41. Von Willebrand Disease von willebrand disease is caused by a deficiency or an abnormality in a protein called von willebrand factor and is characterized by prolonged bleeding. http://www.healthatoz.com/healthatoz/Atoz/ency/von_willebrand_disease.jsp

42. What Is Von Willebrand Disease? von willebrand disease is an inherited bleeding disorder. http://www.nhlbi.nih.gov/health/dci/Diseases/vWD/vWD_WhatIs.html

DCI Home Blood Diseases von Willebrand Disease : What Is ... What Is ... Causes Who Is At Risk Diagnosis ... Links What Is von Willebrand Disease? Von Willebrand disease is an inherited bleeding disorder. Children born with the disease have one or both of the following: Low levels of a protein that helps the blood to clot, or The protein does not work as it should. This clotting protein is called von Willebrand factor. When some of this factor is missing or defective it can cause prolonged bleeding after an injury or accident. What is clotting? An injury (like a cut) to a blood vessel causes a complex chain of events called the clotting process, which results in a blood clot. Clotting is your body's reaction to bleeding to keep you from losing too much blood. Losing too much blood can be life threatening and can damage your internal organs. What is von Willebrand Factor? Certain proteins in your blood help the blood to clot. Von Willebrand factor is one of those proteins. It is made by the lining of cells in the wall of blood vessels (veins and arteries). When blood vessels are damaged, platelets (small blood cells that collect and stick together to plug cuts and breaks in blood vessels) clump together at the site of the injury. Von Willebrand factor acts like glue that helps the platelets stick together. Von Willebrand factor is also a carrier of clotting factor VIII, another protein that helps your blood to clot. Types of von Willebrand Disease There are three major types of von Willebrand disease:

43. THE MERCK MANUAL--SECOND HOME EDITION, Von Willebrand's Disease In Ch. 173, Blee von willebrand s disease is a hereditary deficiency or abnormality of the von Often, a person with von willebrand s disease has a parent who has a http://www.merck.com/mmhe/sec14/ch173/ch173e.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Blood Disorders Chapter Bleeding and Clotting Disorders Topics Introduction Allergic Purpura Disseminated Intravascular Coagulation Hemophilia ... Thrombophilia Von Willebrand's Disease Von Willebrand's Disease Buy The Book Print This Topic Email This Topic Pronunciations purpura telangiectasia thrombocytopenia Von Willebrand's disease is a hereditary deficiency or abnormality of the von Willebrand factor in the blood, a protein that affects platelet function. The von Willebrand factor is found in plasma, platelets, and the walls of blood vessels. When the factor is missing or defective, platelets cannot adhere to the vessel wall at the site of an injury. As a result, bleeding does not stop as quickly as it should.

44. Erik Adolf Von Willebrand (www.whonamedit.com) Erik Adolf von willebrand Finnish internist, born February 1, 1870, Vasa; died 1949. Associated with von willebrand factor,Willebrand s disease I http://www.whonamedit.com/doctor.cfm/2690.html

Home List categories Eponyms A-Z Biographies by country ... Contact Whonamedit.com does not give medical advice. This survey of medical eponyms and the persons behind them is meant as a general interest site only. No information found here must under any circumstances be used for medical purposes, diagnostically, therapeutically or otherwise. If you, or anybody close to you, is affected, or believe to be affected, by any condition mentioned here: see a doctor. A recommendation: Hypography is an open community about science and all things related Erik Adolf von Willebrand Finnish internist, born February 1, 1870, Vasa; died 1949. Associated eponyms: Von Willebrand factor A factor lacking or defective in patients with von Willebrand's disease I. Willebrand's disease I A familial congenital bleeding disorder characterized by prolonged bleeding time. Willebrand's disease II This disorder resembles a type of von Willebrand’s disease, but the defects appear to be in the platelets, rather than the von Willebrand factor. Biography: Erik Adolf von Willebrand was born in the port city Vaasa, the son of the district engineer Fredrik Magnus von Willebrand and his wife Signe Estlander. After passing the baccalaureate in Vasa in 1888 he entered medical studies at the University of Helsingfors. During the summers of 1894 and 1895 he worked as a physician in Mariehamn, the capital of the Åland islands, partly as a cholera doctor and partly as a subordinate physician to the Mariehamn spa. Here he learned about “Ålandic haemorrhagic disease”. He qualified as a doctor in 1896, and in 1899 he defended a doctoral thesis that dealt with his investigations into the changes in blood after a serious loss of blood, Zur Kenntnis der Blutveränderungen nach Aderlassen. For the rest of his life von Willebrand remained interested in blood and especially in its coagulation properties.

