41. Arch Dermatol -- Pseudoephedrine-Induced Toxic Epidermal Necrolysis, July 2005, We describe the first reported case of toxic epidermal necrolysis (TEN) associatedwith the use of pseudoephedrine, confirmed by inadvertent rechallenge and http://archderm.ama-assn.org/cgi/content/extract/141/7/907

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 141 No. 7, July 2005 Featured Link E-mail Alerts Correspondence Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Nagge JJ Shear NH Contact me when this article is cited Topic Collections Dermatologic Disorders, Other Drug Therapy Adverse Effects Topic Collection Alerts COMMENTS AND OPINIONS Pseudoephedrine-Induced Toxic Epidermal Necrolysis Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. Pseudoephedrine is a sympathomimetic agent that is commonly found in over-the-counter cough and cold preparations. We describe the first reported case of toxic epidermal necrolysis (TEN) associated with the use of pseudoephedrine, confirmed by inadvertent

42. Arch Dermatol -- Moxifloxacin-Associated Drug Hypersensitivity Syndrome With Tox case of moxifloxacinassociated drug-hypersensitivity syndrome associated withtoxic epidermal necrolysis (TEN) and fulminant fatal hepatic failure. http://archderm.ama-assn.org/cgi/content/extract/140/12/1537

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 140 No. 12, December 2004 Featured Link E-mail Alerts Correspondence Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Nori S Travers JB Contact me when this article is cited Topic Collections Liver/ Biliary Tract/ Pancreatic Diseases Hypersensitivity Topic Collection Alerts COMMENTS AND OPINIONS Moxifloxacin-Associated Drug Hypersensitivity Syndrome With Toxic Epidermal Necrolysis and Fulminant Hepatic Failure Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. Moxifloxacin is a newer-generation fluoroquinolone antibiotic treatment of acute bacterial sinusitis, bronchitis, community-acquired

43. Toxic Epidermal Necrolysis toxic epidermal necrolysis is a lifethreatening skin disorder characterized toxic epidermal necrolysis causes the skin to peel in sheets, leaving large http://ymghealthinfo.org/content.asp?pageid=P00321

44. NEJM -- Toxic Epidermal Necrolysis Correspondence from The New England Journal of Medicine toxic epidermal necrolysis. http://content.nejm.org/cgi/content/short/334/14/922

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 334:922-923 April 4, 1996 Number 14 Next Toxic Epidermal Necrolysis Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text Add to Personal Archive Add to Citation Manager E-mail When Cited ... PubMed Citation To the Editor: Roujeau et al. (Dec. 14 issue) present data showing a morbidity of 1 in 230,000 associated with toxic epidermic death rate is assumed to be 15 percent, the mortality rate would be 1 in 1,550,000. It would be interesting to know the actual mortality among their index patients. To put this excess mortality in context, it is similar to the transfusion-associated frequency of human immunodeficiency virus transmission in Germany (1 in 800,000 to 1 in 2,000,000) and the Full Text of this Article References This article has been cited by other articles: Ladhani, S., Joannou, C. L., Lochrie, D. P., Evans, R. W., Poston, S. M. (1999). Clinical, Microbial, and Biochemical Aspects of the Exfoliative Toxins Causing Staphylococcal Scalded-Skin Syndrome. Clin. Microbiol. Rev.

45. NEJM -- Sign In Correspondence from The New England Journal of Medicine toxic epidermal necrolysis. http://content.nejm.org/cgi/content/full/334/14/922

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Access to this article requires sign-in. Subscribers have access to all content. Other registered users have access to research articles six months old and older. If you're a registered user or an activated subscriber SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. Log in via Athens. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access If you'd like to purchase a subscription to NEJM If you're not a subscriber and want FREE limited access... ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.

46. DermIS / Main Menu / DOIA / Alphabetically / Diagnosenames Containing 'toxic Epi alphabetically / diagnosenames containing toxic epidermal necrolysis diagnosis, number of images. toxic epidermal necrolysis (TEN), 11 http://www.dermis.net/doia/abrowser.asp?zugr=d&lang=e&beginswith=toxic epidermal

47. Toxic Epidermal Necrolysis As A Complication Of Treatment With Celecoxib The diagnosis of toxic epidermal necrolysis (TEN) with severe internal mucosal There are two cases of toxic epidermal necrolysis related to celecoxib http://dermatology.cdlib.org/95/case_presentations/TEN2/hsu.html

