61. AllRefer Health - Systemic Lupus Erythematosus (Disseminated Lupus Erythematosus systemic lupus erythematosus (Disseminated Lupus Erythematosus, Lupus, LupusErythematosus, SLE) information center covers causes, prevention, symptoms, http://health.allrefer.com/health/systemic-lupus-erythematosus-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Systemic Lupus Erythematosus Systemic Lupus Erythematosus Definition Treatment Expectations or Prognosis Complications ... Go To Main Page Alternate Names : Disseminated Lupus Erythematosus, Lupus, Lupus Erythematosus, SLE Definition A chronic, inflammatory autoimmune disorder that may affect many organ systems including the skin, joints and internal organs. Systemic Lupus Erythematosus Lupus, Discoid - View of Lesions on the Chest Lupus, Discoid on a Child's Face Systemic Lupus Erythematosus Rash on the Face Lupus, Discoid on the Face

62. AllRefer Health - Systemic Lupus Erythematosus (Pictures, Images, Photos, Diagra systemic lupus erythematosus is a chronic inflammatory autoimmune disorder which may systemic lupus erythematosus Rash on the Face. Related Articles http://health.allrefer.com/pictures-images/systemic-lupus-erythematosus.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Systemic Lupus Erythematosus Systemic lupus erythematosus is a chronic inflammatory autoimmune disorder which may affect many organ systems including the skin, joints and internal organs. The disease may be mild or severe and life-threatening. African-Americans and Asians are disproportionately affected. Related Images Antibodies Circulatory System Graves' Disease Hashimoto's Disease (Chronic Thyroiditis) ... Systemic Lupus Erythematosus Rash on the Face Related Articles Autoimmune Disorders Raynaud's Phenomenon Systemic Lupus Erythematosus Review Date : 9/25/2000 Reviewed By : J. Gordon Lambert, MD, Associate Medical Director; G. Eric Morgan, MS3; RxRemedy From Our Sponsors: A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Par Web Solutions Health Topics: A-Al Am-Az B C-Cj ... Healthopedia.com

63. Lupus Erythematosus related terms systemic lupus erythematosus, cutaneous (discoid) lupus systemic lupus erythematosus (SLE) is an uncommon but severe disorder in which http://www.upei.ca/~cidd/Diseases/immune disorders/lupus erythematosus.htm

related terms: systemic lupus erythematosus, cutaneous (discoid) lupus erythematosus What is lupus erythematosus? There are several forms of lupus erythematosus that are recognized in people, two of which have been identified in dogs. Lupus is an autoimmune disorder, meaning that the body mounts an inappropriate immune response to some part of itself. Systemic lupus erythematosus (SLE) is an uncommon but severe disorder in which the inappropriate immune response is widespread in the body, and can cause arthritis, kidney disease, anemia, and skin disease. Cutaneous lupus erythematosus (CLE) is thought to be a milder variant of SLE, and the problems are confined to the skin. CLE is also called discoid lupus erythematosus How is lupus erythematosus inherited? unknown, but the condition runs in families. What breeds are affected by lupus erythematosus CLE is seen more often than SLE, although both conditions are uncommon. There is a breed predisposition for the collie, Shetland sheepdog, and German shepherd, as well as crosses of these breeds. For many breeds and many disorders, the studies to determine the mode of inheritance or the frequency in the breed have not been carried out, or are inconclusive. We have listed breeds for which there is a consensus among those investigating in this field and among veterinary practitioners, that the condition is significant in this breed.

