81. High-Dose Intravenous Ribavirin Therapy For Subacute Sclerosing Panencephalitis Two patients with subacute sclerosing panencephalitis (SSPE) were treated Effect of ribavirin on subacute sclerosing panencephalitis virus infections in http://aac.asm.org/cgi/content/full/45/3/943

This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Books from ASM Press PubMed PubMed Citation Articles by Hosoya, M. Articles by Suzuki, H. Antimicrobial Agents and Chemotherapy, March 2001, p. 943-945, Vol. 45, No. 3 0066-4804/01/$04.00+0 DOI: 10.1128/AAC.45.3.943-945.2001 American Society for Microbiology High-Dose Intravenous Ribavirin Therapy for Subacute Sclerosing Panencephalitis Mitsuaki Hosoya, Shiro Shigeta, Shuichi Mori, Akemi Tomoda, Seiji Shiraishi, Teruhisa Miike, and Hitoshi Suzuki Department of Pediatrics and Microbiology, School of Medicine, Fukushima Medical University, Fukushima 960-1295, and Department of Child Development, Kumamoto University School of Medicine, Kumamoto 860-0811, Japan Received 11 July 2000/Returned for modification 11 October 2000/Accepted 30 November 2000 ABSTRACT Top Abstract Text References Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively with high doses of intravenous ribavirin combined with intraventricular alpha interferon. The

82. Effect Of Ribavirin On Subacute Sclerosing Panencephalitis Virus Infections In H Effect of ribavirin on subacute sclerosing panencephalitis virus infections inhamsters. Y Honda, M Hosoya, T Ishii, S Shigeta and H Suzuki http://aac.asm.org/cgi/content/abstract/38/4/653

This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Books from ASM Press PubMed PubMed Citation Articles by Honda, Y. Articles by Suzuki, H. Antimicrobial Agents and Chemotherapy, 04 1994, 653-655, Vol 38, No. 4 by the American Society for Microbiology Effect of ribavirin on subacute sclerosing panencephalitis virus infections in hamsters Y Honda, M Hosoya, T Ishii, S Shigeta and H Suzuki Department of Pediatrics, Fukushima Medical College, Japan. The antiviral activity of ribavirin was studied in hamsters infected with subacute sclerosing panencephalitis (SSPE) virus. Ribavirn did not improve the survival of infected hamsters when administered intraperitoneally at the maximal nonlethal dose of 50 mg/kg/day for 10 days. However, when administered intracranially, ribavirin improved the survival of infected hamsters in a dose-dependent manner. The 50% effective dose was calculated

83. Case Report And Molecular Analysis Of Subacute Sclerosing Panencephalitis In A S This is the first case of subacute sclerosing panencephalitis from South Africain which the subacute sclerosing panencephalitis in Southern Africa. http://jcm.asm.org/cgi/content/full/37/3/775

This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Books from ASM Press PubMed PubMed Citation Articles by Vardas, E. Articles by Kreis, S. Journal of Clinical Microbiology, March 1999, p. 775-777, Vol. 37, No. 3 American Society for Microbiology Case Report and Molecular Analysis of Subacute Sclerosing Panencephalitis in a South African Child Eftyhia Vardas, P. M. Leary, Jane Yeats, Waseila Badrodien, and Stephanie Kreis National Institute for Virology and Department of Virology, University of the Witwatersrand, Johannesburg, and Red Cross Children's Hospital, Department of Paediatrics, and Department of Medical Virology, University of Cape Town, Cape Town, South Africa Received 14 September 1998/Returned for modification 27 October 1998/Accepted 8 December 1998 ABSTRACT Top Abstract Text References This is the first case of subacute sclerosing panencephalitis from South Africa in which the molecular characteristics of the causative measles virus were examined. The virus found is

84. Subacute Sclerosing Panencephalitis -- Garg 78 (916): 63 -- Postgraduate Medical subacute sclerosing panencephalitis (SSPE) is a serious disorder of the central subacute sclerosing panencephalitis isolation of measles virus from a http://pmj.bmjjournals.com/cgi/content/full/78/916/63

