1. Stiff-Person Syndrome An article about stiffperson syndrome, a rare progressive neurological disorder. http://healthlink.mcw.edu/article/921988627.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Stiff-Person Syndrome Stiff-person syndrome is a rare progressive neurological disorder characterized by constant painful contractions and spasms of voluntary muscles, particularly the muscles of the back and upper legs. Symptoms may occur gradually, spreading from the back and legs to involve the arms and neck. Symptoms may worsen when the affected individual is anxious or exposed to sudden motion or noise. Affected muscles may become twisted and contracted, resulting in bone fractures in the most severe cases. Individuals with stiff-person syndrome may have difficulty making sudden movements and may have a stiff-legged, unsteady gait. Sleep usually suppresses frequency of contractions. Stiffness may increase and patients may develop a hunched posture (kyphosis) or a swayback (lordosis). Researchers theorize that stiff-person syndrome may be an autoimmune disorder. Other autoimmune disorders such as diabetes, pernicious anemia (a chronic, progressive blood disorder), and thyroiditis (inflammation of the thyroid gland) may occur more frequently in patients with stiff-person syndrome.

2. NINDS Forwarding Page Information sheet compiled by National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/stiffperson_doc.htm

NINDS has redesigned its website and the URL for the page you were seeking has changed. The new URL for this page is /disorders/stiffperson/stiffperson.htm . Please update your bookmark to this page. You will be automatically taken to this page in 5 seconds, or you can click the link to go there now.

3. Stiff-Person Syndrome Information Page National Institute Of Stiffperson (stiff-man syndrome) information sheet compiled by NINDS. http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. Stiff-Person Syndrome An article about stiffperson syndrome, a rare progressive neurological disorder. http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Stiff-Person Syndrome Information Page: National Institute Of Neurological Disor Stiffperson (stiff-man syndrome) information sheet compiled by NINDS. http://www.ninds.nih.gov/disorders/stiffperson/stiffperson.htm

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Stiff-Person Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Stiff-Person Syndrome NINDS Stiff-Person Syndrome Information Page Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Stiff-Person Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Stiff-Person Syndrome? Is there any treatment? The drug diazepam, which relaxes the muscles, provides improvement in most cases. Baclofen, phenytoin, clonidine, or tizanidine may provide additional benefit. In some patients, immunomodulatory treatments such as intravenous immunoglobulin may be beneficial. Physical and rehabilitation therapy may also be needed. What is the prognosis?

6. The Stiff-Person Syndrome An Autoimmune Disorder Affecting The stiffperson syndrome An Autoimmune Disorder Affecting Neurotransmission of -Aminobutyric Acid Lucien M. Levy, MD, PhD, Moderator http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Stiff-Person Syndrome Press Releases: National Institute Of Neurological Disorde Stiffperson (stiff-man syndrome) information sheet compiled by NINDS. http://www.ninds.nih.gov/disorders/stiffperson/press_stiffperson.htm

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Stiff-Person Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Stiff-Person Syndrome Sorry! There are no press releases for: Stiff-Person Syndrome. Use your browser's Back button to return to your previous activity. National Institute of Neurological Disorders and Stroke Home About NINDS Disorders Funding ... Accessibility

8. The Stiff-Person Syndrome An Autoimmune Disorder Affecting The stiffperson syndrome An Autoimmune Disorder Affecting Neurotransmission of -Aminobutyric Acid Lucien M. Levy, MD, PhD, Moderator http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Introduction: Stiff-Person Syndrome - WrongDiagnosis.com Introduction to stiffperson syndrome as a medical condition including symptoms,diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/s/stiff_person_syndrome/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Stiff-Person Syndrome Next sections Basic Summary for Stiff-Person Syndrome Prevalence and Incidence of Stiff-Person Syndrome Prognosis of Stiff-Person Syndrome Causes of Stiff-Person Syndrome ... Symptoms of Stiff-Person Syndrome Next chapters: Sturge-Weber Syndrome Subacute Sclerosing Panencephalitis Syncope Syringomyelia ... Feedback Introduction: Stiff-Person Syndrome Stiff-Person Syndrome: A very rare autoimmune disorder of the central nervous system causing various symptoms, but also sometimes diabetes . The patient usually has anti-GAD antibodies, and about half get a type of secondary diabetes from SMS. Stiff-Person Syndrome: Stiff-person syndrome is a rare progressive neurological disorder characterized by constant painful contractions and spasms of voluntary muscles, particularly the muscles of the back and upper legs. Researching symptoms of Stiff-Person Syndrome: Further information about the symptoms of Stiff-Person Syndrome is available including a list of symptoms of Stiff-Person Syndrome , or alternatively return to research other symptoms in the symptom center Treatments for Stiff-Person Syndrome: Various information is available about treatments available for Stiff-Person Syndrome current research about Stiff-Person Syndrome treatments , or research treatments for other diseases.

