41. ► Turner Syndrome A medical encycopedia article on the topic turner syndrome. http://www.umm.edu/ency/article/000379.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Turner syndrome Overview Symptoms Treatment Prevention Definition: A disorder in women caused by a chromosomal defect. This disorder inhibits sexual development and causes infertility Alternative Names: Bonnevie-Ullrich syndrome; Gonadal dysgenesis; Monosomy X Causes, incidence, and risk factors: Turner syndrome is usually caused by a missing X chromosome. It affects 1 out of 3,000 live births. It is usually sporadic meaning that it is not inherited from a parent. Rarely, a parent silently carries rearranged chromosomes that can result in Turner syndrome in a daughter; this is the only situation in which Turner syndrome is inherited. There are many manifestations of this syndrome, but the main features are short stature , webbing of the skin of the neck, absent or retarded development of secondary sexual characteristics, absence of menstruation, coarctation (narrowing) of the aorta, and abnormalities of the eyes and bones. The condition is either diagnosed at birth because of the associated anomalies, or at puberty when there is absent or delayed menses and delayed development of normal secondary sexual characteristics. Pectus excavatum Review Date: 8/31/2001 Reviewed By: David G. Brooks, M.D., Ph.D., Division of Medical Genetics, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

42. National Library Of Medicine Offers synonyms for turner syndrome, a summary and a list of major features. http://www.nlm.nih.gov/cgi/jablonski/syndrome_cgi?term=Turner syndrome (TS)&

43. Introduction: Turner Syndrome - WrongDiagnosis.com Introduction to turner syndrome as a medical condition including symptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/t/turner_syndrome/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Turner Syndrome Next sections Basic Summary for Turner Syndrome Prevalence and Incidence of Turner Syndrome Symptoms of Turner Syndrome Diagnostic Tests for Turner Syndrome ... Complications of Turner Syndrome Next chapters: Klinefelter syndrome Jacobs syndrome Triple-X syndrome Androgen Insensitivity Syndrome ... Feedback Introduction: Turner Syndrome Turner Syndrome: Rare chromosomal genetic syndrome with one X chromosome and no second sex chromosome (X or Y). People are female as there is no male Y chromosome. The effects are often relatively minor, although sterility is possible. Researching symptoms of Turner Syndrome: Further information about the symptoms of Turner Syndrome is available including a list of symptoms of Turner Syndrome , or alternatively return to research other symptoms in the symptom center Treatments for Turner Syndrome: Various information is available about treatments available for Turner Syndrome , or research treatments for other diseases.

44. Stanford Psychiatry Neuroimaging Laboratory: Turner Syndrome turner syndrome. What is turner syndrome? turner syndrome (45,X) is a genetic disorder that occurs only in females and arises from partial or complete http://spnl.stanford.edu/disorders/turners.htm

What is Turner syndrome? Turner syndrome (45,X) is a genetic disorder that occurs only in females and arises from partial or complete absence of the X chromosome. H.H.Turner first described Turner syndrome in 1938 and the chromosomal basis of this syndrome was established in 1959 by Ford. Turner syndrome occurs in 1 in 2500 female births. The physical phenotype of this syndrome includes: gonadal dysgenesis lack of pubertal maturation infertility short stature shield chest webbing of the neck coarctation of the aorta horseshoe kidney The neurocognitive profile of females with Turner syndrome includes: Preserved verbal skills Specific deficits in visuo-spatial tasks, visual memory, and arithmetic Verbal IQ is greater than Performance IQ T he psychosocial profile of females with Turner syndrome includes: Difficulty with school adjustment and facial affect recognition Social hypersensitivity Poor peer relations What causes Turner Syndrome? Turner syndrome is the only sex chromosome disorder in which complete absence of an X chromosome is compatible with life. The loss of one of the sex chromosomes in Turner syndrome probably occurs after the zygote has formed or just after the fusion of the gametes. It has been determined that approximately 50% of cases have a 45,X karyotype with the remainder having mosaic karyotypes. In addition, it has been found that in 70 to 80 % of the cases, the retained X is maternal in origin. Researchers have begun to speculate as to the possibility that genes are present on the X chromosome which are expressed differently depending on the parental origin of the X chromosome. The effects of genomic imprinting can be analyzed from the standpoint of physical and physiologic parameters in females with Turner syndrome.