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Summary Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Garg, R K Related Collections Other Neurology Postgraduate Medical Journal The Fellowship of Postgraduate Medicine REVIEW Subacute sclerosing panencephalitis R K Garg Correspondence to: Dr Ravindra Kumar Garg, Department of Neurology, King George's Medical College, Lucknow 226 003, India; Submitted 22 May 2001 Accepted 4 September 2001 ABSTRACT TOP ABSTRACT EPIDEMIOLOGY PATHOGENESIS PATHOLOGY CLINICAL FEATURES DIAGNOSIS SSPE IN ADULTS SSPE AND PREGNANCY ACUTE FULMINANT SSPE TREATMENT PROGNOSIS CONCLUSION AN ADULT PATIENT WITH...

85. The Dictionary Of Cell And Molecular Biology - Online! subacute sclerosing panencephalitis. (= SSPE). Chronic progressive illness seenin children a few years after measles infection, and involving demyelination http://www.mblab.gla.ac.uk/~julian/dict2.cgi?6282

86. Sspe.html subacute sclerosing panencephalitis (SSPE) is a progressive neurological TITLE subacute sclerosing panencephalitis presenting as optic neuritis. http://www.indiana.edu/~pietsch/sspe.html

go to Shufflebrain main menu SSPE, the recent literature (subacute sclerosing panencephalitis) A literature search at Indiana University, Bloomington, Indiana web contact: pietsch@indiana.edu Here's what NORD (National Organization for Rare Disorders) says about SSPE: Subacute Sclerosing Panencephalitis (SSPE) is a progressive neurological disorder characterized by inflammation of the brain (encephalitis). The disease may develop due to reactivation of the measles virus or an inappropriate immune response to the measles virus. SSPE usually develops 2 to 10 years after the original viral attack. Initial symptoms may include memory loss, irritability, seizures, involuntary muscle movements, and/or behavioral changes, leading to neurological deterioration. include memory loss, irritability, seizures, involuntary muscle movements, and/or behavioral changes, leading to neurological deterioration. The following items were compiled from MEDLINE, using SilverPlatter and are presented with SilverPlatter's generous permission. Record 1 of 144 in MEDLINE EXPRESS (R) 2000/01-2000/10 TITLE: Comparison of immunoglobulin G heavy-chain sequences in MS and SSPE brains reveals an antigen-driven response [see comments] COMMENTS: Comment in: Neurology 2000 Mar 28;54(6):1214-5

87. Structural Homogeneity Of Human Subacute Sclerosing Panencephalitis Antibodies - Structural homogeneity of human subacute sclerosing panencephalitis antibodies.AD Strosberg, D Karcher and A Lowenthal http://www.jimmunol.org/cgi/content/abstract/115/1/157

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Strosberg, A. D. Articles by Lowenthal, A. ARTICLES Structural homogeneity of human subacute sclerosing panencephalitis antibodies AD Strosberg, D Karcher and A Lowenthal Three homogeneous immunoglobulin fractions were isolated from the serum of a patient with subacute sclerosing panencephalitis (SSPE). All three fractions reacted in immunodiffusion with measles and SSPE virus preparations. The amino-terminal sequence of the light and heavy chains of one of the antibody fractions was determined by automated Edman degradation. A single amino acid residue was obtained at every step, confirming the homogeneity of this human antibody. HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS

88. Immune Response In Subacute Sclerosing Panencephalitis: Reduced Antibody Respons Immune response in subacute sclerosing panencephalitis reduced antibody responseto the matrix protein of measles virus http://www.jimmunol.org/cgi/content/abstract/123/2/884

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Wechsler, S. L. Articles by Fields, B. N. ARTICLES Immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus SL Wechsler, HL Weiner and BN Fields Immune precipitation was used to study the humoral immune response of patients with subacute sclerosing panencephalitis (SSPE). Patients with SSPE have a progressive infection of the CNS by measles or a measles variant despite high serum antibody levels to measles virus as measured by standard serologic techniques. However, when the antibody response to individual measles virus proteins was measured, we found a striking reduction in the ability of sera from patients with SSPE to precipitate the matrix (M) protein as compared to the precipitation of the M protein by sera from normal adults who had natural measles infection in childhood, or