DOJ Contents Toxic epidermal necrolysis as a complication of treatment with celecoxib Ashley G Perna MD, Christy A Woodruff MD, Ramsey F Markus MD, and Sylvia Hsu MD Dermatology Online Journal 9 (5): 25 Department of Dermatology, Baylor College of Medicine, Houston. shsu@bcm.emc.edu Figure 1 Diffuse, confluent bullae on legs. Intravenous immunoglobulin (IVIg) at a dose of 0.75 gram/kg/day for 4 days was initiated; this slowed but did not stop the vesicle formation. Her liver enzymes continued to rise during the IVIg course, and she began to produce bloody sputum. On chest X-ray, her lung fields became progressively more opaque. The patient died on the eleventh day of hospitalization. The patient's medications prior to admission included labetolol, atorvastatin, isosorbide mononitrate, amiodarone, warfarin, ranitidine, furosemide, and thyroxine; occasionally she took acetaminophen, darvocet, and vicodin. She had taken all of these medications for over 1 year. In addition, she was taking phenytoin at a stable dose for 5 years. She denied taking any over-the-counter medications or herbs. To treat her lower back pain, a 2-week course of celecoxib (100 mg orally each day) was begun 18 days prior to the development of the rash. The last celecoxib pill was taken 2 days before the onset of the rash. Because of the close temporal relation between the initiation of celecoxib and the appearance of the skin eruption, and because celecoxib was the only new medication the patient had taken, the etiology of TEN was considered to be most likely a reaction either to the celecoxib alone or to celecoxib in combination with one of her other medications.

48. Treatment Of Severe Drug Reactions: Stevens-Johnson Syndrome, Toxic Epidermal Ne StevensJohnson syndrome and toxic epidermal necrolysis Toxic epidermalnecrolysis (Lyell syndrome). Incidence and drug etiology in France, 1981-1985. http://dermatology.cdlib.org/DOJvol8num1/reviews/drugrxn/ghislain.html

DOJ Contents Treatment of severe drug reactions: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis and Hypersensitivity syndrome Pierre-Dominique Ghislain M.D., Jean-Claude Roujeau, M.D. Dermatology Online Journal 8(1): 5 Department of Dermatology, H6pital Henri Mondor, Universit6 Paris XII, Cr6teil, France Abstract Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) has the highest mortality (30-35%); Stevens-Johnson syndrome and transitional forms correspond to the same syndrome, but with less extensive skin detachment and a lower mortality (5-15%). Hypersensitivity syndrome, sometimes called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), has a mortality rate evaluated at about 10%. Drug reactions are self-limited diseases and therefore, generally treatment is symptomatic. Prompt diagnosis, identification of, and early withdrawal of all suspect drugs are the most important preliminaries. The management of the patients must be undertaken in specialized intensive care units, with the same main types of therapy as for burns: warming of the enviromnent, correction of electrolyte disturbances, administration of a high caloric enteral intake, and prevention of sepsis. Efficacy of drugs used in some case reports is difficult to evaluate: intravenous immunoglobulins, cyclosporin, cyclophosphamide, pentoxyfilline, and thalidomide have all been tried. Corticosteroid use is debated and is probably deleterious in late forms of TEN. For DRESS, corticoids are used in cases of life-threatening systemic impairment. Specific nursing care and adequate topical management reduce associated morbidity and allow a more rapid re-epithelialization of skin lesions.

49. SupportPath.com: Toxic Epidermal Necrolysis Syndrome SupportPath.com leads you to Internet resources for supportrelated informationon hundreds of health, personal, and relationship topics. http://www.supportpath.com/sl_t/toxic_epidermal_necrolysis_syndrome.htm

Toxic Epidermal Necrolysis Syndrome Also called: TENS, Stevens Johnson Syndrome About Us Add-A-Link Email Gallery ... here Online Communities / Message Boards... None Listed Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... Website: http://www.interlog.com/~zzzz/ Description: A webpage to sign up for this Yahoo Group mailing list. Date Added: 06/01/2002 National / International Organizations... UNITED STATES Stevens Johnson Syndrome Foundation Website: http://hometown.aol.com/sjsupport/index.html Description: "The purpose of the foundation is to provide the public and medical communities with information on adverse allergic drug reactions." Date Added: 06/01/2002 Note: Groups are listed alphabetically by U.S. state and then country. None Listed None Listed Professional Organizations of Interest...

