1. The Genetics Of Systemic Lupus Erythematosus Family Study - What Is Lupus? Open research study at University of Minnesota seeking multiple family members with systemic disease to investigate why certain women are prone to this illness through identification of inherited genetic factors. http://www.lupusstudy.org/

The Genetics of Systemic Lupus Erythematosus A research study at the University of Minnesota, sponsored by the National Institute of Health and the Lupus Foundation of Minnesota. Our goal is to identify and understand the genetic factors that contribute to Lupus. We hope to discover why certain people get Lupus by identifying these inherited genetic factors. This research will allow development of better ways to diagnose and treat this disease. Do you or a family member have Systemic Lupus? If so, you can be involved in the search for the cause. We are looking nationwide for individuals with lupus or families with two or more family members with lupus. Timothy W. Behrens, M.D. is the Principal Investigator on this project and is a Professor of Medicine and a Rheumatologist at the University of Minnesota. He is responsible for the overall direction and management of the study. Click here to meet the rest of our staff. University of Minnesota The University of Minnesota is an equal opportunity educator and employer. Home What Does Participation Involve?

2. Handout On Health: Systemic Lupus Erythematosus This booklet is for people who have systemic lupus erythematosus, Systemic lupuserythematosus (SLE) is the form of the disease that most people are http://www.niams.nih.gov/hi/topics/lupus/slehandout/

Health Information Health Topics Order Publications Studies with Patients Patient Research Registries ... NIAMS Coalition Members Health Topics PDF version Publication Date September 1997 Revised August 2003 Handout on Health: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Defining Lupus Understanding What Causes Lupus Symptoms of Lupus ... Acknowledgments Information Boxes Common Symptoms of Lupus Diagnostic Tools for Lupus Warning Signs of a Flare Preventing a Flare ... Promising Areas of Research Systemic Lupus Erythematosus This booklet is for people who have systemic lupus erythematosus, commonly called SLE or lupus, as well as for their family and friends and others who want to better understand the disease. The booklet describes the disease and its symptoms and contains information about diagnosis and treatment as well as current research efforts supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other components of the Department of Health and Human Services' National Institutes of Health (NIH). It also discusses issues such as health care, pregnancy, and quality of life for people with lupus. If you have further questions after reading this booklet, you may wish to discuss them with your doctor. Defining Lupus Lupus is one of many disorders of the immune system known as autoimmune diseases. In autoimmune diseases, the immune system turns against parts of the body it is designed to protect. This leads to inflammation and damage to various body tissues. Lupus can affect many parts of the body, including the joints, skin, kidneys, heart, lungs, blood vessels, and brain. Although people with the disease may have many different symptoms, some of the most common ones include extreme fatigue, painful or swollen joints (arthritis), unexplained fever, skin rashes, and kidney problems.

3. Mixed Connective Tissue Disorder An autoimmune process with symptoms of Scleroderma, systemic lupus erythematosus , Rheumatoid Arthritis and/or other autoimmune diseases. This page describes symptoms and treatments and has lists of useful links. http://hometown.aol.com/lindartc/index.htm

