21. ENTECMED Carat TX4 Platelet Aggregometer Carat TX4 four channel platelet aggregometer for Platelet Function Test, von willebrand Factor Assay (Ristocetin Cofactor) and Drug Response Assay. http://www.entecmed.com/

Entec GmbH Ehrenbergstr. 1, D-98693 Ilmenau Platelet Function Test von Willebrand Factor Assay Drug Response Assay Product features

22. BBC - Health - Ask The Doctor - Von Willebrand's Disease The symptoms and treatment for von willebrand's disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

23. Von Willebrand Disease Excessive or prolonged bleeding could be a sign of von willebrand disease. Learn more about this genetic disorder that affects the blood s ability to clot. http://kidshealth.org/parent/medical/heart/vwd.html

KidsHealth Parents Medical Problems Every parent has dealt with their child's bruises and bloody noses from time to time. For most kids, a bandage and a sympathetic hug is all it takes to get them back in the game. But a small group of parents may notice that their children seem to have constant nosebleeds, unexplained bruising, or prolonged bleeding after a tooth is pulled. Excessive or prolonged bleeding could be a sign of a genetic disorder known as von Willebrand disease. For many people, the symptoms are so mild that they never even know they have the disorder. For those with a more severe form of the disease, a proper diagnosis and treatment plan can help them to live an active life. What Is von Willebrand Disease? Von Willebrand disease, or vWD, is an inherited disorder that impacts the blood's ability to clot properly. It takes its name from Dr. Erik von Willebrand, who first described the condition in 1926. As a group, bleeding disorders (including hemophilia ) are rare. Von Willebrand disease is the most common inherited bleeding disorder, affecting as much as 1% of the population or more. Normally, bleeding occurs when a blood vessel is cut or torn.

24. VetGen - Purebred Animal Genetic (DNA) Disease Testing And Profiling VetGen proudly Announces New DNA test to detect Type I von willebrand's Disease (vWD) in Bernese Mountain Dogs. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

25. Von Willebrand Disease Excessive or prolonged bleeding could be a sign of a genetic disorder known as von willebrand disease. Find out about this rare disorder in this article. http://kidshealth.org/teen/diseases_conditions/genetic/vwd.html

KidsHealth Teens Everyone has to deal with bruises and bloody noses from time to time. But excessive or prolonged bleeding can be a sign of a disorder known as von Willebrand disease. For many people, the symptoms are so mild that they never even know they have the disorder. For those with more severe forms of the disease, though, getting the proper diagnosis and treatment usually makes them less likely to have problems from the condition. What Is von Willebrand Disease? Von Willebrand disease, or vWD, is an inherited disorder - meaning it's passed from parent to child through genes - that affects the blood's ability to clot properly. It takes its name from Dr. Erik von Willebrand, who first described the condition in 1926. As a group, bleeding disorders (including one you may have heard about - hemophilia ) are rare. Von Willebrand disease is the most common inherited bleeding disorder, affecting about 1% to 2% of people. Unlike hemophilia, which usually affects only guys, vWD affects both guys and girls. Normally, bleeding usually occurs when a blood vessel is cut or torn.

26. David Ginsburg David Ginsburg, M.D An article covering von willebrand Factor, coagulation factor V, plasminogen activator inhibitor1, primary pulmonary hypertension and bone marrow transplantation. http://www.hhmi.org/science/genetics/ginsburg.htm

HHMI-NIH Research Scholars Learn about the HHMI-NIH Research Scholars Program, also known as the Cloister Program. More Janelia Farm Research Campus Learn about the new HHMI research campus located in Virginia. More Molecular Genetics of Blood Clotting Summary: David Ginsburg is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders. Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke. von Willebrand Factor The blood-clotting protein von Willebrand factor (VWF) functions as the critical initial bridge connecting blood platelets to the wall of injured blood vessels, thereby helping to control bleeding. VWF also serves as the carrier for factor VIII, the substance missing in patients with hemophilia. Abnormalities in VWF result in von Willebrand disease (VWD), the most common human inherited bleeding disorder. A blood clot formed in vitro...

