Waardenburg's syndrome II Synonyms: Blepharophimosis, dyschromia iridocutanea et dysplasia auditiva (Waardenburg), dyschromia tridocutanea et dysplasia auditiva, dystopia canthi medialis lateroversa, embryonic fixation syndrome, hyperplasia interocularis cum dystopia lateroversa canthi medialis, interoculiiridodermatoauditory dysplasia syndrome, ptosis-epicanthus syndrome. Associated persons: Unknown Gualdi Nicolaas Adolf Halbertsma David Klein Irmgard Mende ... Petrus Johannes Waardenburg Description: A hereditary congenital defect involving pigmentation. It consists of a white forelock, vitiligo, partial or total heterochromic irides, hyperplastic broad high nasal root, lateral displacement of the medial canthi and lacrimal points, hyperplasia of the median portion of the eyebrows, congenital or partial (unilateral) deafness (15-20 % of affected persons). Although the most serious defect in this syndrome is congenital deafness, it is seldom accepted and mentioned by patients. A conspicuous feature is two different coloured eyes.

28. Waardenburg Syndrome
waardenburg syndrome is a genetic disorder that may be evident at birth (congenital). The range and
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Who We Are About WebMD Site Map Health Topics Symptoms ... For a Complete Report Waardenburg Syndrome Important It is possible that the main title of the report Waardenburg Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms
  • WS
Disorder Subdivisions
  • Waardenburg Syndrome Type I (WS1) Waardenburg Syndrome Type II (WS2) Waardenburg Syndrome Type IIA (WS2A) Waardenburg Syndrome Type IIB (WS2B) Waardenburg Syndrome Type III (WS3) Waardenburg Syndrome Type IV (WS4)
General Discussion In most cases, Waardenburg syndrome is transmitted as an autosomal dominant trait. A number of different disease genes have been identified that may cause Waardenburg syndrome in certain individuals or families (kindreds). Resources National Association for Visually Handicapped 22 West 21st Street New York, NY 10010

29. MedlinePlus Medical Encyclopedia: Waardenburg Syndrome
waardenburg syndrome is a group of hereditary conditions characterized by deafness and waardenburg syndrome is inherited as an autosomal dominant trait,
http://www.nlm.nih.gov/medlineplus/ency/article/001428.htm
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Broad nasal bridge Sense of hearing Definition Return to top Waardenburg syndrome is a group of hereditary conditions characterized by deafness and partial albinism (pale skin, hair, and eye color). Causes, incidence, and risk factors Return to top Waardenburg syndrome is inherited as an autosomal dominant trait, meaning only 1 parent has to pass on the gene for a child to be affected. There are 4 types of this syndrome. Type 3 is known as Klein-Waardenburg syndrome. Type 4 is Waardenburg-Shah syndrome. The multiple types of this syndrome result from mutations occurring in different genes. All types share 2 dominant features: hearing loss and partial albinism. The albinism is incomplete and may appear as a white forelock in an otherwise dark head of hair, very pale light-blue eyes, or different-colored eyes. Affected individuals may also have wide separation of the inner corners of the eyes, a broad nasal bridge, and other color changes of the skin. Waardenburg syndrome affects about 1 in every 30,000 people. Almost 90% of patients have an affected parent but the symptoms in the parent can be quite different from those in the child.

30. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Waardenbur
UniProt Knowledgebase keyword waardenburg syndromeProtein which, if defective, causes waardenburg syndrome (WS), an autosomal waardenburg syndrome type IV (WS4), also known as WaardenburgShah syndrome,
http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Waardenburg's Syndrome

