41. Subacute Sclerosing Panencephalitis (SSPE) Definition - Medical Dictionary Defin Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=6341

42. Subacute Sclerosing Panencephalitis Medical Information subacute sclerosing panencephalitis Information from Drugs.com. http://www.drugs.com/enc/subacute_sclerosing_panencephalitis.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Subacute sclerosing panencephalitis Injury Disease Nutrition Poison ... Central nervous system Subacute sclerosing panencephalitis Definition Subacute sclerosing panencephalitis (SSPE) is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles (rubeola) virus. A mutant virus is one that has undergone genetic changes (mutations). Alternative Names SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Causes Ordinarily, the measles virus does not cause brain damage, but certain mutant forms may invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, a dramatic decrease, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are reported each year.

43. ► Subacute Sclerosing Panencephalitis A medical encycopedia article on the topic subacute sclerosing panencephalitis. http://www.umm.edu/ency/article/001419.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Subacute sclerosing panencephalitis Overview Symptoms Treatment Prevention Definition: SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Alternative Names: SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Causes, incidence, and risk factors: Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are annually reported. SSPE tends to occur several years after having measles ( rubeola ), even though recovery from the illness appears to have been normal. More males are affected than females, and the disease generally occurs in children and adolescents.

44. AAP Grand Rounds -- Sign In Page subacute sclerosing panencephalitis in the differential diagnosis of encephalitis . Five cases of subacute sclerosing panencephalitis (SSPE) are reported http://aapgrandrounds.aappublications.org/cgi/content/full/13/2/18

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45. AAP Grand Rounds -- Sign In Page http://aapgrandrounds.aappublications.org/cgi/reprint/13/2/18

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This item requires a subscription. If you have an individual print subscription to AAP Grand Rounds , online access is included. PDF The Changing Character of Subacute Sclerosing Panencephalitis Millichap AAP Grand Rounds. This Article Full Text (HTML) Submit a response Alert me when this article is cited Alert me when eLetters are posted ... Alert me if a correction is posted Services E-mail this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to My File Cabinet ... Download to citation manager PubMed Articles by Millichap, J. G. To view this item, select one of the options below: Sign In: Please use your AAP ID Number or Temporary Activation Code for your User Name. User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Sign Up Become a Member - Join the American Academy of Pediatrics. Subscription Information HOME HELP FEEDBACK ... SEARCH

46. Subacute Sclerosing Panencephalitis Factsheet This leaflet explains about subacute sclerosing panencephalitis (SSPE) which isa rare disease of the brain which results in progressive loss of physical http://www.ich.ucl.ac.uk/factsheets/families/F040291/

Please use the alphabetical index below to find the factsheet you need. Top Top Top Top ... Top Subacute Sclerosing Panencephalitis Contents Introduction What is the cause? How is it diagnosed? Does it have any alternative name? ... Support Groups Introduction This leaflet explains about Subacute sclerosing panencephalitis (SSPE) which is a rare disease of the brain which results in progressive loss of physical and mental skills. What is the cause? SSPE is caused by an unusual response to the measles virus, which lingers in the brain and then reactivates, often many years after the original infection. The presence of the virus within the brain cells prevents them working properly and passing messages to each other. The brain is the control centre of the whole body so blockages in the messages to other parts of the body will prevent those parts working efficiently even though the parts themselves are quite healthy. How is it diagnosed?

47. Subacute Sclerosing Panencephalitis The Essentials on subacute sclerosing panencephalitis Guidelines. Overview The Genome Project and subacute sclerosing panencephalitis http://www.icongrouponline.com/health/Subacute_Sclerosing_Panencephalitis.html

ICON Health Publications Official Health Sourcebooks Search ICON Health Titles: The Official Parent's Sourcebook on SUBACUTE SCLEROSING PANENCEPHALITIS (Dawson encephalitis; Panencephalitis, Subacute Sclerosing) Revised and Updated for the Internet Age P A P E R B A C K Paperback Book Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Paperback Book Shipped in 3 to 5 business days E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Subacute Sclerosing Panencephalitis. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Dawson encephalitis; Panencephalitis, Subacute Sclerosing Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Subacute Sclerosing Panencephalitis: Guidelines Overview What Is Subacute Sclerosing Panencephalitis? Is There Any Treatment?

