81. Scleroderma scleroderma is a chronic, often progressive autoimmune connective tissue disorderin which There are two basic types of scleroderma the systemic from, http://www.uth.tmc.edu/schools/med/imed/med_gen/sclero.htm

Research Aortic Aneurysms and Aortic Dissections Marfan Syndrome Scleroderma ... Contact Us Scleroderma What is scleroderma? What symptoms are involved? The disease name "scleroderma" literally means hard (skleros) + skin (derma) can cause thickening and tightening of the skin, and in some cases serious damage to internal organs including lungs, heart, kidneys, esophagus, and gastrointestinal (GI) tract. There are two basic types of scleroderma: the systemic from, the localized form. However these forms can overlap with other scleroderma-related disorders. Systemic scleroderma is further divided into two forms: limited and diffuse, referring to the degree of skin involvement. Both forms are associated with internal organ damage, but the limited form tends to have less severe organ problems. Persons with the diffuse form have more extensive skin thickening that involves trunk or upper extremities in addition to the face and distal extremities. There is usually significant involvement of the lungs, heart, gastrointestinal tract, and kidneys. Persons with the limited form have skin thickening limited to sites distal to the elbow and knee but can also involving face and neck. Late organ involvement includes hypertension, digital ulceration, and possible digital amputation. Limited scleroderma is often referred to as the CREST from. CREST is an acronym for:

82. RI Scleroderma Support Group For patients and their families in New England and elsewhere. Support, information, events, links, and research fundraisers. http://www.angelfire.com/ri/scleroderma

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83. DermAtlas: Online Dermatology Image Library Dermatology Image,morphea,lipoatroph DermAtlas Dermatology Images stiff skin,scleroderma,sclerodactyly,morphea,lipoatrophy,dermatology image,collagenosis,collagenosis,collagenosis, http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=131

84. Arthritis Research Campaign | Scleroderma Grants scleroderma (or systemic sclerosis) is a rare chronic inflammatory disease causinghardening of connective tissue and may involve many organs including the http://www.arc.org.uk/research/sc.asp

scotland + n. ireland north wales + midlands east + southeast ... south + southwest Scleroderma Scleroderma (or systemic sclerosis) is a rare chronic inflammatory disease causing hardening of connective tissue and may involve many organs including the skin, muscles, heart and lungs. Display Records Study Title Town Amount Academic Secretary Grant for Academic Rheumatology Unit, University of Southampton SOUTHAMPTON The importance of the chemokine MCP-1 in scleroderma LONDON Academic Secretary Grant for the Staffordshire Rheumatology Centre, The Haywood, Stoke on Trent STOKE ON TRENT LEEDS A clinical trial of the prevention of vascular damage in scleroderma with ACE (angiotensin-converting anzyme) inhibitors BANGOR Academic Secretary Grant for the Rheumatology Research Group at the University of Liverpool LIVERPOOL ABERDEEN Academic Secretary Grant for the Department of Rheumatology, University of Wales CARDIFF Academic Secretary Grant for the Musculoskeletal Research Unit, Nuffield Orthopaedic Centre, Oxford OXFORD Academic Secretary Grant for the Division of Genomic Medicine, University of Sheffield

85. Arthritis Research Campaign | Scleroderma The word scleroderma means hard skin . However, many people with sclerodermahave problems not only with their skin but with other parts of their bodies http://www.arc.org.uk/about_arth/booklets/6036/6036.htm

scotland + n. ireland north wales + midlands east + southeast ... south + southwest What is scleroderma? The word 'scleroderma' means 'hard skin'. However, many people with scleroderma have problems not only with their skin but with other parts of their bodies as well. This is the reason why it has a second name, 'systemic sclerosis'. Scleroderma is an uncommon, chronic (persistent) disease. It affects the connective tissues which surround the joints, blood vessels and internal organs beneath the affected area of skin. Women are affected three to four times more often than men. The disease usually starts between the ages of 25 and 50. It only occasionally begins in children or in the elderly. Although there is no cure, proper treatment and care can make it possible for people with scleroderma to lead full, productive lives. There may however be some limitation on your activity. This booklet gives some basic facts about scleroderma. It discusses possible causes, the tests that are undertaken to see if you have the condition, and the range of treatments that are available, and gives addresses of organisations that may be helpful. The better informed you are, the more able you will be to take an active part with your doctor and other health workers in keeping the illness under control.