45. How Von Willebrand Is Inherited Unlike haemophilia, von willebrand disease is not genderrelated. von willebrand types I and II have a dominant inheritance pattern. http://www.haemophilia.org.za/Vonherit.htm

How von Willebrand Disease is Inherited Unlike haemophilia, von Willebrand disease is not gender-related. So the effect is the same regardless of whether the defective von Willebrand factor (vWF) is passed down from the mother or father. It also makes no difference whether the child is a boy or girl; the disease shows up in the same way. If one parent has a defective gene: Each parent contributes one of his/her genes for vWF to his/her child. As shown, there are four possible genetic combinations than can result from this union If both parents have a defective gene: Again, there are four possible genetic combinations. Odds: 2 out of 4 children (50%) will be genetically normal. 2 out of 4 children (50%) will have the defective vWF gene Odds: 1 out of 4 children (25%) will be genetically normal. 2 out of 4 children (50%) will have one defective vWF gene 1 out of 4 children (25%) will have two defective vWF genes, which will result in severe von Willebrand disease. Von Willebrand types I and II have a "dominant" inheritance pattern. That means that in a child with one normal gene and one gene for either of these von Willebrand types, the defective gene in "stronger. So the child will actually have the disease.

46. Other Bleeding Disorders Introduction to von willebrand Disease The other bleeding disorder Classification of von willebrand Disease How von willebrand is inherited http://www.haemophilia.org.za/HemOther.htm

Although millions suffer from it, few people have ever heard of von Willebrand disease, a bleeding disorder that strikes male and female alike. Other Bleeding Disorders Introduction to von Willebrand Disease The "other" bleeding disorder Classification of von Willebrand Disease How von Willebrand is inherited ... Children's Page

47. Von Willebrand's Disease CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00070640.html

Main Search Index Definition Description Causes ... Resources Von Willebrand's disease Definition Von Willebrand's disease is an inherited blood disorder characterized by prolonged bleeding time . It is the most common hereditary bleeding disorder in humans. Description The disease was first described by the Finnish physician Erik von Willebrand in 1926, when he noticed that many members of a large family from the Aland Islands in the Gulf of Bothnia had a bleeding disorder with a distinct inherited pattern. Von Willebrand's disease affects about 1-3% of the world's population, including about 1% of people in the United States. Von Willebrand's disease is classified into three basic types. The mildest form, type 1, occurs in approximately 70-80% of patients. The moderate form of von Willebrand's disease is called type 2 and affects about 20-30% of people with the disease. The most severe form is called type 3. Type 3 disease is very rare, occurring in about one person per million. The classification system for von Willebrand's disease was revised in 1994. The three major types were subdivided into types 1, 2A, 2B, 2M, 2N, and 3. This revision was necessary because of the many different genetic mutations that cause the disorder.

48. Von Willebrand Disease von willebrand’s disease is an inherited condition that involves a deficiency of a clotting factor known as von willebrand factor (vWF). http://www.mesavet.com/library/vonwillebranddisease.htm

Home Client Forms Careers Search MVH WELCOMES NEW DOCTOR Mesa Veterinary Hospital is pleased to announce the arrival of Associate Veterinarian Dr. Michelle Moeller . Dr. Moeller comes to Mesa after completing a year-long internship at Animal Referral and Emergency Center of Arizona, where she focused on small animal medicine and surgery. WE HAVE A WINNER! The winner of our Senior Pet Challenge contest is Lesilie Peterson of Chandler, Arizona. Lesilie owns a senior dog and cats. She'll receive 100 pounds of Hill's Science Diet Dog Food. The winner was selected from the correct entries received. Congratulations Lesilie! von Willebrand Disease von Willebrand’s disease is an inherited condition that involves a deficiency of a clotting factor known as von Willebrand factor (vWF). It is the most common bleeding disorder in dogs and is especially common in Dobermans, but also seen in Scottish terriers, Shetland sheepdogs, German shepherds, golden retrievers, and other breeds. Clinical signs vary from case to case. If there is no surgery early on in a dog’s life, it may be several years before a bleeding episode occurs. Signs may include bleeding from the nose, excess bleeding in intact females in heat, excess bleeding after having puppies, blood in the urine or stool, bleeding from the gums, lameness, or excess bleeding after surgical procedures or if nails are trimmed too short.

