21. HONselect - Stevens-Johnson Syndrome Français, StevensJohnson, syndrome, - Ectodermose érosive pluriorificielle -Fiessinger-Rendu, syndrome. Deutsch, Stevens-Johnson-Syndrom http://www.hon.ch/HONselect/RareDiseases/C07.465.864.558.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Stevens-Johnson Syndrome - Stevens Johnson Syndrome Français: Stevens-Johnson, syndrome - Ectodermose érosive pluriorificielle - Fiessinger-Rendu, syndrome Deutsch: Stevens-Johnson-Syndrom - Erythema multiforme exsudativum majus Español: Síndrome de Stevens-Johnson Português: Síndrome de Stevens-Johnson HONselect ressources Definition: Yes Articles: Yes Images: Yes News: No Conferences: No Clinical trials: No Web sites: English Yes Français Yes Deutsch Yes Español No Português No Home About us Site map Search ... Contact http://www.hon.ch/HONselect/RareDiseases/C07.465.864.558.html Last modified: Wed May 18 2005

22. Stevens-Johnson Syndrome - Stevens Johnson Syndrome - Information Page With HONs A variant of bullous erythema multiforme. It ranges from mild skin and mucous me http://www.hon.ch/HONselect/RareDiseases/EN/C07.465.864.558.html

InitBulle("navy","#F8F8F8","#000066",1); HONcode sites All Web sites HONselect News ... Images HONselect Search English French German Spanish Portuguese the word the part of word in MeSH term in MeSH term and description Information on "Stevens-Johnson Syndrome": Medical hierarchy and definition Research Articles Web resources Medical Images Medical News Medical Conferences Clinical Trials Hierarchy English French German Spanish Portuguese Stevens-Johnson Syndrome Definition: A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown. Synonym(s): Stevens Johnson Syndrome / See also: Erythema Multiforme Browse New search Web resources for "Stevens-Johnson Syndrome" English = Site with HON description - = Site with a robot description info: enter the site: (click below) domain of the site: Introduction: Stevens-Johnson Syndrome - WrongDiagnosis.com www.wrongdiagnosis.com www.stevensjohnsonsyndrome.com

23. Stevens-Johnson Syndrome DESCRIPTION Until recently stevensjohnson syndrome (SJS) was considered to be 695.1 Erythema multiforme (includes stevens-johnson syndrome and toxic http://www.5mcc.com/Assets/SUMMARY/TP0875.html

Stevens-Johnson syndrome DESCRIPTION: Until recently Stevens-Johnson syndrome (SJS) was considered to be the same as erythema multiforme major, a severe form of erythema multiforme in which more than one mucosal surface was involved. Now it is thought that erythema multiforme spectrum is a single entity. The milder form, also known as erythema multiforme-Hebra, either has no mucous membrane involvement, or may involve one mucous membrane. The more severe form is erythema multiforme major, involving more than one mucus membrane. In both these variants, it is a self limited hypersensitivity reaction, usually to a preceding viral infection, and has an excellent prognosis. SJS is a generalized hypersensitivity reaction, usually to a drug, in which the skin and mucus membrane lesions are early manifestation. It may progress to its more severe form, toxic epidermal necrolysis which has a high morbidity and up to 40% mortality. System(s) affected: Skin/exocrine, Nervous, Cardiovascular, Renal/Urologic, Hemic/Lymphatic/Immunologic Genetics: Possibly associated with HLA-B15 Incidence/Prevalence in USA: Difficult to estimate because of confusion with erythema multiforme major, perhaps 0.1/100,000, or less.

