1. Retinoblastoma International: Homepage retinoblastoma International (RBI) is a public charitable organization dedicated to funding research, clinical treatment and international awareness for http://www.retinoblastoma.net/

Retinoblastoma International What is Retinoblastoma? ... Volunteer Retinoblastoma International 4650 Sunset Boulevard MS #88, Los Angeles, CA 90027 fax info@retinoblastoma.net MAP DIRECTIONS RETINOBLASTOMA INTERNATIONAL MORE ABOUT RETINOBLASTOMA INTERNATIONAL What Is Retinoblastoma? Find out more about this devastating children's eye cancer. Celebrities Promote Early Detection Peter Falk, Hunter Tylo, Matthew Ashford, and A. Martinez have contributed their talents to produce a series of Public Service Announcements VIEW VIDEO CLIPS Contribute to RBI (CLICK HERE TO FIND OUT WAYS TO MAKE A DONATION) A New Children’s Audio Book Featuring Award-Winning Cast Members From "Days of Our Lives" Raises Funds To Help Fight Retinoblastoma Find out more about " Emma and the GobbletyGoos ." All proceeds from the CD will be donated to RBI.

2. GeneReviews: Retinoblastoma Describes the genetic connection in regard to this condition. http://www.geneclinics.org/profiles/retinoblastoma/

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3. Retinoblastoma The goal of this website is to inform parents and professionals of the resources available for retinoblastoma with specific focus on Canadian resources. http://www.retinoblastoma.ca/

The goal of this website is to inform parents and professionals of the resources available for Retinoblastoma with specific focus on Canadian resources. Our Mission Our mission is to expand awareness of retinoblastoma Profile Retinoblastoma (RB) is the most common eye cancer in children and it can be inherited. Although the most common eye cancer in children, retinoblastoma is quite rare and occurs in approximately 1 in every 20,0000 births. The goal with retinoblastoma is early detection to maximize the visual outcome and the quality of life of the affected child. Fortunately, the survival rate for affected children i s In order to achieve our goal of early detection, we believe it is important to educate the public and other health professionals on the signs that might manifest themselves with a child that has retinoblastoma. We encourage people to share this information with others as many of the signs are very subtle and may not be picked up even by a health professional, due to the rarity of this disease. EARLY DETECTION IS THE KEY!!!!

4. Mike's Life With Retinoblastoma One parent's account and knowledge of this form of eye tumor. http://www.mrmegabyte.net/rb

On this page What is it? Tony Tony Adults ... Please visit our sponsor's web page and learn all about 3D Baby Ultrasounds! (Mike's Business) Home Retinoblastoma Support

5. Welcome To Retinoblastoma.com Gives a structured overview in a topics format including genetics, classification, diagnosis, treatment and a reference listing. http://www.retinoblastoma.com/guide.htm

If you would like to download a printer-friendly, Adobe Acrobat PDF version of the Parent's Guide to Understanding Retinoblastoma, please click HERE (PDF file size: 400K) Para obtener una copia de en version PDF, por favor haga click (PDF: 250K) If you would like to receive the booklet version of the Parent's Guide to Understanding Retinoblastoma by post, please send us an e-mail message to info@retinoblastoma.com specifying the language version you prefer.

6. Childhood Eye Cancer Trust (CHECT) | Fighting Retinoblastoma The retinoblastoma Sociey has changed its name. to the Childhood Eye Cancer Trust. Please update your bookmarks/favorites http://www.rbsociety.org.uk/

The Retinoblastoma Sociey has changed its name to the Childhood Eye Cancer Trust Please update your bookmarks/favorites Visit our new site by clicking anywhere on the image below Childhood Eye Cancer Trust :: The Royal London Hospital :: Whitechapel Road :: London E1 1BB Registered Charity No. 327493