htmlAdWH('93212823', '728', '90'); Main NEW! Click here to join a group for spouses of people with Autoimmune Disease (Spousal Autoimmune Support Group). What is Mixed Connective Tissue Disorder? How do you know if you have Mixed Connective Tissue Disorder? ... VIVIENDO CON EMTC What is Mixed Connective Tissue Disorder? Mixed Connective Tissue Disorder is an autoimmune process with symptoms of Scleroderma, Myositis, Systemic Lupus Erythematosus , Rheumatoid Arthritis and/or other autoimmune diseases. It is a description of a group of symptoms occurring together. This is different from a diagnosis that describes the underlying process. It is a disorder of the immune system, which normally functions to protect the body against invading infections and cancers, and toxins. In Mixed Connective Tissue Disorder, as in other autoimmune diseases parts of the complex immune system is over-active and produces increased amounts of abnormal antibodies that attack the patient's own organs. Sometimes MCTD is called Overlap Syndrome or Undifferentiated Mix Connective Tissue Disorder. Some writers discriminate between them claiming that each of these are different. Some argue MCTD is not a distinct entity at all, and is just one of the forms of Lupus or Scleroderma. MCTD can affect many parts of the body, including the joints, skin, kidneys, lungs, heart, endocrine, digestive, and nervous system, blood vessels which all are made up of connective tissue. There are reports of psychiatric disturbances similar to those found in Lupus. The signs and symptoms of MCTD differ from person to person, with the symptoms of either Lupus, or Scleroderma, or Myositis or other autoimmune disease being most prevalent. Since its manifestations can vary it is often misdiagnosed. The disease can range from mild to life threatening. It can be mild for many years, and then after about 20 years of having the disease a medical crisis may occur. The lungs and kidneys are particularly at risk. Lungs and kidneys symptoms are particularly serious involvement and should be monitored vigilantly by both the doctor and the patient.

4. Handout On Health Systemic Lupus Erythematosus Handout on Health systemic lupus erythematosus. systemic lupus erythematosus. Defining Lupus. Understanding What Causes Lupus. Symptoms of Lupus http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. THROMBOCYTOPENIA DURING PREGNANCY An in depth look at gestational thrombocytopenia, idiopathic thrombocytopenic purpura, HELLP syndrome, toxemia of pregnancy, TTP and HUS, systemic lupus erythematosus and APA syndrome. http://www.kfshrc.edu.sa/annals/182/97-160.html

Review Article THROMBOCYTOPENIA DURING PREGNANCY Abdul Rahim Gari-Bai, Fachartz (Hematology) As platelets play an important role in primary and secondary hemostasis, any decrease in their count in peripheral blood causes justifiable concern. This is particularly the case during pregnancy, when bleeding problems, particularly during first and third trimester, as well as during and after delivery, often occur. Therefore, thrombocytopenia can be hazardous for pregnant women with such complications. As well, neonates are exposed to a great mechanical stress during the passage through the birth canal, and they may be affected by maternal thrombocytopenia. Because of such hazards to both mother and newborn, a good understanding of the various mechanisms of thrombocytopenia is needed. /l) is usually associated with bleeding risk only after trauma. Moderate thrombocytopenia (10-50x10 /L) can cause spontaneous but usually not serious bleeding. Such serious hemorrhages usually occur at levels below 10x10 /L. Bleeding risk is higher if thrombocytopenia is due to reduced production rather than increased consumption. Prophylactic platelet transfusion is recommended in the former, while in cases of peripheral destruction, platelets are only transfused on a therapeutic basis, i.e., in case of actual bleeding.

6. Lupus Foundation Of America, Inc. The Lupus Foundation of America is the only nationwide voluntary organization exclusively serving the entire lupus community, including patients http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Lupus: Medical Information About The Diseases Of Lupus, Its Causes, Symptoms, Di systemic lupus erythematosus (SLE or Lupus). Medical Author William C.Shiel Jr., MD, FACP, FACR Topics Related to systemic lupus erythematosus http://www.medicinenet.com/systemic_lupus/article.htm

document.writeln(''); MedicineNet Home Arthritis Home Page > Systemic Lupus Search Tips Printer-Friendly Format FREE Newsletters Email to a Friend ... Next Systemic Lupus Erythematosus (SLE or Lupus) Medical Author: William C. Shiel Jr., MD, FACP, FACR What is lupus? What causes lupus? What are the symptoms of lupus? ... Systemic Lupus At A Glance What is lupus? Lupus is a condition of chronic inflammation caused by an autoimmune disease. Autoimmune diseases are illnesses which occur when the body's tissues are attacked by its own immune system. The immune system is a complex system within the body that is designed to fight infectious agents, for example, bacteria, and other foreign invaders. One of the mechanisms that the immune system uses to fight infections is the production of antibodies. Patients with lupus produce abnormal antibodies in their blood that target tissues within their own body rather than foreign infectious agents. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE). Both discoid and systemic lupus are more common in women than men (about eight times more common). The disease can affect all ages but most commonly begins from age 20 to 45 years. It is more frequent in African-Americans and people of Chinese and Japanese descent.