64. Diseases - Lupus - National Jewish Medical And Research Center Lupus (systemic lupus erythematosus). About Lupus. Learn the basics. What is lupus?What happens in the body with lupus? Why does a person get lupus? http://www.nationaljewish.org/disease-info/diseases/rheum/lupus/index.aspx

Skip to Content About National Jewish Disease Information Patient Information ... Contact Us You are here: National Jewish Home Disease Information Diseases We Treat Rheumatologic Conditions Systemic Lupus Erythematosus Lupus (Systemic Lupus Erythematosus) About Lupus Learn the basics: What is lupus? What happens in the body with lupus? Why does a person get lupus? Treatment and Management of Lupus ... What National Jewish and Other Resources Are Available? Resources available at National Jewish: Where else can I get information about lupus? Note: This information is provided to you as an educational service of National Jewish. It is not meant to be a substitute for consulting with your own physician. HIPAA Policy Privacy Change Text Size Email this page to a friend Printer friendly version Site map Questions? Talk to a LUNG LINE nurse at 1-800-222-LUNG (5864) or e-mail us

65. Lupus systemic lupus erythematosus. email this page print this page. Also known asLupus, disseminated lupus erythematosus, lupus erythematosus, SLE, LE http://www.labtestsonline.org/understanding/conditions/lupus.html

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldolase Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiglobulin, Direct Antiglobulin, Indirect Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcitonin Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP C. diff CEA Celiac Disease Tests CF Gene Mutation Chemistry Panels Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity

66. Virtual Hospital: University Of Iowa Family Practice Handbook, Fourth Edition: R systemic lupus erythematosus (SLE) is a systemic illness characterized by chronicinflammation; clinical manifestations are protean. http://www.vh.org/adult/provider/familymedicine/FPHandbook/Chapter07/12-7.html

University of Iowa Family Practice Handbook, Fourth Edition, Chapter 7 Rheumatology: Systemic Lupus Erythematosus David C. Krupp, MD and Mark A. Graber, MD Departments of Family Medicine and Emergency Medicine University of Iowa Hospitals and Clinics and College of Medicine Peer Review Status: Externally Peer Reviewed by Mosby Overview . Systemic lupus erythematosus (SLE) is a systemic illness characterized by chronic inflammation; clinical manifestations are protean. It most commonly has its onset between 15 and 40 years of age and has an 8:1 female-to-male ratio. Genetic, environmental, and hormonal factors play a role in its etiology. The prevalence is 2.9 to 4 per 100,000; SLE is more common in blacks and some Asian populations. Diagnosis of SLE requires the presence of 4 of 11 criteria (see A through K below). Keep in mind that a positive ANA is neither required for a diagnosis of lupus nor sufficient in itself to make a diagnosis of lupus. Initial workup for suspected lupus should include CBC, chemistry panel, ANA, ESR or CRP, CK, UA, ECG, and CXR. Malar rash (fixed, raised, or flat).

67. Virtual Hospital: The International Thoracic Teaching Resource: Diseases Of Alte systemic lupus erythematosus (SLE) icon gif Weakness of the diaphragm causeselevation of the diaphragms in spite of clear lungs or minor basilar http://www.vh.org/adult/provider/radiology/ITTR/SLE/SLE.html

The International Thoracic Teaching Resource: Diseases of Altered Immunity and Diseases of Uncertain Etiology Systemic lupus erythematosus (SLE) Jeffrey R. Galvin, M.D.; Michael P. D'Alessandro, M.D.; Yasayuki Kurihara, M.D. Peer Review Status: Internally Peer Reviewed Clinical Sx: Pleural involvement is the most common respiratory component in patients with SLE. It has been found at the autopsy in from 50-83%. SLE pleuritis is usually associated with small-to-moderate pleural effusions, pleural pain, cough, dyspnea, and fever. Acute lupus pneumonia is a syndrome presenting as an abrupt onset of dyspnea, cough, and fever and in some patients, hemoptysis. Acute lupus pneumonitis is a diagnosis of exclusion. The physician must carefully exclude the possibility of bacterial pneumonia in patients with SLE who present with fever and infiltrates. The risk for developing acute lupus pneumonitis is increased immediately postpartum. Etiology/Pathophysiology: The process of acute lupus pneumonitis and alveolar hemorrhage are histologically similar and are characterized by acute alveolar-capillary damage probably mediated by immune complex deposition. The causes of pulmonary arterial hypertension include (1) interstitial pneumonitis, (2) small pulmonary artery vasculitis, (3) thrombosis, and (4) "primary" pulmonary hypertension. Pathology: Acute lupus pneumonitis is characterized with alveolar wall inflammation, alveolar wall necrosis, alveolar hemorrhage, edema, hyaline membrane formation, infiltration of the interstitium by inflammatory cells, and capillary thrombi.

