1. NORD - National Organization For Rare Disorders, Inc. Offers the synonyms, a general discussion and further resources. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Subacute Scle

2. MedlinePlus Medical Encyclopedia: Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/001419.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Subacute sclerosing panencephalitis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top SSPE; Subacute sclerosing leukoencephalitis; Dawson´s encephalitis Definition Return to top Subacute sclerosing panencephalitis (SSPE) is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant measles (rubeola) virus. A mutant virus is one that has undergone genetic changes (mutations). Causes, incidence, and risk factors Return to top Ordinarily, the measles virus does not cause brain damage, but certain mutant forms may invade the brain, causing severe illness and death. SSPE has been reported in all parts of the world, but in western countries it is considered a rare disease. Fewer than 10 cases per year are reported in the United States, a dramatic decrease, following the nationwide measles immunization program. However, in some countries like India, over 20 cases of SSPE per million people are reported each year. SSPE tends to occur several years after an individual has measles (rubeola), even though the person seems to have fully recovered from the illness. Males are more often affected than females, and the disease generally occurs in children and adolescents.

3. Subacute Sclerosing Panencephalitis - Online Neuropathology Atlas subacute sclerosing panencephalitis Subacute sclerosing encephalitis, SSPE,nuclear inclusion Subacute sclerosing encephalitis, SSPE, http://www.neuropat.dote.hu/panenc.htm

Subacute sclerosing panencephalitis Panencephalitis subacuta sclerotisans Macroscopic Appearance Perivascular Infiltration Mononuclear Infiltration ... Nuclear Inclusion Click on any image for larger view. Relevant Web Sites: Baylor Neurology Case of the Month Subacute Sclerosing Pancephalitis - Kansas University Infection Internet Handbook of Neurology var site="sm5hegeduskdote" Last modified: February 17, 2001 If you have any comments, please, contact Neuroanatomy Structures Online Neuropathology Atlas Internet Handbook of Neurology

4. Subacute Sclerosing Panencephalitis - Online Neuropathology Atlas subacute sclerosing panencephalitis Panencephalitis subacuta sclerotisans. Macroscopic Appearance Perivascular Infiltration (H E) Mononuclear http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Introduction: Subacute Sclerosing Panencephalitis - WrongDiagnosis.com Introduction to subacute sclerosing panencephalitis as a medical conditionincluding symptoms, diagnosis, misdiagnosis, treatment, prevention, http://www.wrongdiagnosis.com/s/subacute_sclerosing_panencephalitis/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Subacute Sclerosing Panencephalitis Next sections Basic Summary for Subacute Sclerosing Panencephalitis Prevalence and Incidence of Subacute Sclerosing Panencephalitis Prognosis of Subacute Sclerosing Panencephalitis Causes of Subacute Sclerosing Panencephalitis ... Symptoms of Subacute Sclerosing Panencephalitis Next chapters: Syncope Syringomyelia Tardive Dyskinesia Tethered Spinal Cord Syndrome ... Feedback Introduction: Subacute Sclerosing Panencephalitis Subacute Sclerosing Panencephalitis: Rare brain condition arising years after measles infection. Subacute Sclerosing Panencephalitis: Subacute sclerosing panencephalitis (SSPE) is caused by a reaction to the measles virus. It can occur anywhere from 2 to 10 years after the original measles illness, and generally results in progressive neurological deterioration due to brain inflammation. Researching symptoms of Subacute Sclerosing Panencephalitis: Further information about the symptoms of Subacute Sclerosing Panencephalitis is available including a list of symptoms of Subacute Sclerosing Panencephalitis , or alternatively return to research other symptoms in the symptom center Treatments for Subacute Sclerosing Panencephalitis: Various information is available about treatments available for Subacute Sclerosing Panencephalitis , or research treatments for other diseases.

6. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Parenchymal An article about subacute sclerosing panencephalitis written by Gary Baumbach, M.D. http://www.vh.org/Providers/TeachingFiles/CNSInfDisR2/Text/PInf.VSSP.html

Infectious Diseases of the Central Nervous System Parenchymal Infections: Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed Subacute sclerosing panencephalitis (SSPE) is one of three types of encephalitis that may occur secondary to measles virus. The other two types are 1) an acute encephalitis characterized by lymphocytic infiltrates in meninges and around vessels associated with the acute rash of measles, and 2) a post-measles demyelinating process which is probably an autoimmune hyperallergenic phenomenon. In this tutorial only subacute sclerosing panencephalitis will be discussed. Subacute sclerosing panencephalitis develops following the reactivation of the latent measles virus. Clinically, it is insidious in its onset, and is characterized by progressive motor and mental deterioration with myoclonus. The course usually runs from 1 to 3 years. The frequency of SSPE is about 1 in 1 million, there is a male-to-female ratio of 4:1, and 85% of the cases arise in a rural environment. The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide

