41. Massachusetts General Hospital Cancer Center Retinoblastoma, Rhabdomyosarcoma, sickle cell disease, Skin Cancer, Soft Tissue Sarcoma, Spinal Cord Tumors, Stroke, Thalassemia, nonsickle cell http://www.massgeneral.org/cancer/

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42. Sickle Cell Society Latest Events The Latest Events organised by SCS. A New NCEPOD Study – sickle cell disease and Thalassaemia What is Sickle Cell Anaemia? http://www.sicklecellsociety.org/

Sickle Cell Society 54 Station Road London, NW10 4UA UK Tel 020 8961 7795 Fax 020 8961 8346 info@sicklecellsociety.org Latest Sickle News Telephone Help Line Nowgen launches Photo 2004 "Human Genetics and Society" competition Latest Events The Latest Events organised by SCS. What is Sickle Cell Anaemia? How can I volunteer my help? Questions and Answers Planet Sickle A special site for young people with Sickle Cell document.write(text); //> For more information contact the Sickle Cell Society on 020 8961 7795. Information, Counselling and caring for those with Sickle Cell Disorders and their families marks our 25th anniversary.

43. Genome.gov | Learning About Sickle Cell Disease Answers to frequently asked questions about sickle cell disease, published by the National Human Genome Research Institute. http://www.genome.gov/10001219

triggerParms["cpp_5"] = "Referer:"+ cppUrlPatch (""); // Optional Home About NHGRI Newsroom Staff ... Specific Genetic Disorders Learning About Sickle Cell Disease Learning About Sickle Cell Disease What do we know about heredity and sickle cell disease? Is there a test for sickle cell disease? NHGRI Clinical Research on Sickle Cell Disease Additional Resources for Sickle Cell Disease Information What do we know about heredity and sickle cell disease? Sickle cell disease is the most common inherited blood disorder in the United States. Approximately 80,000 Americans have the disease. In the United States, sickle cell disease is most prevalent among African Americans. About one in 12 African Americans and about one in 100 Hispanic Americans carry the sickle cell trait, which means they are carriers of the disease. Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and round and glide through blood vessels. In people with sickle cell disease, abnormal hemoglobin molecules - hemoglobin S - stick to one another and form long, rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape. Their shape causes these red blood cells to pile up, causing blockages and damaging vital organs and tissue.

44. Genome.gov | Learning About Sickle Cell Disease Sickle Cell AnemiaBlood Diseases Disorderssickle cell disease is an inherited blood disorder characterized by defective In sickle cell disease, red blood cells are produced but then become http://www.genome.gov/page.cfm?pageID=10001219

45. Sickle Cell sickle cell disease (SCD) is caused by the malfunction of the red blood cells in The gene defect for sickle cell disease is an autosomal recessive http://www.savebabies.org/diseasedescriptions/sicklecell.php

Search Our Site! Sickle Cell Disease (SCD) A Hemoglobinopathy Disorder Save Babies Through Screening Foundation is comprised of volunteers. Some have children who were helped by newborn screening, and some have children who have died, or suffered brain damage. For many of the Foundation's volunteers, joy comes from knowing that your child was saved. Many hours of hard work have been done to help children, maybe even yours. Please let us hear from you. What is it? Sickle Cell Disease (SCD) is caused by the malfunction of the red blood cells in affected individuals causing a very severe form of anemia. Inheritance and Frequency The gene defect for sickle cell disease is an autosomal recessive genetic trait and is unknowingly passed down from generation to generation. This faulty gene only emerges when two carriers have children together and pass it to their offspring. For each pregnancy of two such carriers, there is a 25% chance that the child will be born with the disease and a 50% chance the child will be a carrier for the gene defect. It is estimated that on average, sickle cell disease effects 1 of every 1,300 infants in the general population and approximately 1 of every 400 of African descent. It is seemingly more common in individuals of African and Mediterranean ancestry, however, it is not limited to these groups. Ancestor groups should not be a reason to avoid screening for this disorder. It can be found in children of all backgrounds.

