101. Systemic Lupus Erythematosus: The Disease And Its Patients systemic lupus erythematosus (SLE) is a relatively uncommon autoimmune disorderin which the body=s immune forces are turned against ist own tissues and http://www.elef.rheumanet.org/newsletter/6/systemic.htm

Systemic Lupus Erythematosus: The disease and its Patients Jon Russell, MD, PHD, Health Science Center, University of Texas San Antonio, TX A selection from the Lupus Foundation of America Newsletter Article Library "What is SLE?" Some of you have recently heard yourself ask that questions. I have WHAT? What is Lupus? Other of you have known of that diagnosis for many years, but still meet such questions in conversation with friends or acquaintances. Systemic Lupus Erythematosus (SLE) is a relatively uncommon autoimmune disorder in which the body=s immune forces are turned against ist own tissues and organs. The normal immune system is composed of several different forms of white blood cells which normally circulate in the bloodstream and take up residence in such organs as the spleen and lymph nodes. Their normal function is to recognize and destroy foreign invaders, such as bacteria, which are constantly attempting to gain access. A complex identification system exists which allows these cells to recognize the difference between the body=s normal cells, called self, from those foreign invaders, called non-self. Self-tissues are not normally attacked because they are recognized as belonging there. The problem in Lupus, we believe, is that the fail-safe mechanism, at times, is bypassed. The guardians of the body=s internal peace and safety, the white blood cells, get their identification signals confused and turn their destructive powers on the body=s own tissues because they see them as being foreign. It is as if the National Guard were to become confused in scattered parts of our country, and begin to attack our own citizens, as if they were all agents of the enemy.

102. Vasculitis And Systemic Lupus Erythematosus Vasculitis and systemic lupus erythematosus. Permission Granted by Bay Area LupusFoundation Source Bay Area Lupus Foundation Newsletter Winter, 97/98 http://www.public.asu.edu/~cyndee74/vasculit.htm

Vasculitis and Systemic Lupus Erythematosus Permission Granted by Bay Area Lupus Foundation Source: " Bay Area Lupus Foundation Newsletter" Winter, '97/98 Article written for BALF by Niall E. Roche, M.D. What is Vasculitis? Many patients with SLE have heard of the term "vasculitis" and know that it can be associated with lupus. However not many people have a clear understanding of what vasculitis is and how it may affect them. Vasculitis is inflammation of blood vessels and may affect both arteries and veins. Fortunatedly it is a rare complication, but its symptoms can range from minor to life-threatening. What are the Clinical Features? Large vessel arterial involvement is very uncommon in vasculitis, but may result in gangrene of digits or part of a limb. The vessels most commonly involved are the large vessels of the lower and upper limbs. Patients may present with bluish discoloration of the fingers and toes, pain from poor circulation, or an absent pulse in a digit. In some patients who have the antiphospholipid syndrome, abnormal clotting may be the underlying cause. If internal blood vessels supplying the intestine are involved, patients may present with lower abdominal pain and/or blood in the bowel.

103. UniProt Knowledgebase Keyword: Systemic Lupus Erythematosus Protein involved in the systemic lupus erythematosus (SLE), a chronic autoimmunedisease where the immune system is overactive and produces too many http://www.expasy.org/cgi-bin/get-entries?KW=Systemic lupus erythematosus

104. Health Care Information Resources Lupus Erythematosus, Systemic Lupus erythematosus, systemic Lupus Home Page excellent collection of Lupus erythematosus, systemic - Lupus Around the World has forums, chat, http://www-hsl.mcmaster.ca/tomflem/lupus.html

The address of this page is: http://hsl.mcmaster.ca/tomflem/lupus.html Lupus Erythematosus, Systemic Links Lupus erythematosus, systemic - Lupus Home Page excellent collection of information from Hamline University in MN Lupus erythematosus, systemic - Lupus Clinical Overview from Dr. Michael Belmont in NY Lupus erythematosus, systemic - Lupus Canada the organization, the disease and links to related sites Lupus erythematosus, systemic - Holly's Lupus and Connective Tissue Diseases Home Page go for the links Lupus erythematosus, systemic - Missouri Chapter Lupus Foundation awareness, education, support and just plain fun Lupus erythematosus, systemic - Living with Lupus lots of supportive links Lupus erythematosus, systemic - Do I have Lupus? an online pamphlet from the U.S. NIAMS Lupus erythematosus, systemic - Handout on Health: Systemic Lupus Erythematosus from the U.S. NIAMS Lupus erythematosus, systemic - KielAID: Kiel Center for Auto-Immune Diseases treatment progress in SLE Lupus erythematosus, systemic - Lupus Letter empowering people through education and information Lupus erythematosus, systemic -

