61. Von Willebrand's Disease This page contains information about von willebrand s Disease. http://www.mamashealth.com/blood/vonw.asp

Mamashealth.com Home Blood Diseases Agnogenic Metaplasia Amyloidosis Aplastic Anemia Diabetes ... Von Willebrand's Disease Links Email Mama What is Von Willebrand's Disease? Von Willebrand's disease is a chronic bleeding disorder where both platelet aggregation and clot formation do not occur properly. It is the most common hereditary bleeding disorder. There are three main variations of Von Willebrand's disease. Each variation varies by the severity of symptoms. Type 1 is a mild disorder. It is the majority of cases. Type 2 is a mild to moderate disorder. It has moderate symptoms. Type 3 is the most severe form of the disorder. It rarely occurs. Von Willebrand's disease is also called pseudohemophilia and vascular hemophilia. It affects women and men equally. Symptoms? The most common symptoms include: bleeding gums blood in the urine nose bleeds urinary tract bleeding blood in the stool easy bruising heavy menstrual flow What causes Von Willebrand's Disease? It is caused by a defect in a clotting factor called Von Willebrand's factor. In many cases, there is also a deficiency of clotting factor VIII. Treatment Options?

62. Von Willebrand's Disease In Dogs Canine von willebrand s Disease. von willebrand’s isn’t so much a disease as a condition. Of all the inherited bleeding disorders in animals (and http://petcaretips.net/von-willebrand-disease.html

For Info on all aspects of pet care and other interesting stuff: Get Your FREE Subscription to: "The Peppy Pets" E-mail First Name Subscribe Von Willebrand's Disease in Dogs Canine Von Willebrand's Disease By Tenna Perry Von Willebrand’s isn’t so much a disease as a condition. Of all the inherited bleeding disorders in animals (and humans) it is the most common. The defect isn’t autosomal (sex linked) so both males and females can suffer from the “disease.” It must be remembered that just because a dog doesn’t show symptoms of von Willebrand’s, it doesn’t mean it can’t be a carrier. Von Willebrand’s was discovered in humans and called a “disease” in the 1920s by a Finnish doctor coincidentally named, von Willebrand. After further research, he was able to figure out the illness was actually linked to a missing factor in the blood’s clotting ability. Modern research has found von Willebrand’s doesn’t lower the number of platelets (the factor in the blood that causes clotting) but changes the platelet’s actual make up. Researchers

63. Von Willebrand Factor: Information From Answers.com von willebrand factor von willebrand factor (vWF, also called Factor VIII related antigen ) is a blood protein of the coagulation system. http://www.answers.com/topic/von-willebrand-factor

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping von Willebrand factor Wikipedia von Willebrand factor Von Willebrand factor (vWF, also called " Factor VIII -related antigen") is a blood protein of the coagulation system . It is defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura Heyde's syndrome , and possibly hemolytic-uremic syndrome Biochemistry Synthesis vWF is a large multimeric glycoprotein present in blood plasma and produced constitutively in endothelium (in the Weibel-Palade bodies megakaryocytes platelets ), and subendothelial connective tissue Structure The basic vWF monomer is a 2050 amino acid protein. Every monomer contains a number of specific domains with a specific function; elements of note are: the D'/D3 domain, which binds to Factor VIII the A1 domain, which binds to: platelet gp1b-receptor heparin possibly collagen the A3 domain, which binds to collagen

64. Von Willebrand's Disease: Definition And Much More From Answers.com von Wil·le·brand s disease ( von wil ?brandz , fôn vil ?-bränts ) n. A hereditary disease characterized by a tendency to hemorrhage, caused. http://www.answers.com/topic/von-willebrand-disease

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Dictionary Medical Term Medical WordNet Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping von Willebrand's disease Dictionary von Wil·le·brand's disease vŏn wÄ­l ə-brăndz , f´n vÄ­l ə-br¤nts n. A hereditary disease characterized by a tendency to hemorrhage, caused by a deficiency or abnormality of the blood proteins that control platelet activity. [After Erik Adolf von Willebrand (1870–1949), Finnish physician.] Medical Term Von Willebrand disease Von Willebrand disease: An inherited bleeding disorder in which a clotting protein called von Willebrand factor is deficient or defective. Von Willebrand factor is made by cells lining the wall of blood vessels. When vessels are damaged, platelets normally clump at the site of the injury. Von Willebrand factor acts as glue to help the platelets clump. Von Willebrand factor is also a carrier of clotting factor VIII, another protein that helps the blood to clot. Von Willebrand disease is the most common inherited bleeding disorder. It occurs in about 1 in every 100 to 1,000 people. There are three major types of von Willebrand disease:

