41. Information About Vascular Dementia At Memantine.com Memantine.com vascular dementia Here you get information about forms ofdiseases, drugs, therapies, care and latest research results. http://www.memantine.com/docs/vascular_dementia/index.php

Vascular Dementia Further links Axura: Information for professionals The care for elderly people and their diseases are a topic for our society, whose importance grows each day. Memantine Alzheimer's Treatment . Calcium enters into the cell, and through secondary processes, the signal is recognized. Such excitotoxicity ultimately leads to neuronal calcium overload and has been implicated in neurodegenerative disorders. Senile Dementia Dementia Care . A signal is produced which due to the lower noise can be recognized and processed which leads to a symptomatic improvement in dementia symptoms. The starting point is the pathological release of glutamate, followed by elevated calcium concentrations. Alzheimer's Research Alzheimer . Dysfunction of glutamatergic neurotransmission is involved in pathomechanism of neurodegenerative dementia. The 2 large studies have shown positive effects of memantine in mild to moderate cases of vascular dementia. Memantine is a NMDA receptor antagonist and protects the glutamatergic system from pathological activation. Clinically-relevant doses of memantine produce improvements in learning under conditions of tonic NMDA receptor activation in Alzheimer's disease. At the same time, Memantine reduces caregiver time by more than 50 hours a month. A signal is produced which due to the lower noise can be recognized and processed which leads to a symptomatic improvement in dementia symptoms. Demenzkranke Verwirrtheit Short Term Memory Loss Symptoms Of Alzheimer's Disease . In the course of the disease, the chronic release of glutamate and the permanently increased intracellular calcium concentration leads to neuronal degeneration (neurodegeneration). Memantine has been developed as a monotherapeutic. Calcium enters into the cell, and through secondary processes, the signal is recognized.

42. Memantine.com - Vascular Dementia Memantine shows positive results in vascular dementia Study of Memantine inMild to Moderate vascular dementia (Abstract). If you can read this text, http://www.memantine.com/en/studies/clinical_studies/vascular_dementia/

Vascular dementia Memantine shows positive results in vascular dementia Two large studies have shown significant improvement in cognitive performance in mild to moderate vascular dementia. Both studies were double blind randomized multicenter studies lasting 28 weeks. Both of them investigated the long-term efficacy and tolerability of memantine in patients with probable diagnosis of vascular dementia. MMM Abstract Figure 3 : Significant Benefit of Memantine on Cognition (ADAS-cog) The first study, titled MMM 300, was conducted in France and included 321 participants with an MMSE between 12 and 20. They were randomized double-blind to receive either 10 mg memantine or placebo twice a day. The primary endpoints were ADAS-cog and CIBIC-Plus MMM Abstract Figure 1 : Significant Benefit of Memantine on Cognition (ADAS-cog) The second study, called the MMM 500 study, took place in Great Britain. It included 579 patients with an MMSE beween 10 and 22, who were also randomized double-blind and received either 20 mg memantine/day or placebo. The primary endpoints were the ADAS-cog and the CGI-C There was a significant benefit in the memantine group compared to the placebo group in the ADAS-cog; after 12 weeks, the memantine patients showed a modest improvement, while the placebo patients remained unchanged from baseline. A real difference was seen at week 28. The placebo patients had worsened by 2 points, whereas during the same time the memantine patients worsened by only 0.5 points from baseline.

