81. Progeria - YourDictionary.com - American Heritage Dictionary Search Mamma.com for progeria . TYPE IN YOUR WORD CLICK GO! Search. Normal, Definitions, Short defs. (Pronunciation Key). pro·ger·i·a Listen pr jîr http://www.yourdictionary.com/ahd/p/p0584550.html

Search Mamma.com for "progeria" Search: Normal Definitions Short defs (Pronunciation Key) pro·ger·i·a Listen: pr -jîr n. A rare congenital disorder of childhood that is characterized by rapid onset of the physical changes typical of old age, usually resulting in death before the age of 20. Also called Hutchinson-Gilford syndrome pro- + Greek g ras old age ; see geriatrics -ia Back to Search Back The American Heritage Dictionary of the English Language, Fourth Edition

82. BioMed Central | Full Text | Dermal Fibroblasts In Hutchinson-Gilford Progeria S HutchinsonGilford progeria syndrome (HGPS, OMIM 176670) is a rare Cao H, Hegele RA LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not http://www.biomedcentral.com/1471-2121/6/27

home journals A-Z subject areas advanced search ... Volume 6 Viewing options Abstract Full text PDF Associated material: PubMed record Related literature: Articles citing this article on Google Scholar Other articles by authors Paradisi M ... Similar articles (PubMed) Tools: E-mail to a friend Download references Post a comment Key E-mail Corresponding author Research article Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress Mauro Paradisi Dayle McClintock Revekka L Boguslavsky Christina Pedicelli Howard J Worman and Karima Djabali VII Divisione, Dermatologia Pediatrica, Istituto Dermopatico Dell'Immacolata IRCCS, Rome, Italy BMC Cell Biology The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2121/6/27 Received Accepted Published This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Outline Abstract Abstract Background Results Discussion ... References Background Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptured nose, alopecia, prominent scalp veins, small face, loss of subcutaneous fat, faint mid-facial cyanosis, and dystrophic nails. HGPS is caused by mutations in

83. BioMed Central | Abstract | Dermal Fibroblasts In Hutchinson-Gilford Progeria Sy HutchinsonGilford progeria syndrome (HGPS, OMIM 176670) is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. http://www.biomedcentral.com/1471-2121/6/27/abstract

home journals A-Z subject areas advanced search ... Volume 6 Viewing options Abstract Full text PDF Associated material: PubMed record Related literature: Articles citing this article on Google Scholar Other articles by authors Paradisi M ... Similar articles (PubMed) Tools: E-mail to a friend Download references Post a comment Key E-mail Corresponding author Research article Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress Mauro Paradisi Dayle McClintock Revekka L Boguslavsky Christina Pedicelli Howard J Worman and Karima Djabali VII Divisione, Dermatologia Pediatrica, Istituto Dermopatico Dell'Immacolata IRCCS, Rome, Italy BMC Cell Biology Published Abstract Background Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptured nose, alopecia, prominent scalp veins, small face, loss of subcutaneous fat, faint mid-facial cyanosis, and dystrophic nails. HGPS is caused by mutations in LMNA , the gene that encodes nuclear lamins A and C. The most common mutation in subjects with HGPS is a

84. AllRefer Health - Progeria (Hutchinson-Gilford Syndrome) progeria (HutchinsonGilford Syndrome) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, tests, http://health.allrefer.com/health/progeria-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Progeria Progeria Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Hutchinson-Gilford Syndrome Definition Progeria is a disease that produces rapid aging starting in childhood. Coronary Artery Blockage Progeria is a rare condition but has come into public awareness because its symptoms strongly resemble normal human aging as well as the appearance of several affected children in movies on national television. Lamin A is the name of the gene recently identified as causing some types of progeria. Lamin A codes for a protein that surrounds the nucleus of cells. Further study of lamin A will hopefully answer why mutations in this gene cause such striking premature aging. Progeria results in rapid aging of children, beginning with

85. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Rare_Disorders/Pro Identification Of Gene Gives Hope To Children With progeria; May Shed Light Online Mendelian Inheritance in Man progeria - progeria medical database http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Rare_Disord