45. Turner Syndrome Article describes turner syndrome, its diagnosis, and treatment. http://rarediseases.about.com/cs/turnersyndrome/a/020803.htm

var zLb=12; var zIoa1 = new Array('Suggested Reading','Internet links on Turner syndrome','http://rarediseases.about.com/cs/turnersyndrome/index.htm'); var zIoa2 = new Array('Elsewhere on the Web','Turner Syndrome Society of the United States','http://turner-syndrome-us.org/'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Information by Disease Type Chromosome Disorders Turner Syndrome Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/7.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stay up to date! Compare Prices Email to a friend ... Print this page Suggested Reading Internet links on Turner syndrome Elsewhere on the Web Turner Syndrome Society of the United States Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Charcot-Marie-Tooth Disease Peyronie's Disease Twin-to-Twin Transfusion Synd Autoimmune Kidney Disease ... Cri-du-Chat Syndrome Related Topics Multiple Sclerosis Parenting Special Needs Sleep Disorders adunitCM(150,100,'x55')

46. Turner Syndrome turner syndrome (45, X Syndrome; BonnevieUlrich Syndrome; Chromosome X, Monosomy X; Gonadal Dysgenesis (45,X); Gonadal Dysgenesis (XO); Monosomy X; http://www.bdid.com/turner.htm

HOME Turner Syndrome (45, X Syndrome; Bonnevie-Ulrich Syndrome; Chromosome X, Monosomy X; Gonadal Dysgenesis (45,X); Gonadal Dysgenesis (XO); Monosomy X; Morgagni-Turner-Albright Syndrome; Ovarian Dwarfism, Turner Type; Ovary Aplasia, Turner Type; Pterygolymphangiectasia; Schereshevkii-Turner Syndrome; Turner-Varny Syndrome) The Turner Center Turner Syndrome Forum A personal account of my growing up with TURNER SYNDROME Turner Syndrome ... HOME

47. Welcome To NHS Direct Online NHS Direct Online Health Encyclopaedia. Turner s syndrome turner syndrome (TS) affects only females, and occurs when one of the two X chromosomes (a http://www.nhsdirect.nhs.uk/en.asp?TopicID=464

48. Welcome To NHS Direct Online Children with turner syndrome often are of normal height for the first 3 years Girls with turner syndrome are usually of normal intelligence with good http://www.nhsdirect.nhs.uk/en.asp?TopicID=464&AreaID=2149&LinkID=1752

49. MedlinePlus Medical Encyclopedia: Turner Syndrome turner syndrome is a genetic condition that occurs only in females. In turner syndrome, the girl s cells are missing an X chromosome, or part of an X http://www.nlm.nih.gov/medlineplus/ency/article/000379.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Turner syndrome Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Pectus excavatum Alternative names Return to top Bonnevie-Ullrich syndrome; Gonadal dysgenesis; Monosomy X Definition Return to top Turner syndrome is a genetic condition that occurs only in females. Female cells normally have two X chromosomes. In Turner syndrome, the girl's cells are missing an X chromosome, or part of an X chromosome. There are a variety of signs and symptoms that can result, but the most common are short height, lack of developing ovaries, and infertility Causes, incidence, and risk factors Return to top Humans have 46 chromosomes, which contain all of a person’s genes and DNA. Two of these chromosomes, the sex chromosomes, determine a person’s gender. Both of the sex chromosomes in females are called X chromosomes. (This is written as XX.) Males have an X and a Y chromosome (written as XY). The two sex chromosomes help a person develop fertility and the sexual characteristics of their gender. In Turner syndrome, the girl does not have the usual pair of two complete X chromosomes. The most common scenario is that the girl has only one X chromosome in her cells. Some girls with Turner syndrome do have two X chromosomes, but one of the X chromosomes is incomplete. In another scenario, the girl has some cells in her body with two X chromosomes, but other cells have only one.