27. The Haemophilia Society The Haemophilia Society is working for people with haemophilia, von willebrand's or a related bleeding disorder and their families to secure the http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

28. NHF | Bleeding Disorders Information Center | Von Willebrand Disease von willebrand disease is a hereditary deficiency or abnormality of the von willebrand factor in The disease was first described by Erik von willebrand, http://www.hemophilia.org/bdi/bdi_types3.htm

This section of our Web site sponsored by: VON WILLEBRAND DISEASE Hemophilia A Hemophilia B von Willebrand Disease Factor I Deficiency Factor II Deficiency Factor V Deficiency Factor VII Deficiency Factor X Deficiency Factor XI Deficiency Factor XII Deficiency Factor XIII Deficiency Thrombophilia von Willebrand Disease What Is It? von Willebrand disease is a hereditary deficiency or abnormality of the von Willebrand factor in the blood, a protein that affects platelet function. It's the most common hereditary disorder of platelet function, affecting both women and men. The disease is estimated to occur in 1% to 2% of the population. The disease was first described by Erik von Willebrand, a Finnish physician who reported a new type of bleeding disorder among island people in Sweden and Finland. In von Willebrand disease, blood platelets don't stick to holes in blood vessel walls. Platelets are tiny particles in the blood that clump together at the site of an injury to prepare for the formation of a blood clot. von Willebrand factor causes them to bind to areas of a blood vessel that are damaged. If there is too little von Willebrand factor or the factor is defective, platelets do not gather properly when a blood vessel is injured.

29. Von Willebrands Sygdom von willebrands sygdom er den mest almindelige arvelige bl¸dersygdom op til ©n procent af befolkningen (b¥de m¦nd og kvinder) kan have den. At have von willebrands sygdom betyder, at man ikke har nok af det protein, der hedder von willebrandfaktor, eller at proteinet er forkert bygget op. von willebrand-faktoren er med til at s¸rge for, at bl¸dninger kan stoppe. http://www.netdoktor.dk/sygdomme/fakta/vonwillebrand.htm

Annonce i NetDoktor i Fagbogen NetDoktor.dk Forside Nyheder Genveje Babyklub Rygestop-service Slankedoktoren Fagbogen Leksikon Sygdomme Medicin Symptomer Sundhed Emner Allergi Angst Depression Inkontinens ... Patientforeninger Service Test dig selv Information Kontakt NetDoktor Om NetDoktor ND i andre lande Von Willebrands sygdom Af Hvad er von Willebrands sygdom? De fleste (cirka 80 procent) har sygdommen i mild grad (type 1) med symptomer som kraftige menstruationer Von Willebrands sygdom er arvelig. Sygdommen skyldes en fejl i gener kromosom Kraftig og langvarig menstruation hovedpine , svimmelhed, Hvordan behandles sygdommen P-piller I Danmark er de tre mest brugte midler til von Willebrands sygdom: desmopressin tranexamsyre faktor VIII/von Willebrand-faktor. Gentag proceduren Octostim Cyklokapron Pamol Panodil Pinex Setamol Udsigt for fremtiden Patientforening Medicin som kan anvendes: Sidst opdateret: GENVEJE: Babyklub Rygestop-service Slankedoktoren Fagbogen LEKSIKON: Sygdomme Medicin Symptomer Sundhed EMNER: Allergi Angst Depression Inkontinens ... Patientforeninger SERVICE: Test dig selv INFORMATION: Kontakt NetDoktor Om NetDoktor ND i andre lande Brugerbetingelser: Vigtige juridiske informationer ... fortrolighedspolitik The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care or attention by a qualified practitioner. The materials in this web site cannot and should not be used as a basis for diagnosis or choice of treatment.