105. The Use Of Herbs In The Treatment Of Systemic Lupus Erythematosus - David L. Hof HealthWorld Online is the Internet s leading resource on alternative medicine,wellness, and mind/body health, featuring the Wellness Inventory whole person http://www.healthy.net/library/books/hoffman/musculoskeletal/lupus.htm

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106. Handbook Of Ocular Disease Management - Systemic Lupus Erythematosus Malar rash on a patient with systemic lupus erythematosus. Signs and Symptomssystemic lupus erythematosus (SLE) commonly presents in young and middleaged http://www.revoptom.com/handbook/oct02_sec7_1.htm

Systemic Lupus Erythematosus Malar rash on a patient with systemic lupus erythematosus. Signs and Symptoms: Systemic lupus erythematosus (SLE) commonly presents in young and middle-aged women, who comprise up to 90% of all SLE sufferers. SLE is three times more common in blacks than in other races, and Asians display an increased incidence of SLE vs. Caucasians. Patients suffer chronic relapses and an unpredictable course secondary to a hyperactive immune system and excessive autoantibody production. Because lupus affects many organ systems, it creates a diverse clinical picture including erythematosus rash, polyarthralgia and arthritis, anemia, and cardiac, renal and neurologic abnormalities. Renal failure is a major cause of death in those suffering from severe, chronic SLE. The skin changes associated with SLE are described as a butterfly rash, often the primary manifestation of SLE. Ocular manifestations, which occur in up to 20% of SLE patients, also may be the initial presenting sign, and may precede systemic signs or symptoms by several months.

107. Elsevier.com - Systemic Lupus Erythematosus systemic lupus erythematosus, Fourth Edition, provides an understanding of the Genes and Genetics of Murine systemic lupus erythematosus Systemic Lupus http://www.elsevier.com/wps/product/cws_home/675750

Home Site map Regional Sites Advanced Product Search ... Systemic Lupus Erythematosus Book information Product description Audience Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view SYSTEMIC LUPUS ERYTHEMATOSUS To order this title, and for more information, go to http://books.elsevier.com/bookscat/links/details.asp?isbn=0124339018 Fourth Edition Edited By Robert Lahita , Chairman of Medicine and Vice President of Jersey City Medical Center, Campus of the Liberty Healthcare System Jersey City, NJ U.S.A. Description Systemic Lupus Erythematosus, Fourth Edition , provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. Four-color illustrations throughout, this book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, and newest methods of therapy of antiphospholipid syndrome are given in this newest edition of a classic reference. Audience Immunologists, basic and clinical researchers, rheumatologists, dermatologists, clinical researchers studying women and health, hospital and medical school libraries.

108. Systemic Lupus Erythematosus systemic lupus erythematosus. Chronic autoimmune disease which produces symptomsvarying from mild to lifethreatening. Characteristically affects young http://www.aic.cuhk.edu.hk/web8/systemic_lupus_erythematosus.htm

All these topics are covered in the Not so BASIC course. Click here for details Systemic lupus erythematosus Chronic autoimmune disease which produces symptoms varying from mild to life-threatening. Characteristically affects young women but all ages can be affected. Most distinct immunological abnormality is the presence of autoantibodies. Anti-nuclear antibodies to native double-stranded DNA are diagnostic. Course of the disease is characterised by periods of remission and relapse. Epidemiology prevalence 4-280 cases/100 000. Highest in Afro-Caribbeans, followed by Asians male:female = 1:13 disease onset 16-55 years blacks have a worse prognosis Clinical features Constitutional symptoms (very common): fatigue, fever, weight loss Joints: athritis and arthralgia in 95%. Usually non-deforming Skin: involved in 80%. butterfly rash photosensitivity painful mucous membrane lesions alopecia Raynaud's phenomenon purpura urticaria micro-infarcts of fingertips and toes Renal: about 50% develop urinary or functional renal abnormalities but virtually all patients have histological abnormalities proteinuria is most common abnormality, usually presenting within the first 5 years of diagnosis

109. FIRSTConsult - Sdfdsf FIRSTConsult, systemic lupus erythematosus (Patient Education File). Published formedical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1037533&type=103&bref=1

110. COR PULMONALE IN SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE REPORT AND REVIEW OF THE L Reports a case of SLE who presented with severe pulmonary hypertension and corpulmonale without any evidence of parenchymal lung disease. http://www.kfshrc.edu.sa/annals/153/93262.html