7. Canadian Retinoblastoma Society Promotes the interests of patients and their families. http://www.rbsociety.ca

Home Personal Story Board of Directors Membership ... Benefactors The Canadian Retinoblastoma Society is the only registered charity in Canada dedicated to helping Canadian families affected by retinoblastoma. Thank you very much for your contribution. Welcome Page Print this Page The Canadian Retinoblastoma Society is an organization designed to promote the interests of Canadian retinoblastoma patients of all ages and their families. What is Retinoblastoma? Retinoblastoma is a disease that causes the growth of malignant tumors in the retinal cell layer of the eye. The frequency that retinoblastoma occurs has increased over the past 60 years. It now occurs in 1 out of every 15,000 live births. Untreated, retinoblastoma is almost always fatal; therefore, early diagnosis and treatment is critical in saving lives and preserving visual function. The treatment of retinoblastoma depends upon whether or not one or both eyes are involved and the extent of the tumor. Although removing the eye (enucleation) remains a frequent treatment for retinoblastoma, conservative strategies are being increasingly employed. With earlier detection and improved treatment modalities, the prognosis for vision and life in patients with retinoblastoma has improved significantly in the last twenty years. and is not intended to replace medical advice from your doctor.

8. Retinoblastoma Academic review article about developments in the diagnosis and treatment of retinoblastoma. http://www.moffitt.usf.edu/pubs/ccj/v5n4/article2.html

Retinoblastoma Curtis E. Margo, MD, MPH, Lynn E. Harman, MD, and Zuber D. Mulla, MSPH Although treatment outcomes for retinoblastoma have improved, patients with a germline gene mutation carry a high risk for second cancers. Background: Retinoblastoma is the most common intraocular malignancy of infants and children. With early diagnosis and treatment, survival is greater than 90%; however, patients with a germline retinoblastoma mutation have a substantial risk of having a second high-grade malignancy. Methods: The recent developments in the diagnosis and treatment of retinoblastoma are reviewed. Results: Identification of the retinoblastoma germline mutation is now possible with the discovery of the retinoblastoma gene. Patients with the germline mutation have a 51% cumulative risk over 50 years of developing a second malignancy. Several pilot studies using primary chemotherapy for retinoblastoma have shown promising results. Conclusions: Risk assessment and genetic counseling have become more precise with the development of laboratory methods to identify the retinoblastoma gene. The development of primary chemotherapy regimens to reduce the size of retinoblastoma tumors may decrease the need for radiation therapy and thereby reduce the risk of radiation-related malignancies in patients with the germline mutation. Introduction Retinoblastoma is the most common intraocular malignancy of infancy and childhood. Prior to this century, retinoblastoma was a uniformly fatal disease.

9. Index Clinicianoriented site with histopathological images of those with retinoblastoma. http://www.mrcophth.com/pathology/retinoblastoma/retinoblastoma.html

a Retinoblastoma q Retinoblastoma is the most common primary ocular tumour in childhood. It is also a favourite topic of the examiners as they can test the candidates' knowledge of genetics. If you were given a gross pathology of the eye, comment on the following: the size of the tumour the location of the tumour (endophytic or exophytic; single or multiple; any vitreal seedings) any spread outside the globe (especially of the optic nerve. In optic nerve involvement, there may be abnormal optic nerve enlargement or tumour surrounding the nerve. Extraocular spread is of great prognostic value.) An endophytic retinoblastoma. The tumour grows into the vitreal cavity. (In exophytic type, the tumour grows into the subretinal space). Optic nerve (O) invaded by retinoblastoma (R). Under the microscope, retinoblastoma contains deep blue cells with little cytoplasm. As the tumour cells usually outgrow their blood supplies, necrosis and haemorrhage are common within the tumour. In the slide, you will be expected to comment on: differentiation of the tumour (although this is of little prognostic value) any presence of tumour in the optic nerve.

