81. Pathology Of Systemic Lupus Erythematosus systemic lupus erythematosus (SLE) is a chronic disease with many manifestations.SLE is an autoimmune disease in which the body s own immune system is http://www.mold-survivor.com/lupus.htm

Pathology of Systemic Lupus Erythematosus General Features Systemic lupus erythematosus (SLE) is a chronic disease with many manifestations. SLE is an autoimmune disease in which the body's own immune system is directed against the body's own tissues. The etiology of SLE is not known. It can occur at all ages, but is more common in young women. The production of autoantibodies leads to immune complex formation. The immune complex deposition in many tissues leads to the manifestations of the disease. Immune complexes can be deposited in glomeruli, skin, lungs, synovium, mesothelium, and other places. Many SLE patients develop renal complications. Laboratory Testing The presence of autoantibodies can usually be determined by the antinuclear antibody (ANA) test performed on patient serum from blood. The titer, or strength, of the ANA gives a rough indication of the severity of the disease. Not all positive ANA tests indicate autoimmune disease, particularly when the titer is low. After a positive screening ANA test, more specific tests for SLE include detection of auto-antibodies to double stranded DNA and to Smith antigen. Dermatologic Manifestations Skin rashes are common with SLE. The most characteristic rash is seen across the malar region of the face, the so-called "butterfly rash" that is accentuated by sun exposure. SLE must be distinguished from discoid lupus erythematosus (DLE) which affects the skin (but only in sun exposed regions) and is unlikely to be associated with systemic illness, such as renal disease. A biopsy of sun exposed skin that is not involved with a rash will demonstrate immune complex deposition with SLE, but not with DLE.

82. Systemic Lupus Erythematosus systemic lupus erythematosus Adler, Jonathan. systemic lupus erythematosus ,eMedicine Journal, January 26 2001, Volume 2, Number 1 http://ist-socrates.berkeley.edu/~jmp/Lupus.html

Systemic Lupus Erythematosus What is Lupus? Who Gets Lupus? Why Does Lupus Occur? Clinical Manifestations of Lupus ... Getting Help Emily Newfield UCB-UCSF Joint Medical Program Physiology - Learning Object #1 References: Cotran RS, Kumar V, Collins T. Pathologic Basis of Disease, 6th Edition. W.B. Saunders Co. pp. 188 - 195, 216 - 225 Adler, Jonathan. "Systemic Lupus Erythematosus", eMedicine Journal, January 26 2001, Volume 2, Number 1 Nowicki, Stella "Antiphospholipid Antibody Syndrome and Pregnancy", eMedicine Journal, September 28 2001, Volume 2, Number 9 Click here for the Peer Review page

83. BBC - Health - Conditions - Systemic Lupus Erythematosus A guide to SLE, facts about the condition and where to go for support. http://www.bbc.co.uk/health/conditions/sle1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index FRIDAY 9th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Systemic lupus erythematosus Dr Rob Hicks The autoimmune disease lupus is thought to affect up to 30,000 people in the UK, mostly women. Discover the common symptoms and treatments that can relieve them. In this article What is it? What are the symptoms? How many people are affected? Prevention ... Treatment What is it? Systemic lupus erythematosus (SLE), often simply called lupus, is a chronic inflammatory disease that affects the blood vessels and connective tissues of the skin. It's an autoimmune disease where the body turns upon itself, causing the tissues to become inflamed and swollen. SLE is not contagious. The precise cause is unknown, although it may be triggered by hormones, infections, sunlight or stress. What are the symptoms? There are many possible symptoms. These may be mild or severe, with flare-ups occurring intermittently. SLE often begins with a skin rash over the nose and cheeks that is shaped like a butterfly and made worse by exposure to the sun. This may be accompanied by tiredness and pains in the joints. Thrombophlebitis, hair loss, painless mouth ulcers, headaches, anaemia, fits, high blood pressure, pleurisy, pericarditis and kidney disease may all occur.

