101. MedicalSource.com_D2R: Your Source For Scleroerma - Sclerodermasupport - Sclerod MedicalSource.com Your Source For scleroderma sclerodermasupport -sclerodermasupport.com. http://sclerodermasupport.com/

102. United Scleroderma Foundation Inc. physical and emotional effects of scleroderma, but facing them alone can bedevastating. The mission of the United scleroderma Foundation is to provide http://swcybermall.com/scleroderma/

united scleroderma foundation inc. New Mexico Chapter About Our Foundation Upcoming Events About Scleroderma Symptoms ... How You Can Help MISSION STATEMENT It's hard enough to face the debilitating physical and emotional effects of scleroderma, but facing them alone can be devastating. The mission of the United Scleroderma Foundation is to provide educational and emotional support for scleroderma patients and their families. USF is committed to increasing awareness of this devastating disease and raising essential research dollars to determine its cause enhance treatment and find a cure. For More Information contact: United Scleroderma Foundation The New Mexico State Chapter 4720 Cutting Ave. NW Albuquerque, NM E-mail: SuarezTD@aol.com This web site is sponserd by ARTistic Internet Services, Albuquerque, NM

103. BBC - Health - Conditions - Scleroderma The affects of scleroderma and how it can be treated. http://www.bbc.co.uk/health/conditions/scleroderma1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index FRIDAY 9th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Scleroderma Dr Rob Hicks There may be no cure for the skin-thickening disease scleroderma, but there are many forms of treatment that can help you lead as normal a life as possible. In this article What is it? Causes What happens? Symptoms ... Treatment What is it? The immune system that should protect the body attacks it instead Scleroderma - from the Greek words for 'hard' and 'skin' - is an autoimmune disease. In such diseases, the immune system that should protect the body attacks it instead. In this case, it targets the connective tissue found in skin, muscles and organs. This causes inflammation and scarring, which eventually leaves skin thickened, muscles weakened and organs damaged. There are many forms of scleroderma, but the main two are localised scleroderma, which affects just the skin - and systemic sclerosis, which also affects the internal organs. Around 18 to 20 people per million are diagnosed with scleroderma each year in the UK. It generally starts before the age of 50 and women are more commonly affected than men.

104. BBC - Health - Awareness Campaigns - Scleroderma Awareness Week Details of the national campaign to increase awareness of scleroderma. http://www.bbc.co.uk/health/awareness_campaigns/nov_scleroderma.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index FRIDAY 9th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Scleroderma Awareness Week 7 to 11 November 2005 In this article What is Scleroderma Awareness Week? What is scleroderma? Symptoms Management and treatment ... Where can I find out more? What is Scleroderma Awareness Week? The campaign aims to raise awareness of scleroderma, offering advice and support to sufferers and raising funds for research projects. The Raynaud's and Scleroderma Association is currently trying to find out whether people with scleroderma are getting the services they need as early diagnosis is vital. The results of the questionnaire will be announced during the awareness week. What is scleroderma? Scleroderma, also known as systemic sclerosis, is a connective tissue disease, which in its worst form, is potentially fatal. It affects the internal organs and the blood vessels and can drastically change people's lives making daily living both painful and difficult. Lack of independence means there is often a heavy burden on family members and carers. Scleroderma is the most deadly of the connective tissue diseases. The worst complications have a death rate similar to that of lung cancer. There's an overwhelming need for more research in order to improve the quality and quantity of life for those patients who suffer from this disease. Early diagnosis is essential if patients are to be given early treatment to slow down the progression of the disease and the opportunity to take part in clinical trials.

105. Sclreoderma NSW http://www.sclerodermansw.org/

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106. DermIS / Main Menu / DOIA / Progressive Systemic Scleroderma / Images Progressive Systemic scleroderma / images. images for the diagnosis ProgressiveSystemic scleroderma . Click to enlarge. Click to enlarge. http://dermis.multimedica.de/doia/diagnose.asp?zugr=d&lang=e&diagnr=710110&topic

107. Scleroderma, Northwestern Center For Clinical Research, Feinberg School, Northwe scleroderma is a disease that primarily affects the skin, where parts of the skin Autoimmune problems are another important feature of scleroderma, http://www.nccr.northwestern.edu/scleroderma.htm