65. AllRefer Health - Von Willebrand's Disease von willebrand s Disease information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, tests, support groups http://health.allrefer.com/health/von-willebrands-disease-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Von Willebrand's Disease Von Willebrand's Disease Definition Treatment Expectations or Prognosis Complications ... Go To Main Page Definition Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting. Blood Clot Formation Blood Clots Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy.

66. Von Willebrand's Disorder von willebrand s disorder (VWD) is an inherited bleeding disorder. People with von willebrand s may have frequent nosebleeds, easy bruising, http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Von_Willebrands_d

67. Von Willebrand Disease - Wikipedia, The Free Encyclopedia See also von willebrand factor for the normal function of that coagulation factor Sadler, JE Biochemistry and Genetics of von willebrand factor. http://en.wikipedia.org/wiki/Von_Willebrand_disease

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Von Willebrand disease From Wikipedia, the free encyclopedia. Von Willebrand's disease (vWD) is the most common hereditary coagulation abnormality described in humans. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. It is known to affect humans and, in veterinary medicine dogs Contents Symptoms Diagnosis Classification and types Classification ... edit Symptoms The various types of vWD present with varying degrees of bleeding tendency . Severe internal or joint bleeding is rare (only in type 3 vWD); bruising nosebleeds heavy menstrual periods (in women) and blood loss during childbirth (rare) may occur. edit Diagnosis When suspected, blood plasma of a patient needs to be investigated for quantitative and qualitative deficiencies of vWF. This is achieved by measuring the amount of vWF in a vWF antigen assay and the functionallity of vWF with a glycoprotein (GP)Ib binding assay, a

68. Von Willebrand Factor - Wikipedia, The Free Encyclopedia von willebrand factor (vWF, also called Factor VIIIrelated antigen ) is a blood It is defective in von willebrand disease and is involved in a large http://en.wikipedia.org/wiki/Von_Willebrand_factor

You did it! Over US$240,000 was donated in the 21-day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Von Willebrand factor From Wikipedia, the free encyclopedia. Von Willebrand factor (vWF, also called " Factor VIII -related antigen") is a blood protein of the coagulation system . It is defective in von Willebrand disease and is involved in a large number of other diseases, including thrombotic thrombocytopenic purpura Heyde's syndrome , and possibly hemolytic-uremic syndrome Contents Biochemistry Synthesis Structure Function ... edit Biochemistry edit Synthesis vWF is a large multimeric glycoprotein present in blood plasma and produced constitutively in endothelium (in the Weibel-Palade bodies megakaryocytes (α-granules of platelets ), and subendothelial connective tissue edit Structure The basic vWF monomer is a 2050 amino acid protein. Every monomer contains a number of specific domains with a specific function; elements of note are: the D'/D3 domain, which binds to Factor VIII the A1 domain, which binds to:

69. Von Willebrand Factor Antigen , The von willebrand factor antigen assay is used to diagnose von *When type 2B von willebrand disease is suspected, the ristocetin response...... http://peir.path.uab.edu/coag/article_143.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Information Test Menu Test Order Form Test Menu Von Willebrand Factor Antigen Email this article Printer friendly page Primary Name Von Willebrand Factor Antigen Synonym Synonym Contraction VWF Ag Contraction Contraction UAB Procedure Number CPT Code Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. Specimen Accepted Daily including weekends Times Available Test Performed Two days a week Available Stat? Pathologist's approval required. Description The von Willebrand factor antigen assay is used to diagnose von Willebrand disease as it measures plasma von Willebrand factor concentration. When used in combination with the cofactor test, the antigen test helps distinguish von Willebrand disease types 1 and 2. Reference Interval Critical Value Therapeutic Range Follow-up Test *The von Willebrand factor antigen test is usually run together with the ristocetin cofactor test and the factor VIII activity assay, forming the von Willebrand disease profile.