49. Von Willebrand S Disease (vWD) A Type Of Hemophilia In Dogs von willebrand s disease is a type of hemophilia (bleeding disorder) in dogs caused by a lack of a specific blood clotting factor. http://www.peteducation.com/article.cfm?cls=2&cat=1614&articleid=488

50. Von Willebrand's Disease Most people, however, are not as familiar with von willebrand s disease and hear von willebrand s disease is also an inherited blood clotting defect and http://www.marvistavet.com/html/body_von_willebrand_s_disease.html

Most people are familiar with hemophilia A, an inherited blood clotting defect in human beings affecting only male children. Most people, however, are not as familiar with von Willebrand's disease and hear of it for the first time when they ask questions about breeding their dog. Von Willebrand's disease is also an inherited blood clotting defect and breeds at high risk should be screened before being allowed to breed. WHAT IS VON WILLEBRAND'S FACTOR? When there is something wrong with one's von Willebrand's factor, platelets to do not stick together properly and inappropriate prolonged wound bleeding occurs. TYPES OF VON WILLEBRAND'S DISEASE Unlike the genetics of Hemophilia A in humans, which is reviewed in detail in virtually every high schoole biology class as a sex linked recessive trait, von Willebrand's disease is not as simple. Males and females are equally affected and the inheritance seems to be recessive but complicated. DIAGNOSIS OF VON WILLEBRAND'S DISEASE: BLOOD TESTING AND DNA TESTING Classically, testing for von Willebrand's disease is accomplished by measuring von Willebrand's factor in a blood sample. The amount of factor in the patient's serum is compared to that found in "normal" dogs. The patient's results are compared to the normal and expressed in a percentage (thus it is possible for a patient to have >100% as their result).

51. Von Willebrand's Disease Dogs that are carriers of von willebrand s disease but not likely to to be affected by von willebrand s disease, in most cases. So a level of 3% http://www.vetinfo.com/dvonwillebrands.html

Sitemap vetinfo vetindex catindex ... Secure e-mail subscription form Please note: The information on our site is for everyone to read. Please use it as often as you like. Please use the search engine or one of the indexes to access the information you need on our website. Subscriber Info The income from subscriptions helps defray the cost of maintaining the site and allows us to keep the large amount of information on www.vetinfo.com free to our readers. vonWillebrand's disease vonWillebrand's Disease care von Willebrand's disease von Willerand's and anemia also see blood disorders vonWillebrand's Disease care Question: Dear Dr. Richards, I recently had our 5 1/2 month old Doberman tested for vonWillebrand's Disease before I had her spayed. She has the disease. My vet said that she had only 3% of the vonWillebrand's factor, which sounds pretty bad to me. The plan is to take her in the afternoon before her surgery and give her a plasma transfusion, then do the surgery the next morning. I know nothing about this disease or what to expect or how to take care of her in the future. I have looked for information on the internet and what I have

52. InterPro: IPR002035 Von Willebrand Factor, Type A The von willebrand factor is a large multimeric glycoprotein found in blood In von willebrand factor, the type A domain (vWF) is the prototype for a http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002035

53. InterPro: IPR001846 Von Willebrand Factor, Type D One of the functions of von willebrand factor (vWF) is to serve as a The secondary structure of the von willebrand factor type A domain in factor B of http://www.ebi.ac.uk/interpro/IEntry?ac=IPR001846

54. Von Willebrand's Disease von willebrand s disease is an inherited bleeding disorder that prevents blood from clotting properly. http://my.webmd.com/hw/health_guide_atoz/stv5464.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... Support Organizations Von Willebrand's disease Von Willebrand's disease is an inherited bleeding disorder that prevents blood from clotting properly. In this disease, a protein in the body's blood system (von Willebrand factor) is missing or does not work well, and the blood cells (platelets) cannot stick together normally to form clots at the site of bleeding. Symptoms of von Willebrand's disease may include excessive bleeding after injury, frequent nosebleeds, heavy menstrual flow, easy bruising, blood in the urine or stool, and bleeding from the gums. Equal numbers of men and women have this disease. Von Willebrand's disease can be treated with medication that increases the amount of von Willebrand clotting factor in the blood. Treatment also focuses on preventing and stopping bleeding.