24. Treatment Of Severe Drug Reactions: Stevens-Johnson Syndrome, Toxic Epidermal Ne 1. stevensjohnson syndrome and Toxic epidermal necrolysis Medication useand the risk of stevens-johnson syndrome or toxic epidermal necrolysis. http://dermatology.cdlib.org/DOJvol8num1/reviews/drugrxn/ghislain.html

DOJ Contents Treatment of severe drug reactions: Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis and Hypersensitivity syndrome Pierre-Dominique Ghislain M.D., Jean-Claude Roujeau, M.D. Dermatology Online Journal 8(1): 5 Department of Dermatology, H6pital Henri Mondor, Universit6 Paris XII, Cr6teil, France Abstract Severe skin adverse drug reactions can result in death. Toxic epidermal necrolysis (TEN) has the highest mortality (30-35%); Stevens-Johnson syndrome and transitional forms correspond to the same syndrome, but with less extensive skin detachment and a lower mortality (5-15%). Hypersensitivity syndrome, sometimes called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), has a mortality rate evaluated at about 10%. Drug reactions are self-limited diseases and therefore, generally treatment is symptomatic. Prompt diagnosis, identification of, and early withdrawal of all suspect drugs are the most important preliminaries. The management of the patients must be undertaken in specialized intensive care units, with the same main types of therapy as for burns: warming of the enviromnent, correction of electrolyte disturbances, administration of a high caloric enteral intake, and prevention of sepsis. Efficacy of drugs used in some case reports is difficult to evaluate: intravenous immunoglobulins, cyclosporin, cyclophosphamide, pentoxyfilline, and thalidomide have all been tried. Corticosteroid use is debated and is probably deleterious in late forms of TEN. For DRESS, corticoids are used in cases of life-threatening systemic impairment. Specific nursing care and adequate topical management reduce associated morbidity and allow a more rapid re-epithelialization of skin lesions.

25. Stevens-Johnson Syndrome Associated With Single High Dose Of Lamotrigine In A Pa Exact rates of stevensjohnson syndrome with lamotrigine are not known, stevens-johnson syndrome was linked in this case with a single higher dose of http://dermatology.cdlib.org/111/correspondence/lamotrigine/famularo.html

DOJ Contents Stevens-Johnson syndrome associated with single high dose of lamotrigine in a patient taking valproate Giuseppe Famularo MD PhD , Claudio De Simone MD , Giovanni Minisola MD Dermatology Online Journal 11 (1): 25 1. Department of Internal Medicine, San Camillo Hospital, Rome, Italy. gfamularo@scamilloforlanini.rm.it2. Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy. cdesimone@uni.net 3. Departmnt of Internal Medicine, San Camillo Hospital, Rome, Italy. gminisola@scamilloforlanini.rm.it The overall incidence of lamotrigine-induced serious rash is approximately 0.3 percent in adult patients with epilepsy receiving adjunctive therapy, and this risk seems to be largely confined to the first months of treatment [ ]. Exact rates of Stevens-Johnson syndrome with lamotrigine are not known, but are reported as 0.02 percent in adults from the German Rash Registry [ ]. This case history along with the lack of other potential confounding factors were highly suggestive of lamotrigine-induced Stevens-Johnson syndrome; use of the Naranjo scale indicated a probable relationship of causality [ When lamotrigine was started the patient was also receiving valproate for several years; no adverse effects, including any minor skin rash, were recorded while on valproate monotherapy. However, valproate is known to augment lamotrigine availability via reduced glucuronidation, which increases the risk of serious rash if patients are concomitantly given lamotrigine [

26. THE MERCK MANUAL--SECOND HOME EDITION, Stevens-Johnson Syndrome And Toxic Epider stevensjohnson syndrome and toxic epidermal necrolysis are two forms of the In stevens-johnson syndrome, a person has blistering of mucous membranes, http://www.merck.com/mmhe/sec18/ch203/ch203e.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Skin Disorders Chapter Itching and Noninfectious Rashes Topics Introduction Dermatitis Drug Rashes Erythema Multiforme ... Rosacea Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Buy The Book Print This Topic Email This Topic Pronunciations allopurinol barbiturates carbamazepine corticosteroid ... urethra Stevens-Johnson syndrome and toxic epidermal necrolysis are two forms of the same life-threatening skin disease that cause rash, skin peeling, and sores on the mucous membranes. In Stevens-Johnson syndrome, a person has blistering of mucous membranes, typically in the mouth, eyes, and vagina, and patchy areas of rash. In toxic epidermal necrolysis, there is a similar blistering of mucous membranes, but in addition the entire top layer of the skin (the epidermis) peels off in sheets from large areas of the body. Both disorders can be life threatening.