68. Lupus (Systemic Lupus Erythematosus) Lupus is an autoimmune disease in which a person’s immune system attacks variousorgans or cells of the body causing damage and dysfunction. http://www.emedicinehealth.com/articles/5382-1.asp

Search September 9, 2005 Registration Healthcare Professionals You are in: Immune System Lupus (Systemic Lupus Erythematosus) Lupus Overview While lupus is a chronic illness, it is characterized by periods when the disease activity is minimal or absent (remission) and when it is active (relapse or flare). The outlook for patients with SLE today is much better than years ago because of greater awareness and better tests leading to earlier diagnosis and treatment and more effective and safer medications. Last updated: Aug 10, 2005 Lupus Causes Sections Lupus Overview Lupus Causes Lupus Symptoms When to Seek Medical Care Exams and Tests ... Authors and Editors Dementia is not something that happens only to older people. Learn about causes and treatment options. Stress, fear, or worries can lead to severe anxiety, which can have a serious impact on your life. Do you need to seek help? Anxiety Asthma Cholesterol Depression ... Healthcare Professionals We subscribe to the HONcode principles. Verify here Medicine is a constantly changing science, and clearly established therapies are not always available for every condition. New research findings necessitate continual changes in drug and treatment therapies. The authors, editors, and publisher of this journal have used reasonable efforts to provide up-to-date, accurate information that is within generally accepted medical standards at the time of publication. However, as medical science is ever evolving, and human error is always possible, the authors, editors, and publisher (or any other involved party) do not guarantee total accuracy or comprehensiveness of the information in this article, nor are they responsible for omissions, errors, or the results of using this information. The reader should confirm the accuracy of the information in this article from other sources. In particular, all drug doses, indications, and contraindications should be confirmed in package inserts.

69. MedlinePlus Medical Encyclopedia: Systemic Lupus Erythematosus systemic lupus erythematosus rash on the face systemic lupus erythematosus (SLE)is a chronic, inflammatory autoimmune disorder. http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Systemic lupus erythematosus Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Calling your health care provider Illustrations Systemic lupus erythematosus Lupus, discoid - view of lesions on the chest Lupus, discoid on a child's face Systemic lupus erythematosus rash on the face ... Antibodies Alternative names Return to top Disseminated lupus erythematosus; SLE; Lupus; Lupus erythematosus Definition Return to top Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disorder . It may affect many organ systems including the skin, joints, and internal organs. Causes, incidence, and risk factors Return to top Normally, the immune system controls the body's defenses against infection. In SLE and other autoimmune diseases, these defenses are turned against the body and rogue immune cells attack tissues. Antibodies may be produced that can react against the body's blood cells, organs, and tissues. These lead immune cells to attack the affected systems, producing a chronic (long-term) disease. The mechanism or cause of autoimmune diseases is not fully known, but many researchers suspect it occurs following infection with an organism that looks similar to particular proteins in the body, which are later mistaken for the organism and wrongly targeted for attack.

70. Systemic Lupus Erythematosus Hub Links to information and resources for systemic lupus erythematosus. http://www.genomelink.org/lupus/

Systemic lupus erythematosus hub Systemic lupus erythematosus is an autoimmune disease that may affect many organs including the joints, skin, kidneys, heart, lungs, blood vessels, and brain. Although people with the disease may have many different symptoms, some of the most common ones include extreme fatigue, painful or swollen joints (arthritis), unexplained fever, skin rashes, and kidney problems. Two of the questions researchers are studying are who gets lupus and why. We know that many more women than men have lupus. Lupus is three times more common in black women than in white women and is also more common in women of Hispanic, Asian, and Native American descent. Acne Allergy Antibiotics Antioxidants ... Treatment of Systemic Lupus Erythematosus: An Update - Michelle Petri, M.D., M.P.H., Johns Hopkins University School of Medicine, Baltimore, Maryland. The role of epstein-barr virus in systemic lupus erythematosus - by Micah T. McClain , John B. Harley and Judith A. James. Cortical Blood Flow and Reactivity in Systemic Lupus Erythematosus - by Steven G. Pavlakis, M.D., Darren R. Gitelman, M.D., Rima G. Kopelman, M.D. and Isak Prohovnik, PhD., College of Physicians and Surgeons, Columbia University. Rheumatology: Systemic Lupus Erythematosus - by Hajime Toyoshima, M.D., Ph.D., Peter P. Toth, M.D., Ph.D. and Mark A. Graber, M.D. Department of Family Medicine University of Iowa.