86. Scleroderma - Symptoms, Treatment And Prevention Symptoms, Treatment and Prevention of scleroderma. http://www.healthscout.com/ency/68/311/main.html

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87. InteliHealth: Scleroderma InteliHealth Featuring Harvard Medical School s consumer health information.For more than 550 diseases and conditions, learn What Is It?, Symptoms, http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/10646.html

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88. Sclero The scleroderma Center at Boston University School of Medicine and Boston The scleroderma Center is part of the Boston University Arthritis Center, http://medicine.bu.edu/sc/sclero.htm

Joseph H. Korn, MD, Director Robert Simms, MD, Associate Director, Clinical Programs Peter Merkel MD, Clinical Trials Kate Schrade, Admin. Asst. Clinical Programs Tina Elias-Todd, MD Fellow Harrison Farber MD, Pulmonary Eugene Kissin, MD, Fellow Dennis Liu, MD Fellow Arthur Theodore MD, Pulmonary Basic Research Programs Allesandra Farina, MD Robert Lafyatis, MD Raphael Lemaire, Ph.D. Lauren Kim, MD Fellow Tako Ogawa, MD David Strehlow, PhD Russell Widom, PhD The Scleroderma Center at Boston University School of Medicine and Boston Medical Center is a multidisciplinary effort encompassing basic and clinical research, clinical trials and patient care. The Scleroderma Center is part of the Boston University Arthritis Center, which has an extensive research program in immunology, molecular and cell biology, biochemistry and epidemiology. Clinical care is provided at the Boston Medical Center, including clinical trials at the NIH-funded Clinical Research Center of Boston University Medical Center. Research is supported by grants from the NIH, Arthritis Foundation, Scleroderma Research Fund, and kind gifts from patients and corporate donors. The support we receive allows us to provide a broad range of clinical and advisory services to patients with scleroderma and other autoimmune diseases. Clinical Programs Over the last 9 years, approximately 800 patients with scleroderma have been evaluated, including patients from Southeast Asia, South America, the Middle East and various parts of the U.S. Special programs for the evaluation of lung disease and pulmonary hypertension are in place. Our program is part of the international Scleroderma Clinical Trials Consortium, a group that conducts multicenter trials of therapies in scleroderma. We currently have two studies for skin disease in early scleroderma, anti-body to TGFß and interferon ß-1.

89. Scleroderma - UMMC An indepth report on the causes, diagnosis, treatment, and prevention of scleroderma. http://www.umm.edu/patiented/articles/what_scleroderma_000088_1.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Home Medical Reference Patient Education Scleroderma WHAT IS SCLERODERMA? The name scleroderma is appropriately derived from the Greek word skleros , which means hard, and derma , which means skin. The disease is categorized as a rheumatologic disorder because it affects the connective tissues in the body. Scleroderma is a rare disease marked by the following: Damage to the cells lining the walls of small arteries. An abnormal build-up of tough scar-like fibrous tissue in the skin. Patients with scleroderma may develop either a localized or a systemic (widespread) form of the disease. Localized Scleroderma Localized scleroderma usually affects only the skin on the hands and face. Its course is very slow and it rarely, if ever, becomes systemic see below ] or causes severe complications. There are two primary forms of localized scleroderma: morphea and linear scleroderma. Morphea Scleroderma. In morphea scleroderma patches of hard skin form and can persist for years. Eventually, however, they may improve or even disappear. There is less than a 1% chance that this disorder will progress to systemic scleroderma. Linear Scleroderma.

90. ► Systemic Sclerosis (scleroderma) A medical encycopedia article on the topic Systemic sclerosis (scleroderma) http://www.umm.edu/ency/article/000429.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Systemic sclerosis (scleroderma) Overview Symptoms Treatment Prevention Definition: A diffuse connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. Alternative Names: CREST syndrome; Progressive systemic sclerosis; Scleroderma Causes, incidence, and risk factors: The cause of scleroderma is unknown. The disease may produce local or systemic symptoms. The course and severity of the disease varies widely in those affected. Excess collagen deposits in the skin and other organs produce the symptoms. Damage to small blood vessels within the skin and affected organs also occurs. In the skin, ulceration, calcification, and changes in pigmentation may occur. Systemic features may include fibrosis and degeneration of the heart, lungs, kidneys and gastrointestinal tract. The disease usually affects people 30 to 50 years old. Women are affected more often than men. Risk factors are occupational exposure to silica dust and polyvinyl chloride. Raynaud's phenomenon Review Date: 11/26/2001 Reviewed By: Birgit Kovacs, M.D., Division of Rheumatology, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