48. An Unusual Case Of Adult-Onset Subacute Sclerosing Panencephalitis (SSPE) An Unusual Case of AdultOnset subacute sclerosing panencephalitis (SSPE) T.KARNAUCHOW1*, JP ROSSITER1, P. ROTA3, WJ BELLINI3, M. MELANSON2 http://www.cacmid.ca/abstracts/a21.html

An Unusual Case of Adult-Onset Subacute Sclerosing Panencephalitis (SSPE) T. KARNAUCHOW *, J.P. ROSSITER , P. ROTA , W.J. BELLINI , M. MELANSON Departments of Pathology and of Neurology, Kingston General Hospital and Queen's University, Kingston, ON; Centers for Disease Control, Atlanta, GA OBJECTIVE: SSPE is a rare, progressive, fatal disease of the CNS caused by a persistent infection with measles virus (MV). Adult-onset SSPE is very uncommon, with >85% of cases occurring in the 5-15 year-old age group. We describe the case of a 31 year old Sri Lankan immigrant with SSPE. METHODS: Brain biopsy was examined by light and electron microscopy (EM) and by immunohistochemistry. MV was detected by RT-PCR, and sequencing of H and N genes was performed. RESULTS: A 31 year-old male presented with a one month history of right arm and hand weakness. His past medical history was significant for mild developmental delay, and for bilateral uveitis which stabilized with steroid treatment at the time of diagnosis (1990). Imaging studies showed multiple non-enhancing subcortical lesions, and electroencephalograms showed patterns suggestive of SSPE. MV CF IgG titers were 1:128 (serum), and 1:8 (CSF). Biopsy revealed numerous Cowdry type A inclusions in neurons within the cerebral cortex and in oligodendrocytes of the white matter. Unusually prominent white matter vacuolation was also observed. EM revealed an abundance of intracellular MV nucleocapsid structures. Diagnosis was confirmed by immunohistochemistry and by RT-PCR of MV RNA. Preliminary sequence analysis of H and N genes indicates that this is a wild-type MV, belonging to clade D. Further characterization of this virus will be reported.

49. ScienceDaily Browse Topics Health/Conditions_and_Diseases Gale Encyclopedia of Medicine subacute sclerosing panencephalitis The OfficialParent s Sourcebook on subacute sclerosing panencephalitis A Revised http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Neurologica

50. Log In Problems Read about a fatal case of a postinfectious neurologic complication of measlesin an internationally adopted child 9 years after he arrived in the United http://www.medscape.com/viewarticle/414739_print

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51. CJNS - Subacute Sclerosing Panencephalitis Presenting With Unilateral Periodic M Abstract Background subacute sclerosing panencephalitis (SSPE) is a rare Conclusions subacute sclerosing panencephalitis may have asymmetric http://www.cjns.org/30novtoc/subacute.html

Abstract Close Window Subacute Sclerosing Panencephalitis Presenting with Unilateral Periodic Myoclonic Jerks Zaitoon M. Shivji, Ibrahim S. Al-Zahrani, Yousef A. Al-Said, Mohammed M.S. Jan Abstract: Background: Case Report: A 12-year-old boy, who was seen at a later stage with atypical manifestation of myoclonic body jerks confined entirely unilaterally, combined with contralateral periodic EEG complexes. One could assume clinically that the more diseased hemisphere was responsible for generating the jerks. However, brain magnetic resonance imaging revealed asymmetric hemispheric changes suggesting that the less neurologically damaged hemisphere is responsible for generating the unilateral myoclonic jerks. This has led to the interpretation that the more severely damaged hemisphere has lost the neuronal connectivity required to generate these periodic myoclonic jerks. Conclusions: Subacute sclerosing panencephalitis may have asymmetric hemispheric involvement, not only early, but also in the advanced stages of the disease, which can result in unilateral periodic myoclonic jerks.

52. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis. neurology Chronic progressive illness seenin children a few years after measles infection and involving http://poisonevercure.150m.com/subacute_sclerosing_panencephali.htm

subacute sclerosing panencephalitis neurology Chronic progressive illness seen in children a few years after measles infection and involving demyelination of the cerebral cortex Virus apparently persists in brain cells : usually considered a slow virus disease (18 Nov 1997)

53. Arch Neurol -- Abstract: Substantial Spontaneous Long-term Improvement In Subacu Of 118 cases of subacute sclerosing panencephalitis identified in an extensivefollowup study subacute sclerosing panencephalitis in an Identical Twin http://archneur.ama-assn.org/cgi/content/abstract/35/8/494

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 35 No. 8, August 1978 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Risk WS Chemali R Articles that cite this article Contact me when this article is cited Substantial spontaneous long-term improvement in subacute sclerosing panencephalitis. Six cases from the Middle East and a review of the literature W. S. Risk, F. S. Haddad and R. Chemali Of 118 cases of subacute sclerosing panencephalitis identified in an extensive follow-up study in the Middle East, six patients were found by personal interview to have experienced substantial spontaneous long-term improvement. To our knowledge, this rate of 5% for such improvement is

54. Arch Neurol -- Abstract: Fulminating Adult-Onset Subacute Sclerosing Panencephal Arch Neurol. 2003;6011601161. Context subacute sclerosing panencephalitis (SSPE)is a rare, slow viral infection caused by a defective measles virus. http://archneur.ama-assn.org/cgi/content/abstract/60/8/1160