71. Systemic Lupus Erythematosus (SLE, Or Lupus) systemic lupus erythematosus, also known as SLE, or simply lupus, is a diseasethat is characterized by periodic episodes of inflammation of and damage to http://www.chw.org/display/PPF/DocID/1653/router.asp

Juvenile Rheumatoid Arthritis Juvenile Ankylosing Spondylitis Psoriatic Arthritis Systemic Lupus Erythematosus (SLE, or Lupus) ... Common Types of Juvenile Arthritis and Other Rheumatic Diseases : Systemic Lupus Erythematosus (SLE, or Lupus) E-mail this page Print this page Systemic Lupus Erythematosus (SLE, or Lupus) What is lupus? FDA Approves New Lupus Test In the summer of 2002, the US Food and Drug Administration (FDA) approved the first significant new screening test for lupus in four decades. The test is expected to detect up to 20 percent of cases that normally would have gone undetected using today's testing methods, and the test is meant to combat the severest and potentially fatal form of the disease. Blood tests devised in the 1960s have been used to detect an antibody produced by some lupus patients. However, the new test, which will not be available nationwide for some time, will detect the disease among patients who do not produce this antibody. Always consult your physician for more information. Systemic lupus erythematosus, also known as SLE, or simply lupus, is a disease that is characterized by periodic episodes of inflammation of and damage to the joints, tendons, other connective tissues, and organs, including the heart, lungs, blood vessels, brain, kidneys, and skin. The heart, lungs, kidneys, and brain are the organs most affected. Lupus affects each individual differently and the effects of the illness range from mild to severe. Lupus can potentially be fatal.

72. Systemic Lupus Erythematosus -- ECureMe.com UPDATED SARS INFORMATION,Check health symptoms, make a self diagnosis, ask adoctor or veterinarian online, view an encyclopedia of diseases treatments, http://www.ecureme.com/emyhealth/data/Systemic_lupus_erythematosus.asp

DisplayAd("468","60"); eCureMe Life : Your Healthy Living. Click Here! Welcome, eCureMe.com Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health September 9, 2005 eCureMe Life Medical Supplies Calorie Count Physician Search ... Hospital Directory Systemic Lupus Erythematosus more about Systemic Lupus Erythematosus Normal Abnormal Abnormal This is an autoimmune disease (the body's immune system mistakenly attacks itself). The disease is also called, "SLE", or "lupus." Almost every organ in the body is susceptible to this disease.

73. Systemic Lupus Erythematosus (SLE) Disorders often associated with scleroderma include autoimmune diseases such assystemic lupus erythematosus (SLE). http://www.sclero.org/medical/symptoms/associated/lupus/a-to-z.html

www.sclero.org So you'd like to learn more about scleroderma? an Amazon guide by Shelley Ensz, ISN President Our site menu requires pop-ups and javascript enabled. About the ISN Join/Donate Languages Medical Scleroderma Experts Symptoms Newsroom Message Board Support Stories Support Groups SWA Sites to Surf!