43. Memory And Aging Center: Vascular Dementia vascular dementia can occur quite suddenly or progress slowly over time, Many people with vascular dementia also suffer from depression which can result http://memory.ucsf.edu/Caregivers/vd.html

Checklist Safety Principles Living Arrangements Caregiving by Diagnosis Alzheimer's Disease Amytrophic Lateral Sclerosis Corticobasal Degeneration Creutzfeldt-Jakob Disease ... Progressive Supranuclear Palsy Vascular Dementia Resources/Link Search this site Vascular Dementia Caregiving Challenges Strategies for Coping Safety Environment Caregiving Challenges Vascular dementia can occur quite suddenly or progress slowly over time, and the varying aspects of this disease can prove quite challenging for a caregiver. It can often occur with , which further complicates its progression. The most prominent changes are seen in executive functioning , and include problems with thinking, walking, and performing everyday activities . Many people with vascular dementia also suffer from depression which can result in less motivation to continue their usual activities or a lack of interest in the world around them. At times, people with vascular dementia may go through long periods without noticeable changes, or even improvements, but should another stroke occur, symptoms can rapidly progress. The lack of memory for events or people can make the individual extremely anxious about daily life. This can be exhibited with asking questions and repeating information, preparing for appointments/day care well ahead of time, and use of notes and reminders endlessly.

44. Memory And Aging Center: Vascular Dementia The term vascular dementia (VaD) is usually reserved for an insidiously For more information, go to our vascular dementia section of our LINKS and http://memory.ucsf.edu/Education/Disease/vad.html

General Introduction Diseases Alzheimer's Disease Amytrophic Lateral Sclerosis Corticobasal Degeneration Creutzfeldt-Jakob Disease ... Progressive Supranuclear Palsy Vascular Dementia Topics Emotions Executive Functions Genetics Imaging ... Normal Aging Treatment Medications Alternative Treatments Non-Medical Intervention Search this site VASCULAR DEMENTIA (VaD) Indicates link to glossary definition Introduction One of the most common attributes of aging is a progressive change in our blood vessels (vasculature), and when these changes occur in the brain (cerebrum) they are referred to as cerebrovascular disease. The most common vascular change associated with age is the accumulation of cholesterol and other substances in the blood vessel walls. This results in the thickening and hardening of the walls as well as narrowing of the lumen of the vessels (the space where blood flows), which can result in a reduction or even a complete cessation of blood flow to brain regions supplied by the affected artery. When this occurs suddenly the result is a stroke, with symptoms ranging from weakness, to incoordination, to abnormal sensations, depending on the location of the injury in the brain. In some cases, a sudden loss of cognitive function (such as language, memory, complex visual processing, or organizational skills) can occur.

45. Dementia And Vascular Disease In Europe, the prevalence of vascular dementia is estimated to be 1.54.8% forindividuals The clinical profile of vascular dementia will be described. http://www.dcmsonline.org/jax-medicine/2000journals/February2000/vascdement.htm

Dementia And Vascular Disease Zoe Arvanitakis, M.D. Zoe Arvanitakis, M.D. is with the Department of Neurology at Mayo Clinic Jacksonville. This paper is supported in part by the NIA grant AG16574 and the State of Florida Alzheimer's Disease Initiative Program. Introduction In the Western world, vascular disease is thought to be the second most common cause of dementia, following Alzheimer's disease. Vascular disease is at least partially preventable and treatable, so increasing awareness of this association may decrease the incidence of dementia. This paper will discuss the controversies about vascular disease and dementia, while stating the known facts on which doctors can base clinical decisions. Vascular disease may lead to subtle cognitive changes, which in turn could be a warning sign of impending dementia. This provides the clinician the opportunity to identify individuals at risk and to institute preventive measures. In the United States, about 500, 000 people suffer from a stroke each year and stroke is the third leading cause of death. It has long been known that cognitive deficits may result from a stroke, yet only recently have studies shown that dementia occurs in approximately one-fourth to one-third of stroke cases. The prevalence of all forms of dementia, including vascular dementia, increases with age. In Europe, the prevalence of vascular dementia is estimated to be 1.5-4.8% for individuals between the ages of 70 and 80 years old.