50. MedlinePlus: Turner's Syndrome Overviews; Frequently Asked Questions about turner syndrome (Turner s Syndrome Genetics; Genetics Home Reference turner syndrome (National Library of http://www.nlm.nih.gov/medlineplus/turnerssyndrome.html

@import url(http://www.nlm.nih.gov/medlineplus/images/advanced.css); Skip navigation Other health topics: A B C D ... List of All Topics Turner's Syndrome Contents of this page: From the NIH Overviews Prevention/Screening Genetics ... Teenagers Search MEDLINE/PubMed for recent research articles on Turner's Syndrome You may also be interested in these MedlinePlus related pages: Endocrine System (Hormones) Genetics/Birth Defects From the National Institutes of Health Clinical Features of Turner Syndrome (National Institute of Child Health and Human Development) Overviews Frequently Asked Questions about Turner Syndrome (Turner's Syndrome Society of the United States) Turner Syndrome: A Guide for Families (Turner's Syndrome Society of the United States) - Large PDF file Also available in: Spanish Prevention/Screening Genetic Testing for Newborns at Increased Risk (American Association for Clinical Chemistry) Clinical Trials ClinicalTrials.gov: Turner Syndrome (National Institutes of Health) Genetics Genetics Home Reference: Turner syndrome (National Library of Medicine) Genetic Features of Turner Syndrome (National Institute of Child Health and Human Development) Research Newly Mapped Gene for Ruptured Heart May Lead to Life-Saving Treatment (American Heart Association) Directories AACE Physician Finder (American Association of Clinical Endocrinologists) Turner's Syndrome Society of the US: Local Chapters (Turner's Syndrome Society of the United States) Organizations MAGIC Foundation National Institute of Child Health and Human Development Turner's Syndrome Society of the United States Children

51. Clinical Trial: Turner Syndrome: Genotype And Phenotype Adult women with turner syndrome have an increased risk of high blood turner syndrome (TS) is a sporadic disorder affecting approximately 1/2500 live http://www.clinicaltrials.gov/ct/gui/show/NCT00006334

Home Search Browse Resources ... About Turner Syndrome: Genotype and Phenotype This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center (CC) August 25, 2004 Sponsored by: National Institute of Child Health and Human Development (NICHD) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose This study will examine the clinical and genetic factors related to Turner syndrome, a disorder of the female sex chromosomes. Humans have 23 pairs of chromosomes-thin strands of DNA-in the nucleus of every cell, which contain genes that determine our hereditary makeup. One pair of chromosomes is the sex chromosomes, designated X and Y. Females normally have two X chromosomes; however, patients with Turner syndrome have only a single X chromosome or one normal and one defective X chromosome. This abnormality can cause medical problems such as a webbed neck, low-set ears, and heart or kidney defects. It can also cause short stature, lack of sexual development and improperly functioning ovaries. Adult women with Turner syndrome have an increased risk of high blood pressure, diabetes mellitus and osteoporosis. This study will try to identify the genes responsible for the specific medical problems associated with the disorder. Females 7 years of age and older with X chromosome defects may be eligible for this 3- to 5- day inpatient study at the National Institutes of Health Clinical Center in Bethesda, Maryland. Participants will have a comprehensive physical examination, including (with the patient's permission) photographs of abnormal physical findings to document characteristics of Turner syndrome. Patients will have their body measurements (height, weight, hip and waist) taken and blood drawn for clinical and research purposes. Patients will be given a "metabolic diet," with meals designed to contain specific amounts of salt and carbohydrate to allow accurate measurements of blood pressure and glucose (sugar) metabolism.