74. Clinical Trial: Study Of Systemic Lupus Erythematosus This protocol will evaluate patients with systemic lupus erythematosus (SLE) andtheir relatives Condition. Lupus Nephritis systemic lupus erythematosus http://www.clinicaltrials.gov/ct/gui/show/NCT00001372

Home Search Browse Resources ... About Study of Systemic Lupus Erythematosus This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center (CC) January 19, 2005 Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose This protocol will evaluate patients with systemic lupus erythematosus (SLE) and their relatives to learn more about how the disease develops and changes over time. It will also study genetic factors that make a person susceptible to SLE. Patients 10 years of age and older with known or suspected SLE and their relatives may be eligible for this study. Patients will be evaluated with a medical history and physical examination, blood and urine tests. Other procedures may include: 1. Electrocardiogram 2. 24-hour urine collection 3. Imaging studies, such as chest and joint X-rays, magnetic resonance imaging (MRI) scans, bone scans, and bone densitometry. 4. Questionnaire about the degree of disease activity, and survey of risk factors for disease complications.

75. Clinical Trial: Ultraviolet Light Therapy For Systemic Lupus Erythematosus systemic lupus erythematosus, Procedure ultraviolet A1 light treatment Patients ages 15 to 70 with symptomatic systemic lupus erythematosus meeting http://www.clinicaltrials.gov/ct/gui/show/NCT00004375

Home Search Browse Resources ... About Ultraviolet Light Therapy for Systemic Lupus Erythematosus This study is currently recruiting patients. Verified by National Center for Research Resources (NCRR) January 2004 Sponsors and Collaborators: National Center for Research Resources (NCRR) Louisiana State University Information provided by: National Center for Research Resources (NCRR) ClinicalTrials.gov Identifier: Purpose OBJECTIVES: I. Evaluate the mechanisms of ultraviolet A-1 light therapy in patients with systemic lupus erythematosus and normal controls. Condition Intervention Phase Systemic Lupus Erythematosus Procedure: ultraviolet A-1 light treatment Phase II MedlinePlus related topics: Lupus Study Type: Interventional Study Design: Treatment Further Study Details: Expected Total Enrollment: 20 Study start: September 1991 PROTOCOL OUTLINE: Treatment with ultraviolet A-1 light is administered 5 days a week for 6 weeks, at the lowest dose or frequency required to maintain a response. The dose and frequency are progressively decreased over the next 9 weeks. Eligibility Ages Eligible for Study: 15 Years - 70 Years, Genders Eligible for Study: Both

76. Lupus Erythematosus The systemic disease, known as systemic lupus erythematosus (SLE) can be Fatal evolution of systemic lupus erythematosus associated with Crohn s disease http://www.thedoctorsdoctor.com/diseases/lupus_erythematosus.htm

Background Lupus erythematosus is an autoimmune disorder striking every organ system. Its many presentations can mimic many diseases. This disease requires close cooperation between the treating physician and the pathologist. The systemic disease, known as Systemic Lupus Erythematosus (SLE) can be diagnosed with 4 or more of the 11 criteria below, either serially or simultaneously, during any interval of observation. In general, arthritis and joint complaints comprise the majority of initial signs and symptoms but ultimately 80% of patients will present with skin manifestations. Patients may be treated with corticosteroids and immunosuppressive agents. However, these patients are immunocompromised and infections are common. Death is usually secondary to infectious complications, renal failure, or central nervous system disease. The story of lupus does not end here. There are several well-established variants, such as Discoid Lupus Erythematosus (DLE), that involve selected organ systems and present with different ANA patterns. The outline below describes some of these important clinical variants. Outline Epidemiology Synonyms Incidence Age Sex Geography Genetic Non-genetic Disease Associations Crohn's disease Epstein-Barr virus Guillain-Barre syndrome Mid-dermal elastolysis Porphyria TEN Pathogenesis SLE DNaseI DLE SCLE

77. CCHS Clinical Digital Library systemic lupus erythematosus (Comphrehensive Version) Access document systemic lupus erythematosus (Lupus) in Children and Adolescents Table of http://cchs-dl.slis.ua.edu/patientinfo/immunology/autoimmune/systemic.html