7. THE MERCK MANUAL, Sec. 19, Ch. 265, Childhood Infections subacute sclerosing panencephalitis A progressive, usually fatal, brain disorder occurring months to usually years after an attack of measles and http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. Symptoms Of Subacute Sclerosing Panencephalitis - WrongDiagnosis.com Symptoms of subacute sclerosing panencephalitis including signs, symptoms,incubation period, duration, and correct diagnosis. http://www.wrongdiagnosis.com/s/subacute_sclerosing_panencephalitis/symptoms.htm

Home Symptoms Diseases Risks ... Subacute Sclerosing Panencephalitis Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Subacute Sclerosing Panencephalitis Next sections Misdiagnosis of Underlying Causes of Subacute Sclerosing Panencephalitis Treatments for Subacute Sclerosing Panencephalitis Statistics about Subacute Sclerosing Panencephalitis Statistics by Country for Subacute Sclerosing Panencephalitis ... Articles about Subacute Sclerosing Panencephalitis Next chapters: Syncope Syringomyelia Tardive Dyskinesia Tethered Spinal Cord Syndrome ... Feedback Symptoms of Subacute Sclerosing Panencephalitis General information about symptoms of Subacute Sclerosing Panencephalitis: The symptom information on this page attempts to provide a list of some possible symptoms of Subacute Sclerosing Panencephalitis. This symptom information has been gathered from various sources, may not be fully accurate, and may not be the full list of symptoms of Subacute Sclerosing Panencephalitis. Furthermore, symptoms of Subacute Sclerosing Panencephalitis may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of symptoms and whether they are indeed symptoms of Subacute Sclerosing Panencephalitis. List of symptoms of Subacute Sclerosing Panencephalitis: The list of symptoms mentioned in various sources for Subacute Sclerosing Panencephalitis includes:

9. MedlinePlus Medical Encyclopedia Subacute Sclerosing subacute sclerosing panencephalitis, a definition and a look at the causes, incidence and risk factors. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. Subacute Sclerosing Panencephalitis Information Page: National Institute Of Neur subacute sclerosing panencephalitis information sheet compiled by NINDS, theNational Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/subacute_panencephalitis/subacute_panencephal

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Subacute Sclerosing Panencephalitis Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Subacute Sclerosing Panencephalitis NINDS Subacute Sclerosing Panencephalitis Information Page Synonym(s): Dawson Disease Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Subacute Sclerosing Panencephalitis? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Subacute Sclerosing Panencephalitis? Is there any treatment? What is the prognosis? When not treated with immunomodulators (interferon) and antivirals (ribavirin and inosine pranobex) SSPE is almost always a fatal disease. Death usually occurs between 1 and 3 years after onset, although some spontaneous remissions (up to 5%) have been reported. What research is being done?

11. Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis (SSPE) is a progressive, debilitating, and fatal brain disorder caused by infection with a mutant (rubeola) http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Parenchymal Parenchymal Infections subacute sclerosing panencephalitis Subacute sclerosingpanencephalitis (SSPE) is one of three types of encephalitis that may http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/PInf.VSSP.html

Infectious Diseases of the Central Nervous System Parenchymal Infections: Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed Subacute sclerosing panencephalitis (SSPE) is one of three types of encephalitis that may occur secondary to measles virus. The other two types are 1) an acute encephalitis characterized by lymphocytic infiltrates in meninges and around vessels associated with the acute rash of measles, and 2) a post-measles demyelinating process which is probably an autoimmune hyperallergenic phenomenon. In this tutorial only subacute sclerosing panencephalitis will be discussed. Subacute sclerosing panencephalitis develops following the reactivation of the latent measles virus. Clinically, it is insidious in its onset, and is characterized by progressive motor and mental deterioration with myoclonus. The course usually runs from 1 to 3 years. The frequency of SSPE is about 1 in 1 million, there is a male-to-female ratio of 4:1, and 85% of the cases arise in a rural environment. The gross pathology of subacute sclerosing panencephalitis, which is shown on this slide

13. CPS CPSP Resource Article Subacute Sclerosing Panencephalitis subacute sclerosing panencephalitis in Perspective CPSP resource article published September 2000 Principal investigator W. Walop, PhD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Virtual Hospital: Infectious Diseases Of The Central Nervous System: Subacute Sc subacute sclerosing panencephalitis. Gary Baumbach, MD, Department of Pathology, The histology of subacute sclerosing panencephalitis is nicely http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/229.html

Infectious Diseases of the Central Nervous System Subacute Sclerosing Panencephalitis Gary Baumbach, M.D., Department of Pathology, University of Iowa College of Medicine Peer Review Status: Internally Peer Reviewed The histology of subacute sclerosing panencephalitis is nicely demonstrated on this slide. Note the perivascular lymphocytic infiltrates, the intense gliosis, and the virtual lack of any normal histological features in the background. Section Top Title Page Virtual Hospital Home Virtual Children's Hospital Home ... University of Iowa http://www.vh.org/adult/provider/pathology/CNSInfDisR2/Text/229.html