84. Systemic Lupus Erythematosus systemic lupus erythematosus (SLE). SLE is an immunemediated disease in whichthe immune system attacks the body s own organs. What causes this to happen http://www.mesavet.com/library/sle.htm

Home Client Forms Careers Search MVH WELCOMES NEW DOCTOR Mesa Veterinary Hospital is pleased to announce the arrival of Associate Veterinarian Dr. Michelle Moeller . Dr. Moeller comes to Mesa after completing a year-long internship at Animal Referral and Emergency Center of Arizona, where she focused on small animal medicine and surgery. WE HAVE A WINNER! The winner of our Senior Pet Challenge contest is Lesilie Peterson of Chandler, Arizona. Lesilie owns a senior dog and cats. She'll receive 100 pounds of Hill's Science Diet Dog Food. The winner was selected from the correct entries received. Congratulations Lesilie! Systemic Lupus Erythematosus (SLE) SLE is an immune-mediated disease in which the immune system attacks the body's own organs. What causes this to happen is unknown, but certain breeds are thought to be affected more often. These include Shetland sheepdogs (Shelties), collies, Afghan hounds, and German shepherds. Symptoms can begin showing slowly, or very suddenly. Commonly, animals are brought in to the vet for lameness which is being caused by arthritis or muscle inflammation, but they may also be brought in for anorexia, weakness, fever, seizures, or swollen lymph nodes.

85. About - Lupus Erythematosus. systemic lupus erythematosus, also called lupus or SLE for short, belongs to thefamily of rheumatic diseases. Rheumatic diseases affect joints, http://www.orthop.washington.edu/uw/tabID__3376/ItemID__38/mid__10313/Articles/D

Home Site Map Contact Us Links ... All Articles Lupus Erythematosus. University of Washington, Seattle Last updated Thursday, December 23, 2004 About Basics of lupus erythematosus Systemic lupus erythematosus, also called lupus or SLE for short, belongs to the family of rheumatic diseases. Rheumatic diseases affect joints , muscles and other parts of the body, and often involve abnormalities of the immune system. Lupus can affect not only joints and muscles but also skin, kidneys, nervous system, lungs, heart and the blood-forming organs. Lupus is an autoimmune disease in which the tissues of the body are attacked by the overly active immune system and is treated by suppressing the immune system. There are two common forms of lupus: discoid and systemic. Discoid lupus is a disease of the skin which is often chronic and leads to scarring. It may be limited to the skin and not be associated with disease in any other body systems. In other cases, discoid lupus may be one of the features of the systemic form of lupus. This information focuses on the systemic form of the disease. How useful was this page or article?

86. Entrez PubMed systemic lupus erythematosuslike syndrome in monkeys fed alfalfa sprouts roleof a nonprotein amino acid. Malinow MR, Bardana EJ Jr, Pirofsky B, Craig S, http://www.nutritionandmetabolism.com/pubmed/7071589

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87. DermAtlas: Online Dermatology Image Library Dermatology Image,lupus Erythematosu Comments, This 42year-old woman with systemic lupus erythematosus developeddigital DermAtlas VERMILLION BORDER - lupus erythematosus, systemic http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=-349425327

88. Systemic Lupus Erythematosus (SLE) What is systemic lupus erythematosus ? Introduction systemic lupus erythematosus (SLE)is a chronic disease with many manifestations. http://medindia.net/patients/patientinfo/sle.asp

Bookmark This Page About Us Contact Us Feedback ... Log In September 9, 2005 Home Directories Professionals Consumer Health ... My Health Record Search Web Medindia.com Medindia Advanced Search P owered By G o o g l e Medindia Disease/Health Information Systemic Lupus Erythematosus SYSTEMIC LUPUS ERYTHEMATOSUS Page 1 Disease info Related Topics Medical Acronyms Amazing Body Facts Phobias Medical Syndromes ... Teeth Chart Interactives (Flash) Brain Depression Eye Donation Brain Death Angioplasty ... Which doctor should I consult ? What is Systemic Lupus Erythematosus ? Introduction Systemic lupus Erythematosus (SLE) is a chronic disease with many manifestations. SLE is an autoimmune disease in which the body's own immune system is directed against the body's own tissues ( the body harms its own healthy cells and tissues ) leading to inflammation of various body tissues. It can occur at all ages, but is more common in young women. In addition, lupus can run in families, but the risk that a child or a brother or sister of a patient will also have lupus is still quite low. Etiology Lupus is a complex disease, the cause of which is unknown. In addition, some autoantibodies join with substances from the body's own cells or tissues to form molecules called immune complexes. A buildup of these immune complexes in the body also contributes to inflammation and tissue injury in persons with lupus. Researchers do not yet understand all the factors that cause inflammation and tissue damage in lupus.