55. One Percent Of Americans Have Von Willebrand Disease: What Is It? von willebrand Disease (VWD) is a hereditary bleeding disorder that involves a protein in the blood called von willebrand factor, or VWF, which helps our http://healthlink.mcw.edu/article/1030552013.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Children's Health Genetics By keywords: Receive Health Link via email! Subscribe now >> One Percent of Americans Have Von Willebrand Disease: What Is It? Most of us have become accustomed to life's bumps and bruises...and scrapes, cuts, sprains and strains. We've all had those clumsy times where life seems like nothing but a series of minor mishaps. We're able to ignore many of these injuries, while others are easily put right with a bandage or a few days' rest. But for children and young adults with abnormal reactions to life's accidents - including heavy bleeding, bleeding that doesn't stop, or very frequent bruising - testing for von Willebrand disease could be in order. Von Willebrand disease (VWD) is a hereditary bleeding disorder, in fact, one of the most common bleeding disorders known: it affects about 1% of all Americans. The illness involves a protein in the blood called von Willebrand factor, or VWF, which helps our blood to clot. People with von Willebrand disease don't have enough of the factor available in their blood, or the VWF that is present doesn't perform effectively. Simple injuries can bring on heavier and longer bleeding episodes than usual or cause frequent bruises to form under the skin. Men and women can both have VWD, but women are usually more symptomatic, with heavy menstrual bleeding (menorrhagia) being a common symptom.

56. Von Willebrand Disease Causes Excessive Bleeding People with von willebrand disease may bleed easily, particularly after surgery, such as a tonsillectomy or oral surgery, that involves the mucous http://healthlink.mcw.edu/article/1031002252.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Blood/Blood Pressure Genetics By keywords: clotting disorders blood diseases von Willebrand disease Receive Health Link via email! Subscribe now >> Von Willebrand Disease Causes Excessive Bleeding Q: When my teenage grand-niece had her tonsils removed, she bled badly. The doctor suggested that her parents be tested for bleeding disorders. It turns out her mother (my brother's daughter) carries the gene for von Willebrand disease. She was told the male carries the disease. Is it possible I am also a carrier? I have had surgery with no problems. A: Whenever our skin or mucus membranes are cut, about a dozen clotting factors work together to make a clot. One clotting factor is von Willebrand factor, and when this factor is mutated, you have von Willebrand disease . People with von Willebrand disease may bleed easily, particularly after surgery on mucus membranes, such as a tonsillectomy or oral surgery. Nearly 1% of all people have von Willebrand disease, but some are only affected mildly and some are never diagnosed. Women with von Willebrand disease are more often diagnosed because they may notice increased menstrual bleeding.

57. Von Willebrand's Disease von willebrand’s Disease (vWD) is the most common inherited bleeding This blood protein is commonly referred to as von willebrand’s Factor (vWF). http://www.geocities.com/schlosser44/vWD.html