May 1995 COR PULMONALE IN SYSTEMIC LUPUS ERYTHEMATOSUS: A CASE REPORT AND REVIEW OF THE LITERATURE M. Jawaid Akhtar, MRCP(UK), FRCP(Ire); Sulaiman Al-Majed, FRCP(C) From the Divisions of Cardiology (Dr. Akhtar) and Chest (Dr. Al-Majed), Department of Medicine, King Khalid University Hospital, Riyadh. Address reprint requests and correspondence to Dr. Akhtar: Division of Cardiology, Department of Medicine (38), College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia. Accepted for publication 10 August 1994. Pulmonary hypertension is rare in patients with systemic lupus erythematosus (SLE) although pulmonary involvement occurs in about 50%. Pulmonary hypertension without obvious pulmonary infiltration is even rarer, the mechanism of which is unclear. We report here a case of SLE who presented with severe pulmonary hypertension and cor pulmonale without any evidence of parenchymal lung disease. Case Report The patient was a 19-year-old Saudi female who was admitted to King Khalid University Hospital, Riyadh with a two-year history of dyspnea, easy fatigability, palpitations, anorexia, loss of weight, dry cough and episodic attacks of fever every three to four months with night sweats for the last two years. Five days prior to admission she developed pain in various large and small joints with swelling in interphalangeal and right wrist joints and described features of Raynaud's phenomenon. Chest roentgenogram showed cardiomegaly with prominent pulmonary conus. No lung infiltrate was noticed. High resolution computed tomography (CT) scan was not done. Ultrasound of the abdomen revealed an enlarged liver with mild ascites. Pulmonary function test revealed a restrictive pattern with decreased diffusion lung capacity. Ventilation/perfusion scan of the lungs did not reveal any evidence of pulmonary embolism. Cross-sectional echocardiography and Doppler studies revealed significant enlargement of the right atrium and right ventricle with dilated pulmonary artery and moderate degree of pericardial effusion. Moderate tricuspid incompetence was also detected.

111. Trends In Deaths From Systemic Lupus Erythematosus --- United States, 1979--1998 systemic lupus erythematosus (SLE) is a serious autoimmune disease of unknownetiology Mortality and causes of death in systemic lupus erythematosus. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5117a3.htm

Trends in Deaths from Systemic Lupus Erythematosus - United States, 19791998 Systemic lupus erythematosus (SLE) is a serious autoimmune disease of unknown etiology that can affect several organs. Because SLE affects connective tissues and because painful joints and arthritis are among its most common manifestations, this disease is classified with arthritis and other rheumatic diseases ( ). SLE is one of the more fatal forms of rheumatic diseases and non-Causcasian race is a risk factor for death from SLE; however, trends in death from SLE have not been analyzed recently. To characterize deaths from SLE, CDC reviewed SLE deaths during 19791998. This report presents the results of that analysis, which indicate that marked age-, sex-, and race-specific disparities exist in SLE death rates and that death rates have increased by approximately 70% during the study period among black women aged 4564 years. Prevention of deaths requires early recognition and diagnosis of SLE and appropriate therapeutic management. The analysis used National Center for Health Statistics Multiple Cause-of-Death Public Use Data Tapes for 19791998. These national mortality statistics were based on data from death certificates filed in state vital statistics offices. Demographic data (e.g., age and race/ethnicity) listed on death certificates were reported by funeral directors, usually from information provided by the decedent's family. Causes of death listed on death certificates were reported by a physician, medical examiner, or coroner by using a format specified by the World Health Organization and endorsed by CDC. An SLE death was defined as any death of a U.S. resident coded with an underlying cause of death of systemic lupus erythematosus (

112. Lupus Erythematosus, Systemic - Libman-Sacks Disease - Information Page With HON A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of http://www.hon.ch/HONselect/Selection/C17.300.480.html

InitBulle("navy","#F8F8F8","#000066",1); HONcode sites All Web sites HONselect News ... Images HONselect Search English French German Spanish Portuguese the word the part of word in MeSH term in MeSH term and description Information on "Lupus Erythematosus, Systemic": Medical hierarchy and definition Research Articles Web resources Medical Images Medical News Medical Conferences Clinical Trials Hierarchy English French German Spanish Portuguese Lupus Erythematosus, Systemic Definition: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Synonym(s): Libman-Sacks Disease / Lupus Erythematosus Disseminatus / Systemic Lupus Erythematosus / Disease, Libman-Sacks / Narrow term(s): Lupus Nephritis Lupus Vasculitis, Central Nervous System

113. National Institute Of Arthritis And Musculoskeletal And Skin Diseases Home Page Bullet Hormone Replacement Not Associated with Severe lupus Flares More Bullet Several new fact sheets on bone diseases are available More http://www.niams.nih.gov/

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