91. Scleroderma Detailed information on scleroderma, including symptoms, diagnosis, and treatment. http://www.healthsystem.virginia.edu/uvahealth/peds_arthritis/sclero.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation UVa Health Topics A to Z FIND A DOCTOR Pediatric Arthritis Pediatric Rheumatology MAKE AN APPOINTMENT ... CLINICAL TRIALS Search This Site CREST Syndrome A less severe form of scleroderma is called CREST . The CREST syndrome represents the following symptoms: C alcium skin deposits R aynaud's phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous) E sophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach)

92. Scleroderma DESCRIPTION scleroderma (systemic sclerosis SSc) is a chronic disease of unknown Treatment with bleomycin has caused a sclerodermalike syndrome http://www.5mcc.com/Assets/SUMMARY/TP0832.html

Scleroderma DESCRIPTION: Scleroderma (systemic sclerosis [SSc]) is a chronic disease of unknown etiology, characterized by diffuse fibrosis, degenerative changes, and vascular abnormalities in the skin, articular structures and other organs (kidneys, lung, heart, gastrointestinal and skeletal muscles). The majority of manifestations have vascular features (e.g., Raynaud's phenomenon), but frank vasculitis is rarely seen. It can range from a mild disease, affecting the skin, to a systemic disease that can cause death in a few months. Divided into two major clinical variants: Diffuse - distal and maximal extremity and truncal skin thickening Limited - restricted to the fingers, hands and face. CREST syndrome (calcinosis, Raynaud's phenomenon, poor esophageal mobility, sclerodactyly, telangiectasia) closely analogous with limited scleroderma. System(s) affected: Skin/Exocrine, Renal/Urologic, Cardiovascular, Gastrointestinal, Musculoskeletal, Pulmonary Genetics: Familial clustering is rare, but has been seen Incidence/Prevalence in USA: Predominant age: Young adult (16-40 years); middle age (40-75 years)

93. For Some Patients, Scleroderma Runs Deep Although skin hardening is the most obvious sign of scleroderma, it is by nomeans the most dangerous The disease can cause lifethreatening problems in http://healthlink.mcw.edu/article/1031002255.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Skin/Dermatology Immune Disorders Musculoskeletal Disorders By keywords: scleroderma connective tissue diseases Autoimmune Diseases Skin Diseases ... rheumatic diseases Receive Health Link via email! Subscribe now >> For Some Patients, Scleroderma Runs Deep The term ‘scleroderma’ comes from the Greek words for ‘hard skin’,” says M. E. Csuka, MD , Associate Professor of Medicine at the Medical College of Wisconsin. “Its most obvious manifestation is thickening and hardening of the skin, and that’s how we usually make the diagnosis.” Although it’s the most obvious sign of scleroderma, skin hardening is by no means the most dangerous symptom of this baffling disease. Patients who have this thickened, hard skin experience decreases in physical functioning and limits in the activities of daily living. But for the most part this skin problem is not what causes them their most serious morbidity and mortality,” says Dr. Csuka. In fact the disease can run much deeper and cause life-threatening problems in the lungs, heart, esophagus, gastrointestinal tract and kidneys. According to the Scleroderma Foundation, an estimated 300,000 people in the United States have the disease. Women are about four times more likely than men to develop scleroderma, which is considered both a rheumatic disease and a connective tissue disease. Rheumatic diseases are characterized by inflammation and pain in the muscles, joints or fibrous tissue. A connective tissue disease affects the major substances in the skin, tendons and bones.

94. Scleroderma In some cases, scleroderma also affects the blood vessels and internal organs.scleroderma is one of a group of arthritic conditions called connective http://www.cnn.com/HEALTH/library/DS/00362.html