8. LUPUS ASSOCIATION (SINGAPORE) About systemic lupus erythematosus (SLE) in Singapore, for the layperson and the patient. Chinese guide also available. http://home1.pacific.net.sg/~lupusas/

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9. MedlinePlus Lupus Search MEDLINE/PubMed for recent research articles on Lupus . systemic lupus erythematosus . Cutaneous and Discoid . Therapy http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Lupus: Medical Information About The Diseases Of Lupus, Its Causes, Symptoms, Di systemic lupus erythematosus is a chronic inflammatory condition caused by anautoimmune disease. Lupus can cause disease of the skin, heart, lungs, http://www.medicinenet.com/systemic_lupus/

document.writeln(''); MedicineNet Home Arthritis Home Page Search Tips What's Inside the Systemic Lupus Health Center Systemic Lupus Erythematosus Main Article 10 Medications related to Systemic Lupus 17 Doctor's Views related to Systemic Lupus 6 Health Features related to Systemic Lupus ... Systemic Lupus RSS feed Our Systemic Lupus Erythematosus Main Article provides a comprehensive look at the who, what, when and how of Systemic Lupus Systemic lupus erythematosus is a chronic inflammatory condition caused by an autoimmune disease. Lupus can cause disease of the skin, heart, lungs, kidneys, joints, and nervous system. When only the skin is involved, the condition is called discoid lupus. When internal organs are involved, the condition is called systemic lupus erythematosus (SLE). Arthritis and Pain Arthritis Questions to Ask Your Doctor Join the discussion on the Arthritis Message Boards Health News on Systemic Lupus Gene Discovery Gives Clues to Immune Dysfunction Cancer Drug Also Fights Lupus, Rheumatoid Arthritis Gene Marker May Improve Lupus Care Key Player in Inflammation Found View All Systemic Lupus Health News Systemic Lupus related Doctor's Views Doctor: Getting the Most from Your Doctor’s Appointment How to Choose a Doctor Coping with a Bad Disease - Community Counts Lupus: Does Stress Affect Lupus?

11. Genelabs Technologies, Inc. Discovers, develops and commercializes therapies for systemic lupus erythematosus, viral diseases and cancer. Located in Redwood City, California.(Nasdaq GNLB) http://www.genelabs.com/

Company Profile Pipeline Management Team Board of Directors Company Profile Pipeline Management Team Board of Directors ... Glossary of Terms

12. SLE Pathology of systemic lupus erythematosus. Return to the tutorial menu. The images as described below have file sizes ranging from 50 to 250k. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Lupus/Systemic Lupus Erythematosus (SLE) systemic lupus erythematosus (sisTEM-ick LOO-pus systemic lupus erythematosusinvolves chronic inflammation that can affect many parts of the body, http://www.arthritis.org/conditions/DiseaseCenter/lupus.asp

Welcome! Log In Create Profile Search Arthritis.org Keyword advanced search Español Questions and Answers Assess Your Joint Health ... 51 Ways to Be Good to Your Joints Lupus/Systemic Lupus Erythematosus (SLE) If your question is not answered here, please contact one of our information specialists. What Is It? What Are the Symptoms? What Causes It? How Is It Diagnosed? ... Información en Español What Is It? Systemic Lupus Erythematosus (sis-TEM-ick LOO-pus err-ah-theme-ahTOE-sus) is a chronic (long-lasting) rheumatic disease which affects joints, muscles and other parts of the body. Lupus involves inflammation (the immune system's response to kill foreign agents, virus, bacteria). Systemic lupus erythematosus involves chronic inflammation that can affect many parts of the body, including: Heart Lungs Skin Joints Blood-forming organs Kidneys Nervous system There are several types of lupus: Discoid lupus affects the skin. Drug-induced lupus occurs because of a reaction to drugs. Symptoms, however, disappear once the drugs are discontinued. Crossover, or overlap, syndromes indicate features that overlap with another rheumatic disease.

