81. Sickle Cell Disease Center The sickle cell disease Research Center’s mission is to actively and aggressively participate in the substantive development of basic research and training http://www.utdallas.edu/research/sickle-cell/

Dr. Betty Pace Director Sickle Cell Disease Research Center The University of Texas at Dallas Sickle Cell Disease Research Center (SCDRC) The UTD SCDRC came into existence on August 1, 2001 with the primary goal of establishing biomedical research programs to develop a gene therapy cure for sickle cell disease. As of September 1, 2004, Dr. Betty Pace, formerly the associate director of SCDRC and associate professor of molecular and cell biology, became its director. A medical doctor, Dr. Pace also holds a clinical associate professor appointment at UT Southwestern. Commitment, Responsibility, Service : The foundation upon which our program research efforts are built. That, in turn, enables us to develop partnerships with other institutions, individuals and families affected with sickle cell disease. The UTD SCDRC together with the UT Southwestern Medical Center Sickle Cell Program, led by Dr. George Buchanan, has formed the Southwestern Sickle Cell Center that has successfully competed for an NIH Comprehensive Sickle Cell Center grant for $7.8 million for the period of April 1, 2003 through March 21, 2008. This is the first NIH Comprehensive Sickle Cell Center funded in the state of Texas.

82. Sickle Cell Disease Of The Spleen sickle cell disease of Spleen From the Virtual Pathology Museum, Department of Pathology, University of Connecticut Health Center. http://radiology.uchc.edu/eAtlas/HEM/697.htm

Search Frames Search No frames PathWeb Home Feed Back ... About Spleen with Sickle Cell Disease Click on Image to Enlarge it Spleen with Sickle Cell Disease A small multiply infarcted spleen in a case of a patient with sickle cell anemia: Notice the extremely distorted external appearance of this spleen, with multiple, depressed scars. The normal slate gray appearance of this spleen in visualized in the areas between the depressed scars. Significant reduction of splenic size is common in patients with sickle cell anemia and is referred to auto-amputation. (Description By:T.V.Rajan, M.D. ) (Image Contrib. by:Melinda Sanders, M.D. UCHC ) Sickle Cell Disease Etiology Due to single base mutation in the sixth amino acid on the beta globin chain leading to a substitution of glutamic acid for valine Autsomal recessive Pathogenesis Abnormal beta-globin results in polymerization of the hemoglobin with deoxygenation resulting in a change in red cell shape Abnormal cells form occlusive aggregates which result in infarct of the spleen.

83. Virtual Children's Hospital: Pediatrics: Sickle Cell Trait It does not turn into sickle cell disease. It is not contagious. A type of sickle cell disease called sickle cell anemia occurs when a person inherits http://www.vh.org/pediatric/patient/pediatrics/faq/sicklecell.html

Pediatrics Sickle Cell Trait Department of Pediatrics Children's Hospital of Iowa Peer Review Status: Internally Peer Reviewed Creation Date: March 1993 Last Revision Date: March 1993 What is hemoglobin? Hemoglobin (Hb) is the special protein within the red blood cells that carries oxygen from the lungs to the rest of the body. Hemoglobin is what makes your blood look red in color. Where does your hemoglobin come from? Your hemoglobin type is inherited through family genes. The color of your hair, the color of your eyes, your body build, and your hemoglobin type are all examples of things about you that are determined by genes. You receive one gene for hemoglobin type from your mother and one from your father. Hemoglobin A or normal adult hemoglobin is the most common type. There are over 500 different types or variations of hemoglobin. What is hemoglobin S? Sickle hemoglobin or hemoglobin S is a hemoglobin type that is most common in the African-American population. However, it does occur in other racial groups including the white population. What is Sickle Cell Trait?