Feinberg School Northwestern Center for Clinical Research Scleroderma About NCCR Home Organization History Staff Education and Training Overview Clinical Research Coordinators Navigating the Research Maze Seminars Clinical Research Advisory Board Lecture Series NCCR Navigator E-Newsletter Educational Events For Patients Clinical Research Types of Research Studies Register for Research Support and Information Links ... Contact Us For Investigators Clinical Trials Assistance Contact Us For Industry NCCR Advantage Contact Us Scleroderma What is scleroderma? Scleroderma is a disease that primarily affects the skin, where parts of the skin become thick and hard. Similar changes can occur in other organs as well such as the heart, lungs, kidneys, and gastro-intestinal tract. Two major types of scleroderma exist. The first is localized scleroderma and only involves the skin and muscles. The second is systemic scleroderma which involves organs other than the skin and muscles. This type is more properly known as systemic sclerosis. Symptoms of systemic scleroderma include arthritis and fever, symptoms common to other auto-immune diseases. The causes of scleroderma are unknown. Genetics play an obvious role, but so do some environmental factors. A link has been found between such chemicals as silica dust, toluene, and benzene and Scleroderma.

108. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Search results for scleroderma CONDITION AND pain ALLFIELDS are shown below . Recruiting, scleroderma Cyclophosphamide or Transplantation (SCOT) http://www.clinicaltrials.gov/ct/search?term=Scleroderma[CONDITION] pain[ALL-FIE

109. Clinical Trial: Scleroderma Registry The scleroderma Registry will conduct genetic analyses for diseaserelated genes in Official Title scleroderma Family Registry and DNA Repository http://www.clinicaltrials.gov/ct/gui/show/NCT00074568

Home Search Browse Resources ... About Scleroderma Registry This study is currently recruiting patients. Verified by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) March 2005 Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Information provided by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ClinicalTrials.gov Identifier: Purpose Scleroderma is likely caused by a combination of factors, including an external trigger (infection or other exposure) and a genetic predisposition. The Scleroderma Registry will conduct genetic analyses for disease-related genes in patients with scleroderma and their family members (parents, brothers, and sisters). Condition Systemic Sclerosis Scleroderma MedlinePlus related topics: Scleroderma Study Type: Observational Study Design: Natural History, Cross-Sectional, Case Control, Retrospective/Prospective Study Official Title: Scleroderma Family Registry and DNA Repository Further Study Details: Expected Total Enrollment: 5000 Study start: September 2000 Scleroderma refers to a group of diseases that involve the abnormal growth of connective tissue, which supports the skin and internal organs. Scleroderma can affect the skin, making it hard and tight; it can also damage the blood vessels and internal organs such as the heart, lungs, and kidneys. Estimates for the number of people in the United States with the systemic (body-wide) form of scleroderma range from 40,000 to 165,000. The number of people with all scleroderma-related disorders is between 250,000 and 992,500.

110. Morphoea (localised Scleroderma, Morphea). DermNet NZ Authoritative facts about the skin from the New Zealand Dermatological Society. http://dermnetnz.org/immune/morphoea.html

@import url("/common/screen.css"); DermNet NZ Ad Authoritative facts about the skin from the New Zealand Dermatological Society Incorporated Home For patients For doctors ... Site map Search: Home Immune Morphoea Morphoea (morphea) is an uncommon persistent condition in which there are areas of thickened skin. It is also known as localised scleroderma . It may affect adults or children. In nearly all cases the cause of morphoea is unknown. It can however sometimes follow: Localised injury Tick bites - it has been associated with Lyme disease (not known in New Zealand) Pregnancy Measles and other viral infections Autoimmune diseases including lichen sclerosus and lichen planus Clinical features Plaques. This is the most common pattern of morphoea. There are thickened scar-like oval patches of skin from 1- 20 cm or more in diameter. They start off mauve in colour, then over several months they usually become ivory white in the middle with a lilac edge. Old lesions may be brown. The surface is smooth, shiny and hairless. The patches do not sweat. Several plaques may be present, on both sides of the trunk and limbs distributed asymmetrically. Superficial Morphoea Usually affecting middle-aged women, superficial morphoea presents as symmetrical mauve-coloured patches in the skin folds, particularly the groin, armpits and under the breasts.