46. Sickle Cell And African-Americans sickle cell disease is a generic term for a group of genetic disorders The diagnosis of sickle cell disease is primarily based on hemoglobin http://www.blackhealthcare.com/BHC/SickleCell/Description.asp

Home Diabetes Hypertension Coronary Heart Disease ... Healthy Lifestyles Category Description Epidemiology Prevention Diagnosis and Evaluation ... End Stage Organ Disease Disease Center Diabetes Hypertension Coronary Heart Disease Stroke ... Healthy Lifestyles Community Issues The Problem Closing the Gap Initiatives Healthy Lifestyles Healthy Lifestyle library Community Resources Closing the Gap Initiatives About Us General Information Press Releases Corporate Profile Become a Sponsor ... Privacy Statement Sickle Cell Anemia - Description Sickle cell disease is a generic term for a group of genetic disorders characterized by the predominance of hemoglobin S (Hb S). These disorders include sickle cell anemia, the sickle beta thalassemia syndromes, and hemoglobinopathies in which Hb S is in association with another abnormal hemoglobin that not only can participate in the formation of hemoglobin polymers but also is present in sufficient concentration to enable the red cells to sickle. Examples of the latter disorders include hemoglobin SC disease, hemoglobin SD disease, and hemoglobin S O Arab disease. The sickle cell disorders are found in people of African, Mediterranean, Indian, and Middle Eastern heritage. In the United States, these disorders are most commonly observed in African Americans and Hispanics from the Caribbean, Central America, and parts of South America. In contrast to these diseases is sickle cell trait. Individuals with sickle cell trait (Hb AS) have a normal beta globin gene (bA) and a bS globin gene, resulting in the production of both normal hemoglobin A and hemoglobin S, with a predominance of Hb A. Their red blood cells sickle only under unusual circumstances such as marked hypoxia and the hyperosmolar environment of the renal medulla (resulting in hyposthenuria).

47. Sickle Cell Anemia Sickle Cell Anemia Updated February 2, 2005. What is sickle cell disease? Sickle Cell Trait Types of sickle cell disease http://www.noah-health.org/en/blood/sicklecell/

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Heart and Blood Change text size: Sickle Cell Anemia Updated: February 2, 2005 What is Sickle Cell Disease? The Basics Causes/Genetics Screening/Prevention Sickle Cell Trait ... Types of Sickle Cell Disease Information Resources Organizations Research Facilities Care and Treatment Clinical Trials Hydroxyurea Management of Acute Chest Syndrome Pain Management ... Umbilical Cord and Bone Marrow Transplants Special Groups Especially For Children Especially for Teens For Families For Teachers and Employers ... For Women Researched by NOAH Contributing Editor: NOAH Team NOAH Heart and Blood > Sickle Cell Anemia Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

48. Sickle Cell Disease / Family Village sickle cell disease Association of America, Inc. is helping to promote finding a universal cure for Frequently Asked Questions About sickle cell disease http://www.familyvillage.wisc.edu/lib_scd.htm

Sickle Cell Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Sickle Cell" Who to Contact Sickle Cell Disease Association of America 16 S. Calvert Street, Suite 600 Baltimore, Maryland 21202 410.528.1555 Office 410.528.1495 Fax 800.421.8453 General Public E-Mail: scdaa@sicklecelldisease.org Website: http://sicklecelldisease.org/ The Sickle Cell Disease Association of America, Inc. (SCDAA), formerly know as the National Association for Sickle Cell Disease (NASCD) was founded in 1971 to provide an effective coordinated community-based approach to developing and implementing strategies to resolve issues surrounding sickle cell disease. Through three decades, SCDAA and its Member Organizations have demonstrated how community-based organizations can work with local and state government agencies in furtherance of national health care objectives. Sickle Cell Disease Association of America, Inc. is helping to promote finding a universal cure for sickle cell disease, and helping to improve the quality of life for individuals and families where sickle cell disease related conditions exist. The American Sickle Cell Anemia Association 10300 Carnegie Avenue Cleveland Clinic / East Office Building (EEb18) Cleveland, Ohio 44106

49. Sickle Cell Anemia Complications of sickle cell disease may include pain, stroke, Newborns with sickle cell disease are often placed on penicillin to prevent pneumonia and http://www.labtestsonline.org/understanding/conditions/sickle.html

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldolase Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiglobulin, Direct Antiglobulin, Indirect Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcitonin Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP C. diff CEA Celiac Disease Tests CF Gene Mutation Chemistry Panels Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity

50. Sickle Cell Test: The Test Because sickle cell disease is a genetically inherited disorder, The test can fail to detect hemoglobin S (sickle cell disease or trait) under the http://www.labtestsonline.org/understanding/analytes/sickle/test.html

TESTS Test not listed? A/G Ratio ACE ACT ACTH AFB Culture AFP Maternal AFP Tumor Marker Albumin Aldolase Aldosterone Allergies ALP Alpha-1 Antitrypsin ALT Ammonia Amylase ANA Antibody Tests Antiglobulin, Direct Antiglobulin, Indirect Antiphospholipids Antithrombin Apo A Apo B ApoE Genotyping aPTT AST Autoantibodies Bicarbonate Bilirubin Blood Culture Blood Gases Blood Smear BMP BNP Bone Markers BRCA BUN C-peptide CA-125 CA 15-3 CA 19-9 Calcitonin Calcium Cardiac Biomarkers Cardiac Risk Cardiolipin Antibodies Catecholamines CBC CCP C. diff CEA Celiac Disease Tests CF Gene Mutation Chemistry Panels Chlamydia Chloride Cholesterol CK CK-MB CMP CMV Coagulation Factors Complement Levels Cortisol Creatinine Creatinine Clearance CRP CRP, high-sensitivity

51. Genomics|HuGENet|Reviews|Hb S Allele And Sickle Cell Disease The mission of the Office of Genomics and Disease Prevention is to integrate advances in human genetics into public health research, policy, and programs. http://www.cdc.gov/genomics/hugenet/reviews/sickle.htm

home reviews Hb S allele and sickle cell disease Archived: May 2000 This article was published in American Journal of Genetics 2000 May 1; 151(9): 839-845 PubMed ID: 10791557 Sickle Hemoglobin ( Hb S ) Allele and Sickle Cell Disease Allison Ashley-Koch , Quanhe Yang , and Richard S. Olney Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Office of Genomics and Disease Prevention, GA Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Birth Defects and Developmental Disabilities, Birth Defects and Genetic Diseases Branch, Atlanta, GA. July 1, 1998 (updated August 5, 1998) Abstract Gene Gene Variants Disease ... Medical Literature Search ABSTRACT Beta globin is a major component of adult hemoglobin. The gene for beta globin is located on chromosome 11 and there are over 475 allelic variants. One of these variants, sickle hemoglobin ( Hb S ), is responsible for sickle cell disease, one of the most prevalent genetic diseases, affecting over 50,000 Americans. Most individuals with sickle cell disease have African and Mediterranean ancestry. It is believed that the high frequency of the ( Hb S ) variant is maintained in these populations by the increased resistance to malaria infection in heterozygous carriers, those individuals who possess one copy of the normal beta globin gene (Hb A) and one copy of the sickle variant (

52. Overview, Cincinnati Children's Hospital Medical Center Stroke as a complication in children with sickle cell disease; Pathogenesis of the vasoocclusive crisis in sickle cell tissues http://www.cincinnatichildrens.org/svc/alpha/b/blood/programs/sickle-cell/

Home Contact Us Site Map Go to Advanced Search ... Sickle Cell Center Overview Newsletter Related Links Faculty Consultations ... News Releases Sickle Cell Center Overview The Comprehensive Sickle Cell Center at Cincinnati Children's Hospital Medical Center receives 1,000-plus outpatient visits, with an average of more than 200 admissions and 1,000 inpatient days, per year. The center staff follows approximately 240 patients. Funded by a major grant from the National Institutes of Health , as well as grants from the National Heart Lung and Blood Institute and the Ohio Department of Health , the Sickle Cell Center carries out various education and counseling programs for affected families and the community. Sickle Cell Center Research Interests Stroke as a complication in children with sickle cell disease Pathogenesis of the vaso-occlusive crisis in sickle cell tissues Pathogenesis of thrombotic events Ion transport channels in normal and abnormal red cells Pathogenesis and prevention of acute chest syndrome Use of cord blood banking and blood and marrow transplantation for patients with severe sickle cell disease Psychological coping to determine whether children affected with sickle cell disease relate normally with their peers Improving newborn screening follow-up and services for individuals and families at the community level In collaboration with the University of Cincinnati College of Medicine , the Sickle Cell Center staff is studying the regulation of fetal hemoglobin synthesis and mechanisms regulating red blood cell development and ion transport. These collaborative efforts are now part of a center grant for Sickle Cell Disease supported through the National Institutes of Health.