70. Von Willebrand Disease Profile The von willebrand disease profile is available from the UAB Coagulation Service to detect, classify, and monitor von willebrand disease (vWD). http://peir.path.uab.edu/coag/article_160.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Information Test Menu Test Order Form Clinical Conditions Von Willebrand Disease Profile Email this article Printer friendly page The von Willebrand disease profile is available from the UAB Coagulation Service to detect, classify, and monitor von Willebrand disease (vWD). Select each individual assay for further information. V WD profile: Von Willebrand factor (vWF) antigen VWF activity (ristocetin cofactor) Factor VIII assay Follow-up vWD profile when type 2 von Willebrand disease is suspected: VWF multimers Ristocetin response curve Top of Page

71. Dr. Koop - Von Willebrand’s Disease von willebrand s disease is a hereditary caused by a deficiency of von von willebrand factor helps to stick to the blood vessel wall and to each other, http://www.drkoop.com/ency/93/000544.html

Home Health Reference Von Willebrand’s disease Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Von Willebrand’s disease Injury Disease Nutrition Poison ... Prevention Von Willebrand’s disease Definition: Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting. Causes, incidence, and risk factors: Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy. The disease is very common, affecting at least 1% of the population. A family history of a bleeding disorder is the primary risk factor. In women with heavy or prolonged menstrual bleeding, Von Willebrand's is more common in Caucasian women than African American women. New Features Fewer Migraines Skin Cancer Atkins/Low Carb Diets Learn More About Migraines * All Health Centers * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure

72. Entrez PubMed Our aim was to determine whether or not levels of von willebrand factor contributed to We measured plasma viscosity, fibrinogen, von willebrand factor, http://www.particleandfibretoxicology.com/pubmed/9712338

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73. Von Willebrand's Disease Medical Information von willebrand s disease Information from Drugs.com. http://www.drugs.com/enc/von_willebrand_s_disease.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Von Willebrand's disease Injury Disease Nutrition Poison ... Blood clots Von Willebrand's disease Definition Von Willebrand's disease is a hereditary bleeding disorder caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to stick to the blood vessel wall and to each other, which is necessary for normal blood clotting. Causes Von Willebrand's disease is the most common hereditary bleeding disorder. It affects both sexes approximately equally. Most cases are mild, and bleeding may occur after a surgical procedure or tooth extraction. The condition is worsened by the use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Bleeding may decrease during pregnancy. The disease is very common, affecting at least 1% of the population. A family history of a bleeding disorder is the primary risk factor. In women with heavy or prolonged menstrual bleeding, Von Willebrand's is more common in Caucasian women than African American women.

74. Von Willebrand Disease, Cincinnati Children's Hospital Medical Center Cincinnati Children s Hospital Medical Center discusses von willebrand Disease (vWd) and occurs in both males and females. http://www.cincinnatichildrens.org/health/info/blood/diagnose/von-willebrand.htm

Home Contact Us Site Map Go to Advanced Search ... Sickle Cell Anemia von Willebrand Disease Home Care Overview Tests and Procedures Conditions and Diagnoses von Willebrand Disease Related Services Hemophilia Program Blood Disease Center The most commonly inherited bleeding disorder is von Willebrand Disease (vWd) and occurs in both males and females. What is von Willebrand Factor? Von Willebrand Factor (vWF) is a clotting protein in the blood. It is produced in the cells that line the blood vessels and then is released into the blood stream. Bleeding occurs when blood vessels are injured. Platelets, a type of blood cell, stick to the injured vessel and form a platelet plug. Von Willebrand factor acts as a glue to help the platelets stick to the injury site. Simultaneously, other coagulation factors work together to form a clot, further sealing the area of damage. How does someone get von Willebrand Disease? Von Willebrand Disease is known as an inherited or genetic disorder meaning it is passed down through families through information in the cells called genes. What are the signs and symptoms of von Willebrand Disease?