Home Von Willebrand's Disease Canine Hip Dysplasia Demodectic Mange ... Thyroid Dysfunction VON WILLEBRAND'S DISEASE Von Willebrand’s Disease (vWD) is the most common inherited bleeding disorder in dogs. This informational site was created for puppy buyers, breeders, and owners of the American Pit Bull Terrier (APBT) and American Staffordshire Terrier (AST). This page is dedicated to vWD in regards to the APBT and AST, with a few references to other breeds of dogs affected. Table of Contents WHAT IS vWD? CLINICAL SIGNS BLOOD TESTING AND RANGES STRICT PROTOCOL YOU MUST FOLLOW FOR TESTING ... vW LINKS WHAT IS vWD? Testing for vWD is not a routine procedure, unless the vet was actively suspicious that there was a problem. You would need to ask for it. Unless there were symptoms present, or unless the vet had dealt with a positive APBT or AST before. CLINICAL SIGNS The clinical signs of vWD are typical of a platelet function defect, such as spontaneous hemorrhage for mucosal surfaces, epistaxis, hematuria, melena and excessive hemorrhage from surgery or trauma. Stillbirths, neonatal deaths, prolonged bleeding at tail docking, ear cropping or dewclaw removals are other common manifestations. Bleeding from gums, excessive umbilical cord bleeding at birth, excessive bleeding from toenails cut too short, and bleeding after elective procedures. Some other clinical signs are: bloody stools, feces, hematochezia , forelimb lameness, forelimb swelling, generalized lameness or stiffness, head, face, ears, jaw, nose, nasal, swelling, hematuria, hemorrhage of any body part or clotting failure, hind limb lameness, hind limb swelling, hyphema, neck swelling, pale, pelvic or perennial swelling, petechiae or ecchymoses, red or brown urine, swelling skin or subcutaneous, swelling, mass external abdomen, tachycardia, thoracic swelling..

58. Von Willebrand Factor Laboratory Medicine is a division of the Massachusetts General Hospital, Department of Pathology, and consists of the MGH Clinical Laboratories and the http://www.mgh.harvard.edu/labmed/lab/coag/handbook/CO006200.htm

Laboratory Medicine Laboratories Coagulation Handbook von Willebrand Factor Coag Test Handbook Index From: Elizabeth M. Van Cott, M.D., and Michael Laposata, M.D., Ph.D., "Coagulation." In: Jacobs DS et al, ed. The Laboratory Test Handbook , 5th Edition. Lexi-Comp, Cleveland, 2001; 327-358. von Willebrand Factor [CO006200] Related Information Coagulation Factor Assays Factor VIII Concentrate Synonyms Multimer Assay; Ristocetin Cofactor; Ristocetin-Induced Platelet Aggregation Assay; von Willebrand Factor Antigen; von Willebrand Factor Assay; von Willebrand Factor Collagen-Binding Assay; von Willebrand Factor Multimer Assay Applies to Acute Phase Reactant; DDAVP; Desmopressin; Factor VIII:von Willebrand Factor Ratio Test Includes Assays for von Willebrand factor (vWF) activity (ristocetin cofactor), vWF antigen, and factor VIII should be ordered. If indicated by these results, a vWF multimer analysis and/or low-dose ristocetin aggregation assay can be ordered. Abstract von Willebrand factor (vWF) mediates platelet adhesion to injured endothelium, the first step in hemostasis. It also helps maintain factor VIII levels. When vWF is deficient, patients have a bleeding disorder called von Willebrand disease (vWD). vWD is the most common hereditary bleeding disorder, of which several subtypes are recognized (see below).

59. Introduction: Von Willebrand Disease - WrongDiagnosis.com Introduction to von willebrand disease as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/v/von_willebrand_disease/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Von Willebrand disease Next sections Basic Summary for Von Willebrand disease Prevalence and Incidence of Von Willebrand disease Prognosis of Von Willebrand disease Symptoms of Von Willebrand disease ... Diagnostic Tests for Von Willebrand disease Next chapters: Dwarfism Achondroplasia Primary Immune Deficiency Selective IgA Deficiency ... Feedback Introduction: Von Willebrand disease Von Willebrand disease: An often undiagnosed congenital bleeding disorder Researching symptoms of Von Willebrand disease: Further information about the symptoms of Von Willebrand disease is available including a list of symptoms of Von Willebrand disease , other diseases that might have similar symptoms in differential diagnosis of Von Willebrand disease , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Von Willebrand disease: Research more detailed information about misdiagnosis of Von Willebrand disease failure to diagnose Von Willebrand disease , or research misdiagnosis of other diseases Statistics and Von Willebrand disease: Various sources and calculations are available in statistics about Von Willebrand disease prevalence and incidence statistics for Von Willebrand disease , and you can also research other medical statistics in our statistics center Contents for Von Willebrand disease:

60. OMIM - VON WILLEBRAND DISEASE http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=193400

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