27. DermAtlas: Online Dermatology Image Library Dermatology Image,Stevens-Johnson Sy Comments, This 35year-old woman developed stevens-johnson syndrome followingthe administration of oflaxacin. Note the large hemorrhagic bullae under the http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=33

28. Hardin MD : Stevens-Johnson Syndrome From the University of Iowa s Hardin MD, Internet sources on stevensjohnson syndrome. http://www.lib.uiowa.edu/hardin/md/stevensjohnson.html

Stevens-Johnson Syndrome A Hardin MD Just Plain Links Page Return to Hardin MD : Home AIDS +Pictures Allergies +Pictures Child Skin Rashes +Pictures Childrens Diseases +Pictures Cold Sores +Pictures Erythema Multiforme +Pictures Eye Diseases +Pictures Herpes Infections +Pictures Immune System +Pictures Medical Pictures +Pictures Mycoplasma Infections +Pictures Oral Diseases +Pictures Pink Eye +Pictures Sepsis +Pictures Skin Pictures Staph Infection +Pictures Toxic Epidermal Necrolysis +Pictures Stevens-Johnson Syndrome Pictures Stevens-Johnson syndrome Directory Medical Library, Karolinska Institute, Sweden Stevens-Johnson syndrome Medical Library, Karolinska Institute, Sweden Stevens Johnson syndrome foundation Westminster, Colorado Stevens-Johnson syndrome SJ Parrillo, CV Parillo / eMedicine.com Stevens Johnson syndrome Family village, Univ Wisconsin, Madison Dangerous drug eruptions : Stevens-Johnson syndrome Amal K. Kurban, Boston Univ, Robin L. Travers, Chestnut Hill, Massachusetts Stevens-Johnson Syndrome Pictures Stevens-Johnson syndrome DermAtlas (Dermatology Image Atlas), Johns Hopkins Univ

29. New Treatment For Acute Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis A synopsis and links about a new treatment for Stevens Johnson syndrome (2002) br / http://www.aao.org/aao/education/library/memberalert/stevens_johnson.cfm

var gMenuControlID=0; var menus_included = 0; var jsPageAuthorMode = 0; var jsSessionPreviewON = 1; var jsDlgLoader = '/education/library/memberalert/loader.cfm'; var jsSiteID = 1; var jsSubSiteID = 119; var kurrentPageID = 5536; document.CS_StaticURL = "http://www.aao.org/aao/"; document.CS_DynamicURL = "http://www.aao.org/aao/"; 2005 Annual Meeting 2005 Subspecialty Day 2005 AAOE Program 2005 Mid Year Forum ... Help Exact match Print Version Member Login Academy Homepage Clinical Education ... Review/Claim CME New Treatment for Acute Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are moderate and severe variations of the same adverse reaction (usually to drugs or mycoplasma pneumonia) which result in blistering and sloughing of skin and mucosal membranes, and carry a high risk of mortality. With the seemingly unstoppable acute phase often lasting several weeks, SJS and TEN have always been a challenge to treat. Despite round-the-clock application of lubricant ointments, antibiotic and steroid drops, and daily lysis of adhesions using a glass rod, the majority of patients still end up with a lifetime of ocular problems. These sequelae range from mild dry eye, ongoing inflammation, scarred eyelids, entropion with trichiasis, photophobia, and decreased vision, to chronic corneal ulcers, corneal vascularization, total limbal deficiency, complete loss of tears, significant vision loss or blindness, constant severe pain, or complete loss of one or both eyes.