52. Clinical Trial: A Study To Evaluate Subjects With Turner Syndrome Treated With G Official Title Characterization of Subjects with turner syndrome Treated Are girls with turner syndrome who are being or will be treated with Nutropin http://www.clinicaltrials.gov/ct/gui/show/NCT00097552

Home Search Browse Resources ... About A Study to Evaluate Subjects with Turner Syndrome Treated with Growth Hormone This study is currently recruiting patients. Verified by Genentech July 2005 Sponsored by: Genentech Information provided by: Genentech ClinicalTrials.gov Identifier: Purpose This study is a multicenter, open-label, observational, postmarketing surveillance study of Genentech growth hormone (GH) products in the treatment of girls with Turner syndrome in the United States and Canada. Condition Phase Turner Syndrome Phase IV MedlinePlus related topics: Turner's Syndrome Genetics Home Reference related topics: Turner syndrome Study Type: Observational Study Design: Natural History, Longitudinal, Defined Population, Prospective Study Official Title: Characterization of Subjects with Turner Syndrome Treated with Growth Hormone in the National Cooperative Growth Study (NCGS) Further Study Details: Study start: May 1997; Expected completion: December 2099 Last follow-up: December 2099; Data entry closure: December 2099 Eligibility Ages Eligible for Study: up to 17 Years, Genders Eligible for Study: Female

53. Turner Syndrome : American Pregnancy Association The characteristics, diagnosis, and treatment of turner syndrome. http://www.americanpregnancy.org/birthdefects/turnersyndrome.html

American Pregnancy Association home about partners press room ... tribute gift search Preventing Pregnancy Getting Pregnant Infertility Adoption ... Consider Donating Most Popular Articles Understanding Ovulation Ovulation Calendar Pregnancy Signs and Symptoms Bleeding During Pregnancy ... birth defects Turner Syndrome Turner syndrome is a chromosomal condition that occurs when one of the two X chromosomes found in females is missing or incomplete. It is a chromosomal condition that only affects females. It is one of the most common chromosomal conditions occurring in about 1 out of every 2,500 live female births. What causes Turner syndrome? Turner syndrome is caused by the complete or partial absence of one of the two X chromosomes normally found in a woman. There are no know reasons for the complete or partial absence of one of the X chromosomes and the condition appears to occur randomly. How is Turner syndrome diagnosed? Turner syndrome is diagnosed using a blood test known as a karyotype. The karyotype blood test analyzes the chromosomal composition of the individual and determines whether the X chromosome is absent. What are the characteristics of someone with Turner syndrome?

54. Turner Syndrome CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00069390.html

Main Search Index Definition Description Causes ... Resources Turner syndrome Definition Turner syndrome is a disorder of the chromosomes affecting females, where one of the two X chromosomes is partially or completely absent. Description Chromosomes are structures in the nucleus of every cell in the body. Chromosomes contain the genetic information necessary to direct the growth and functioning of all the cells and systems of the body. A normal person has a total of 46 chromosomes in each cell, two of which are responsible for determining the sex of that person. Normally, females have two X chromosomes and males have one X and one Y chromosome. In Turner syndrome, an error very early in development results in an abnormal number and arrangement of chromosomes. Most commonly, a patient with Turner syndrome will be born with 45 chromosomes in each cell rather than 46. The missing chromosome is an X chromosome. About 1 in every 8,000 babies born has Turner syndrome. No cause has been identified for Turner syndrome. At birth, female babies with Turner syndrome are below average in weight and length. They have slightly swollen hands and feet, and sometimes have swelling at the nape of the neck. Girls with Turner syndrome are shorter than normal, and have short, webbed necks with extra, loose skin. The jaw is usually small and the ears are large. An extra fold of skin is often seen on either side of the nose, close to the eye (called an epicanthic fold). The chest is usually quite broad, with increased distance between the nipples.