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 60 No. 8, August 2003 Featured Link E-mail Alerts Observation Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Gagnon A Bouchard RW Articles that cite this article ISI Web of Science (2) ... Contact me when this article is cited Topic Collections Viral Infections Encephalitis Topic Collection Alerts Fulminating Adult-Onset Subacute Sclerosing Panencephalitis in a 49-Year-Old Man Alexis Gagnon, MD Arch Neurol. Subacute sclerosing panencephalitis (SSPE) is a rare, slow viral infection caused by a defective measles virus. It is characterized by progressive mental deterioration associated with motor impairment and prominent myoclonus. In about 10% of all cases, the disease can progress rapidly and lead to death

55. Subacute Sclerosing Panencephalitis SSPE is a progressive, debilitating, and fatal brain disorder caused by infectionwith a mutant () virus (a measles virus that has undergone certain genetic http://adam.about.com/encyclopedia/001419.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zCMt='a00' About Healthcare Center Healthcare Center Essentials ... Surgeries and Procedures zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Allergies Arthritis Asthma Breast Cancer ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/7.htm','');w(xb+xb); Search Healthcare Center ENCYCLOPEDIA INDEX Injury Disease Nutrition Poison ... Z Subacute sclerosing panencephalitis Overview Symptoms Treatment Prevention Definition: SSPE is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles rubeola ) virus (a measles virus that has undergone certain genetic changes or mutations). Alternative Names: SSPE; Subacute sclerosing leukoencephalitis; Dawsons encephalitis Causes, incidence, and risk factors: Measles virus usually doesn't cause brain damage, but certain mutant forms can invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, decreasing the frequency of this disease dramatically, following the nationwide

56. Entrez PubMed subacute sclerosing panencephalitis (SSPE), a neurodegenerative disease causedby a persistent slow virus infection with a mutated measles virus, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8

57. Entrez PubMed subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorderof childhood and early adolescence. It is caused by persistent defective http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

58. Subacute Sclerosing Panencephalitis Topic - Unified Search Environment subacute sclerosing panencephalitis MSH/MH/D013344 DXP/DI/U001404 ICD9CM/PT/046.2 LCH/PT/U004505 CSP/PT/20422360 MSH/PM/D013344 MSH/PM/D013344 http://www.use.hcn.com.au/portals/shared/subject.`Subacute Sclerosing Panencepha

Subacute Sclerosing Panencephalitis Topic Tree Definition: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8) Synonyms and Source Vocabularies: Subacute Sclerosing Panencephalitis Dawson's encephalitis SSPE Van Bogaert's Leukoencephalitis Leukoencephalitis, Subacute Sclerosing DEMENTIA, DECEREBRATE Dawson's inclusion body encephalitis Van Bogaert's sclerosing leukoencephalitis subacute inclusion body encephalitis subacute sclerosing leukoencephalopathy Measles Inclusion Body Encephalitis Encephaltis, Inclusion Body, Measles

59. SUBACUTE SCLEROSING PANENCEPHALITIS DAWSON’S ENCEPHALITIS REVISITED PEDIATRIC O subacute sclerosing panencephalitis DAWSON’S ENCEPHALITIS REVISITED PEDIATRIC ONCALL. http://www.pediatriconcall.com/fordoctor/casereports/sspe.asp

DOCTOR CORNER Search GO Home Back Ask Doctor Post Query Education Image Gallery Teaching Files Question of the day Specialist Answers Latest Updates Conference Journal Search Original Articles Clinical Trials Search For Pediatricians Hospitals Special Schools Drug Index ... Sign Out SUBACUTE SCLEROSING PANENCEPHALITIS (DAWSON’S ENCEPHALITIS) – REVISITED UserName Password New Register Forgot password Dr.Ira Shah M.D, DNB, DCH(Gold Medalist), FCPS Case Report: Discussion: Subacute Sclerosing Panencephalitis (SSPE) is rare chronic encephalitis caused by persistent measles virus infection of the central nervous system. It was first described by Dawson in 1933. The incidence of SSPE has decreased over years since the introduction of live attenuated measles vaccine. Infact, in USA after 1982, less than 5 new cases have been registered from the entire country. Children with SSPE are more likely to have been infected with natural measles than vaccine virus. The risk of SSPE after measles is 4.0 in 1,00,000 cases as compared to a risk after measles vaccine of 0.14 in 1,00,000 cases. When measles is contracted in children younger than 1 year of age, the risk for SSPE is 16 times greater than when measles is contracted in children older than 5 years of age. The median interval between measles and onset of SSPE is 8 years. No adequate treatment is currently available. Administration of inosiplex (100 mg/kg/d) may prolong survival. Administration of interferon is of uncertain benefit. Carbamazepine is recommended for myoclonus induced falling episodes. Measles vaccination is the most important measure to prevent SSPE.

60. Karger Publishers subacute sclerosing panencephalitis in Bulgaria (19782002) The epidemiologyof subacute sclerosing panencephalitis (SSPE) has changed substantially http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowFulltext&ProduktNr=

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