89. Systemic Lupus Erythematosus (SLE). Patients with or suspected to have systemic lupus erythematosus (SLE) systemic lupus erythematosus (SLE) is a syndrome characterized by clinical http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=5675&nbr=3813

90. Systemic Lupus Erythematosus (SLE). systemic lupus erythematosus (SLE) is a syndrome characterized by clinicaldiversity, changes in the disease activity over time, and by aberrant http://www.guideline.gov/summary/summary.aspx?doc_id=5675

91. Adult Health Advisor 2004.2: Systemic Lupus Erythematosus systemic lupus erythematosus (SLE) is an autoimmune disease. This means that yourbody s defenses against infection are attacking your own tissue. http://www.med.umich.edu/1libr/aha/um_lupus_crs.htm

Adult Health Topics All Health Topics Find a UMHS Doctor Search Adult Topics Search All Topics This information is approved and/or reviewed by U-M Health System providers but it is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Index Spanish version Systemic Lupus Erythematosus What is systemic lupus erythematosus (SLE)? Systemic lupus erythematosus (SLE) is an autoimmune disease. This means that your body's defenses against infection are attacking your own tissue. This causes inflammation. Areas of the skin or joints become painful, red, and swollen. Other parts of the body can also become inflamed and injured, including the muscles, kidneys, nervous system, blood, lungs, and heart. SLE, also called lupus, is a serious, chronic disease, which means it rarely goes away completely. Some people have severe, even fatal, cases of lupus, but for most people symptoms can be controlled. Lupus affects mainly young women. In the US it is more common among African American, Hispanic, Asian, and Native American women than Caucasians.

92. Lupus Erythematosus, Systemic This document on systemic lupus erythematosus is provided by H. Michael Belmont This booklet describes what systemic lupus erythematosus is and covers http://omni.ac.uk/browse/mesh/D008180.html

low graphics Lupus Erythematosus, Systemic Lupus Erythematosus, Systemic Lupus Erythematosus, Systemic / pathology broader: Autoimmune Diseases other: Addison Disease Antiphospholipid Syndrome Arthritis, Rheumatoid Dermatitis Herpetiformis ... Thyroiditis, Autoimmune Lupus Erythematosus, Systemic Lupus Clinical Overview This document on systemic lupus erythematosus is provided by H. Michael Belmont of The Lupus Clinic, Hospital for Joint Diseases, New York University Medical Center. Topics covered include symptoms, systemic effects, diagnostic procedures and pitfalls and errors. Lupus Erythematosus, Systemic Handout on health : systemic lupus erythematosus This booklet on systemic lupus erythematosus is produced by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). This booklet describes what systemic lupus erythematosus is and covers clinical signs and symptoms, diagnosis, available treatments, health care, pregnancy, and quality of life for people with lupus. Aimed at people who have systemic lupus erythematosus, and their families, this booklet was revised in February 2000. Patient Education Handout [Publication Type] Lupus Erythematosus, Systemic

93. Systemic Lupus Erythematosus - Swedish Medical Center, Seattle, Washington systemic lupus erythematosus Swedish Medical Center, Seattle, Washington. http://www.swedish.org/14582.cfm

PDF Version Search Send-to-Friend Health Library Home ... Conditions InBrief Systemic Lupus Erythematosus (Lupus) by Rick Alan Definition Causes Risk Factors ... Prevention Definition Systemic lupus erythematosus (or lupus) is an autoimmune disease that causes inflammation of joints, tendons, skin and other connective tissues and organs. It causes the immune system to produce antibodies that attack the body's healthy cells and tissues. Causes The cause of lupus is unknown. Researchers believe it is caused by a combination of: Genetic factors Environmental factors, which may include: Sunlight (U-V rays) Stress Viral or other type of infection Antibiotics (especially those containing penicillin or sulfa) Risk Factors A risk factor is something that increases your chance of getting a disease or condition. Risk factors for lupus include: Sex: female Age: late teens to early 30s Race: Black, Native American, Asian and Hispanic Symptoms The symptoms of lupus vary from mild to extremely severe and debilitating. In some patients, only part of the body (for example, the skin) is affected. In others, many parts of the body are affected. Though symptoms of lupus can be chronic, they usually flare up and subside intermittently. Common symptoms include: Swollen and/or painful joints Fever Skin rashes over areas exposed to sunlight (especially on the nose and cheeks) Extreme fatigue Butterfly Rash on the Face www.nucleusinc.com