30. Significance Of Von Willebrand Factor In Septic And Nonseptic Significance of von willebrand Factor in Septic and Nonseptic Patients with Acute Lung Injury Lorraine B. Ware , Mark D. Eisner http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

31. National Hemophilia Foundation For All Bleeding Disorders | Hemophilia, Von Will Learn About Bleeding Disorders like Hemophilia, von willebrand Disease and von willebrand disease is a hereditary deficiency or abnormality of the von http://www.hemophilia.org/bleeding_disorders/vwd.htm

Become an NHF Member Subscribe to NHF eNotes, our Monthly Newsletter Donate to NHF Join our Discussion Groups ... Types of Bleeding Disorders von Willebrand Disease What Is It? von Willebrand disease is a hereditary deficiency or abnormality of the von Willebrand factor in the blood, a protein that affects platelet function. It's the most common hereditary disorder of platelet function, affecting both women and men. The disease is estimated to occur in 1% to 2% of the population. The disease was first described by Erik von Willebrand, a Finnish physician who reported a new type of bleeding disorder among island people in Sweden and Finland. In von Willebrand disease, blood platelets don't stick to holes in blood vessel walls. Platelets are tiny particles in the blood that clump together at the site of an injury to prepare for the formation of a blood clot. von Willebrand factor causes them to bind to areas of a blood vessel that are damaged. If there is too little von Willebrand factor or the factor is defective, platelets do not gather properly when a blood vessel is injured. von Willebrand factor is found in plasma, platelets and blood vessel walls. When the factor is missing or defective, the first step in plugging a blood vessel injury (platelets adhere to the vessel wall at the site of the injury) doesn't take place. As a result, bleeding doesn't stop as quickly as it should, although it usually stops eventually.

32. VetGen - Purebred Animal Genetic (DNA) Disease Testing And Profiling DNA testing for von willebrands disease and color gene testing for presence of e and b alleles. Also mating charts for Schipperke and Labradors. http://www.vetgen.com/

VetGen... the leader in veterinary genetic disease research and genetic disease detection services for purebred animals. Using VetGen's services, combined with our valuable DNA Profiling and DNA Storage, for the first time in history, animal breeders and owners have the opportunity to eliminate targeted inherited diseases in a growing number of breeds. VetGen Services About VetGen Current Services Quality Control and Warranty Research Canine Current Services Breeding Strategies References Feline Current Services DNA Test for vWD Bernese Mountain Dogs VetGen proudly Announces New DNA test to detect Type I von Willebrand's Disease (vWD) in - Bernese Mountain Dogs. DNA Test for vWD Kerry Blue Terriers VetGen proudly Announces New DNA test to detect Type I von Willebrand's Disease (vWD) in - Kerry Blue Terriers Coat Color Litters by Design VetGen™ proudly presents the Revolutionary "ChromaGene™" Coat Color Prediction Service for a variety of breeds "ChromaGene™"Test for Schipperkes

33. LA Kelley Communications Communication experts for the bleeding disorders community for 14 years http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

34. The Other Bleeding Disorder Information on the three types of von willebrand Disease as well as treatments. http://www.haemophilia.org.za/Vonwil2.htm

The "Other" Bleeding Disorder W hat is the most common inherited bleeding disorder, the one that affects many millions of people around the world, and up to two million in the United States You may be surprised to hear that it is not haemophilia. It is von Willebrand disease , a related disorder that few people have heard of, unless they have it or know someone who does. Why is such a common illness such a secret? Perhaps because the disease is usually less severe than haemophilia, it has not generated the kind of publicity, educational efforts and support that other chronic illnesses have. In fact, it is often so mild, it is not diagnosed at all. Some people live with the disease for many years before getting an accurate diagnosis. For more severely affected patients, this lack of knowledge has caused real suffering. Fortunately, substantial progress has been made in recent years. The von Willebrand gene has been identified and research is underway to develop gene therapy. As research continues, however, the challenge continues to educate healthcare professionals and the public about this disorder. That is the best way to assure those with von Willebrand that they will receive proper diagnoses and treatment. The Basics of von Willebrand Von Willebrand disease is not a type of haemophilia. Like haemophilia, von Willebrand disease does make it difficult to stop bleeding when an injury occurs. But the two disorders have different causes, different symptoms an many cases, different patterns of inheritance and different treatments.