84. Other Topics: Current Treatment For Sickle Cell Anemia We tested Rod and, indeed, he had inherited sickle cell disease. Parents are often confused about screening for sickle cell disease and the National http://www.thedoctorwillseeyounow.com/articles/other/sicklecell_3/

IN THIS ARTICLE What is sickle cell disease? The current treatment Dark patches of skin above the temples may be a sign of Giant Cell Arteritis, a serious, though treatable, condition. more... OTHER TOPICS Human genome project Current Treatment for Sickle Cell Anemia Robert G. Lerner, M.D. For the past eight years, I've been treating a patient, I'll call him Rod. When I first met Rod, he was hospitalized and frightened, facing an uncertain future from a serious disease. Rod knew he had some variety of sickle cell disorder because both of his parents had sickle cell trait. We tested Rod and, indeed, he had inherited sickle cell disease. Parents are often confused about screening for sickle cell disease and the National Institutes of Health (NIH) has provided a useful guide designed for use by parents. Thanks to a new medicine, hydoxyurea, sickle cell sufferers like Rod now have a better chance of living an almost normal life, with fewer painful attacks and hospitalizations. Rod's Medical Story Rod's childhood was mostly uneventful, although he had many episodes of aches and pains as he was growing up. At 18, he was hospitalized with his first "sickle cell crisis," where red cells broke down and blocked blood flow, especially in tiny arteries throughout Rod's body. Rod was even treated with exchange transfusion on one occasion when his lungs were plugged up with misshapen sickle cells and his life was in danger we replaced his defective red blood cells with normal red blood cells. Exchange transfusion is not an ordinary part of medical care for crisis but, sometimes, it can be life saving when a patient has an acute chest syndrome like Rod did. Since then, he's had many crises and many medical problems, including episodes of severe abdominal and back pains, skin ulcers and bone and joint damage.

85. Action Medical Research - Sickle Cell Disease sickle cell disease covers a group of inherited blood disorders which affect sickle cell disease, she pointed out, currently affects 10000 people in the http://www.action.org.uk/news_media/sickle_cell.php

Sickle Cell Disease The situation Normal red blood cells A sickle red blood cell from a patient with sickle cell anaemia Sickle cell disease covers a group of inherited blood disorders which affect mainly Afro-Caribbean people, as well as people in parts of Europe, South America and the Middle East. Racism? UK member of parliament Jane Griffiths, who represents Reading East, had no hesitation in suggesting that racial prejudice was holding up research into sickle cell disease when she spoke in a debate at the House of Commons early in the year 2000. Sickle cell disease, she pointed out, currently affects 10,000 people in the UK, compared with cystic fibrosis which affects 7,000 people. Both are genetic disorders, yet awareness and funding for cystic fibrosis is far greater than that of sickle cell disease. The difference is, of course, that the majority of people affected by sickle cell disease are black. Although it also affects people in parts of Asia and the Middle East, sickle cell disease hits Afro-Caribbean communities hardest. Due to immigration, sickle cell disease is now undoubtedly a British disease. Following the debate in the Commons, Jane Griffiths MP said:

86. SICKLE CELL DISEASE LEG ULCERS I have had very positive experience with Trental in sickle cell disease. Huntley AC Sickle cell ulcers treated with pentoxifylline a case report. http://dermatology.cdlib.org/rxderm-archives/sickle-cell-disease

SICKLE CELL DISEASE: LEG ULCERS - Yesterday I saw a 29 yo male with a history of sickle cell anemia and also a history of generalized pustular psoriasis of Von Zumbusch which began in childhood. I had taken care of him about 10 years ago when he was getting frequent sickling crises and experiencing poor control of his GPP with methotrexate. Since Tegison became available his hematologist has kept him controlled with it, dosing it 10-25 mg a day prn. Currently his main problem is recurrent and recalcitrant lower leg ulcers. He states that these have been the main source of his disability and pain in the past decade. They have been multiple and nearly constant. He has been treated with Procuren at a Wound Care Center with only temporary success. He has been through a few skin grafting attempts, only to have rapid ulcer recurrence and graft breakdown. His current ulcers are of mid-dermal depth, and the largest is 4x11 cm. They have not been biopsied. Several types of synthetic dressings (Duoderm, N-terface, Allevyn) have also been of little help. My current plans are: 1. Biopsy 2. Try Iodosorb dressings 3. Try Trental. Does anyone know if Trental works for this type of problem? If SS disease makes RBC's less deformable and Trental makes them more deformable, it might. Dr. Ely? Gene Sienkiewicz, M. D. - I have had very positive experience with Trental in sickle cell disease. In the patient I treated, not only did the recalcitrant ulcers heal and stay healed, the incidence and duration of crises improved markedly. Based on that experience, our hematology department put all the sicklers on Trental. Huntley AC: Sickle cell ulcers treated with pentoxifylline: a case report. Wounds: 3(5):192-194. 1991. Art Huntley MD Dermatololgy UC Davis -