111. Scleroderma - FAQs From ArthritisCentral.com A. scleroderma literally means hard skin. It is a multisystemic disorder not A. CREST syndrome is a limited form of scleroderma and literally CREST http://www.arthritiscentral.com/html/faqscler.htm

Frequently Asked Questions Scleroderma Q. What is scleroderma? A. Scleroderma literally means hard skin. It is a multisystemic disorder not simply limited to the skin and may also involve the heart, lungs and kidneys. It is often associated with Raynaud's Phenomenon which is a color change in the extremities often secondary to exposure to cold, trauma or stress. Diffuse cutaneous forms of disease are referred to as systemic sclerosis. Limited cutaneous forms, overlapping syndromes, and localized forms are referred to as linear sclerosis or morphea. The limited cutaneous forms are also referred to as CREST syndrome and have a strong association with certain antibodies, such as the anticentromere antibody and overall has a better prognosis (see next question). Q. What is CREST syndrome? A. CREST syndrome is a limited form of scleroderma and literally CREST stands for Calcinosis, Raynaud's phenomenon, Esophageal dysmotility (often given rise to heartburn symptoms and lower esophagitis), Sclerodactyly which refers to the sclerodermatous changes of the fingers, and Telangiectasias which are dilated venules, capillaries and arterioles involving the hands, face, lips or mouth. It is often associated with an anticentromere antibody and has a relatively good prognosis, but needs to be followed carefully for the development of pulmonary hypertension or pulmonary fibrosis. Patients with CREST syndrome can also have progressive Raynaud's Phenomenon even leading to auto?amputation of the digits. Another feature that is sometimes associated with CREST syndrome is the presence of biliary cirrhosis.

112. Pediatric Arthritis & Other Rheumatic Diseases - Scleroderma There are two forms of scleroderma localized scleroderma and systemic sclerosis . Other names for the localized form are morphea and linear scleroderma. http://uuhsc.utah.edu/healthinfo/pediatric/arthritis/sclero.htm

CREST Syndrome A less severe form of scleroderma is called CREST . The CREST syndrome represents the following symptoms: C alcium skin deposits R aynaud's phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous) E sophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach) S clerodactyly (skin damage on fingers) T elangiectasia (spider veins), limits skin damage to the fingers. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure. Scleroderma What is scleroderma? There are two forms of scleroderma: localized scleroderma and systemic sclerosis. Localized scleroderma can be seen more frequently in children than the systemic form. It may involve patches of the skin on the trunk, arms, legs, or head. Other names for the localized form are morphea and linear scleroderma. Systemic sclerosis is a chronic, degenerative disease that affects the joints, skin, and internal organs. Scleroderma is also associated with blood vessel abnormalities. Systemic sclerosis occurs only rarely in children.

113. Berkeley Parents Network: Scleroderma Does anyone have the skin disease called scleroderma? I d be interested in treatments Hi, I have had a client in my nutrition practice with scleroderma. http://parents.berkeley.edu/recommend/medical/scleroderma.html

Berkeley Parents Network Home Members Post a Msg Reviews ... Search Scleroderma Berkeley Parents Network Reviews > Scleroderma Nov 2002 Does anyone have the skin disease called scleroderma? I'd be interested in treatments and any dermatologist recomendations. Thannks!! Anon Hi, I have had a client in my nutrition practice with scleroderma. As it is an autoimmune disease, we worked on mitigating inflammation through dietary changes, particularly foods that may be provocative. We further checked out any exposures that could be triggers, such as heavy metals. Additionally, stress reduction and exercise played important roles in her feeling better. Nori Hudson I was diagnosed with sclera derma shortly after giving birth to my first child. It is a serious autoimmune disease that needs to be monitored - you should be seeing a rheumatologist. I recently saw a dermatologist who told me he works with sclera derma patients as prescribed by the rheumatologist. A well known rheumatologist, who happens to specialize in sclera derma, is Dr. Neal Birnbaum at 2100 Webster in SF. So far he has not offered any treatment, and as I understood it there are no medications that rid one of the disease or even can control it's progression, but there are medications that can assist in relieving pain and discomfort. As I had been nursing until recently I have not explored any of the meds. Good luck. anon Home Reviews Advice Members ... Search Please send questions and comments to Berkeley Parents Network Last updated: Oct 25, 2003

114. Uhrad.com - Musculoskeletal Imaging Teaching Files Case Forty Eight Systemic Sclerosis (scleroderma) Discussion Progressivesystemic sclerosis (scleroderma) is a disorder of connective tissue http://www.uhrad.com/msiarc/msi048.htm