31. Gina Lynn's Waardenburg Syndrome Home Page
Home Page and Support Group for Waardenburg s Syndrome.
http://www.webspawner.com/users/waardenbergsyndrome/
Gina Lynn's Waardenburg Syndrome Home Page
Hello there! My name is Gina Lynn, and I was diagnosed with Waardenburg's Syndrome (WS) in November of 2000. I am one of the lucky ones who has experienced no hearing loss. However, I do have Endolymphatic Hydrops (ELH), which is one of many possible flags for WS. Other symptoms of ELH may consist of any combination of: dizziness/vertigo, nausea, tinnitis (ringing in ears), extreme sensitivity to loud noises/bright lights/rapid air pressure changes/rapid increases in atmospheric moisture, depression, panic/anxiety attacks, poor depth perception (or spacial orientation), pain/fullness/popping/moisture/itching in ears, seeing things moving at the corners of the eyes that aren't really there, mental confusion/fogginess, a feeling that things are somehow "unreal or dreamlike", eyestrain, difficulties with speech and concentration, headaches, feeling off-balance or that the ground is moving or tilting, severe muscle pains in legs/ankles/feet, etc.
Flags unique to Waardenburg's Syndrome may consist of:
hearing loss (sometimes, not always), different colored eyes (heterochromia - usually one blue, one brown), brilliant blue eyes, unusual pigmentation of hair, skin, and/or eyes, premature graying (hair/eyelashes), white forelocks, hair loss, broad nasal bridge, widely-spaced inside corners of eyes, eyebrows that grow together, vitiligo (depigmentation/white patches of skin), severe PMS- or peri-menopausal-like symptoms. On rare occasions, WS has been associated with other conditions present at birth: intestinal disorders (such as Hirschsprung's), elevation of the shoulder blade or disorders of the spine. A facial abnormality, known as cleft lip and/or palate, also has been associated with WS. There are at least four types of WS that are determined by which of the markers one exibits.

32. Dr. Koop - Waardenburg Syndrome
waardenburg syndrome is a group of hereditary conditions characterized by and partial (pale skin, hair and eye color).
http://www.drkoop.com/ency/93/001428.html
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Waardenburg syndrome
Definition: Waardenburg syndrome is a group of hereditary conditions characterized by deafness and partial albinism (pale skin, hair and eye color).
Causes, incidence, and risk factors: Waardenburg syndrome is inherited as an autosomal dominant trait; only one parent has to pass on the gene for a child to be affected. There are four types of this syndrome. (Type 3 is known as Klein-Waardenburg syndrome; Type 4 is Waardenburg-Shah syndrome.) The multiple types of this syndrome result from mutations occurring in different genes. All types share two dominant features: hearing loss and partial albinism. The albinism is incomplete and may appear as a white forelock in an otherwise dark head of hair, very pale light-blue eyes, or two different colored eyes . Affected individuals may also have wide separation of the inner corners of the eyes, a broad nasal bridge, and other color changes of the skin.

33. Waardenburg's Syndrome
Waardenburg s Syndrome is a rare disorder that results from an autosomal dominant mutation Waardenburg s Syndrome type 3, or Kleinwaardenburg syndrome,
http://www.brown.edu/Courses/BI0032/neurcrst/waar.htm
Waardenburg's Syndrome Waardenburg's Syndrome is a rare disorder that results from an autosomal dominant mutation as a deletion in Pax-3 . Some of the characteristics of this syndrome may include pigment abnormalities, deafness, and defects in the neural crest derivative tissue. In 1951, Waardenburg defined the main features of the syndrome:
  • Prominent broad nasal root Connection of the medial part of the eyebrows (unibrow) White forelock Two differently-colored eyes (one usually brown and the other bright blue) Deafmutism
There are four types of Waardenburg's Syndrome: types 1, 2, 3, and 4. Type 1 is characterized by displacement of the folds in the eyelid; hearing loss occurs in 20% of those suffering from this first type. The incidence is about 1/40,000. Although type 2 is more frequent than type 1, type 2 has a higher frequency of deafness; hearing loss/deafness occurs in 50% of those suffering from this second type. Waardenburg's Syndrome type 3, or Klein-Waardenburg Syndrome, is extremely rare. In addition to the characteristics of type 1, musculoskeletal abnormalities are observed in type 3 as well. Type 4 is also known as Waardenburg-Shah syndrome. WS is inherited, and the chance of the carrier passing on the gene to their offspring is 50%. The gene that is thought to cause WS is the

34. Waardenburg Syndrome: Definition And Much More From Answers.com
Waar·den·burg syndrome ( wôr dnbûrg , vär - ) n. A hereditary syndrome characterized by varying degrees of deafness and facial bone defects.
http://www.answers.com/topic/waardenburg-syndrome
showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Dictionary Medical Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping Waardenburg syndrome Dictionary Waar·den·burg syndrome w´r dn-b»rg , v¤r
n. A hereditary syndrome characterized by varying degrees of deafness and facial bone defects and by variation in pigmentation of the skin, hair, or eyes. [After Petrus Johannes Waardenburg (1886–1979), Dutch ophthalmologist.]
Medical
Waar·den·burg syndrome w´r dn-b»rg , v¤r
n. An inherited syndrome marked by displacement of the medial canthi and lacrimal puncta, a broad nasal bridge, multicolored or hyperpigmented irises, cochlear deafness, and a white forelock. Wikipedia Waardenburg syndrome Waardenburg syndrome is a genetic disorder associated with hearing loss and changes in skin and hair pigmentation . The syndrome is named for Dutch ophthalmologist Petrus Johannes Waardenburg who first described it. Pigmentation changes may include irises of varying color ( heterochromia iridis ), or a patch of white or grey hair. Hearing loss may be absent, moderate, or profound.