50. Stevens Johnson Syndrome Foundation provide emotional support for people with Stevens Johnson Syndrome and ToxicEpidermal Necrolysis. Stevens Johnson Syndrome/toxic epidermal necrolysis http://www.sjsupport.org/

Welcome to Make a Donation Home SJS Shop SJS Fact Sheet ... SJS Walk Navigation IVIG treatment SJS/TEN Discussion Julie's Story Web Site Translator ... Tell A Friend(s) [click here] Help support the SJS Foundation by purchasing SJS awareness products. "Bringing light to the abyss of ignorance" The Stevens Johnson Syndrome Foundation (Julie Foundation for allergic drug reactions) is a non-profit organization. The purpose of the foundation is to provide the public and medical communities with information on adverse allergic drug reactions. Our goal is to make the public aware of adverse reactions, so that a quick diagnosis may be made and the offending drug stopped as soon as possible. Allergic drug reactions are the fourth leading cause of death in the United States [ Read more ]. Adverse Drug Reactions may cause over 100,000 deaths among hospitalized patients each year [ Read more ]. Less then 1% of all drug reactions are reported to the FDA. The public needs to know what to look for when taking any drug and seek medical attention immediately in the event of a reaction in order to prevent permanent damage. The SJS Foundation is also doing medical research into SJS/TEN The Stevens Johnson Syndrome Support Group originated in May of 1995. The Group's purpose is to provide emotional support for people with Stevens Johnson Syndrome and Toxic Epidermal Necrolysis.

51. Norfloxacin-Induced Toxic Epidermal Necrolysis -- Sahin Et Al. 39 (4): 768 -- Th OBJECTIVE To report a case of toxic epidermal necrolysis (TEN) in a man who wastreated with oral norfloxacin for prostatitis. http://www.theannals.com/cgi/content/abstract/39/4/768

HOME HELP CONTACT US SUBSCRIPTIONS ... CURRENT ISSUE QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Published Online, 15 February 2005, www.theannals.com , DOI 10.1345/aph.1E530. The Annals of Pharmacotherapy : Vol. 39, No. 4, pp. 768-770. DOI 10.1345/aph.1E530 This Article Extracto Full Text PDF For Our Patients ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... [Order Reprint] PubMed PubMed Citation Articles by Sahin, M. T. Articles by Filiz, E. E Norfloxacin-Induced Toxic Epidermal Necrolysis Mustafa Turhan Sahin, MD Medical Faculty, Department of Dermatology, Celal Bayar University, Manisa, Turkey Serap Ozturkcan, MD Medical Faculty, Department of Dermatology, Celal Bayar University Isil Inanir, MD Medical Faculty, Department of Dermatology, Celal Bayar University Elif E Filiz, MD Medical Faculty, Department of Dermatology, Celal Bayar University Reprints: Dr. Sahin, Mansuroglu Mahallesi, 273/1 Sokak, Cemre Apt. A-Blok, No: 36/3-3, 35030 Bornova, Izmir, Turkey, fax 90 236 2370213

52. The Annals -- Sign In Page OBJECTIVE To report a case of toxic epidermal necrolysis (TEN) in a man who was toxic epidermal necrolysis (TEN) is a rare but potentially lethal, http://www.theannals.com/cgi/content/full/39/4/768

HOME HELP CONTACT US SUBSCRIPTIONS ... CURRENT ISSUE QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This item requires a Subscription to The Annals of Pharmacotherapy Online. NOTE: If you would like to purchase an article in quantity, Greg Johnson , or order single copies at The Annals secure site Full Text Norfloxacin-Induced Toxic Epidermal Necrolysis Sahin et al. Ann Pharmacother. This Article Abstract Extracto PDF For Our Patients ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... [Order Reprint] PubMed PubMed Citation Articles by Sahin, M. T. Articles by Filiz, E. E To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$25.00

53. Bextra - Bextra Lawyer, Bextra Attorney, Bextra Law, Bextra Lawsuit, Reactions - toxic epidermal necrolysis, Yes No. Death, Yes No. Other Skin Problems, Yes No.Comments. Click the submit button to send your case evaluation to an http://www.bextralegalhelpcenter.org/Bextra_Toxic_Epidermal_Necrolysis.html