89. Lymphocyte Subsets At Different Stages Of Subacute Sclerosing Panencephalitis: A of subacute sclerosing panencephalitis a study with monoclonal antibodies in patients with subacute sclerosing panencephalitis, eight of whom were http://jnnp.bmjjournals.com/cgi/content/abstract/49/6/713

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Marrosu, M. G. Articles by Ennas, M. G. Journal of Neurology, Neurosurgery, and Psychiatry, 1986, Vol 49, 713-715 PAPERS Lymphocyte subsets at different stages of subacute sclerosing panencephalitis: a study with monoclonal antibodies MG Marrosu, C Cianchetti and MG Ennas Lymphocyte subsets in cerebrospinal fluid (CSF) and peripheral blood were studied using monoclonal antibodies, in patients with subacute sclerosing panencephalitis, eight of whom were at stage 2 and seven at stage 4.

90. Subacute Sclerosing Panencephalitis: Serial Electroencephalographic Studies -- W subacute sclerosing panencephalitis serial electroencephalographic studies.CH Wulff. A total of 42 EEGs from five patients with subacute sclerosing http://jnnp.bmjjournals.com/cgi/content/abstract/45/5/418

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Wulff, C. H. Journal of Neurology, Neurosurgery, and Psychiatry, 1982, Vol 45, 418-421 PAPERS Subacute sclerosing panencephalitis: serial electroencephalographic studies CH Wulff A total of 42 EEGs from five patients with subacute sclerosing panencephalitis were studied. Periodic complexes were noticed in 35 (83%) of these. The interval between the complexes shortened in all patients with progression of the illness. The gradual EEG changes may reflect the increasing number of infected cells as well as an on-going accumulation of immature virus structures. The records without complexes were either from

91. Arch Pediatr Adolesc Med -- Abstract: Ocular Manifestations Of Subacute Sclerosi We report a case of subacute sclerosing panencephalitis (SSPE) with severeperipheral chorioretinal pigment changes in addition to the more typical pigment http://archpedi.ama-assn.org/cgi/content/abstract/130/9/1019

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 130 No. 9, September 1976 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager Articles in PubMed by Morgan B Williamson R Contact me when this article is cited Ocular manifestations of subacute sclerosing panencephalitis B. Morgan, D. N. Cohen, A. D. Rothner and R. Williamson We report a case of subacute sclerosing panencephalitis (SSPE) with severe peripheral chorioretinal pigment changes in addition to the more typical pigment clumping in the macula. The differential diagnosis of peripheral inactive chorioretinitis, the typical ocular findings, and clinical course of SSPE are discussed. HOME CURRENT ISSUE PAST ISSUES COLLECTIONS ... HELP

92. Dorlands Medical Dictionary subacute sclerosing panencephalitis, (SSPE) a rare and devastating form ofleukoencephalitis usually affecting children and adolescents. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

93. Subacute Sclerosing Panencephalitis In An Identical Twin -- Park And Kohl 104 (6 subacute sclerosing panencephalitis in an Identical Twin of the most dreadedlongterm sequelae of measles, subacute sclerosing panencephalitis (SSPE). http://pediatrics.aappublications.org/cgi/content/extract/104/6/1390

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) P ... Citation Map Services E-mail this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Park, S. Y. Articles by Kohl, S. Related Collections PEDIATRICS Vol. 104 No. 6 December 1999, pp. 1390-1394 EXPERIENCE AND REASON: Subacute Sclerosing Panencephalitis in an Identical Twin The first 300 words of the full text of this article appear below. Due to vaccination efforts, measles and its sequelae may no longer be endemic in the United States although there is still the problem of imported measles. We present a case, probably related to the last national measles epidemic in this country (1989-1990 in which an identical twin developed one of the most dreaded long-term sequelae of measles, subacute sclerosing panencephalitis (SSPE). CASE REPORT In mid-August 1998, a 9-year-old girl of Cambodian descent was hospitalized for evaluation of a progressive neurologic illness.