30. AllRefer Health - Erythema Multiforme (Lyell's Syndrome, Stevens-Johnson Syndrom Erythema Multiforme (Lyell s Syndrome, stevensjohnson syndrome, Toxic EpidermalNecrolysis) information center covers causes, prevention, symptoms, http://health.allrefer.com/health/erythema-multiforme-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Erythema Multiforme Erythema Multiforme Definition Treatment Expectations or Prognosis Complications ... Go To Main Page Alternate Names : Lyell's Syndrome, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis Definition Erythema multiforme is a skin disorder resulting from an allergic reaction Erythema Multiforme on the Hands Erythema Multiforme, Circular Lesions - Hands Erythema Multiforme, Target Lesions on the Palm Erythema Multiforme on the Leg Erythema Multiforme on the Hand Exfoliation Following Erythroderma Erythema multiforme is a type of hypersensitivity (allergic) reaction that occurs in response to medications, infections, or illness. Medications associated with erythema multiforme include sulfonamides, penicillins, barbiturates, and phenytoin. Associated infections include

31. AllRefer Health - Erythema Multiforme Prognosis (Expectations) (Lyell's Syndrome Erythema Multiforme (Lyell s Syndrome, stevensjohnson syndrome, Toxic EpidermalNecrolysis) information center covers Prognosis (Expectations). http://health.allrefer.com/health/erythema-multiforme-prognosis.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Erythema Multiforme : Prognosis of Erythema Multiforme Erythema Multiforme Definition Treatment Expectations or Prognosis Complications Calling Your Health Care Provider Go To Main Page Alternate Names : Lyell's Syndrome, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis Erythema Multiforme Prognosis (Expectations) Mild forms of erythema multiforme usually resolve without difficulty in 2 to 6 weeks, but they may recur. More severe forms may be difficult to treat. Stevens-Johnson syndrome and toxic epidermal necrolysis are associated with high death rates. Previous Top Next Jump to another section Definition Erythema Multiforme Treatment Erythema Multiforme Prognosis Erythema Multiforme Complications Calling Your Health Care Provider Topics that might be of interest to you Cellulitis Herpes Simplex Myocarditis Sepsis ... Skin Lesion Biopsy Other Topics Allergic Reactions Antibody Bullae Central Nervous System ... Vision Problems Review Date : 4/15/2003 Reviewed By : Michael Lehrer, M.D., Department of Dermatology, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

32. Stevens-Johnson Syndrome Definition - Medical Dictionary Definitions Of Popular Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=14086

33. DermIS / Main Menu / DOIA / Stevens-Johnson Syndrome / Images stevensjohnson syndrome / images, deutsch english español portugues français images for the diagnosis stevens-johnson syndrome http://dermis.multimedica.de/doia/diagnose.asp?zugr=d&lang=e&diagnr=695120&topic

34. DermIS / Main Menu / DOIA / Stevens-Johnson Syndrome / Info information on the diagnosis stevensjohnson syndrome Stevens-Johnsonsyndrome may present with mucosal lesions only or both mucosal and skin lesions. http://dermis.multimedica.de/doia/diagnose.asp?zugr=d&lang=e&diagnr=695120&topic

35. Aidsmap | Stevens-Johnson Syndrome Affects Mother And Son Taking Nevirapine Investigators from Uganda reported two cases of stevensjohnson syndrome thatoccurred Nevirapine-induced stevens-johnson syndrome in a mother and son. http://www.aidsmap.com/en/news/55E68DBB-4A17-4C8B-86CF-924C5D270735.asp