87. Sickle Cell Disease - Children's Hospital Boston Usually diagnosed at birth, sickle cell disease is an inherited red blood cell disorder leading to anemia and episodes of blood vessel occlusion that lead http://www.childrenshospital.org/clinicalservices/Site1973/mainpageS1973P0.html

or find by letter: A-F G-L M-R S-Z Sickle Cell Disease Sickle Cell Disease About Sickle Cell Disease Diagnosis Receiving Treatment at Children's Emergency Care ... Contact Us Return to Blood Disorders Home Clinical Services Sickle Cell Disease The Sickle Cell Program at Children's Hospital Boston provides consultation for the diagnosis, treatment and long-term health maintenance for children and young adults with sickle cell disease of all types (most commonly HbSS, HbSC and sickle-beta thalassemia). Usually diagnosed at birth, sickle cell disease is an inherited red blood cell disorder leading to anemia and episodes of blood vessel occlusion that lead to a wide variety of clinical symptoms. Expert, Coordinated Care The physicians and nurses at the Sickle Cell Program help optimize the well-being of more than 200 affected children and their families by focusing on health maintenance strategies, such as preventive therapies, screening for acute complications and the importance of recognizing the early signs of life threatening or chronic complications. Because sickle cell can affect nearly every major organ in the body, children in this program will also be treated by physicians form other specialty programs at Children's, on an as needed basis. National Leadership The Sickle Cell Program at Children has adopted a leadership role in improving the quality of life for children affected by sickle cell disease. It is a clinical core for the Boston Comprehensive Sickle Cell Center, one of 10 National Institute of Health-funded centers in the United States, and it serves as a member of the New England Pediatric Sickle Cell Consortium.

88. Sickle Cell Disease sickle cell disease is a genetic blood disorder that affects the hemoglobin within the red blood cells. http://www.stjude.org/disease-summaries/0,2557,449_2162_2955,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_Clinical_Science); In order for our site to display correctly you will need a newer version of your web browser. The following browsers support numerous web standards including CSS, XHTML, and the DOM (a universal means of controlling the behavior of web pages): v7 or higher (all platforms), Mozilla FireFox (Windows), Camino (Mac OS X), Galeon (Linux GNOME Desktop) or other browser stemming from the Mozilla.org project. Opera v7 or higher (Windows, Linux) Apple's Safari (Mac OS X) Konqueror (Linux KDE Desktop) Microsoft Internet Explorer v6 or higher (Windows) or v5 or higher (Macintosh) St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help Hematologic Disorders Home Clinical Science Home Disease Information Hematologic Disorders Related Topics Sickle Cell Disease Parent Information Transfusions reduce ACS in sickle cell patients Sickle cell may delay brain growth Symposiums at St. Jude

89. The Scientist :: Murine Gene Therapy Corrects Symptoms Of Sickle Cell Disease, M Murine Gene Therapy Corrects Symptoms of sickle cell disease. By Jennifer Fisher Wilson return to webpage. Want to read more? http://www.the-scientist.com/yr2002/mar/research3_020318.html

Please login or register DAILY E-MAIL RSS HANDHELD CURRENT ISSUE DAILY NEWS UPFRONT FEATURE ... return to webpage RESEARCH Murine Gene Therapy Corrects Symptoms of Sickle Cell Disease By Jennifer Fisher Wilson return to webpage Want to read more? This article is in our premium content section. Gain access to our rich archive containing 17+ years of The Scientist exclusive online-only content, and detailed survey results. Back to top The Scientist support@the-scientist.com

90. WHAT IS SICKLE CELL DISEASE? sickle cell disease is an inherited condition that is most common among people whose The red blood cells of people with sickle cell disease contain an http://www.defiers.com/scd.html