94. Systemic Lupus Erythematosus & systemic lupus erythematosus (SLE) is a complex autoimmune disease characterizedby a loss of immunologic tolerance to a multitude of selfantigens. http://www.broad.mit.edu/mpg/idrg/projects/sle.html

genome center home programs inflammatory disease research group systemic lupus erythematosus Systemic Lupus Erythematosus The Project The primary goal of this project is to identify the genes which predispose humans to developing Systemic Lupus Erythematosus (SLE). Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a loss of immunologic tolerance to a multitude of self-antigens. It involves many organs and results in autoantibody production and tissue injury. Also, it mainly affects women of child-bearing age. Genetics of Systemic Lupus Erythematosus Epidemiological data suggest an important role for genes in the etiology of lupus, and previous genetic studies have implicated the HLA locus, complement genes, and low-affinity IgG (Fcgamma) receptors in SLE pathogenesis. Relevant OMIM links: LUPUS ERYTHEMATOSUS, SYSTEMIC; SLE Linkage Studies Association Studies Relevant links for general information Lupus Foundation of America, Inc. The Lupus Site National Institute of Arthritis and Musculoskeletal and Skin Diseases-Handout on Health: Systemic Lupus Erythematosus Last modified: Thu May 22 16:56:39 EDT 2003 Webmaster WICGR Home WI Home Contact Us ... Related Links

95. HSS - Conditions & Treatments : Systemic Lupus Erythematosus (SLE) Conditions Treatments systemic lupus erythematosus (SLE) http://www.hss.edu/Conditions/Systemic-Lupus-Erythematosus-(SLE)

var pgName = 'Condition Article'; var pgType = 'conditions'; Find a Physician Conditions and Treatments Departments and Services Research Education Giving to HSS About HSS Home / Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus (SLE) Text Audio Video Clinical Trials Fc Receptor Function in Normals and Systemic Lupus Erythematosus (SLE) document.write(textIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Clinical-Trial-93029')); document.write(audioIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Clinical-Trial-93029','0')); document.write(videoIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Clinical-Trial-93029','0')); PROMISSE: Predictors of Pregnancy Outcome: Biomarkers in Anti-Phospholipid Antibody Syndrome (APS) and Systemic Lupus Erythematosus (SLE) document.write(textIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Clinical-Trial-22122')); document.write(audioIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Clinical-Trial-22122','0')); document.write(videoIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Clinical-Trial-22122','0')); Lupus and Lupus Nephritis (Kidney Inflammation) document.write(textIcon('Conditions/Systemic-Lupus-Erythematosus-(SLE)/Lupus-And-Kidney-Inflammation'));

96. Disease Category Listing (144): Systemic Lupus Erythematosus CenterWatch Listing of Clinical Research Trials for systemic lupus erythematosus. http://www.centerwatch.com/patient/studies/cat144.html

Clinical Trials: Systemic Lupus Erythematosus California Upland; Boling Clinical Trials Research Study for Systemic Lupus Erythematosus Upland; Boling Clinical Trials Research Study for Severe Acute Systemic Lupus Erythematosus Colorado Colorado Springs; Arthritis Associates and Osteoporosis Center of Colorado Springs Research Study for Systemic Lupus Erythematosus Florida Research Study for Systemic Lupus Erythematosus Research Study for Severe Acute Systemic Lupus Erythematosus Illinois Chicago; University of Chicago - Section of Reproductive Endocrinology and Infertility The PROMISSE Study Kansas Kansas City; University of Kansas Medical Center Research Institute HSC# 9955, A randomized, double-blind, placebo-controlled, multicenter, Phase II/III study to evaluate the safety and efficacy of a B-cell depleting therapy in the treatment of patients with active moderate to severe systematic lupus erythematosus. Maryland Chevy Chase; The Center for Rheumatology and Bone Research - Chevy Chase, MD Do you have Systemic Lupus Erythematosus? Laurel; The Center for Rheumatology and Bone Research - Laurel, MD

97. Systemic Lupus Erythematosus Links, Articles And Topics At Suite101.com Links, topics and articles at Suite101 related to systemic lupus erythematosus. http://www.suite101.com/subjectheadings/contents.cfm/1027

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98. EMJA: Godfrey & Ryan, Systemic Lupus Erythematosus: Current Management systemic lupus erythematosus is an autoimmune disease that may affect many organs, Currently, minor manifestations of systemic lupus erythematosus http://www.mja.com.au/public/issues/175_03_060801/godfrey/godfrey.html