55. Your Child | Turner Syndrome What is turner syndrome, and what do I need to know about testing and treatment? turner syndrome is a genetic condition that occurs in females who have only http://www.med.umich.edu/1libr/yourchild/turners.htm

YOUR CHILD HOME Your Child Topics UMHS HOME Turner Syndrome What is Turner syndrome, and what do I need to know about testing and treatment? Turner syndrome is a genetic condition that occurs in females who have only one X chromosome, instead of the usual two. Typical features include short stature (height); webbed neck; underdeveloped breasts; abnormalities of the eyes and bones; and not getting your period (no menstruation). To learn more about genetics and to better understand how genes cause syndromes, see Your Child: Genetic Syndromes If your daughter has the physical features of Turner syndrome, then she should be tested to find out for sure whether she has it. A blood test can be done to check for the absence of an X chromosome. Sometimes she may need to have an ultrasound to check her uterus and ovaries. Sometimes, Turner syndrome is inherited from a parent, so genetic counseling is recommended for families with a daughter who has the condition. There is no cure for Turner syndrome but there are lots of treatments to help your daughter in many ways. Growth hormone is sometimes given to increase the height of a girl with Turner syndrome. Sex hormones can also be given starting at about 13 years of age to promote the development of secondary sexual characteristics (pubic hair and breasts), however all girls with Turner syndrome will still be infertile even after hormone therapy. For more information on health care for girls with Turner, the American Academy of Pediatrics has a

56. The Hormone Foundation Endocrinology And Turner Syndrome turner syndrome can cause physiologic and psychological problems that can The most common features of turner syndrome are short stature and reduced or http://www.hormone.org/resources/fact_sheets/turner.htm

Home Bilingual Fact Sheets Search area... 5 miles 10 miles 25 miles 50 miles Advanced search Endocrinology and Turner Syndrome Why is it important to know about Turner Syndrome? Turner syndrome can cause physiologic and psychological problems that can affect normal development and maturation in females, even if it is not usually life-threatening. Effective treatment is available to minimize some of these effects and reduce many of the associated symptoms, if it is started soon enough. It is important to identify those with Turner syndrome early so that treatment can begin and promote normal growth and development as girls enter puberty. What is Turner Syndrome? Turner syndrome occurs in females when one of the X (female) chromosomes is missing or damaged. Typically, females have two X chromosomes (XX). These chromosomes not only determine the sex of a person but also have other influences. Sexual definition affects physiologic growth and development as well psychological development. The most common features of Turner syndrome are short stature and reduced or absent development of the ovaries. As adults, women with this disorder are typically infertile. Other complications of Turner syndrome include defects of the kidneys and/or heart, thyroid disease, arthritis and skeletal disorders, and development of type 2 diabetes. As children, the onset of puberty is delayed if the disorder has not been identified and treatment begun. Such delays in sexual development may lead to poor social development and low self esteem. In addition, some girls may experience learning difficulties, particularly in the subject of mathematics. Problems such as underactive thyroid glands, abnormal liver function tests, a propensity to ear infections and hearing deficits, can also be seen. Symptoms may vary widely among those affected.

57. Turner Syndrome - Womens Health And Medical Information On MedicineNet.com Women s Health information covers breast, cancer, heart, pregnancy, sexual health, and mature women related conditions. http://www.medicinenet.com/turner_syndrome/article.htm

document.writeln(''); MedicineNet Home Women's Health Home Page > Turner Syndrome Search Tips Printer-Friendly Format FREE Newsletters Email to a Friend ... Next Turner Syndrome What is Turner Syndrome? General Appearance Stature Puberty/Reproduction ... Incidence of Appearance Traits What is Turner syndrome? Turner syndrome is a genetic disorder affecting only females, in which the patient has one X chromosome in some or all cells; or has two X chromosomes but one is damaged. Signs of Turner syndrome include short stature, delayed growth of the skeleton, shortened fourth and fifth fingers, broad chest, and sometimes heart abnormalities. Women with Turner syndrome are usually infertile due to ovarian failure. Diagnosis is by blood test (karyotype). Turner syndrome affects approximately 1 out of every 2,500 female live births worldwide. It embraces a broad spectrum of features, from major heart defects to minor cosmetic issues. Some individuals with Turner syndrome may have only a few features, while others may have many. Almost all people with Turner syndrome have short stature and loss of ovarian function, but the severity of these problems varies considerably amongst individuals. General Appearance Individuals with Turner syndrome may have a short neck with a webbed appearance, a low hairline at the back of the neck, and low-set ears. Hands and feet of affected individuals may be swollen or puffy at birth, and often have soft nails that turn upward at the ends when they are older. All these features appear to be due to obstruction of the