75. Von Willebrand Disease : BPL (Bio Products Laboratory) Information and supply of high quality plasma derived products to treat bleeding and clotting disorders such as hepatitis, haemophilia, immunoglobin and http://www.bpl.co.uk/public/therapy_areas/coagulation/von_willebrand.asp

skip to main content skip to footer About BPL About the organisation ... Therapy Areas Coagulation Factors - Haemophilia A - Haemophilia B - Von Willebrand Disease - Factor VII Deficiency ... - Useful Links Immunoglobulins - Introduction - Normal Immunoglobulins - Specific Immunoglobulins - News - Immunoglobulins ... - Useful Links Human Albumin Solution - Albumin 4.5% Solution - Albumin 20% Solution - News - Albumin - Useful Links ... Useful Links von Willebrand Disease This disorder results from a deficiency or defect in the protein known as von Willebrand Factor (vWF). It is named after the Swedish clinician who first discovered the disease. vWF is involved in more than one stage of blood clotting. It is the protein that binds platelets to damaged tissue and promotes platelet aggregation at the earliest stage of clot formation. It also acts as a stabiliser of Factor VIII. In plasma, Factor VIII is bound to vWF which protects it and stops its breakdown. vWD is quite a common condition, and as many as 1 in 100 of the population may be mildly affected, although most are not aware of it because they have no serious symptoms. Fortunately, a large majority of those affected do not have the most severe form of vWD. The disorder is not sex-linked and both males and females may be affected. The bleeding problems experienced by vWD patients are often mucosal (nose bleeds, gastrointestinal bleeds, heavy menstrual bleeding for women, etc.). Some people with vWD receive treatment with the hormone analogue DDAVP (which is not a blood product). Where DDAVP is not effective, then replacement using plasma-derived vWF concentrates takes place.

76. Project Red Flag > More Information On Von Willebrand's Disease Can you be more specific on how one gets von willebrand Disease? von willebrand disease is usually inherited from one parent who has an abnormal von http://www.projectredflag.org/common_questions/more_von_willebrand.htm

Become an NHF Member Subscribe to NHF eNotes, Our Monthly Newsletter Donate to NHF Common Questions About Bleeding Disorders ... Common Questions Common Questions About Bleeding Disorders More Information on von Willebrand Disease Can you be more specific on how one gets von Willebrand Disease? von Willebrand disease is usually inherited from one parent who has an abnormal von Willebrand factor gene. The abnormal gene is located on a chromosome called an autosomal chromosome or an autosome, rather than a sex-linked (X) chromosome. Therefore, both men and women may pass the VWD gene to their offspring. A parent with von Willebrand disease has a 50% chance of passing the disease to each of his or her children, male or female. VWD also can occur in families with no known family history of the disorder. Individuals whose VWD is the result of such a mutation may also pass the disease to their children. What is von Willebrand factor?

77. Project Red Flag > What's Von Willebrand Disease? von willebrand disease (VWD) is the most common bleeding disorder in women and girls (1% to 2% of the population or, approximately 1.4 to 2.8 million http://www.projectredflag.org/common_questions/what_is_von_willebrand.htm

Become an NHF Member Subscribe to NHF eNotes, Our Monthly Newsletter Donate to NHF Common Questions About Bleeding Disorders ... Common Questions Common Questions About Bleeding Disorders What's von Willebrand Disease? von Willebrand disease (VWD) is the most common bleeding disorder in women and girls (1% to 2% of the population or, approximately 1.4 to 2.8 million nationwide). VWD, which is genetically transmitted from generation to generation, is caused by a defect or deficiency of an essential blood clotting protein called von Willebrand factor. Symptoms of VWD include heavy menstrual periods, frequent or prolonged nosebleeds, easy bruising and prolonged bleeding following injury, surgery, child birth or dental work. Even though the symptoms of VWD are caused by a problem with the blood, it is frequently misdiagnosed as a gynecologic problem by doctors who are not familiar with the condition. In fact, it is thought that many of the over 30,000 women who have hysterectomies performed to treat severe bleeding every year might actually have a bleeding disorder. There is no cure for VWD, but it can be treated effectively. Treatment includes birth control pills, desmopressin acetate (DDAVP) and certain clotting factor concentrates containing von Willebrand factor. DDAVP comes in two forms: an injectable form and a concentrated nasal spray (it is very easy to learn how to self-administer either form of DDAVP).