35. Waardenburg Syndrome Medical Information
waardenburg syndrome Information from Drugs.com. waardenburg syndrome is a group of hereditary conditions characterized by deafness and partial albinism
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Waardenburg syndrome
Definition
Waardenburg syndrome is a group of hereditary conditions characterized by deafness and partial albinism (pale skin, hair, and eye color).
Causes Waardenburg syndrome is inherited as an autosomal dominant trait, meaning only 1 parent has to pass on the gene for a child to be affected. There are 4 types of this syndrome. Type 3 is known as Klein-Waardenburg syndrome. Type 4 is Waardenburg-Shah syndrome. The multiple types of this syndrome result from mutations occurring in different genes. All types share 2 dominant features: hearing loss and partial albinism. The albinism is incomplete and may appear as a white forelock in an otherwise dark head of hair, very pale light-blue eyes, or different-colored eyes. Affected individuals may also have wide separation of the inner corners of the eyes, a broad nasal bridge, and other color changes of the skin. Waardenburg syndrome affects about 1 in every 30,000 people. Almost 90% of patients have an affected parent but the symptoms in the parent can be quite different from those in the child.

36. WAARDENBURG SYNDROME : Contact A Family - For Families With Disabled Children: I
Contact a Family is a UK charity for families with disabled children. We offer information on specific conditions and rare disorders.
http://www.cafamily.org.uk/Direct/w10.html
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yes no Waardenburg syndrome (WS) is an inherited condition which may be associated with a range of features. The main characteristics of WS include hearing impairment (see Deafness Gut Motility Disorders ) or features including upper limb abnormalities and cleft lip and/or palate . Individuals with WS have a normal lifespan. Researchers have described four main types of WS. A diagnosis of the particular type of WS depends upon detecting the fault in the causative gene. The different types of WS vary in the physical characteristics present. The most common types of WS are Type 1 and Type 2, which are distinguished on the basis of widely spaced eyes. This feature is present in Type 1 and absent in Type 2. However, hearing impairments are more common in Type 2. Type 3 (Klein-Waardenburg syndrome) is rare and is associated with upper limb abnormalities. Type 4 (Waardenburg-Hirschsprung disease), which is also uncommon, is associated with associated with colon problems originating from the time of birth. Inheritance patterns
A number of genes have been associated with WS and different genes are associated with the different types of WS. In most cases, WS is inherited as an autosomal dominant trait. The genetics of Waardenburg-Hirschsprung disease is slightly different as this type of WS is inherited as an autosomal recessive trait.

37. Waardenburg Syndrome Definition - Medical Dictionary Definitions Of Popular Medi
Online Medical Dictionary and glossary with medical definitions.
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38. Information About Waardenburg Syndrome
This site contains information about waardenburg syndrome.
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What is Waardenburg Syndrome? Waardenburg syndrome is an genetic disorder characterized by varying degrees of hearing loss and changes in skin and hair pigmentation. Waardenburg syndrome is named after a Dutch eye doctor named Petrus Johannes Waardenburg who first noticed that people with differently colored eyes often had a hearing impairment. Characteristics of Waardenburg Syndrome? One of the most common characteristics of Waardenburg syndrome is two differently colored eyes. One eye is usually brown and the other blue. In some cases, one eye has two different colors. Some individuals with Waardenburg syndrome may have unusually brilliant blue eyes. Another common characteristic of Waardenburg syndrome is distinctive hair coloring. A person with Waardenburg syndrome may have a patch of white hair or premature gray hair as early as age 12. Other physical characteristics are: a wide space between the inner corners of eyes, hearing loss low frontal hairline, and connecting eyebrows. Types of Waardenburg Syndrome?

39. Waardenburg Syndrome - Causes Of Hearing Loss - Hearing Loss
A world of information about deafness and children with hearing loss.
http://www.raisingdeafkids.org/hearingloss/causes/ws.jsp

40. Causes Of Waardenburg Syndrome - Waardenburg Syndrome - Causes Of
A world of information about deafness and children with hearing loss.
http://www.raisingdeafkids.org/hearingloss/causes/wscauses.jsp

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