35. DNA Studies In Doberman Von Willebrand’s Disease. DNA Studies in Doberman von willebrand s Disease. our discovery of the mutation that causes von willebrand s disease (vWD) in the Doberman Pinscher. http://www.vetgen.com/vwdrpt.html

DNA Studies in Doberman von Willebrand's Disease. The Mutation Discovered and a DNA Test Developed by George J. Brewer, Professor, Department of Human Genetics and Internal Medicine, University of Michigan Medical School, Co-Founder of VetGen LLC Our research team is very excited about our discovery of the mutation that causes von Willebrand's disease (vWD) in the Doberman Pinscher. Credit for the discovery must include my colleagues, Dr.'s Patrick Venta, Vilma Yuzbasiyan-Gurkan, and William Schall, of the College of Veterinary Medicine at Michigan State University, and to Dr. Jianping Li, who works in my laboratory at the University of Michigan as well as at VetGen LLC, and who did all the DNA sequencing. This discovery is a nice example of the productive cooperation between the two universities and the company mentioned, as well as four funding organizations that provided support, The Doberman Pinscher Foundation of America, Inc., The Orthopedic Foundation for Animals, the Morris Animal Foundation, and the American Kennel Club. The mutation itself has some interesting aspects. For one thing, precisely the same mutation has occurred in some human patients with vWD. It is a little unusual to see mutations be identical across species. This shows how closely we are related to our canine brethren! Second, the mutation is of a type such that completely normal von Willebrand's factor (vWf) is made about 5-10% of the time. Technically, the mutation is called a splice site mutation, with alternative splicing occurring about 90-95% of the time. That jargon won't mean much to the average Doberman breeder or owner, but let me explain what is happening in layperson language. It may be useful for the Doberman fancy to understand the mutation to a certain extent, because its nature explains why it was so confusing to understand for a long time, and it also explains why affected Dobermans have a milder disease than, say, affected Scotties.

36. Sheltie Von Willebrand’s Disease Can Now Be Diagnosed By A DNA Test von willebrand s disease vWD, an inherited bleeding disorder, The vWD test available in the past has been an assay of von willebrand factor protein. http://www.vetgen.com/sheltvwd.html

Sheltie von Willebrand's Disease Can Now Be Diagnosed by a DNA Test by George J. Brewer, Professor, Department of Human Genetics and Internal Medicine, University of Michigan Medical School and Patrick J. Venta, Assistant Professor, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, Co-Founders of VetGen LLC Von Willebrand's disease vWD, an inherited bleeding disorder, usually comes in two major types, type I and type III. (There is also a rarer Type II, not relevant to Shelties). Type III is a severe bleeding disorder with a high risk of spontaneous bleeding as well as a risk of serious bleeding from trauma and surgery. It is probably best known in Scottish Terriers. Type I is milder, with most of the risk coming from trauma or surgery. It is probably best known in Doberman Pinschers. The Sheltie breed has type III vWD, the severe type. There may also be a second less prevalent defect, causing some Shelties to have the less severe Type I vWD, but this is uncertain at present. Enter the era of DNA testing! DNA tests have now been developed for the type III vWD of Scotties, the type I vWD of Dobermans, and the type III vWD for Shelties. These DNA tests can be done at any age, can be done from mouth swabs collected by the breeder/owner (the swabs pick up cells from inside the mouth which provide the DNA), and unambiguously classify dogs for the rest of their lives into affected, carrier, and clear animals. With this test the breeder can rapidly eliminate the vWD disease gene from the breed. If a particularly valuable dog turns out to be a carrier, it can be bred to a clear animal, and non-carrier puppies saved for the next round of breeding.

37. NVHP Nederlandse Vereniging Van Hemoflie-Patiënten Belangenvereniging voor mensen met hemofilie en aanverwante (erfelijke) afwijkingen in bloedstolling, zoals de ziekte van von willebrand, de ziekte van Glanzmann en Trombocytopenie (ITP of de ziekte van Werlhof). http://www.nvhp.nl/

38. Pets Health von willebrand s Disease VON WILLERBRAND’S DISEASE. von willebrand’s disease (wVD) is the most common inherited bleeding disorder in dogs. http://www.cah.com/dr_library/vwd.html