uhrad.com - Musculoskeletal Imaging Teaching Files Case Forty Eight - Systemic Sclerosis (Scleroderma) (Image #1 and Image #2) (Image #3 and Image #4) Click On Images for Enlarged View Clinical History: Not given. Findings: Image #1 is a plain film of the hand demonstrating acroosteolysis of the distal tufts of the bilateral fourth and fifth distal phalanges. Image #2 is a plain film of the hands in a second patient with the same diagnosis demonstrating acroosteolysis as well as flexion contractures. Image #3 is a PA chest x-ray demonstrating mild basilar interstitial prominence as well as calcifications projecting over the left shoulder soft tissues. Image #4 is a plain film of the pelvis demonstrating extensive soft tissue calcifications. Diagnosis: Systemic sclerosis (scleroderma). Discussion: Progressive systemic sclerosis (scleroderma) is a disorder of connective tissue dysfunction which affects whole organ systems including skin, lungs, GI, heart, kidneys and musculoskeletal. The characteristic radiographic presentation is generally defined as soft tissue atrophy, calcifications, and distal phalangeal resorption in the hand. In addition, recently described findings include erosion involving the distal interphalangeal disease (DIP) and less commonly proximal interphalangeal (PIP) joints. Although there has been no definite pathogenesis identified, it is felt that progressive systemic sclerosis secondary to a structural defect in the microvasculature. This is supported by the fact that there are often vascular changes identified in multiple tissues.

115. Antibiotic Therapy, Rheumatic Disease, Antibiotics, Arthritis, Rheumatoid,Lupus, regarding the treatment and causes of rheumatoid arthritis, scleroderma, lupus,juvenile rheumatoid arthritis, fibromyalagia and related diseases. http://www.roadback.org/

Harris Interactive, the fastest growing market research firm in the world, known for the Harris Poll and its pioneering Internet-based research, will be conducting an on-line survey of the experiences of people with rheumatic diseases (e.g. rheumatoid arthritis and scleroderma). The Road Back Foundation (RBF) is supporting this important study. If you have an interest in participating in the survey and/or receiving a copy of the results, please sign onto the RBF's emailing list found on this homepage (www.roadback.org). More news to follow! Welcome to The Road Back Foundation The Road Back Foundation (RBF), founded by patient-volunteers in 1993, is a non profit organization dedicated to support, research and education regarding the treatment and causes of rheumatoid arthritis, scleroderma, lupus, juvenile rheumatoid arthritis, fibromyalgia and related diseases. A particular focus of the Foundation is treatment and research using safe, low-cost, low-dose antibiotic therapy proven effective in NIH-sponsored clinical trials. The Road Back Foundation takes its name from a book based on the pioneering work of the late Thomas McPherson Brown, MD who successfully treated thousands of grateful rheumatic patients with antibiotic therapy.

116. Scleroderma Index UV Murav´av, et al., a Russian Study. What is scleroderma? General informationconcerning the disease s symptoms, its causes, and treatment. http://www.dmso.org/articles/scleroderma/

Scleroderma Index Studies: "Further Observations on the Effect of Dimethyl Sulfoxide in Patients with Generalized Scleroderma (Progressive Systemic Sclerosis)" Authur L. Scherbel, Lawrence J. McCormack, and John K. Layle "The Efficacy of Long-Term Application of Dimethyl Sulfoxide in a Complex Therapy of Patients with Systemic Scleroderm" "What is Scleroderma?" : General information concerning the disease's symptoms, its causes, and treatment.

117. ANTIBIOTICS TO TREAT RHEUMATOID ARTHRITIS, SCLERODERMA, LUPUS, JUVENILE RHEUMATO Antibiotic treatment for rheumatoid arthritis, scleroderma, lupus, juvenilerheumatoid arthritis, polymyositis, dermatomyositis, Reiter s Syndrome, http://www.rheumatic.org/

Home Scientific Publications Frequently Asked Questions Information for you and your doctor ... Useful Links A LEGACY OF HEALTH The life and work of Thomas McPherson Brown M.D TREATMENT OF INFLAMMATORY RHEUMATIC DISEASE WITH LOW DOSE ANTIBIOTIC THERAPY: RHEUMATOID ARTHRITIS, SCLERODERMA, LUPUS, POLYMYOSITIS, DERMATOMYOSITIS, PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS, REITER'S SYNDROME AND JUVENILE RHEUMATOID ARTHRITIS The information on this site is provided by physicians experienced in the treatment of inflammatory rheumatic diseases with low dose antibiotics according to the protocol developed by the late Dr. Thomas McPherson Brown, M.D. and by many of the multiple thousands of patients who have benefited from this treatment. The website includes all the information necessary to administer this therapy. Physicians should not attempt antibiotic therapy until they have read the protocol completely as this therapy is unlike any other they may be currently using. There are many components to these diseases and their treatment and antibiotic therapy must be tailored to the individual. Treatment periods are usually long and medication and dosage adjustments may be required. WWW http://www.rheumatic.org