Home About Us Contact Us Your Legal Rights ... Reactions Toxic Epidermal Necrolysis What is toxic epidermal necrolysis? Toxic epidermal necrolysis is a life-threatening skin disorder characterized by a blistering and peeling of the top layer of skin. This disorder can be caused by a drug reaction most often penicillin or another disease. About one-third of all diagnosed cases of toxic epidermal necrolysis are a result of unknown causes. What are the symptoms of toxic epidermal necrolysis? Toxic epidermal necrolysis can cause the skin to peel off in sheets, leaving large areas that look scalded. The loss of skin causes fluids and salts to ooze from the raw, damaged areas which can easily become infected. The following are the most common symptoms of toxic epidermal necrolysis. However, each person may experience symptoms differently: A painful, red area that spreads quickly The top layer of skin may peel without blistering Scalded-looking raw areas of flesh Discomfort Fever Condition spread to eyes, mouth, and genitals The symptoms of toxic epidermal necrolysis may resemble other dermatologic conditions. Consult a physician for diagnosis.

54. Advances In Skin & Wound Care: Toxic Epidermal Necrolysis Full text of the article, toxic epidermal necrolysis from Advances in Skin Wound Care, a publication in the field of Health Fitness, is provided free http://www.findarticles.com/p/articles/mi_qa3977/is_200001/ai_n8890551

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Advanced Search Home Help IN free articles only all articles this publication Automotive Sports 10,000,000 articles - not found on any other search engine. FindArticles Jan/Feb 2000 Content provided in partnership with 10,000,000 articles Not found on any other search engine. Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Toxic epidermal necrolysis Jan/Feb 2000 by Staley, Marlys J Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. Toxic epidermal necrolysis Arevalo JM, Lorente JA. Skin coverage with Biobrane biomaterial for the treatment of patients with toxic epidermal necrolysis. J Burn Care Rehabil 1999;20:406-10. ABSTRACT COMMENTS Continue article Advertisement This article provides a quick overview oif toxic epidermal necrolysis (TEN) and a treatment alternative that was successful in a burn unit in Spain. It is important to note that the 25% to 80% mortality rate for this disease has declined over the past decade, primarily because patients with TEN are being cared for in specialized burn units by teams who are able to appropriately manage individuals with Large areas of skin loss. Use of Biobrane, a temporary skim substitute, ore 8 patients, demonstrated an improvement over previous treatment with topical antimicrobials. The skin substitute had benefits in cost, comfort, and availability over biologic dressings.

55. Age And Ageing: Toxic Epidermal Necrolysis In 77 Elderly Patients - Lyell Syndro Full text of the article, toxic epidermal necrolysis in 77 elderly patients Lyell Syndrome from Age and Ageing, a publication in the field of Health http://www.findarticles.com/p/articles/mi_m2459/is_n6_v22/ai_14736615

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Advanced Search Home Help IN free articles only all articles this publication Automotive Sports 10,000,000 articles - not found on any other search engine. FindArticles Age and Ageing Nov 1993 Content provided in partnership with 10,000,000 articles Not found on any other search engine. Related Searches Aged / Diseases Toxic epidermal necrolysis / Research Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Toxic epidermal necrolysis in 77 elderly patients - Lyell Syndrome Age and Ageing Nov, 1993 by Sylvie Bastuji-Garin Mina Zahedi Jean-Claude Guillaume Jean-Claude Roujeau Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. Summary Toxic epidermal necrolysis is a rare, severe drug-induced disorder characterized by extensive epidermal loss. This study used the data of a national survey looking for all cases which occurred during a five-year period. The incidence of toxic epidermal necrolysis (cases/million/year) was 2.7 times higher among elderly than among younger adults. In the elderly population no female preponderance was found but clinical patterns were similar. The fatality of toxic epidermal necrolysis was twice as high in the elderly patients (51%) as in the younger (25%). The drugs incriminated in most cases of toxic epidermal necrolysis were the same in both groups (NSAIDs, antibacterials and anticonvulsants).