53. Sickle Cell Disease In Childhood: Part I. Laboratory Diagnosis, Pathophysiology sickle cell disease is the most common single gene disorder in black Americans, In general, this is the mildest variant of sickle cell disease, http://www.aafp.org/afp/20000901/1013.html

Advanced Search AAFP Home Page Journals Vol. 62/No. 5 (September 1, 2000) Sickle Cell Disease in Childhood: Part I. Laboratory Diagnosis, Pathophysiology and Health Maintenance DORIS L. WETHERS, M.D., A patient information handout on sickle cell disease, written by Clarissa Kripke, M.D., assistant editor of AFP, is provided on page 1027. S ickle cell disease is the most common single gene disorder in black Americans, affecting approximately one in 375 persons of African ancestry. Sickling conditions are also common in persons from Mediterranean countries, Turkey, the Arabian peninsula and the Indian subcontinent. Many Spanish-speaking persons in the United States, as well as people from the Caribbean and parts of South and Central America, are affected. The first description of sickle cell disease, published in 1910, was followed by six decades of genetic, hematologic, pathologic, clinical and molecular observations. Since the mid-1970s, two longitudinal prospective studies of children with sickle cell disease have produced a large body of clinical data on the evolution of the disease from birth. The U.S. study followed 3,500 patients with sickle cell disease through sickness and health.

54. Sickle Cell Disease In Childhood: Part II. Diagnosis And Treatment Of Major Comp Complications of sickle cell disease occur suddenly and can rapidly become severe. A child with sickle cell disease who is acutely ill is usually best http://www.aafp.org/afp/20000915/1309.html

Advanced Search AAFP Home Page Journals Vol. 62/No. 6 (September 15, 2000) Sickle Cell Disease in Childhood: Part II. Diagnosis and Treatment of Major Complications and Recent Advances in Treatment DORIS L. WETHERS, M.D., Treatment advances over the past 25 years have significantly decreased morbidity and mortality in children with sickle cell disease. Aggressive management of fever, early diagnosis of acute chest syndrome, judicious use of transfusions and proper treatment of pain can improve quality of life and prognosis for these children. Prophylactic hydroxyurea therapy has been shown to reduce the incidence and severity of pain crises in adults with sickle cell disease and has been effective in limited studies conducted in children. Research into stem cell transplantation provides hope that a cure for sickle cell disease may be possible. (Am Fam Physician 2000;62:1309-14.) C omplications of sickle cell disease occur suddenly and can rapidly become severe. Infection, acute splenic sequestration crisis, aplastic crisis, acute chest syndrome, stroke, cholelithiasis, renal disease and pain are the major complications of this disease in children. Some complications lend themselves to simple management, whereas others, including aseptic necrosis of the hip, priapism and leg ulcers, require prompt referral for specialized treatment Table 1 ). A child with sickle cell disease who is acutely ill is usually best managed in a facility that can provide pediatric tertiary care.

55. Sickle Cell Disease Management, NHLBI The fourth edition of The Management of sickle cell diseasedeveloped by physicians, nurses, psychologists, and social workers who specialize in the care http://www.nhlbi.nih.gov/health/prof/blood/sickle/

HOME SITE INDEX CONTACT US TIPS ... Publications The Management of Sickle Cell Disease (Final VersionJuly 12, 2002) The fourth edition of The Management of Sickle Cell Disease developed by physicians, nurses, psychologists, and social workers who specialize in the care of children and adults with sickle cell diseasedescribes the current approach to counseling and also to management of many of the medical complications of sickle cell disease. It is organized into four parts: Diagnosis and Counseling, Health Maintenance, Treatment of Acute and Chronic Complications, and Special Topics. Multiple new therapies are now available for children and adults with sickle cell disease, and often the options to be chosen present a dilemma for both patients and physicians. This book does not provide answers to many of these newer questions but rather explains the choices available. It is to serve as an adjunct to recent textbooks that delve more deeply into all aspects of the disorder. NIH Publication No. 02-2117. 188 pages. You may obtain the document in the following ways: View online (in formats below) [PDF document, 768 K

