121. Scleroderma - Lucile Packard Children's Hospital There are two forms of scleroderma localized scleroderma and systemic sclerosis.Localized scleroderma can be seen more frequently in children than the http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/arthritis/sclero.html

Day Hospital Rheumatology Rheumatologists Scleroderma CREST Syndrome A less severe form of is called CREST . The CREST syndrome represents the following symptoms: C alcium skin deposits R aynaud's phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous) E sophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach) S clerodactyly (skin damage on fingers) T elangiectasia (spider veins), limits skin damage to the fingers. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure. What is scleroderma? There are two forms of scleroderma: localized scleroderma and systemic sclerosis. Localized scleroderma can be seen more frequently in children than the systemic form. It may involve patches of the skin on the trunk, arms, legs, or head. Other names for the localized form are morphea and linear scleroderma. Systemic sclerosis is a chronic, degenerative disease that affects the joints, skin, and internal organs. Scleroderma is also associated with blood vessel abnormalities. Systemic sclerosis occurs only rarely in children.

122. Atlas Of Dermatology Localized scleroderma affecting the tongue and perioral skin scleroderma, Clinicalpicture (1081). Linear scleroderma scleroderma, Clinical picture (1085) http://atlases.muni.cz/atl_en/main nenadory vazregr.html

123. Log In Problems scleroderma is an autoimmune disease afflicting the skin and viscera. Two expertsdiscuss its prevalence, prognosis, issues surrounding diagnosis, http://www.medscape.com/viewarticle/501603

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124. Scleroderma Women are about four times more likely than men to be afflicted with scleroderma,a chronic disease that most often strikes women during middle age. http://www.healthywomen.org/content.cfm?L1=3&L2=69

125. OBGYN.net - Scleroderma & Pregnancy - A. Iqbal, MD OBGYN.net Medical Professionals page, contains daily news, events calendar,clinical information, and links to featured sections, articles, http://www.obgyn.net/displayppt.asp?page=/english/pubs/features/presentations/iq

126. FIRSTConsult - Sdfdsf FIRSTConsult, scleroderma (Patient Education File). Published for medical studentsand primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1037518&type=103&bref=1

127. NewYork-Presbyterian Hospital Vascular Care: Scleroderma Health information about scleroderma from NewYorkPresbyterian. The UniversityHospitals of Columbia and Cornell. http://wo-pub2.med.cornell.edu/cgi-bin/WebObjects/PublicA.woa/5/wa/viewHContent?

128. Scleroderma - Children's Hospital Boston CREST Syndrome A less severe form of scleroderma is called CREST. There aretwo forms of scleroderma localized scleroderma and systemic sclerosis. http://www.childrenshospital.org/az/Site1565/mainpageS1565P0.html

or find by letter: A-F G-L M-R S-Z My Child Has... Home Scleroderma Scleroderma Programs that treat this condition or perform this procedure Rheumatology Program Samara Jan Turkel Clinical Center CREST Syndrome A less severe form of scleroderma is called CREST . The CREST syndrome represents the following symptoms: Calcium skin deposits Raynaud phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous) Esophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach) Sclerodactyly (skin damage on fingers) Telangiectasia (spider veins), limits skin damage to the fingers. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure. What is scleroderma? There are two forms of scleroderma: localized scleroderma and systemic sclerosis. Localized scleroderma can be seen more frequently in children than the systemic form. It may involve patches of the skin on the trunk, arms, legs, or head. Other names for the localized form are morphea and linear scleroderma. Systemic sclerosis is a chronic, degenerative disease that affects the joints, skin, and internal organs. Scleroderma is also associated with blood vessel abnormalities. Systemic sclerosis occurs only rarely in children.

129. Untitled Document http://www.srfcure.org/home/

130. Polymyositis Management Rheumatology Diffuse Polymyositis Management. Book. Home Page, CardiovascularMedicine, Dentistry, Dermatology, Emergency Medicine, Endocrinology http://www.fpnotebook.com/RHE24.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Rheumatology Diffuse Assorted Pages Amyloidosis Antiphospholipid Antibody Syndrome Systemic Lupus Erythematosus Polymyalgia Rheumatica ... Medication Causes of Myositis Polymyositis Management Dermatomyositis Management Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Practice Management Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Rheumatology Index Bone Cardiovascular Medicine Dermatology Diffuse Examination Infectious Disease Intra-Articular Disorders Laboratory General Marfans Myofascial Neurology Osteoarthritis Pain Pediatrics Pharmacology Procedure Radiology RA Spondylitis Symptom Evaluation Page Diffuse Index Amyloidosis Behcet's Syndrome Lupus Anticoagulant Antiphospholipid Lupus Systemic Polymyalgia Rheumatica Polymyositis Background Polymyositis DDx Polymyositis Evaluation Polymyositis Management Polymyositis Types Idiopathic Sjogren's Syndrome Systemic Sclerosis See Also Dermatomyositis Polymyositis Management: General Measures Prevent atrophy and contractures in Myositis Passive Stretching and splinting Strength-building after inflammation decreases Dermatomyositis Skin Lesions See Pruritus Management Consider high potency Topical Corticosteroid Avoid Sun Exposure (especially in photosensitivity)

131. The Scientist :: Scleroderma Exposed, Sep. 30, 2003 http://www.biomedcentral.com/news/20030930/02

Please login or register DAILY E-MAIL RSS HANDHELD CURRENT ISSUE DAILY NEWS UPFRONT FEATURE ... ARCHIVES Sep. 30, 2003 Previous Archive Next DAILY NEWS Scleroderma exposed Systematic analysis provides means for early detection of systemic scleroderma By Cathy Holding Comparison of gene expression profiles using microarray analysis of tissues from patients suffering from systemic scleroderma and of those from unaffected individuals is reported in the September 29, 2003 PNAS by Michael Whitfield and colleagues at University of California at San Francisco . Results provide the possibility of a means of identifying affected individuals before symptoms appear and of early treatment to prevent the disease becoming sufficiently advanced to threaten the life of the patient ( PNAS , DOI:/10.1073/pnas.1635114100, September 29, 2003). Gene expression profiles in cell lines derived from tissues constituting normal skin provided explanation for the observed expression profiles. Fibroblast cell lines outgrown from the biopsies failed to give differential gene expression profiles, precluding their use for diagnostic purposes. An expression profile similar to B lymphocytes suggested the involvement of this inflammatory cell type where previously only T cells were thought to be present, providing a new direction for research into the disease. In addition, several potential diagnostic disease markers were identified. "This approach has the advantage of identifying multiple genes representing multiple different cell types in a complex disease whose underlying pathogenesis is still unknown. From a research perspective, it may give rise to new hypotheses about pathogenesis that can be tested," the authors conclude.

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