10. Humoral And Cellular Autoimmune Responses In Stiff Person Syndrome Humoral and Cellular Autoimmune Responses in Stiff Person Syndrome TOBIAS LOHMANNa , MARCO LONDEIb , MOHAMMED HAWAc and R. DAVID G. LESLIEc http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Article: NINDS Stiff-Person Syndrome Information Page: NINDS - WrongDiagnosis.co Medical article NINDS stiffperson syndrome Information Page NINDS including allsymptom, diagnosis, misdiagnosis, treatment and prevention information. http://www.wrongdiagnosis.com/artic/ninds_stiff_person_syndrome_information_page

Home Symptoms Diseases Risks ... Newsletter Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: NINDS Stiff-Person Syndrome Information Page: NINDS Next chapters: NINDS Stroke Information Page: NINDS NINDS Sturge-Weber Syndrome Information Page: NINDS NINDS Subacute Sclerosing Panencephalitis Information Page: NINDS NINDS Sydenham Chorea Information Page: NINDS ... Feedback NINDS Stiff-Person Syndrome Information Page: NINDS Article title: NINDS Stiff-Person Syndrome Information Page: NINDS Main condition: Stiff-Person Syndrome Conditions: Stiff-Person Syndrome What is Stiff-Person Syndrome? Is there any treatment? The drug diazepam, which relaxes the muscles, provides improvement in most cases. Baclofen, phenytoin, clonidine, or tizanidine may provide additional benefit. Physical and rehabilitation therapy may also be needed. What is the prognosis? There is no cure for stiff-person syndrome. The long-term prognosis for individuals with stiff-person syndrome is uncertain. Management of the disorder with drug therapy may provide significant improvements and relief of symptoms.

12. Immunotherapy Treatment Shows Dramatic Results For Rare Immunotherapy Treatment Shows Dramatic Results For Rare Neurological Disorder Stiff Person Syndrome http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Stiff Person Syndrome stiffperson syndrome is an extremely rare progressive neurological disorder characterized by persistent stiffness (rigidity) and spasms of certain http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Stiff-person Syndrome Research Researchers at RuprechtKarls-University in Heidelberg, Germany, investigatedwhether the excitability of neurons in the motor cortex is enhanced in http://rarediseases.about.com/b/a/119474.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/7.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stiff-person syndrome research Rare/Orphan Diseases Blog Main From Mary Kugler Your Guide to Rare / Orphan Diseases FREE Newsletter. Sign Up Now! October 16, 2004 Stiff-person syndrome research Researchers at Ruprecht-Karls-University in Heidelberg, Germany, investigated whether the excitability of neurons in the motor cortex is enhanced in stiff-person syndrome , and if this is related to autoimmunity against glutamic acid decarboxylase (GAD). They compared 21 individuals with stiff-person syndrome with 14 age-matched controls using testing of motor neuron excitability. They also examined the levels of anti-GAD antibodies in the blood and cerebrospinal fluid. The findings suggested that motor neuron hyperexcitability in stiff-person syndrome is related to anti-GAD autoimmunity. The research was published in the April 2004 issue of Neurology Email to a Friend Display Latest Headlines Read Archives powered by Movable Type Advertisement Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Charcot-Marie-Tooth Disease Peyronie's Disease Twin-to-Twin Transfusion Synd Autoimmune Kidney Disease ... Cri-du-Chat Syndrome adunitCM(150,100,'x55')