56. AllRefer Health - Sickle Cell Anemia (Anemia - Sickle Cell, Hemoglobin SS Diseas Sickle Cell Anemia (Anemia Sickle Cell, Hemoglobin SS Disease (Hb SS), sickle cell disease) information center covers causes, prevention, symptoms, http://health.allrefer.com/health/sickle-cell-anemia-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Sickle Cell Anemia Sickle Cell Anemia Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Anemia - Sickle Cell, Hemoglobin SS Disease (Hb SS), Sickle Cell Disease Definition Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped. As a result, they function abnormally and cause small blood clots. These clots give rise to recurrent painful episodes called "sickle cell pain crises." Red Blood Cells, Sickle Cell Red Blood Cells, Normal

57. Sickle Cell Disease Association Of The Piedmont A sickle cell disease and HIV AIDS agency in Greensboro, North Carolina. http://www.scdap.org/

QUICK VIEW - SITE PAGES Click HERE for Job Opportunities Mission Statement Sickle Cell Page HIV/AIDS Page AIDS Research ... Wake Forest Center PLEASE VISIT OUR SPECIAL CORPORATE PARTNER POLO RALPH LAUREN FOR MEN, WOMEN AND CHILDREN'S STYLES > click on logo Sickle Cell Disease Association of the Piedmont 1102 E. Market Street Greensboro, North Carolina 27401 Phone: (336)274-1507 E-Mail: scdap@scdap.org MAILING ADDRESS: Sickle Cell Disease Association of the Piedmont PO Box 20964 Greensboro, North Carolina 27420 Phone: (336)274-1507 SCDAP High Point Office 401 Taylor Avenue High Point, North Carolina 27260 Phone: (336)886-2437 E-Mail: scdap@scdap.org SCDAP Winston-Salem Office 1225 E. fifth St. Winston-Salem, NC 27101 Phone: (336)723-1390 E-Mail: scdap@scdap.org ATTENTION! If you cannot see our introductory page then your computer did not come with Flash 5 Player installed. It takes less than a minute to install and you will need it in the future as you surf the WEB. Click HERE to install it and then come back to our page. OR Click HERE to visit all our other site pages.

58. Welcome To The Sickle Cell Disease Foundation Of California Annual sickle cell disease Golf Classic Scott Zuniga Memorial Scholarship Fund sickle cell disease Awareness to be Highlighted by New US Postage Stamp. http://www.scdfc.org/

Calendar of Events Annual Sickle Cell Disease Golf Classic Camp Crescent Moon 2005 Support Our Donors ... HIPAA Notice of Privacy Practices 6133 Bristol Parkway, #240, Culver City, CA 90230 Phone (310) 693-0247 • Toll free (877) 288-2873 • Fax (310) 693-0266 Email: info@scdfc.org

59. Sickle Cell - Health And Medical Information Produced By Doctors - MedicineNet.c Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygencarrying protein within the red http://www.medicinenet.com/sickle_cell/article.htm

document.writeln(''); MedicineNet Home > Sickle Cell search help Printer-Friendly Format FREE Newsletters Email to a Friend ... Next Sickle Cell Disease (Sickle Cell Anemia) Medical Author: William C. Shiel Jr., MD, FACP, FACR What is sickle cell anemia? How is sickle cell anemia inherited? What conditions promote the sickling (distortion) of the red blood cells in sickle cell anemia? ... Sickle Cell Anemia At A Glance What is sickle cell anemia? Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels causing tissue and organ damage and pain. Sickle cell anemia is one of the most common inherited blood anemias. The disease primarily affects Africans and African Americans. It is estimated that in the United States, some 50,000 African Americans are afflicted with the most severe form of sickle cell anemia. Overall, current estimates are that one in 1,875 U.S. African American is affected with sickle cell anemia. How is sickle cell anemia inherited?

60. The Sickle Cell Disease Program At St. Louis Children’s Hospital. The sickle cell disease Program at St. Louis Children’s Hospital provides comprehensive diagnosis and treatment of children with sickle cell disease, http://www.stlouischildrens.org/?tabid=96&acn=view&aid=149

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