46. Multi-infact Dementia: European Description Vascular (formerly arteriosclerotic) dementia, which includes vascular dementiamay coexist with dementia in Alzheimer s disease (to be coded F00.2), http://www.mentalhealth.com/icd/p22-or02.html

Multi-infact Dementia European Description The ICD-10 Classification of Mental and Behavioural Disorders World Health Organization, Geneva, 1992 Contents F01 Vascular Dementia F01.1 Vascular Dementia Of Acute Onset F01.1 Multi-Infarct Dementia F01.2 Subcortical Vascular Dementia ... F01.3 Mixed Cortical And Subcortical Vascular Dementia F01 Vascular Dementia Vascular (formerly arteriosclerotic) dementia, which includes multi-infarct dementia, is distinguished from dementia in Alzheimer's disease by its history of onset, clinical features, and subsequent course. Typically, there is a history of transient ischaemic attacks with brief impairment of consciousness, fleeting pareses, or visual loss. The dementia may also follow a succession of acute cerebrovascular accidents or, less commonly, a single major stroke. Some impairment of memory and thinking then becomes apparent. Onset, which is usually in later life, can be abrupt, following one particular ischaemic episode, or there may be more gradual emergence. The dementia is usually the result of infarction of the brain due to vascular diseases, including hypertensive cerebrovascular disease. The infarcts are usually small but cumulative in their effect. Diagnostic Guidelines The diagnosis presupposes the presence of a dementia as described above. Impairment of cognitive function is commonly uneven, so that there may be memory loss, intellectual impairment, and focal neurological signs. Insight and judgement may be relatively well preserved. An abrupt onset or a stepwise deterioration, as well as the presence of focal neurological signs and symptoms, increases the probability of the diagnosis; in some cases, confirmation can be provided only by computerized axial tomography or, ultimately, neuropathological examination.

47. Log In Problems The relationship between vascular disease of the brain and cognitive impairmentis unclear. http://www.medscape.com/viewarticle/452842

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48. Log In Problems vascular dementia is the commonest form of dementia in the elderly after Alzheimer´sdisease. http://www.medscape.com/viewarticle/463501_5

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49. Vascular Dementia - Alzheimer's Disease International of a number of mini strokes is often sufficient to cause vascular dementia.vascular dementia and Alzheimer s disease frequently occur together and they http://www.alz.co.uk/alzheimers/vascular.html

Home Donate Search Contact us ... Research Vascular dementia Vascular dementia accounts for about 20% of all cases of dementia. Vascular disease occurs where blood vessels are damaged and the supply of oxygen is at risk. If oxygen supply fails in the brain, brain cells are likely to die leading to a series of mini strokes (infarcts) and possible vascular dementia. The mini strokes that cause vascular dementia are often so slight that they cause no immediate symptoms, or they may cause some temporary confusion. However, each stroke destroys a small area of cells in the brain by cutting off its blood supply and the cumulative effect of a number of mini strokes is often sufficient to cause vascular dementia. Vascular dementia and Alzheimer's disease frequently occur together and they may often act in combination to cause dementia. Symptoms Mental decline is likely to have a clear start date and symptoms tend to progress in a series of steps following each attack, suggesting that small strokes have been occurring May include severe depression, mood swings and epilepsy

50. Wordbank On The Mental Health Foundation Website vascular dementia. spacer. Also known as multiinfarct dementia. The second mostcommon type of dementia which occurs as a result of lack of blood and http://www.mentalhealth.org.uk/wordbank.cfm?wordid=257&wbletter=V

51. Alzheimer's Research Trust - Funding Research Into Alzheimer's Disease And Relat alzheimers,dementia,vascular dementia,senility,alzheimers disease,alzheimersresearch alzheimers,dementia,vascular dementia,senility,alzheimers disease http://www.alzheimers-research.org.uk/scientists/

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52. BestTreatments Vascular Dementia vascular dementia. This type of dementia happens when blood vessels near thebrain get vascular dementia can happen suddenly if you have a stroke. http://www.besttreatments.co.uk/btuk/glossary/11529.html