15. Subacute Sclerosing Panencephalitis Surveillance United States subacute sclerosing panencephalitis Surveillance United States http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. CPS: CPSP Resource Article Subacute Sclerosing Panencephalitis Quality information on children s health and wellbeing, such as vaccination,pregnancy, infant care, healthy eating, common illnesses, safety, http://www.cps.ca/english/CPSP/Resources/Rsspe.htm

Subacute Sclerosing Panencephalitis in Perspective CPSP resource article published September 2000 Principal investigator : W. Walop, PhD Three different forms of infections in the central nervous system have been associated with the measles virus: acute postinfectious encephalitis, acute progressive infectious encephalitis (also known as measles inclusion body encephalitis or MIBE) and subacute sclerosing panencephalitis (SSPE). The postinfectious encephalitis is considered an autoimmune reaction, MIBE appears as a direct attack by the virus on the brain cells, while SSPE is a slow viral infection of the central nervous system, usually resulting in death within months or years. Can measles vaccine cause MIBE? From 1995 to 1998, no definite cases of SSPE were reported through the Canadian Paediatric Surveillance Program (CPSP). In 1999, however, two definite cases, as defined by very high serum and CSF IgG ratios in the presence of typical clinical manifestations, were identified through the CPSP. There also was a Canadian case report on MIBE caused by the vaccine strain of the measles virus, published in 1999.

17. Subacute Sclerosing Panencephalitis Garg 78 (916) 63 subacute sclerosing panencephalitis R K Garg http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. CPS: CPSP Subacute Sclerosing Panencephalitis Quality information on children s health and wellbeing, such as vaccination,pregnancy, infant care, healthy eating, common illnesses, safety, http://www.cps.ca/english/CPSP/Studies/panencephalitis.htm

Subacute sclerosing panencephalitis Duration of study Principal investigator Dr. Wikke Walop, Division of Immunization, Bureau of Infectious Diseases, Laboratory Centre for Disease Control, Tunney's Pasture 0603E1, Ottawa ON Study publications/presentations CPSP resource Subacute Sclerosing Panencephalitis in Perspective CPSP highlight What does the CPSP have to do with public health? Publication The Canadian Paediatric Surveillance Program: Beyond collecting numbers Presentations Subacute sclerosing panencephalitis: A report on the Canadian Pediatric Surveillance Program The Canadian Paediatric Surveillance Program (CPSP): An epidemiological tool in action The Canadian Paediatric Surveillance Canadian Paediatric Surveillance Program (CPSP): Congenital rubella syndrome (CRS), subacute sclerosing panencephalitis (SSPE) and acute flaccid paralysis (AFP): Relationship of frequency to vaccine status Home ... Site map

19. Subacute Sclerosing Panencephalitis Findings At MR Imaging subacute sclerosing panencephalitis Findings at MR Imaging, Diffusion MR Imaging, and Proton MR Spectroscopy R. Nuri Senera http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Subacute Sclerosing Panencephalitis, A Measles Complication, In An International subacute sclerosing panencephalitis (SSPE), a postinfectious neurologic Symposium to ICNA/CNS subacute sclerosing panencephalitis meeting Update. http://www.cdc.gov/ncidod/eid/vol6no4/bonthius.htm

Past Issue Vol. 6, No. 4 Jul–Aug 2000 Download Article PDF Help Feedback Dispatch Subacute Sclerosing Panencephalitis, a Measles Complication, in an Internationally Adopted Child Daniel J. Bonthius,* Nicholas Stanek,† and Charles Grose* *Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA; †Department of Neurology, Medical Associates Clinic, Dubuque, Iowa, USA A healthy 13-year-old boy who had spent the first 4.5 years of his life in an orphanage in Thailand before adoption by an American couple became ill with subacute sclerosing panencephalitis and died several months later. The boy had most likely contracted wild-type measles in Thailand. Measles complications are a risk in international adoptions. Undiagnosed infections in internationally adopted children have been receiving increasing attention throughout the past decade. HIV, hepatitis viruses, Treponema pallidum Mycobacterium tuberculosis , and intestinal parasites frequently complicate such adoptions ( ). Subacute sclerosing panencephalitis (SSPE), a postinfectious neurologic complication of measles, can also occur. We describe a fatal case of SSPE in an internationally adopted child 9 years after he arrived in the United States. Case Report A 13-year-old boy of Thai descent was referred to the pediatric neurology clinic at the University of Iowa Hospital with cognitive difficulties and a progressive movement disorder. The boy was born in 1984 and spent the first 4 ½ years of his life in an orphanage in Thailand before being adopted by an American couple from Dubuque, Iowa. His adoptive parents were told by the adoption agency that the boy's medical history was unremarkable. No history of measles was reported. At adoption, the child appeared healthy and well nourished, and at no time afterwards did he have an illness suggestive of measles. Shortly after arrival, he displayed a short attention span and easy distractibility, for which he was eventually diagnosed with attention deficit hyperactivity disorder. He was treated with low-dose methylphenidate for several years with good results.

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