56. TREATMENT OF TOXIC EPIDERMAL NECROLYSIS (TEN) toxic epidermal necrolysis (ten) is a common and potentially dangerous Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis. http://www.medbc.com/annals/review/vol_15/num_1/text/vol15n1p17.asp

Annals of Burns and Fire Disasters - vol. XV - n. 1 - March 2002 TREATMENT OF TOXIC EPIDERMAL NECROLYSIS (TEN) Brambilla G. , Brucato F. , Angrisano A. , Palmieri G. Divisione di Medicina Interna II, Ospedale Niguarda Ca’ Granda, Milan, Italy Divisione di Pediatria, Ospedale “Caduti Bollatesi”, Bollate, Milan SUMMARY. Toxic epidermal necrolysis (ten) is a common and potentially dangerous mucocutaneous disease characterized by rash, bullae, and diffuse exfoliation of wide cutaneous surface areas. A description is given of the disease, also known as Lyell’s syndrome, and it is distinguished from similar conditions. Information is provided regarding the epidemiology, aetiology, and pathogenesis of TEN, as well as its clinical features. Diagnosis and therapy are also considered. Pharmacological therapy is required, particularly with cyclosporin. Definition Toxic epidermal necrolysis (TEN), also known as Lyell’s syndrome, is a widespread life-threatening mucocutaneous disease that is particularly observed secondary to drug-taking. It characterized by rash, bullae, and diffuse exfoliation of wide cutaneous surface areas, as in second-degree burns. Separation of the dermal-epidermal junction causes Nikolsky’s sign and gives the skin the typical “wet dressing” appearance. Classification In 1956 Lyell distinguished two entities in the description of toxic epidermal necrolysis: the Staphylococcal Scalded Skin Syndrome (SSSS) and what is now known as TEN.1

57. Cornell Physicians: Toxic Epidermal Necrolysis Health information about toxic epidermal necrolysis from NewYorkPresbyterian.The University Hospitals of Columbia and Cornell. http://wo-pub2.med.cornell.edu/cgi-bin/WebObjects/PublicA.woa/4/wa/viewHContent?

58. Toxic Epidermal Necrolysis toxic epidermal necrolysis drug treatment. Browsing results for Toxic EpidermalNecrolysis. A B C D E F G H I J K L M N O P Q R S T U V W X Y Z http://browse.drugs.com/cond-toxic_epidermal_necrolysis.html

Advanced Search Or click the first letter of a drug name: A B C D ... Z Browsing results for Toxic Epidermal Necrolysis A B C D ... Z Definition: Erythema multiforme is a skin disorder resulting from an allergic reaction. Drugs related to Toxic Epidermal Necrolysis infliximab (consumer information) Remicade (consumer information) Remicade for IV Injection (professional information) Home Drug Interactions Pill Identification Question.com ... About Drugs.com The drugs.com drug database is powered by Micromedex TM and Multum TM Micromedex data last updated 5 August 2005. Micromedex Physicians Desk Reference data last updated 18 July 2005. Multum data last updated 15 August 2005. We subscribe to the HONcode principles. Verify here Most Popular Drug Searches: Abilify Acetaminophen Aciphex Adderall ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Popular Searches Viagra Cialis Levitra Lipitor ... Pain Relief Advertisement

59. Dangerous Drug Eruptions--Toxic Epidermal Necrolysis (TEN) toxic epidermal necrolysis Clinical Manifestations toxic epidermal necrolysisTreatment. Almost invariably, admission to a burn or intensive care unit http://www.bu.edu/cme/modules/2002/drugerup02/content/3-ten.htm

Dangerous Drug Eruptions Toxic Epidermal Necrolysis (TEN) Clinical Manifestations Differential Diagnosis Etiology Treatment Toxic Epidermal Necrolysis: Clinical Manifestations With TEN, more diffuse erythema as well as SJS-type lesions are generally seen. Typically, sheets of desquamating epidermis are observed which separate easily with lateral pressure. This is known as Nikolsky's sign. Mucosal, GI, and respiratory tract erosions and bullae may be present, as in SJS: however, more than 30% of body surface area has epidermal detachment. Fever, leukopenia, skin pain, and anxiety are common clinical findings with TEN. Toxic Epidermal Necrolysis: Differential Diagnosis Clinical and histopathologic features help to differentiate TEN from: Exfoliative erythroderma: flaking desquamation and diffuse erythema are seen in this patient with an exacerbation of psoriasis. Large sheets of epidermis are not seen separating from the underlying dermis. The Nikolsky sign is negative (lateral pressure does not cause sloughing of the epidermis) Staphylococcal scalded skin syndrome in an infant: the epidermal split is more superficial than in TEN. This is appreciated on skin biopsy (frozen section may be performed for faster results).

60. Accessing Article To compare acute ocular complications of toxic epidermal necrolysis (TEN) toxic epidermal necrolysis (TEN) is a severe acute druginduced condition http://www.nature.com/eye/journal/vaop/ncurrent/full/6701653a.html

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