Basics Parents' Guide Espanol Depression WHAT IS SICKLE CELL DISEASE? SICKLE CELL DISEASE: THE BASICS Sickle cell disease is an inherited condition that is most common among people whose ancestors come from Africa, the Middle East, the Mediterranean basin, and India. In the U.S., it affects primarily African Americans, about 0.3% of whom have some form of sickle cell disease, and approximately 10% of whom carry the sickle cell trait. There are approximately 80,000 individuals in the United States with sickle cell disease. The red blood cells of people with sickle cell disease contain an abnormal type of hemoglobin, the oxygen-carrying pigment, called hemoglobin S. The deficiency of oxygen in the blood causes hemoglobin S to crystallize, distorting the red blood cells into a sickle shape, making them fragile and easily destroyed, leading to anemia. The "sickled" blood cells then are unable to squeeze through the smaller blood vessels (arterioles and capillaries). When the tissues are deprived of an adequate blood supply, painful symptoms occur. Complications can include stroke, bone pain, kidney damage and breathing problems. The recurrent pain caused by the disease can interfere with many aspects of the patients' lives including education, employment, and psychosocial development. NORMAL HEMOGLOBIN AND SICKLE HEMOGLOBIN The second difference between the two types of cells is their longevity. Sickle cells do not live as long as normal cells. Normal, healthy cells can survive for about 120 days, while the more fragile sickle cells can survive for about 60 days or less. Unfortunately, the body cannot make new red blood cells as fast as it loses sickle blood cells. As a result, a sickle cell patient has fewer red blood cells and less hemoglobin than normal red blood cells. This decreased hemoglobin (called anemia), in turn, results in less oxygen being available for use by the cells of the body.

91. Sickle Cell Disease And Sickle Cell Trait sickle cell disease is an inherited disorder that affects red blood cells. sickle cell disease affects more than 72000 Americans, primarily those of African http://www.idph.state.il.us/HealthWellness/sicklecell.htm

Sickle Cell Disease and Sickle Cell Trait What is sickle cell disease? Sickle cell disease is an inherited disorder that affects red blood cells. Sickle cell disease affects more than 72,000 Americans, primarily those of African heritage, but also those of Arabian, Asian, Caribbean, Indian, Mediterranean, and South and Central American descent. The most common types of sickle cell disease are SS, SC and S beta thalassemia. Other more rare diseases include SD Punjab, SO Arab, S Lepore and SE disease. Sickle cell disease is a lifelong condition that may result in serious health problems. Complications can include painful episodes (crises), anemia (low hemoglobin), organ damage, infections, lung problems, leg ulcers, bone damage and strokes. What is sickle cell trait? Sickle cell trait is a condition in which there is one gene for the formation of sickle hemoglobin and one for the formation of normal hemoglobin. Sickle cell trait occurs in one out of every 10 African Americans. Usually, people with sickle cell trait do not have any medical problems and they can lead normal lives. They do not develop sickle cell disease. What is hemoglobin?

92. PAIN In The Child With Sickle Cell Disease Pain in the child with sickle cell disease Publication. http://www.doh.wa.gov/EHSPHL/PHL/Newborn/Pain.htm

You are here: DOH Home EHSPHL Home PHL Home NBS Home ... Employees PAIN in the Child with Sickle Cell Disease PAIN in the child with Sickle Cell Disease PAINFUL EPISODES IN THE CHILD WITH SICKLE CELL DISEASE Painful episodes occur in children with sickle cell disease as a complication of the disease. These episodes more commonly occur in older children, but often happen in infants and young children. WHAT CAUSES THE PAINFUL EPISODES? The exact cause of the pain is not known. It is thought that the red blood cells (RBC's) become trapped inside a blood vessel and interfere with normal blood flow. If blood flow is reduced in even a small area of the body, it can cause pain. Sometimes swelling is seen in the area of the pain. In children under 2 years of age the swelling usually occurs in the hands and/or feet. Older children can have swelling in the arms and/or legs. Swelling usually does not mean that something is seriously wrong, but in rare cases, swelling and pain are caused by infection in the bone. A child with swelling other than hands and feet should be seen by a doctor. WHERE IS THE PAIN?

