101. Log In Problems Diagnostic criteria have been updated based on new understandings in clinical presentation and genetic mechanisms. Because of phenotypic variability, http://www.medscape.com/viewarticle/495642

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102. Log In Problems Epilepsy in TSC occurs in 8090% of affected individuals during their lifetime. Learn more about management options in this population including http://www.medscape.com/viewarticle/495644

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103. Tuberous Sclerosis Presenting In Late Adult Life -- Zarei Et Al. 73 (4): 436 -- tuberous sclerosis is a neurocutaneous autosomal dominant disorder with an We present an index case of tuberous sclerosis in a 59 year old woman with a http://jnnp.bmjjournals.com/cgi/content/full/73/4/436

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Abstract Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Zarei, M Articles by Yates, J R W Related Collections Other Neurology Genetics Journal of Neurology Neurosurgery and Psychiatry Journal of Neurology Neurosurgery and Psychiatry SHORT REPORT Tuberous sclerosis presenting in late adult life M Zarei V P Collins S Chandran D Valler J N P Higgins D A S Compston and J R W Yates Correspondence to: Received 28 November 2002 In final revised form 15 May 2002 Accepted 20 May 2002 ABSTRACT A 59 year old woman presented with a three year history of left sided weakness. Magnetic resonance imaging of the brain showed

104. American Family Physician: Tuberous Sclerosis Full text of the article, tuberous sclerosis from American Family Physician, a publication in the field of Health Fitness, is provided free of charge by http://www.findarticles.com/p/articles/mi_m3225/is_n2_v43/ai_10459096

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Advanced Search Home Help IN free articles only all articles this publication Automotive Sports 10,000,000 articles - not found on any other search engine. FindArticles American Family Physician Feb 1991 Content provided in partnership with 10,000,000 articles Not found on any other search engine. Related Searches Tuberous sclerosis / Diagnosis Tuberous sclerosis / Physiological aspects Tuberous sclerosis / Complications Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Tuberous sclerosis American Family Physician Feb, 1991 by James Provenzale Salvatore A. Deluca Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. [TABLES HAVE BEEN OMITTED] Although tuberous sclerosis is an inherited disorder with an autosomal dominant pattern of transmission, 50 percent of cases are sporadic. The disease is characterized by mental retardation, seizures and adenoma sebaceum; however, mental deficiency is not always present. Approximately 30 percent of patients have normal intelligence. Seizures are always present in patients with mental retardation and in most patients with normal intelligence.1 Cutaneous markers, a characteristic feature of the disease, include adenoma sebaceum (a slightly elevated rash that is most commonly seen in the nasolabial folds and on the cheeks); the shagreen patch (a roughened area of skin usually seen in the midline of the lower back), and hypopigmented spots in the midline of the lower back or anywhere on the trunk and limbs. The hypopigmented areas on the trunk and limbs may not be visible to the unaided eye, but can be seen under ultraviolet light.

105. FIRSTConsult - Sdfdsf FIRSTConsult, tuberous sclerosis complex (Patient Education File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1037553&type=103&bref=1

106. FIRSTConsult - Sdfdsf FIRSTConsult, tuberous sclerosis complex (Medical Condition File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1014389&type=101&bref=1

107. Tuberous Sclerosis Complex Suryavanshi NM, Kashyape SS, Kashyape Pawan, Phalke V Peerreviewed open access biomedical speciality periodical from India covering various aspects of child health. http://www.ijppediatricsindia.org/article.asp?issn=0019-5456;year=2004;volume=71

108. RDInfo- Research And Development Information Charity Details tuberous sclerosis Association Details (Hits 897 ) Aims , To support people with tuberous sclerosis and their families or carers; http://www.rdinfo.org.uk/queries/ListCharityDetails.asp?CharityID=239

109. IRSC - Neurological Disorders, Tuberous Sclerosis The Internet Resources for Special Children (IRSC) Global disABILITY resource is dedicated to communicating information relating to the needs of children http://www.irsc.org:8080/irsc/irscmain.nsf/sub?readform&cat=Neurological Disorde