78. The Diagnosis And Treatment Of Von Willebrand Disease In Children von willebrand disease is the most common bleeding disorder seen in children Because the bleeding symptoms in von willebrand disease are generally mild, http://www.pulsus.com/Paeds/07_04/klas_ed.htm

forgot your password? ORIGINAL ARTICLES April 2002, Volume 7, Number 4: The diagnosis and treatment of von Willebrand disease in children RJ Klaassen, JM Halton von Willebrand disease is the most common bleeding disorder seen in children and it affects approximately 1% of the population. Because the bleeding symptoms in von Willebrand disease are generally mild, the diagnosis is often delayed. Prompt diagnosis and management can help to avoid potentially life-threatening bleeding events and unnecessary exposure to blood products. In this review, the various types of von Willebrand disease are outlined, the difficulties in diagnosis are discussed and the therapeutic approach to this common disorder is described. Key Words: Child; Factor VIII; von Willebrand disease; von Willebrand factor

79. Rural Nurse Organization Clinic Digital Library What is von willebrand Disease? Access document; What Causes von willebrand Disease? Access document; Who Gets von willebrand Disease? http://ruralnurseorganization-dl.slis.ua.edu/patientinfo/hematology/bleedingdiso

Patient/Family Resources by Topic: Hematology Von Willebrand Disease Patient/Family Resources Pediatrics Spanish Miscellaneous See also: General Hematology Patient/Family Resources Von Willebrand Disease Clinical Resources National Heart, Lung and Blood Institute: Homepage Diseases and Conditions Index: Table of contents Blood Diseases: List of documents Von Willebrand Disease: Table of contents What is von Willebrand Disease?: Access document What Causes von Willebrand Disease?: Access document Who Gets von Willebrand Disease?: Access document What are the Signs and Symptoms of von Willebrand Disease?: Access document How is von Willebrand Disease Diagnosed?: Access document How is von Willebrand Disease Treated?: Access document Living with von Willebrand Disease: Access document Frequently Asked Questions about von Willebrand Disease: Access document Summary: Access document Links to More Information about von Willebrand Disease: Access document Canadian Hemophilia Society Homepage Von Willebrand Disease: Table of contents Introduction: Access document Types of Von Willebrand Disease: Access document Heredity: Access document Symptoms: Access document Diagnosis: Access document Treatment: Access document Blood Products: Access document Precautions: Access document Summary Chart of Factor Deficiencies: Access document MedlinePlus Medical Encyclopedia: Table of contents Von Willebrand Disease: English Spanish Bleeding Disorders: English Spanish Merck Manual - Second Home Edition

80. Rural Nurse Organization Clinic Digital Library von willebrand (Keyword search) List of documents. Miscellaneous von willebrand Disease Clinical Resources. HealthWeb Homepage http://ruralnurseorganization-dl.slis.ua.edu/clinical/hematology/bleedingdisorde

Clinical Resources by Topic: Hematology Von Willebrand Disease Clinical Resources Pediatrics Genetics Clinical Guidelines News ... Miscellaneous Resources See also: General Hematology Clinical Resources Von Willebrand Disease Patient/Family Resources The Merck Manual 17th Ed.-1999: Table of contents Chapter 131: Hemostasis and Coagulation Disorders: Table of contents General: Access document Hemostasis: Access document Chapter 133: Platelet Disorders: Table of contents General: Access document Platelet Dysfunction: Access document Von Willebrand's Disease: Access document Family Practice Handbook 4th Ed.-2001: Table of contents Chapter 6: Hematologic, Electrolyte, and Metabolic Disorders: Table of contents Bleeding Disorders: Access document Medicine, Ob/Gyn, Psychiatry, and Surgery (eMedicine): Table of contents Von Willebrand Disease: Access document Platelet Disorders: Access document Pediatrics Resources See also General Pediatrics Resources Pediatrics (eMedicine): Table of contents Von Willebrand Disease: Access document Genetics Resources See also General Genetics Resources Online Mendelian Inheritance in Man: Homepage Von Willebrand (Keyword search): List of documents Clinical Guidelines National Guideline Clearinghouse: MeSH browse Detailed search von Willebrand (Keyword search): List of documents News Resources Doctor's Guide to the Internet Homepage Haematology News List of documents Von Willebrand (Keyword search): List of documents Miscellaneous Von Willebrand Disease Clinical Resources HealthWeb: Homepage Hematology: Table of contents Clinical Resources:

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