93. Chest Syndrome With Sickle Cell Disease A fact sheet that briefly describes Chest Syndrome with sickle cell disease, its symptoms, treatments, general outcomes and follow up. http://www.doh.wa.gov/EHSPHL/PHL/Newborn/chest.htm

You are here: DOH Home EHSPHL Home PHL Home NBS Home ... Employees Chest Syndrome Chest Syndrome WHAT IS CHEST SYNDROME? Chest syndrome is a common cause of hospitalization in children with sickle cell anemia. Chest syndrome is a term to describe the chest pain, fever and "pneumonia-like" cough in a person with sickle cell disease. Many times it is mistaken for pneumonia. This problem can be fatal in the child with sickle cell disease. WHAT CAUSES CHEST SYNDROME? Although the reasons are not clearly understood, it is believed that "sickled cells" clump together in the small blood vessels either in the lungs or moves there from somewhere else in the body. Sometimes this is triggered by a lung infection like pneumonia. Chest syndrome can also develop right before, during, or after an episode of pain in the abdomen or bones. There are no methods available to separate pneumonia from chest syndrome caused by blocked vessels. That is why your child may be treated like he/she has both. WHAT ARE THE SYMPTOMS OF CHEST SYNDROME?

94. Priapism In Sickle Cell Anemia Looks at the course, management and complications of this disease. http://www.fpnotebook.com/HEM49.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Hemoglobin Anemia ... Thalassemia Assorted Pages Hemoglobinopathy Sickle Cell Anemia Cerebrovascular Accident in Sickle Cell Anemia Hand Foot Syndrome ... Priapism in Sickle Cell Anemia Priapism in Sickle Cell Anemia Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Practice Management Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Hemoglobin Index Approach Anemia Thalassemia Sickle Sickle Complications CVA Sickle Complications Hand Foot Sickle Complications Hematuria Sickle Complications Priapism See Also Priapism Course Resolves spontaneously May occur frequently Management Medications Nifedipine 10 mg (in repeated doses) Nitroglycerin patch (0.2 - 0.4 mg/hour)

95. Sickle Cell Anemia Disease Profile Images of all 24 human chromosomes and different genes that have been mapped to them. Free wall poster available from Web site. http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/sca.shtml

Human Genome Project Information Genomics:GTL Microbial Genome Program home The U.S. Department of Energy Biological and Environmental Research program funds this site. Genetic Disease Profile: Sickle Cell Anemia For more about the gene that causes sickle cell anemia, see the HBB Gene Profile . The following was adapted from NIH Publication No. 96-4057. Sickle Cell Timeline - Herrick provides the first formal description of sickle cell anemia when he reports that the blood smear of a dental student at the Chicago College of Dental Surgery contains "pear-shaped and elongated forms." - Hahn and Gillespie associate the sickling of red blood cells with low oxygen conditions. - Sherman reports that the sickling of red blood cells in the absence of oxygen is caused by a change in the hemoglobin molecule structure. - Watson suggests that the presence of fetal hemoglobin in the red blood cells of sickle cell newborns is the reason they do not show disease symptoms. - Noted physical chemist Linus Pauling and associates publish "Sickle Cell Anemia, a Molecular Disease" in

96. Sickle Cell Anemia - MayoClinic.com sickle cell anemia is an inherited blood disease that causes pain, organ damage and other problems. Treatments may reduce pain and prevent complications. http://www.mayoclinic.com/invoke.cfm?id=DS00324

97. SickleCellNew3 Provides a first hand look at sickle cell Anemia, built by a person suffering from the disease. Frequently asked questions and a personal diary of the owner's own battle with this disease. http://www.geocities.com/HotSprings/Spa/3194/

Glad You Stopped By! My initial intention for building this site was in response to the numerous sites that seemed targeted for the medical profession. After viewing several of these sites, I wondered where the Sicklers were and why hadn't they built any sites? Then it dawned on me... I'm a Sickler and I haven't built a site!  Although I'm not a medical professional, I hope this site can shed some light on Sickle Cell Anemia from a personal view. Page descriptions are below and I invite you  to browse the entire site. Hopefully, we'll both learn something in the end! The Sickle Cell Forum Been looking for people, living with Sickle Cell anemia like you? The Sickle Cell Forum is the place to be! The input has been lively and there's a definite community forming. To join our growing family, simply click on the link below. See you there, Charles Click to Join The Sickle Cell Forum For information about me, be sure to read the "About Me" page. The "Sickle Cell Diaries" is my personal account of life with Sickle Cell.