Glossary vascular dementia This type of dementia happens when blood vessels near the brain get damaged, so the brain doesn't get enough blood. Some of the cells in the brain die, which causes symptoms such as confusion and memory problems. Vascular dementia can happen suddenly if you have a stroke. Or it can come on gradually if you have a series of little strokes (this is called multi-infarct dementia). If you have a stroke, some symptoms might clear up with treatment. But they may gradually get worse. Close window

53. Map & Graph: Countries By Mortality: Vascular Dementia vascular dementia; vascular dementia of acute onset; Multiinfarct dementia;Subcortical vascular dementia; Mixed cortical and subcortical vascular dem http://www.nationmaster.com/graph-T/mor_vas_dem

Supporter Benefits Signup Login Sources ... Pies Factoid #31 Mexico has the most Jehovah's Witnesses per capita in the OECD Interesting Facts Make your own graph: Hold down Control and click on several. Compare All Top 5 Top 10 Top 20 Top 50 Top 100 Bottom 100 Bottom 20 Bottom 10 Bottom 5 All (desc) in category: Select Category Agriculture Crime Currency Democracy Disasters Economy Education Energy Environment Food Geography Government Health Identification Immigration Industry Internet Labor Language Lifestyle Media Military Mortality People Religion Sports Taxation Transportation with statistic: view: Correlations Printable graph / table Pie chart Scatterplot with ... * Asterisk means graphable. What's new? Our next offering Latest newsletter Student area Lesson plans Top Countries The most requested countries (descending order): United States Canada India China ... Mortality : Vascular dementia View this stat: Per capita Show map full screen Country Description Definition: Total for all ages and sexes. Database compiled January 2004. Total of figures for: Vascular dementia Vascular dementia of acute onset Multi-infarct dementia Subcortical vascular dementia Mixed cortical and subcortical vascular dem Amount Spain Finland Cuba ... Korea, South

54. Map & Graph: Countries By Mortality: Vascular Dementia (per Capita) vascular dementia; vascular dementia of acute onset; Multiinfarct dementia;Subcortical vascular dementia; Mixed cortical and subcortical vascular dem Per http://www.nationmaster.com/graph-T/mor_vas_dem_cap

Supporter Benefits Signup Login Sources ... Pies Factoid #144 The top five countries of origin for refugees are all in Africa Interesting Facts Make your own graph: Hold down Control and click on several. Compare All Top 5 Top 10 Top 20 Top 50 Top 100 Bottom 100 Bottom 20 Bottom 10 Bottom 5 All (desc) in category: Select Category Agriculture Crime Currency Democracy Disasters Economy Education Energy Environment Food Geography Government Health Identification Immigration Industry Internet Labor Language Lifestyle Media Military Mortality People Religion Sports Taxation Transportation with statistic: view: Correlations Printable graph / table Pie chart Scatterplot with ... * Asterisk means graphable. What's new? Our next offering Latest newsletter Student area Lesson plans Top Countries The most requested countries (descending order): United States Canada India China ... Mortality : Vascular dementia (per capita) View this stat: Totals Show map full screen Country Description Definition: Total for all ages and sexes. Database compiled January 2004. Total of figures for: Vascular dementia Vascular dementia of acute onset Multi-infarct dementia Subcortical vascular dementia Mixed cortical and subcortical vascular dem Per capita figures expressed per 1000000 population Amount Finland 179.00 deaths per 1 million people

55. HON - News : Walking Problems May Predict Dementia But other kinds of abnormal gait are warning signs of vascular dementia, And that is good news because vascular dementia is potentially preventable. http://www.hon.ch/News/HSN/510503.html

Speech On / Off HONcode sites All Web sites HONselect News ... X Y Z Browse archive: A J J M ... J Other news for: Walking Brain Aging Alzheimer Disease Resources from HONselect Walking Problems May Predict Dementia But researchers say preventive measures are possible By Ed Edelson HealthScoutNews Reporter WEDNESDAY, Nov. 27 (HealthScoutNews) Peculiar kinds of abnormal walking in the elderly can be warning signs of the mind-sapping condition called dementia, a study finds. Although this might sound very scary to an older person who is unsteady on his feet, it's actually good news, researchers say. "The last thing I want to do is create a panic about walking slower," says Dr. Joe Verghese, assistant professor of neurology at Albert Einstein College of Medicine and lead author of a report on the finding, which appears in tomorrow's issue of the New England Journal of Medicine.