Home Issues Email alerts Classifieds ... Search Editorial Systemic lupus erythematosus: current management Use the available agents innovatively, and aggressively treat the risk factors for premature vascular disease MJA Systemic lupus erythematosus is an autoimmune disease that may affect many organs, especially the skin, musculoskeletal, vascular and renal systems. It occurs predominantly in women of childbearing age, but also affects people in their sixth decade or older. In these patients, female predominance is less marked and renal disease less common. The natural history of the disease has changed over the past 20-30 years; survival rates have increased from 50% at five years in the 1950s to 80%-90% at 10 years in the 1990s. The explanations for this improvement include earlier diagnosis, recognition of milder disease, advances in medical therapy, and better supportive care, including renal replacement therapy. Despite these advances, the standardised mortality ratio for lupus remains at 3. Morbidity and mortality rates are bimodal, with early events related to disease activity or infection and later events often due to premature vascular disease such as stroke and myocardial ischaemia. Currently, minor manifestations of systemic lupus erythematosus (cutaneous, musculoskeletal, fatigue) are managed with non-steroidal anti-inflammatory drugs (NSAIDs), antimalarial drugs (particularly hydroxychloroquine) and low-dose corticosteroids. The selective COX-2 inhibitors, celecoxib (a sulfonamide) and rofecoxib, are now available in Australia. With their lower gastrointestinal toxicity, they represent a significant advance. Patients with lupus, however, have a high prevalence of sulfonamide allergy (20% in some studies) and 30%-50% have antiphospholipid antibodies, which are associated with arteriovenous thrombosis and miscarriages (the antiphospholipid syndrome). Case reports of thrombotic events in patients with antiphospholipid antibodies taking COX-2 inhibitors necessitate judicious use of these drugs until further data are available.

99. Second EULAR Course On Systemic Lupus Erythematosus — British Society For R Related. Local resources. Second EULAR Course on systemic lupus erythematosusEvents Second EULAR Course on systemic lupus erythematosus Courses http://www.rheumatology.org.uk/education/event/eularcoursesle

Skip to content SiteMap Normal Text Large Text ... Guidelines Sections Publications Media Centre Membership BHPR ... Contact Us Personal tools You are not logged in Log in Register Search You are here: Home Events Second EULAR Course on Systemic Lupus Erythematosus Home Events BSR Courses Prizes Log in Name Password Forgotten password Register Related Local resources Events Courses BSR Introductory Musculoskeletal Ultrasound Course for Rheumatologists - FULL BSR Paediatric Course 2005 BSR Core Course 2005 - FULL BSR Foot and Ankle Course 2005 - FULL EULAR 10th Jubilee Musculoskeletal Ultrasound Course Views View iCalendar vCalendar State: published Second EULAR Course on Systemic Lupus Erythematosus Document Actions When 04 Sep 2005 to 09 Sep 2005 Where San Miniato, Italy

100. European Lupus Erythematosus Federation Lupus in internet Further informations about systemic lupus erythematosus andrelated topics in internet. SLE systemic lupus erythematosus http://www.elef.rheumanet.org/

E UROPEAN L UPUS E RYTHEMATOSUS F EDERATION Welcome to the home page of ELEF ! Survey What is Lupus? History of ELEF Aims of ELEF ELEF addresses (Register) Official Addresses and further informations about ELEF and the members of ELEF, the national organisations of Lupus Groups in Europe. "Caring And Sharing" The Newsletter of ELEF is published twice a year. Lupus in internet Further informations about systemic lupus erythematosus and related topics in internet. Mednet-Rheuma Please send questions or comments to elef@rheumanet.org Converted to HTML by Team-RheumaNet WHAT IS LUPUS? So few have heard of it, yet worldwide it's seen as more common than leukaemia muscular dystrophy and multiple sclerosis. 90% of the patients who suffer from Lupus are female of childbearing age. Even young children can be affected by lupus. Lupus is a condition whereby the body's defence mechanism goes into overdrive and starts to attack itself. The symptoms are many and varied, and the illness often seems to mimic other diseases. This gives rise to difficulty in diagnosis and the condition can be overlooked, sometimes for years, unless the General Practioner or consultant is alert to the possibility of lupus. LUPUS IS NOT CONTAGIOUS Lupus can be triggered - at puberty - during the menopause - after childbirth - after viral infection - through sunlight - as a result of trauma - after a prolonged course of medication THE SYMPTOMS These may include - extreme fatigue - joint and muscle pain - eye problems - depression

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