10. RETINOBLASTOMA: HOME Provides information and support for families coping with the diagnosis and treatment of retinoblastoma. http://www.eyecancermd.org/retinoblastoma/

HOME ADULT EYE TUMORS Anatomy of the Eye Eye Tumors ... Contact Us RETINOBLASTOMA Anatomy of the Eye Diagnosis Examination Under Anesthesia Treatment ... PRINT VERSION (PDF) Change font size: Small Large document.selectStream.stream.value = fontSelection; Cancer is always a frightening diagnosis, and when it affects children, the situation is overwhelming. Eye cancer in children, though rare, is the third leading cancer of childhood. Retinoblastoma, a cancer of the retinal eye tissue, is the most common eye cancer in children. It affects approximately one in eighteen thousand live births without regard to race or gender. This number, in fact, probably underestimates the number of cases because children remain at risk for retinoblastoma during the first five years of life. Retinoblastoma can be a particularly distressing form of cancer as it is potentially fatal and can result in vision loss of one or both eyes. Fortunately, almost all children in North America can be successfully treated for retinoblastoma. Not only are children no longer dying of this disease, in most cases, with early diagnosis and treatment, children with retinoblastoma do not have to have an eye removed and will keep normal vision. When they first learn of their child's diagnosis, many families want to gather as much information as possible. Because it is such a rare disease, there is very little information about retinoblastoma available to families. This website is designed to give you more information about retinoblastoma. It will discuss diagnosis, treatment options, follow-up, and the genetic aspects of retinoblastoma. It will also include common issues faced by parents that have been faced with a diagnosis of retinoblastoma in their child. Our aim is to help families better understand and effectively cope with retinoblastoma.

11. Retinoblastoma Concise description of factors, survival rates, and treatment strategies for retinoblastoma. http://www.stjude.org/disease-summaries/0,2557,449_2167_3003,00.html

@import url(/StJude/CDA/Common/CSS/default.css); @import url(/StJude/CDA/Common/CSS/default_lists.css); @import url(/StJude/CDA/Common/CSS/default_content_types.css); @import url(/StJude/Common/CSS/St_Jude_Clinical_Science); In order for our site to display correctly you will need a newer version of your web browser. The following browsers support numerous web standards including CSS, XHTML, and the DOM (a universal means of controlling the behavior of web pages): v7 or higher (all platforms), Mozilla FireFox (Windows), Camino (Mac OS X), Galeon (Linux GNOME Desktop) or other browser stemming from the Mozilla.org project. Opera v7 or higher (Windows, Linux) Apple's Safari (Mac OS X) Konqueror (Linux KDE Desktop) Microsoft Internet Explorer v6 or higher (Windows) or v5 or higher (Macintosh) St. Jude Children's Research Hospital Finding Cures. Saving Children. About St. Jude News Donate Now Contact Us ... Ways to Help Solid Tumors Home Clinical Science Home Disease Information Solid Tumors Related Topics Solid Tumor Parent Information RBRCH Supportive Protocol / Clinical Study Jacob Simons Solid Tumor Division Disease Information Solid Tumor : Retinoblastoma Alternative Names: None Definition Retinoblastoma Patients may be born with retinoblastoma Incidence An estimated 250-300 children a year will develop retinoblastoma in the United States.

12. Indiacancer.org - Retinoblastoma Highlights important information often overlooked about retinoblastoma and its treatment. http://www.indiacancer.org/coca/r/retino.html

Retinoblastoma What is the Retina? What is Retinoblastoma? How is Retinoblastoma detected? What are staging and grading? ... What is the importance of follow up? What is the Retina? The retina is a lining of nervous tissue located at the back of the two eyes. It is a photosensitive layer, that is, it is responsible for sensing light and forming images. The Eye (Cut Section) What is Retinoblastoma? This is a cancer of the retina. Although it can occur at any age, it generally occurs before 5 years of age. It maybe unilateral , that is, only on one side, or bilateral , that is, in both eyes. Usually, the tumor is confined to the eye socket without spreading to the adjacent tissues. Retinoblastoma has a tendency to be hereditary , i.e., it can run in families, but this is not always the case. If hereditary, it usually occurs at an younger age and tends to be bilateral. Because it is hereditary, the

13. Retinoblastoma Covers cellular classification, staging, treatment options, and types of retinoblastoma, with references for each topic. http://www.uoc.muni.cz/guidelines/1deti/RETINOBL.htm