14. HK Lupus Association Support group for patients and families affected by systemic lupus erythematosus. http://www.hklupus.org.hk/

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15. Systemic Lupus Erythematosus (SLE) Clinical Overview Clinical overview of systemic lupus erythematosus (SLE), a chronic, usually lifelong, potentially fatal autoimmune disease. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Systemic Lupus Erythematosus A resource for families and physicians caring for children with systemic lupuserythematosus and other rheumatic diseases. http://www.goldscout.com/page2.html

id=13897 Systemic Lupus Erythematosus This page is provided by Thomas J. A. Lehman MD Delivering the best care - with great care Dr. Lehman is the author of many textbook chapters and articles on the care of children and young adults with SLE. He practices in New York City Click here for more information about Dr. Lehman or the Hospital for Special Surgery. Unsure if you are getting the best care? Click here for information on a book I have written about childhood rheumatic disease which discusses lupus in much more detail What is systemic lupus erythematosus? Systemic lupus erythematosus SLE ) is a challenging 'autoimmune' whose wide variety of manifestations makes it a necessary part of the differential diagnosis for children and adolescents with many different presenting complaints. Nonspecific complaints of fatigue and malaise are the most common initial symptoms of SLE in children and adolescents. The typical 'butterfly' rash is present in less than one-third of affected children. Many pediatricians dismiss SLE from their differential diagnosis as 'uncommon in childhood', but positive tests for

17. Lupus Trust Of New Zealand - Home Page Volunteer organisation dedicated to raising awareness of systemic lupus erythematosus (SLE) within the New Zealand community. http://www.lupus.org.nz/

The Lupus Trust of New Zealand is a self-funded non-profit organization served by volunteers. Registered Charity Number AK1187700 We are committed to understanding and supporting people with Lupus and related autoimmune diseases. Please visit our Objectives page for further information. FastCounter by bCentral Last modified: 02 December, 2004

18. Genes In The Interferon System Important In Systemic Lupus Two genes with very strong associations with the disease systemic lupus erythematosus (SLE) have been identified by a team of scientists headed by http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. SLE systemic lupus erythematosus (SLE) is a chronic disease with many manifestations . systemic lupus erythematosus. malar rash in a young girl, gross. http://www-medlib.med.utah.edu/WebPath/TUTORIAL/SLE/SLE.html

Pathology of Systemic Lupus Erythematosus Return to the tutorial menu. The images as described below have file sizes ranging from 50 to 250k. General Features Systemic lupus erythematosus (SLE) is a chronic disease with many manifestations. SLE is an autoimmune disease in which the body's own immune system is directed against the body's own tissues. The etiology of SLE is not known. It can occur at all ages, but is more common in young women. The production of autoantibodies leads to immune complex formation. The immune complex deposition in many tissues leads to the manifestations of the disease. Immune complexes can be deposited in glomeruli, skin, lungs, synovium, mesothelium, and other places. Many SLE patients develop renal complications. Laboratory Testing The presence of autoantibodies can usually be determined by the antinuclear antibody (ANA) test performed on patient serum from blood. The titer, or strength, of the ANA gives a rough indication of the severity of the disease. Not all positive ANA tests indicate autoimmune disease, particularly when the titer is low. After a positive screening ANA test, more specific tests for SLE include detection of autoantibodies to double stranded DNA and to Smith antigen. Antinuclear antibody (ANA) test with homogenous pattern, Hep2 cell substrate, FITC immunofluorescence.

20. Lupus/Systemic Lupus Erythematosus (SLE) Lupus/systemic lupus erythematosus (SLE) If your question is not answered here, please contact one of our information specialists. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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