International Edition MEMBER SERVICES The Web CNN.com Home Page World U.S. Weather ... Autos SERVICES Video E-mail Newsletters Your E-mail Alerts RSS ... Contact Us SEARCH Web CNN.com In association with: WOMEN'S HEALTH Hair/Nails/Skin Corns and calluses Nail fungus Ingrown toenails Moles ... Vitiligo INFORMATION CENTERS: Pick a category Health Centers Family Health Men's Health Women's Health Children's Health Seniors' Health Working Life Pain Management Condition Centers Immune System Allergy Alzheimer's Arthritis Respiratory System Cancer Endocrine System Digestive System Heart and Blood Infectious Disease Mental Health Note: All links within content go to MayoClinic.com Diseases and Conditions Scleroderma From MayoClinic.com Special to CNN.com Overview In some cases, scleroderma also affects the blood vessels and internal organs. Scleroderma is one of a group of arthritic conditions called connective tissue disorders. In these disorders, a person's antibodies are directed against his or her own tissues. Researchers haven't established a definitive cause for scleroderma. About 150,000 Americans have the disease. It's more common in women than in men and more common in adults than in children. Scleroderma can run in families, but in most cases it occurs without any known family tendency for the disease. It's not considered contagious or cancerous, but this chronic condition can greatly affect self-esteem and the ability to accomplish everyday tasks. Arthritis Signs and symptoms In addition to thickening and hardening of your skin, scleroderma can cause your skin to lose its elasticity and become shiny as it stretches across underlying bone. Other signs and symptoms may include:

95. AllRefer Health - Systemic Sclerosis (Scleroderma) (CREST Syndrome, Progressive Systemic Sclerosis (scleroderma) (CREST Syndrome, Progressive Systemic Sclerosis,scleroderma) information center covers causes, prevention, symptoms, http://health.allrefer.com/health/systemic-sclerosis-scleroderma-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Systemic Sclerosis (Scleroderma) Systemic Sclerosis (Scleroderma) Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : CREST Syndrome, Progressive Systemic Sclerosis, Scleroderma Definition Scleroderma is a diffuse connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs. Raynaud's Phenomenon CREST Syndrome Sclerodactyly Telangiectasia The cause of scleroderma is unknown. The disease may produce local or systemic symptoms. The course and severity of the disease varies widely in those affected.

96. About - Scleroderma. scleroderma is a disease that can affect the skin, joints, blood vessels, The word scleroderma means hard skin. Most people with scleroderma have http://www.orthop.washington.edu/uw/scleroderma/tabID__3376/ItemID__54/Articles/

Home Site Map Contact Us Links ... All Articles Scleroderma. University of Washington, Seattle Last updated Tuesday, December 28, 2004 About Basics of scleroderma Scleroderma is a disease that can affect the skin, joints , blood vessels, and internal organs. The word scleroderma means "hard skin." Most people with scleroderma have problems with their skin and other parts of their bodies. How useful was this page or article? This article is rated out of 5 stars (63 ratings). Not useful at all Not very useful Useful Very useful Extremely useful Arthritis Children Research Spine ... Tumor Service Team Physicians to the UW Huskies Varsity Athletes...And You! Privacy statement Editorial policy Problems or questions? Contact the webmaster

97. THE MERCK MANUAL--SECOND HOME EDITION, Scleroderma In Ch. 68, Autoimmune Disorde Symptoms of scleroderma may occur as part of mixed connective tissue disease, scleroderma can cause scar tissue to accumulate in the lungs, resulting in http://www.merck.com/mmhe/sec05/ch068/ch068c.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Bone, Joint, and Muscle Disorders Chapter Autoimmune Disorders of Connective Tissue Topics Introduction Eosinophilic Fasciitis Mixed Connective Tissue Disease Polymyositis and Dermatomyositis ... Relapsing Polychondritis Scleroderma Sj¶gren's Syndrome Systemic Lupus Erythematosus Scleroderma Buy The Book Print This Topic Email This Topic Pronunciations angiotensin biliary cirrhosis corticosteroid ... telangiectasia Scleroderma (systemic sclerosis) is a chronic disorder characterized by degenerative changes and scarring in the skin, joints, and internal organs and by blood vessel abnormalities. The cause of scleroderma is not known. The disorder is 4 times more common in women than in men and is rare in children. Symptoms of scleroderma may occur as part of mixed connective tissue disease, and some people with mixed connective tissue disease develop severe scleroderma.

98. Scleraderma Lung Study http://sclerodermalungstudy.medsch.ucla.edu/

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99. DermIS / Main Menu / DOIA / Localized Scleroderma / Images Localized scleroderma / images. images for the diagnosis Localized scleroderma .Click to enlarge. Click to enlarge. Click to enlarge. http://www.dermis.net/doia/diagnose.asp?zugr=d&lang=e&diagnr=701000&topic=t

100. Discovery Health :: Diseases & Conditions :: Scleroderma scleroderma is a widespread autoimmune disorder. It causes the skin and otherbody parts to slowly degenerate, thicken, and stiffen. http://health.discovery.com/encyclopedias/illnesses.html?article=3066&page=1

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