56. Dementia, Vascular Patient Education Handout Publication Type; Dementia, Vascular;. Facts aboutdementia what is vascular dementia? This fact sheet, one of a series from http://omni.ac.uk/browse/mesh/D015140.html

low graphics Dementia, Vascular broader: Dementia other: AIDS Dementia Complex Alzheimer Disease Creutzfeldt-Jakob Syndrome Huntington Disease ... Pick Disease of the Brain narrower: Dementia, Multi-Infarct NINDS : Binswanger's disease information page This Web resource on Binswanger's disease (also called subcortical dementia) is produced by the National Institute of Neurological Disorders and Stroke (NINDS). A description of Binswanger's disease is provided, and available treatments, prognosis, and current research activities are all discussed. Links to related organisations are provided. This resource has a US focus. Patient Education Handout [Publication Type] Dementia, Vascular Facts about dementia : what is vascular dementia? This fact sheet, one of a series from the Alzheimer's Society intended for patients and carers, explains briefly the causes of vascular dementia (one of the commonest forms of which is stroke), its symptoms, diagnosis and treatment. The document is also available here as a PDF, requiring Adobe Acrobat Reader. Patient Education Handout [Publication Type] Dementia, Vascular

57. Alzheimers Australia vascular dementia is the second most common cause of dementia after Alzheimer s Binswanger’s disease (also known as Subcortical vascular dementia) http://www.alzheimers.org.au/content.cfm?infopageid=440

58. Dementias vascular dementia is a term for dementia associated with problems in the Binswanger’s Disease is a subcortical vascular dementia which was once http://www.psychnet-uk.com/dsm_iv/dementia.htm

59. NEJM -- Vascular Dementia Book Review from The New England Journal of Medicine vascular dementia. http://content.nejm.org/cgi/content/short/344/24/1872

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 344:1872 June 14, 2001 Number 24 Next Vascular Dementia Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF Add to Personal Archive Add to Citation Manager ... Find Similar Articles Edited by John Stirling Meyer, Gaiane M. Rauch, Helmut Lechner, and Carlo Loeb. 310 pp., illustrated. Armonk, N.Y., Futura, 2001. $88. ISBN 0-87993-425-5. This book summarizes the latest information on the diagnosis and treatment of patients with vascular dementia. The authors, experts in the field, wrote this updated edition for neurologists and others who care for our growing elderly population. Vascular dementia is potentially more amenable to treatment than Alzheimer's disease. Experts in dementia do not agree on basic diagnostic criteria, which makes discussing vascular dementia inherently difficult. Since Hachinski defined the original criteria for multi-infarct dementia in the 1970s, several additional sets of diagnostic

60. NEJM -- Vascular Dementia: Cerebrovascular Mechanisms And Clinical Management Book Review from The New England Journal of Medicine vascular dementiaCerebrovascular Mechanisms and Clinical Management. http://content.nejm.org/cgi/content/extract/352/24/2561

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 352:2561 June 16, 2005 Number 24 Next Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text Add to Personal Archive ... Find Similar Articles (Current Clinical Neurology.) Edited by Robert H. Paul, Ronald Cohen, Brian R. Ott, and Stephen Salloway. 356 pp., illustrated. Totowa, N.J., Humana Press, 2005. $145. ISBN 1-58829-366-1. Hardly a week passes without a new report describing an association between vascular risk factors and dementia. With our rapidly growing elderly population, dementia is becoming an increasing public health burden. This book is an update on the link between cerebrovascular disease and dementia. Although several other books have been published on the subject, there is still a need for a definitive work that reduces ambiguity about what vascular dementia is and what we might do about it, and this one fits

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