118. Scleroderma In autoimmune diseases like scleroderma, normal molecules of the body are scleroderma can range from a localized disease that primarily affects the skin http://www.fhcrc.org/research/diseases/scleroderma/

@import "/wrapper/global.css"; @import "/wrapper/wrapper.css"; Scleroderma Disease Background Description of Disease Who is at Risk? National Cancer Institute Dictionary Our Research Overview of Fred Hutchinson Research Research Highlights Innovative new treatments for autoimmune diseases Uncovering the genetic secrets of autoimmune disease Relevant Articles Fred Hutchinson Publications Disease Background Description of the Disease Scleroderma is a chronic autoimmune disease. Its hallmark feature is fibrosis, which means hardening of the skin (derived from "sklero" or hard and "derma" referring to skin). In autoimmune diseases, a person's immune system attacks the body, resulting in inflammation of various organs or tissues. The components of the immune system responsible for this effect are antibodies and cells. Antibodies are proteins produced by white blood cells typically made in response to infection caused by pathogens like bacteria and viruses. In autoimmune diseases like scleroderma, normal molecules of the body are mistakenly recognized by immune-system cells and antibodies, and are targeted for destruction. Scleroderma can range from a localized disease that primarily affects the skin to a more serious illness known as systemic sclerosis, causing damage to multiple parts of the body. Tissues that can be affected include the skin, joints, digestive tract, lung and kidney.

119. Untitled Document The diagnosis of scleroderma in 1936 coincided with a severe case of measles . In comparing his art before and after scleroderma onset (1935), http://www.musc.edu/rheumatology/klee.html

About MUSC Education Medical Center Research ... Library MUSC Directory Web Division of Rheumatology and Immunology Home Faculty Publications Training Program ... Contact Us Paul Klee Director's Welcome Rheumatology: FAQs Newsletter Clinical Trials ... Site Index By E. Carwile LeRoy and Richard Silver Paul Klee was perhaps the most famous person to develop scleroderma (systemic sclerosis) and die from it. Born in a suburb of Bern, Switzerland, he trained in art in Munich and became a principal in the "Blue Rider" school which included Kandinsky, whose painting gave the movement its name. The members of this school contributed integrally to the development of art as we know it today. Their ability to convey a mood with abstract figures remains impressive. Klee's position as a pioneer in modern art has increased steadily in the decades since his death in 1940, four years after the diagnosis of scleroderma was made at age 56. Klee studied, taught and practiced etching from 1898-1914, when on a trip to Tunisia with August Macke and Louis Moilliet he embraced color and temporarily became occupied with cubism. Recognition of his works increased steadily from 1908 to the present. His work was exhibited in New York in 1924, in London in 1934, and, in 1931, 252 works were exhibited at the Kunstverein in Dusseldorf in 1931; in addition, there were numerous exhibitions in Munich. Having previously interacted with Kandinsky, Macke, Marc, Kubin (the Blue Rider artists), he met Delauney, Le Fauconnier, Kahnweiler and Uhde in Paris in 1912, where he saw the work of Picasso, Braque, Matisse and Rousseau. Klee was a revered teacher and kept extensive and methodical notes on his paintings, placing importance on his titles for interpretation by his audience.

120. Scleroderma Foundation - Michigan Chapter - Landing Page PLEASE NOTE Online registration for the scleroderma Foundation Michigan Chapter s26th Annual Walk and Run has ENDED ! This event will be held on Sunday, http://www.justgiving.com/26thwalkrun

Visa and Mastercard accepted PLEASE NOTE: Online registration for the Scleroderma Foundation Michigan Chapter's 26th Annual Walk and Run has ENDED ! This event will be held on Sunday, June 12, 2005 at Shain Park in beautiful downtown Birmingham, MI from 9 am - 2 pm. Thank you for your interest in our event and in supporting our mission. You can help us make this event the most SPECTACULAR walk and run we've ever held by following these easy and fun steps: Step One: Click the GET STARTED button below. Step Two: Register for the event! If you plan to walk or run with us, be sure to register online, which is the easiest way to register. You can also learn how to register via US Mail, fax or at the event by clicking here Step Three: Create your online Personal Fundraising Page! You will then be able to collect pledges to support our event with ease and enthusiasm. Click here to learn more about incentives you can earn for collecting pledges. Step Four: Send out your website link, which will be provided to you, to your family, friends, co-workers and everyone you know so they can help you reach your fundraising goal. Our easy-to-navigate web pages will guide you through each action mentioned above step-by-step. If you experience any difficulty, please contact Jennifer Viano at 248.865.7259.

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