SEARCH THIS SITE: Home Online Resources The Library Von Willebrand's TOPIC: Please select one... 9/11 Pets Loving Devotion A 9/11 Story Acupuncture and Tellington Ttouch Acupuncture in The Treatment For Animals Acupuncture-Uses and Benefits Addison's Disease (Hypoadrenocorticism) Addison's Disease-Newer Treatment Options Aging and Your Pet Age Analogy For Your Pet Aggression At The Vets Office Aggressive Behavior In Multi-Cat Households Aggression At The Vets Office ALLERGIES Anal Sac Disease ANEMIA- AUTOIMMUNE HEMOLYTIC Anesthesia and Your Pet Antifreeze Poisoning Arthritis Treatments For Cats and Dogs Asthma-Bronchitis in Cats Babesiosis in Dogs Babies and Pets-Introduction of Bacterial Skin Infections Behavior Guides for Cats Behavior Guides for Dogs Behavior Drug Therapy Birds Feeding Guide for Pet Birds Birds- Care of Bladder Stones (uroliths) Cardiac Diseases of Cats and Dogs Cat Breeds Cat Litter Cat Scratch Fever-Bartonellosis Cataracts and Your Pet Cerebellar Hypoplasia Cheytiella Dermatitis in Pets Chocolate Poisoning in Dogs Chronic Wasting Disease Clostridial Enteritis and Diarrhea in Your Pet Constipation and Your Cat Cruciate Ligament Damage and Repair Cushings Disease-Hyperadrenocorticism Cushings-Treatment of Dental Care and Your Cat Dental Tooth Abscess Diarrhea Dietary Management Demodex Mange in Dogs and Cats Dental Care Dental Care and Your Cat Dental Care Special Promotion for Your Pet Dermatomyositis Diabetes in Cats Diabetes in Dogs Digestive Disturbances in Cats Digestive Disturbances in Dogs Disasters and Emergencies-Be Prepared

39. October 1994 - Von Willebrand Disease von willebrand disease (VWD) is the most common congenital bleeding von willebrand disease is caused by mutations in von willebrand factor (VWF). http://www.itxm.org/Archive/tmu10-94.htm

October, 1994 VON WILLEBRAND DISEASE Margaret V. Ragni, M.D., M.P.H., Medical Director, Hemophilia Center of Western Pennsylvania INTRODUCTION Von Willebrand disease (VWD) is the most common congenital bleeding disorder. It is estimated to occur at a frequency of one in 100 individuals, but is symptomatic in only about one in 10,000. Von Willebrand disease is caused by mutations in von Willebrand factor (VWF). The gene for von Willebrand Factor is located on chromosome 12, and the disease is inherited in an autosomal manner, affecting both males and females. Von Willebrand factor is a glycoprotein consisting of disulfide-linked high molecular weight multimeric FVIII proteins (multimers), and is synthesized in megakaryocytes and endothelial cells, and stored in platelets and endothelial cells. Von Willebrand factor serves as a carrier protein for FVIII and promotes platelet aggregation after vessel injury. Von Willebrand disease is a clinically heterogeneous disease with a number of disease variants, each characterized by different quantitative and/or qualitative defects in von Willebrand factor. It is import to determine the specific von Willebrand disease variant in order to establish the best and safest treatment for each patient. Recently a revised simplified classification system for von Willebrand disease was proposed by the international Society of Thrombosis and Hemostasis (ISTH) (Sadler JE.

40. Von Willebrand's Disease It is caused by a lack of von willebrand factor (vWF), which plays an essential role in the What does von willebrand s disease mean to your dog you? http://www.upei.ca/~cidd/Diseases/clinical pathology/von Willebrand's disease.ht

What is von Willebrand's disease? Von Willebrand's disease (vWD) is a common, usually mild, inherited bleeding disorder in people and in dogs. It is caused by a lack of von Willebrand factor (vWF), which plays an essential role in the blood clotting process. Normally the body responds to an injury causing bleeding through a complex defence system. This consists of local changes in the damaged blood vessels, activation of blood cells called platelets, and the coagulation process. A reduction in von Willebrand factor leads to abnormal platelet function and prolonged bleeding times. Affected dogs are prone to bleeding episodes such as nose bleeds, and generally experience increased bleeding with trauma or a surgical procedure. Three forms of the disease are distinguished based on vWF concentration and function. Dogs with Type I vWD (by far the most common) have mild to moderate bleeding abnormalities, depending on the level of vWF. The much rarer types II and III vWD cause severe bleeding disorders. How is von Willebrand's disease inherited?

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