15. Arch Neurol Abstract Stiff-Person Syndrome Following West Nile Neuropathology Collection Email Alerts stiff-person syndrome Following West Nile Fever Sharon Hassin-Baer, MD ; Eilon D. Kirson, MD, PhD http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Stiff-Person Syndrome stiffperson syndrome stiff-person syndrome is a rare progressive neurological Individuals with stiff-person syndrome may have difficulty making http://www.health-nexus.com/stiff-person_syndrome1.htm

The #1 Health information site Health-Nexus.Net Health-Nexus.Org Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Stiff-Person Syndrome Stiff-Person Syndrome ... Stiff-Person Syndrome Stiff-person syndrome is a rare progressive neurological ... severe cases. Individuals with stiff-person syndrome may have difficulty making ... Stiff Person Syndrome Health, nutrition, and fitness from a Christian perspective. ... and Fitness: Stiff Person Syndrome Stiff Person Syndrome: Part One Stiff Person Syndrome: Part Two Stiff Person Syndrome Sites Subject ... Cleveland Clinic - Stiff-Person Syndrome Provided is a description of this rare disease, followed by a discussion about the treatment and prognosis. eMedicine - Stiff Person Syndrome : Article by Nancy Rodgers- ... Stiff Person Syndrome - Stiff person syndrome is rather unique among neurologic diagnoses because of its lack of significant similarity to any other neurologic ... Stiff Person Syndrome Sites Web sites devoted to health, nutrition, and fitness. ... Most of the links below are direct links to pages on stiff person syndrome (SPS, a.k.a. ...

17. Clinical Study 02-N-0122, Natural History And Immunopathogenesis Of MR Spectroscopy GAD Recruitment Keyword(s) Stiff Person Syndrome SPS Condition(s) stiffperson syndrome Investigational Drug(s) http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. Stiff Person Syndrome And Anesthesia Case Report Bouw Et Al. 97 Stiff Person Syndrome and Anesthesia Case Report Jans Bouw, MD* , Karin Leendertse, MD* , Marina A. J. Tijssen, MD PhD , and http://tmsyn.an.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Clinical Trial: Cause, Development, And Progression Of Stiff-Person Syndrome stiffperson syndrome (SPS) is a progressive neurological disorder characterized by The stiff-person syndrome an autoimmune disorder affecting http://www.clinicaltrials.gov/ct/show/NCT00030940

Home Search Browse Resources ... About Cause, Development, and Progression of Stiff-Person Syndrome This study is currently recruiting patients. Verified by National Institutes of Health Clinical Center (CC) February 3, 2005 Sponsored by: National Institute of Neurological Disorders and Stroke (NINDS) Information provided by: National Institutes of Health Clinical Center (CC) ClinicalTrials.gov Identifier: Purpose This study will explore the role of various immune factors involved in producing the disease symptoms in stiff-person syndrome (SPS) and follow disease progression in patients. SPS is a progressive disease in which unexpected noises, touches or stressful events set off muscle spasms and stiffness. It is thought to be an autoimmune disease in which the body produces antibodies that attack certain healthy tissues. A better understanding of the disease may help researchers design new therapies. Patients of any age with SPS may be eligible for this study, except those who: - Lack of serum anti-GAD antibodies - Have very advanced disease that precludes traveling - Have severe cardiovascular, renal, or other end-organ-disease states

20. Neurology -- Sign In Page GAD antibodies in stiffperson syndrome Fujii M, Li M, Lutfi B, Kyhos J,McElroy B. High dose intravenous immune globulin for stiff-person syndrome. http://www.neurology.org/cgi/content/full/63/11/1999

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This item requires a subscription to Neurology Online. Full Text GAD antibodies in stiff-person syndrome Chang and Lang Neurology. This Article Full Text (PDF) Correspondence: Submit a response ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Chang, T. Articles by Lang, B. Related Collections Stiff person syndrome All Immunology Autoimmune diseases To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$20.00 Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

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