94. Subacute Sclerosing Panencephalitis : Experience Of A Tertiary Referral Centre I Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India. http://www.neurologyindia.com/article.asp?issn=0028-3886;year=1996;volume=44;iss

95. Intravenous With Intrathecal Interferon In Subacute Sclerosing Panencephalitis., Recent literature from different countries has revealed variable results ofinterferon treatment in subacute sclerosing panencephalitis (SSPE). http://www.neurologyindia.com/article.asp?issn=0028-3886;year=1995;volume=43;iss

96. CMAJ -- Please Take Our Questionnaire Three children with subacute sclerosing panencephalitis (SSPE), 12 patients withmultiple sclerosis (MS) and 12 healthy persons were studied by the http://www.cmaj.ca/cgi/content/abstract/118/5/509

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97. Bienvenue Dans Le Monde Des Oiseaux Bleus Nonprofit organisation to fight against sclerosing subacute panencephalitis, a.k.a. Van Bogaert Disease, a progressive neurological disorder caused by the measles virus. Includes information about the disease. http://oiseau.bleu.free.fr/en/en_welcome.php

Welcome Welcome to the world of our children struck by Subacute Sclerosing Panencephalitis (SSPE). Welcome to our world, the world of all the people that love our children, take care of them, help them day after day. It is not an easy world but it is not a sad and dull world, it is a world of fight, sometimes hostile, but also a world of energy, courage, generosity. In a word, it is a world of love. It is our world. is a beautiful tale Everyday, families and children have to struggle in order to stabilize this virus. Welcome to our world, the world of blue birds and all the people that love and take care of them. Élizabeth Bonneau-Bréant

98. SUBACUTE-SCLEROSING PANENCEPHALITIS: Contact A Family - For Families With Disabl Contact a Family is a UK charity for families with disabled children. We offerinformation on specific conditions and rare disorders. http://www.cafamily.org.uk/Direct/s64.html

printer friendly SUBACUTE-SCLEROSING PANENCEPHALITIS home how we can help medical information index of conditions ... how you can help Did you find this page helpful? yes no Subacute-Sclerosing Panencephalitis: SSPE Subacute Sclerosing Panencephalitis is a serious viral encephalitis of children and young adults. It is a late manifestation of measles virus infection, developing between usually 6 and 12 years after natural measles infection. Cases can also follow immunization with measles vaccine but at a lesser frequency than after natural measles. The annual incidence is about 1 per million. It is believed that measles immunisation significantly reduces the risk of developing SSPE. Males are more commonly affected, as are those living in rural areas. Mortality is very high. Those who survive do so with considerable intellectual and also physical impairment. The precise sequence of events that results in the development of this disease in a tiny proportion of the population is not known. The great majority of children who develop SSPE are known to have had an attack of classical measles, usually many years before. Over 50 per cent of cases have had the disease at the unusually early age of under two years. The onset of the illness is insidious, the first signs are behavioural disturbances or a decline in school performance. Not infrequently the family are told that the cause for these behavioural or school problems is 'psychological.' Progression of the illness will vary from child to child but evidence that this is a more serious illness usually begins with loss of motor control and co-ordination. This often starts with characteristic jerking movements which may at first appear as clumsiness. These jerking movements are known as myoclonic seizures. Grand mal (also called tonic-clonic) seizures may also occur. As the condition worsens problems with swallowing and speech develop and vision may be impaired.

99. Sclerosing Panencephalitis, Subacute (SSPE) Definition - Medical Dictionary Defi Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=6312

100. Penn State Faculty Research Expertise Database (FRED) sclerosing Leukoencephalitis, subacute, sclerosing panencephalitis, subacute.Leukoencephalitides, subacute sclerosing, Leukoencephalitis, Van Bogaert http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D013344

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