Retinoblastoma Table of Contents GENERAL INFORMATION CELLULAR CLASSIFICATION STAGE INFORMATION Intraocular Extraocular Reese-Ellsworth classification for intraocular tumors St. Jude Children's Research Hospital clinical staging system TREATMENT OPTION OVERVIEW INTRAOCULAR RETINOBLASTOM A Unilateral disease Bilateral disease EXTRAOCULAR RETINOBLASTOMA RECURRENT RETINOBLASTOMA GENERAL INFORMATION This treatment information summary on retinoblastoma is an overview of prognosis, diagnosis, classification, and treatment. The National Cancer Institute created the PDQ database to increase the availability of new treatment information and its use in treating patients. Information and references from the most recent published literature are included after review by pediatric oncology specialists. Cancer in children is rare. A team approach, incorporating the skills of the local physician, radiation therapists, pediatric medical oncologists/hematologists, rehabilitation specialists, and social workers, is imperative to ensure that patients receive the best treatment. In order for advances to be made in treating these patients, therapy is best delivered in the context of a clinical trial at a major medical center that has expertise in treating children. Only through entry of all eligible children into appropriate, well-designed clinical trials will progress be made against these diseases. Guidelines for pediatric cancer centers and their role in the treatment of pediatric patients with cancer have been outlined by the American Academy of Pediatrics.[1]

14. ACS :: Detailed Guide: Retinoblastoma (An Eye Cancer) Comprehensive overview of risks, causes, prevention, detection, diagnosis, staging, and treatment of retinoblastoma. http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?dt=37

15. Retinoblastoma Treatment,Symptoms Of Retinoblastoma,Eye Cancer Retinoblastoma,Re A set of questions and answers about retinoblastoma. http://www.visitech.org/retinoblastoma.html

Seek An Opinion Services Infrastructure Quality Policy ... Know Us Retinoblastoma What is retinoblastoma? Retinoblastoma is a cancer of the eye in children. It originates from the retina, the light sensitive layer, in eye. It is the commonest eye tumor of the eye in childhood. . This tumor may involve one (75% of cases) or both (25% of cases) eyes in a child. Untreated, retinoblastoma is almost always fatal, hence the importance of early diagnosis and treatment Is it hereditary? Yes in some cases it may be hereditary. Majority of cases (90%) has no family history of such disease; while a small percentage (10%) of newly diagnosed cases have other family members with retinoblastoma. Of all the cases of retinoblastoma, in 60% of cases it does not get transmitted to the next generation, while in 40% of cases it may get transmitted in the next generation. Therefore it is important to have a genetic counseling before having a baby to determine the risk of another child getting the same disease. Also, the siblings and children of the patients with retinoblastoma should be examined periodically in their childhood to detect any possible tumor early. What are the symptoms of retinoblastoma?

16. About The Eye Cancer Retinoblastoma Retinoblastoma Basics The New York Eye Cancer Center is one of the premier centers in the country for the treatment of retinoblastoma and other pediatric eye tumors. http://www.eyecancer.com/conditions/Retinal Tumors/retino.html

17. About The Eye Cancer Retinoblastoma Retinoblastoma Basics The New York Eye Cancer Center is one of the premier centers in the country for the treatment of retinoblastoma and other pediatric eye tumors. It is http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. Retinoblastoma Eye Cancer - Endophytic Retinoblastoma An Endophytic retinoblastoma. An endophytic retinoblastoma is noted to extend from the retina into the vitreous humor (RetCam Image). http://www.eyecancer.com/conditions/Retinal Tumors/RB3.html

19. Welcome To The Eye Cancer Network Eye Tumor Information, Doctors Orbital Meningioma retinoblastoma Basal Cell Carcinoma World Survey of retinoblastoma Pub Med (Free Literature Search) Link http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Orphans Of The Cancer Storm: Rare Childhood Cancer Support. Provides support and information for families and individuals dealing with either retinoblastoma or optic glioma, two rare tumours of childhood. http://www.orphancancer.org/

This site is best viewed with Internet Explorer, at a screen resolution of 600x800 Welcome to O rphans of the C ancer S torm Click to Enter Site. A Childhood Cancer Awareness Website

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