98. Sickle Cell Anemia Genes and disease provides short descriptions of inherited disorders. It is hosted by the National Center for Biotechnology Information (NCBI), http://www.ncbi.nlm.nih.gov/disease/sickle.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View HBB on chromosome 11 Databases PubMed the literature Key Papers Recent literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Fact Sheet from the National Heart, Lung and Blood Institute, NIH SCDAA Sickle Cell Disease Association of America SICKLE CELL ANEMIA (SCA) is the most common inherited blood disorder in the United States, affecting about 72,000 Americans or 1 in 500 African Americans. SCA is characterized by episodes of pain, chronic hemolytic anemia and severe infections, usually beginning in early childhood. SCA is an autosomal recessive disease caused by a point mutation in the hemoglobin beta gene ( HBB ) found on chromosome 11p15.4. Carrier frequency of HBB varies significantly around the world, with high rates associated with zones of high malaria incidence, since carriers are somewhat protected against malaria. About 8% of the African American population are carriers. A mutation in HBB results in the production of a structurally abnormal hemoglobin (Hb), called HbS. Hb is an oxygen carrying protein that gives red blood cells (RBC) their characteristic color. Under certain conditions, like low oxygen levels or high hemoglobin concentrations, in individuals who are homozygous for HbS, the abnormal HbS clusters together, distorting the RBCs into sickled shapes. These deformed and rigid RBCs become trapped within small blood vessels and block them, producing pain and eventually damaging organs.

99. What Is Sickle Cell Anemia? sickle cell anemia is an inherited blood disease. sickle cell anemia is a serious disease and there is no universal cure. http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.html

DCI Home Blood Diseases Sickle Cell Anemia : What Is ... What Is ... Other Names Causes Who Is At Risk ... Links What Is Sickle Cell Anemia? Sickle cell anemia is an inherited blood disease. That means you are born with it and it lasts a lifetime. Sickle cell anemia affects the red blood cells . Normal red blood cells are smooth and round like doughnuts. They move easily through blood vessels to carry oxygen to all parts of the body. In sickle cell anemia, the red blood cells become hard, sticky, and shaped like sickles or crescents. When these hard and pointed red cells go through the small blood vessels, they tend to get stuck and block the flow of blood. This can cause pain, damage, and a low blood count or anemia. The sickle-shaped red blood cells tend to get stuck in narrow blood vessels, blocking the flow of blood. Anemia is a shortage of red blood cells in your blood. In sickle cell anemia, this shortage of red blood cells occurs because sickle cells do not last very long. It is hard for your body to make new red blood cells fast enough to keep up. Normal red blood cells last about 120 days in the bloodstream. Sickle cells die after only about 10 to 20 days. Sickle cell trait is different from sickle cell anemia. A person with sickle cell trait does not have the disease but carries the gene that causes the disease. Persons with sickle cell trait can pass the gene to their children. For more information on sickle cell trait, see the section on "

100. Science Museum | Your Genes | Sickle-cell Disease sicklecell disease (sickle-cell anaemia) affects the red blood cells, sickle-cell disease sufferers often become anaemic, and may also be affected by http://www.sciencemuseum.org.uk/exhibitions/genes/223.asp

Home Your genes Genes and inheritance Genes and families ... Recessive inheritance Sickle-cell disease Sickle-cell disease (sickle-cell anaemia) affects the red blood cells, which carry oxygen around your body. In people with this condition, the red blood cells become 'sickle' shaped when they are not carrying oxygen. These sickle cells tend to get stuck in small blood vessels, causing pain in the chest and joints. Sickle-cell disease sufferers often become anaemic, and may also be affected by gallstones, eye problems and strokes. There is no cure for this condition, although the symptoms can be treated. Normal (round) and sickle-shaped red blood cells. EM Unit, Royal Free Hospital School of Medicine/Wellcome Photo Library Understanding sickle-cell disease How is sickle-cell disease inherited? next section: Phenylketoneuria ... Shop

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