58. Health Supervision For Children With Turner Syndrome -- Frías Et Al. 111 (3): 6 turner syndrome, as used in this report, refers to a condition characterized by Growth in children with turner syndrome is characterized by a slight http://aappolicy.aappublications.org/cgi/content/full/pediatrics;111/3/692

HOME HELP E-MAIL ALERTS SEARCH This policy is a revision of the policy posted on December 1, 1995. CLINICAL REPORT Abstract of this Article PDF Version of this Article Email this article to a friend Similar articles found in: AAP Policy Online ISI Web of Science PubMed PubMed Citation Search Medline for articles by: Section on Endocrinology, Search for citing articles in: ISI Web of Science (5) Download to Citation Manager PEDIATRICS Vol. 111 No. 3 March 2003, pp. 692-702 CLINICAL REPORT Health Supervision for Children With Turner Syndrome Marsha L. Davenport, MD Committee on Genetics and Section on Endocrinology ABSTRACT This report is designed to assist the pediatrician in caring for the child in whom the diagnosis of Turner syndrome has been confirmed by karyotyping. The report is meant to serve as a for Preventive Pediatric Care" and emphasizes the importance of continuity of care and the need to avoid its fragmentation by ensuring a medical home for every girl with Turner syndrome.

59. Health Supervision For Children With Turner Syndrome -- Frías Et Al. 111 (3): 6 Source Rieser P, Davenport M. turner syndrome A Guide for Families. Houston, TX turner syndrome Society of the United States; 2002. http://aappolicy.aappublications.org/cgi/content/full/pediatrics;111/3/692/F1

HOME HELP E-MAIL ALERTS SEARCH ... [Return to Article] Click on image to view larger version. Fig 1. Growth chart for children with Turner syndrome. Source: Rieser P, Davenport M. Turner Syndrome: A Guide for Families. Houston, TX: Turner Syndrome Society of the United States; 2002. Data derived from Lyon et al. [Return to Article] HOME HELP E-MAIL ALERTS ... SEARCH

60. Turner Syndrome: Keep Kids Healthy Conditions turner syndrome, a chromosomal disorder that can cause girls to have short stature, a failure to begin puberty and infertility. http://www.keepkidshealthy.com/welcome/conditions/turner_syndrome.html

Bookstore Site Map Contact Us Help ... What's New? Search this site: Advanced Search Main Menu Useful Tools Index of Topics Pediatric Problems Parenting Tips ... Web Links Online Resources What's New Reviews Growth Charts Online Forums ... Pediatric News Newsletters: Subscribe to get free news, tips and updates. Recommend Us tell a friend about us or email this page to a friend Advertisement: Puberty Related Links Hypothyroidism Delayed Puberty Short Stature Main Diseases and Conditions Turner Syndrome Turner syndrome is a chromosomal disorder that can cause girls to have short stature , a failure to begin puberty and infertility. Children with Turner syndrome only have one functioning X chromosome (unlike normal females who have two functioning X chromosomes [46, X, X]), and the other one may be absent [45, X] in all cells, or just some cells which is called a mosaic [45, X/46, X, X], or there may be a fragment of the second X chromosome present in some cells. It is not known what causes Turner syndrome and it is not associated with advanced maternal age. Turner syndrome is found in about 1 out of every 2000-3000 live born females. Related Topics Short Stature Other manifestations of Turner syndrome can include having a webbed neck (extra skin folds at the base of the neck)

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