site map contact advanced search home ... about us Aidsmap news Français Português Español YOU ARE HERE: Stevens-Johnson syndrome affects mother and son taking nevirapine printer friendly version send to friend glossary comment Michael Carter , Monday, June 06, 2005 Two cases of the rare side-effect of nevirapine, Stevens-Johnson syndrome, involving a mother and her son, are reported in the June 10 th edition of AIDS . The investigators “are unaware of any previous familial clustering” of Stevens-Johnson syndrome associated with nevirapine treatment. The non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine is a standard component in first-line HAART regimens used in resource-limited settings. It is likely to remain widely used once lower-cost, fixed dose, generic antiretroviral therapy becomes more widely available, and it is anticipated that 100,000s of individuals will initiate antiretroviral therapy with nevirapine. Rash and hepatological toxicities are well documented side-effects of nevirapine therapy, and to minimise the risk of hepatotoxitity it is recommended that women do not initiate treatment with nevirapine if their CD4 cell count is above 250 cells/mm and men if their CD4 cell count is above 400 cells/mm Although rash in the early weeks of nevirapine therapy does not necessarily lead to the discontinuation of treatment, Stevens-Johnson syndrome is a rare, but potentially life-threatening necrosis of the skin and can occur in patients taking nevirapine across CD4 cell counts.

36. Defective Drug Information - Bextra Stevens-Johnson Syndrome A Drug Recall provides Bextra side effects news and resources on drug recalls.Contact a drug recall lawyer for your legal rights! http://www.adrugrecall.com/bextra/stevens-johnson-syndrome.html

This site provides news and legal information about defective drugs which may cause serious side effects. Bextra Bextra Arthritis Blood Clots Claim ... Contact a lawyer Join Our Newsletter! Drugs to Watch Ativan Avandia Baycol Bextra ... Zyprexa Bextra Stevens-Johnson syndrome Allergic reactions to drugs can manifest in many different ways. One in particular is Stevens-Johnson syndrome. Stevens-Johnson syndrome is a potentially deadly skin disease resulting from a drug-induced allergic reaction. Stevens-Johnson syndrome and toxic epidermal necrolysis are two forms of the same skin disease, and usually result from a drug-related reaction. The two forms of this skin disease can be extremely painful as well as deadly. The FDA recalled the COX-2 inhibitor Bextra , which is already linked to these disorders, on April 7, 2005. In addition to Bextra, additional drugs have been linked to Stevens-Johnson syndrome. These drugs include some other non-steroid anti-inflammatory drugs (NSAIDS), Allopurinol, Phenytoin, Carbamazepine, barbiturates, anticonvulsants, and sulfa antibiotics. While the condition can sometimes, but not often, be attributed to a bacterial infection, additional cases have no known cause for the onset of Stevens-Johnson syndrome or toxic epidermal necrolysis. Experts still say that the most common cause is through drug-related allergic reaction. Stevens-Johnson syndrome occurs most commonly in older people, primarily because the drugs associated with the disease tend to be used in older people. Contracting Stevens-Johnson syndrome and toxic epidermal necrolysis is also a risk in people that have AIDS. Potentially higher risk groups are urged to remain observant for any signs of these skin diseases and become knowledgeable of the symptoms that could indicate the presence or onset of Stevens-Johnson syndrome or toxic epidermal necrolysis.

37. Bextra And Stevens-Johnson Syndrome - RYAR.org | Bextra | Bextra Lawyer | Bextra Bextra and stevensjohnson syndrome. » Bextra Information Navigation » Bextra Bextra Stevens Johnson Syndrome » Free Bextra Case Evaluation http://www.ryar.org/bextra/stevens-johnson-syndrome.html