Patient/Family Resources by Topic: Immunology Systemic Lupus Erythematosus Patient/Family Resources Pediatrics Spanish Miscellaneous See also: General Immunology Patient/Family Resources Systemic Lupus Erythematosus Clinical Resources MD Consult: Homepage Health Sciences Library subscription INFO Patient Handouts Table of content Systemic Lupus Erythematosus (Comphrehensive Version) Access document Systemic Lupus Erythematosus English Spanish Arthritis Foundation: Homepage Disease Center: List of documents Lupus/Systemic Lupus Erythematosus (SLE) Access document American College of Rheumatology: Homepage Patient Information: List of documents Systemic Lupus Erythematosus: Access document American Academy of Dermatology: Homepage Public Resource Center: Table of contents Pamphlets List of documents Lupus and the Skin Access document National Institute of Diabetes and Digestive and Kidney Diseases: Homepage Kidney Diseases: Table of contents A-Z List of Topics and Titles: List of documents Lupus Nephritis: Access document American Academy of Family Physicians (familydoctor.org): Homepage Self Care Flowcharts: List of documents Skin Rashes and Other Changes: Access document University of Birmingham (U.K.) Dept of Rheumatology:

78. Lupus Trust Of New Zealand - A History Of Systemic Lupus Erythematosus A HISTORY OF systemic lupus erythematosus Kaposi, a Viennese physician,recognises that lupus erythematosus can produce dangerous constitutional http://www.lupus.org.nz/history.html

A HISTORY OF SYSTEMIC LUPUS ERYTHEMATOSUS Acknowledgements to Dr. Wolfe J Blotzer, Assistant Professor of Medicine University of Maryland School of Medicine and Dr. B. Rose, Rheumatologist, Waikato Hospital, New Zealand. DATE DESCRIPTION 400 B.C. Hippocrates writes about red ulcerating skin lesions which may or may not be connected with lupus. About 1200 A.D. The term lupus is used for the first time to describe red ulcerations on the face. The word lupus literally means wolf and there are two theories as to why it was used. (1) The most common theory is that the skin rash, like a wolf, seemed to eat away the skin and destroy it. The rash, therefore, was said to resemble skin which had actually been bitten by a wolf; and About 1800 A.D. Dr. Willan, a British Dermatologist, includes lupus in his classification of skin diseases. His description of lupus emphasised the destructive nature of the disease and the lack of any treatment. At this time he was probably describing tuberculosis of the skin which is still known as lupus vulgaris rather than lupus erythematosus. Later in the 19th century, Cazenare, a student of French Dermatologist Blett, introduces the term lupus erythematosus and confirms that this is distinct from other ulcerating skin. Sir William Osler, in a series of papers, expands the concept of SLE and describes heart, lung, joint, brain, kidney and stomach symptoms. He also recognises that some cases of SLE occur without skin involvement.

79. Systemic Lupus Erythematosus - Prasterone (withdrawn) Prasterone for the treatment of systemic lupus erythematosus Systemic lupuserythematosus Provisional matrix of consultees and commentators http://www.nice.org.uk/page.aspx?o=98341

80. Systemic Lupus Erythematosus (SLE, Or Lupus) Detailed information on systemic lupus erythematosus (lupus), including causes,symptoms, diagnosis, and treatment. http://www.healthsystem.virginia.edu/uvahealth/peds_arthritis/lupus.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation UVa Health Topics A to Z FIND A DOCTOR Pediatric Arthritis Pediatric Rheumatology MAKE AN APPOINTMENT ... CLINICAL TRIALS Search This Site Systemic Lupus Erythematosus (SLE, or Lupus) What is lupus? Systemic lupus erythematosus, also known as SLE, or simply lupus, is a disease that is characterized by periodic episodes of inflammation of and damage to the joints, tendons, other connective tissues, and organs, including the heart, lungs, blood vessels, brain, kidneys, and skin. The heart, lungs, kidneys, and brain are the organs most affected. Lupus affects each individual differently and the effects of the illness range from mild to severe. Lupus can potentially be fatal. The disease is known to have periods of flare-ups and periods of remission (partial or complete lack of symptoms). Children with lupus can have a large degree of kidney involvement. The severity of the kidney involvement can alter the survival rate of patients with lupus. In some cases, kidney damage is so severe it leads to kidney failure.

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