110. Tuberous Sclerosis - Washington DC tuberous sclerosis Washington Hospital Center is located in Washington DC. http://www.whcenter.org/15936.cfm

cddcodebase = "navtools/topmenu/";cddcodebase367050 = "navtools/topmenu/"; Article Manager Home Back to Health Library Print This Page ... Tuberous sclerosis, hypopigmented macule Tuberous sclerosis Definition: Tuberous sclerosis is a group of two genetic disorders characterized by problems with the skin, brain/nervous system, and kidneys, and a predisposition to tumors. The diseases are named after a characteristic abnormal growth in the brain, which takes the shape of a tuber or root. Alternative Names: Adenoma sebaceum Causes, incidence, and risk factors: Tuberous sclerosis is inherited as an autosomal dominant trait (only one parent must pass on the bad gene for the child to get the disease). However, a high percentage of cases are due to new mutations (which occur in the sperm or egg of one of the parents), so there usually is no family history of the disease. It is one of a group of diseases described as neuro-cutaneous syndromes because of extensive involvement of both the skin and the central nervous system (brain and/or spinal cord). The symptoms of tuberous sclerosis vary considerably: from minimally affected people with normal intelligence and no seizures to severely affected people with profound retardation and frequent, difficult-to-control seizures or serious tumors.

111. Manuscripts On Tuberous Sclerosis Complex From The Neurogenetics/Neuro-Oncology Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to Differential Expression of Neurotrophins in tuberous sclerosis http://www.neuro.wustl.edu/neurogenetics/papers-TSC.html

Tuberous Sclerosis Complex View other Manuscripts: OK Jansen LA, Uhlmann EJ, Crino PB, Gutmann DH, Wong M: Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1 deficient astrocytes. Epilepsia (in press). Ess KC, Kamp CA, Tu BP, Gutmann DH: Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex. Neurology 64:1446-1449, 2005. Fraser MM,Zhu X, Kwon CH, Uhlmann EJ, Gutmann DH, Baker SJ: Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Research 64:7773-9, 2004. Uhlmann EJ, Li W, Scheidenhelm D, Gau C-L, Tamanoi F, Gutmann DH: Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. GLIA 47:180-8, 2004. Ess KC, Uhlmann EJ, Li W, Li H, DeClue JE, Crino PB, Gutmann DH. Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology. GLIA 46:28-40, 2004. Angel P, Tabancay AP, Gau CL, Machado IMP, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J. Biol. Chem. 278:39921-39930, 2003.

112. [P&S Medical Review:Oct:94] Pulmonary Lymphangiomyomatosis In Tuberous Sclerosis Progression to renal failure in tuberous sclerosis patients is a rare phenomenon. In reported cases of tuberous sclerosis and chronic renal failure, http://www.cumc.columbia.edu/news/review/archives/medrev_v2n1_0003.html

Pulmonary Lymphangiomyomatosis in Tuberous Sclerosis: Association with Chronic Renal Failure JONATHAN L. BRISMAN, ANDREW J. KIRSCH, JOHN A. TAYLOR, BARRY D. BIRCH, HANINA H. HIBSHOOSH, AND STEVEN A. KAPLAN Departments of Urology, Squier Urological Clinic, and Pathology ABSTRACT Progression to renal failure in tuberous sclerosis patients is a rare phenomenon. Only twenty-nine such cases have been reported in the literature. Similarly, pulmonary lymphangiomyomatosis (honeycomb lung) is an uncommon complication of tuberous sclerosis occurring in less than 1% of patients. In reported cases of tuberous sclerosis and chronic renal failure, there have been no reported cases with known cystic lung disease. We present the first case of tuberous sclerosis with concomitant end-stage renal failure and cystic lung disease consistent with lymphangiomyomatosis as well as a review of the current literature. CASE REPORT A 28-year old black woman with tuberous sclerosis was admitted to our medical center with left flank pain and gross hematuria. Medical history was significant for bilateral renal cystic disease and seizures until age eleven. At age 21, she was diagnosed as having bullous lung disease with obstructive and restrictive features. She has had several tube thoracostomies for spontaneous pneumothoraces and requires home oxygen therapy. At age 26, she was begun on hemodialysis for end-stage renal failure. Family history is noteworthy for tuberous sclerosis and polycystic renal disease in her brother and father, who died at age 42. She was of average intelligence while her father and brother were mildly retarded. She was awaiting renal transplantation.

113. Tuberous Sclerosis Complex - Cambridge University Press tuberous sclerosis is the prototype of a category of malformations ‘The previous giant of tuberous sclerosis was Manuel Gomez of the Mayo Clinic. http://www.cambridge.org/uk/catalogue/catalogue.asp?isbn=1898683395

114. Illnesses And Disabilities - Tuberous Sclerosis Federal resource NINDS tuberous sclerosis Information Page This on-line tuberous sclerosis is a rare genetic, neurological disorder primarily http://www.4woman.gov/wwd/wwd.cfm?page=87

115. Teams - Team Profile , AIRSD Italian Academy Distributed Scientific Research and SETI Italia Team Giuseppe Cocconi for childhood diseases...... http://d2ol.childhooddiseases.org/memberServices/teamProfile.jsp?id=162

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