@import "../css.css"; Drug Recalls And Other Potentially Dangerous Drugs What Is Product Liability? Proving Fault for Dangerous Products Time Limits for Bringing a Case ... About The Peterson Firm Focus On Defibrillators: Defibrillator Defective Defibrillators Defibrillator Recall Defibrillator Lawyer ... Free Defective Defibrillator Case Evaluation Focus On Vioxx: Vioxx Vioxx Recall Vioxx Side Effects Vioxx News ... Free Vioxx Case Evaluation Focus On Bextra: Bextra Bextra Recall Bextra Side Effects Bextra Lawsuit ... Free Bextra Case Evaluation Other Potentially Dangerous Drugs: Celebrex OxyContin Prempro Accutane ... Zyprexa RYAR Site Resources: E-Mail RYAR.org To A Friend Or Loved One Bookmark RYAR.org Contact RYAR.org RYAR.org Sitemap Bextra and Stevens-Johnson Syndrome Bextra Bextra Recall Bextra Side Effects Bextra News ... Free Bextra Case Evaluation Bextra, a drug manufactured by pharmaceutical giant Pfizer, was approved in America by the Food and Drugs Administration in November 2001. This drug was known as a cox-2 inhibitor, which was prescribed for osteoarthritis, menstrual cramps, and adult pain management. Other cox-2s had been approved around the same time, and collectively these cox-2 inhibitors were widely welcomed by both professionals and patients. This was because the non-steroid anti-inflammatory drugs traditionally prescribed for these problems affected both the cox-1 enzyme and the cox-2 enzyme produced by the body. Because the cox-1 enzyme is responsible for protecting the lining of the stomach, many patients suffered chronic gastric problems. However, cox-2 inhibitors like Bextra were able to isolate and inhibit just the cox-2 enzyme, thus reducing the risk of gastric problems dramatically.

38. Stevens-Johnson Syndrome stevensjohnson syndrome is a rare, severe, usually drug-induced skin eruption stevens-johnson syndrome differs from erythema multiforme in that it is a http://www.drhull.com/EncyMaster/S/stevens-johnson.html

Help for sleepless parents Encyclopedia Index S Stevens-Johnson syndrome Search Stevens-Johnson syndrome Stevens-Johnson syndrome is a rare, severe, usually drug-induced skin eruption characterised by wide spread skin eruptions of large dark-red spots (caused by microscopic hemorrhage into the skin - purpura ) with overlying blisters or necrotic (dead tissue) centers erosive mouth ulcers severe eye involvement Stevens-Johnson syndrome differs from erythema multiforme in that it is a more severe disease, and is commonly drug-induced. A drug is found to be involved in about half the cases of Stevens-Johnson syndrome. The top three drugs associated with Stevens-Johnson syndrome are carbamazepine (14 cases per 100,000 users) sulfadoxine and pyrimethamine (10 cases per 100,000 users)

39. BBC - Health - Ask The Doctor - Stevens-Johnson Syndrome The symptoms of stevensjohnson syndrome and how to treat it. http://www.bbc.co.uk/health/ask_the_doctor/stevensjohnson.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index FRIDAY 9th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Stevens-Johnson syndrome My husband's been taken into hospital after developing a strange rash that spread to his mouth and caused masses of blisters in his mouth, eyes and genitals. The doctors think he's had a severe reaction to some antibiotics he was taking for a chronic chest problem (the antibiotics were called co-trimoxazole, I think). Is this an allergy and how quickly will it settle? Maisie Dr Trisha Macnair responds It sounds as though your husband has Stevens-Johnson syndrome, which is a severe form of a rash known as erythema multiforme. It's caused by a cell-mediated hypersensitivity reaction to distinct immunological stimuli, which in simple terms is a form of allergy that often takes days or weeks to develop. Although the illness can be severe, especially at first, it usually settles over a period of about a month. Sometimes the rash comes back again at a later date. Stevens-Johnson syndrome can be triggered by various drugs, especially some types of antibiotics, such as those containing penicillin or, as is the case with co-trimoxazole, sulphonamides.

40. Stevens-Johnson Syndrome stevensjohnson syndrome is the most severe form of erythema multiforme and is Typically, stevens-johnson syndrome affects the mucous membranes of the http://ww3.komotv.com/Global/story.asp?S=2854453

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