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Rare Disorders : Progeria Subtopics See Also: Health: Conditions and Diseases: Genetic Disorders Health: Conditions and Diseases: Nutrition and Metabolism Disorders Search Google: Progeria News Books Links ... Anti-cancer Drugs May Hold Promise For Premature Aging Disorder (August 30, 2005) full story NCI Study Demonstrates That Cellular Defects In Premature Aging Disease Are Reversible (March 7, 2005) full story New Mouse Model Will Aid Research On Premature Aging Syndrome (May 15, 2003) full story Identification Of Gene Gives Hope To Children With Progeria; May Shed Light On Phenomenon Of Aging (April 17, 2003) full story (November 20, 2002) full story The Genetics Of Aging: New Study Says Cell Division Errors May Be The Common Link (March 31, 2000) full story Iowa Researchers Identify Possible Reason For Rare, Accelerated Aging Condition (May 24, 1999) full story [ More news about Progeria by: Icon Health Publications See Larger Image Amazon.com's Price:

86. Definition Of Progeria - WordReference.com Dictionary progeria Definition from dictionary. 1, progeria. a rare abnormality marked by premature aging (gray hair and wrinkled skin and stooped posture) in a http://www.wordreference.com/definition/progeria

Word Reference .com progeria A noun progeria a rare abnormality marked by premature aging (gray hair and wrinkled skin and stooped posture) in a child Category Tree: state condition status abnormality ... abnormalcy progeria Need more information? Ask a question in the forum. Look up "progeria" at Merriam-Webster Look up "progeria" at dictionary.com English Definition Home Suggestions Search Tips See Also: profoundly profoundness profundity profuse ... prognostic progeria: in French in Italian in Spanish

87. Identification Of Gene Gives Hope To Children With Progeria; May Shed Light On P The progeria Research Foundation (PRF), along with the National Institutes of Health (NIH), today announced the discovery of the gene that causes http://www.eurekalert.org/pub_releases/2003-04/nhgr-iog041603.php

Public release date: 16-Apr-2003 E-mail Article Contact: Liza Morris lmorris@spectrumscience.com NIH/National Human Genome Research Institute Identification of gene gives hope to children with progeria; May shed light on phenomenon of aging [Boston, MA – April 16, 2003] – The Progeria Research Foundation (PRF), along with the National Institutes of Health (NIH), today announced the discovery of the gene that causes Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria), a rare, fatal genetic condition characterized by an appearance of accelerated aging in children. "Isolating the Progeria gene is a major achievement for the medical research community," said Francis Collins, MD, PhD, director, National Human Genome Research Institute and the senior author on the report, which appears today in Nature. "The discovery not only gives hope to children and families affected by Progeria, but also may shed light on the phenomenon of aging and cardiovascular disease." Children with Progeria die from complications of cardiovascular disease or arteriosclerosis at an average age of 13. Researchers now believe finding the gene that causes Progeria may lead to answers surrounding the natural aging process and cardiovascular disease. Heart disease and stroke are the first and third leading causes of death in the United States, accounting for more than 40 percent of all deaths. Within just one year of beginning the research, a group of leading scientists from the PRF Genetics Consortium were able to isolate the Progeria gene. Key aspects of the finding include the fact that Progeria is not inherited and that mutations to the gene LMNA (Lamin A) cause Progeria. The Lamin A protein is the structural scaffolding that holds the nucleus together and has been studied for years. Researchers now believe that the defective Lamin A protein makes the nucleus unstable. That cellular instability leads to the process of premature aging in Progeria.

88. Gene Mutation Causes Progressive Changes To Cell Structure In Children With Prog of the National Academy of Sciences (PNAS). progeria is a rare, fatal genetic condition characterized by an appearance of accelerated aging in children. http://www.eurekalert.org/pub_releases/2004-06/prf-gmc060804.php

Public release date: 8-Jun-2004 E-mail Article Contact: Brooke Saltzer bsaltzer@spectrumscience.com Progeria Research Foundation Gene mutation causes progressive changes to cell structure in children with Progeria New study advances drive for treatment and cure for fatal rapid aging disease [Boston, MA – June 8, 2004] – Researchers today announced that a mutation of the Lamin A gene gradually causes devastating effects on cellular structure and function in children with Hutchinson-Gilford Progeria Syndrome (HGPS or Progeria). The study was published in this week's Proceedings of the National Academy of Sciences (PNAS). Progeria is a rare, fatal genetic condition characterized by an appearance of accelerated aging in children. "Although it is a rare disease, Progeria has long been considered to be a model for studying the mechanisms responsible for normal aging" said lead author Robert D. Goldman, Ph.D., Stephen Walter Ranson Professor and Chair, Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine. "This study highlights the importance of the Lamin A gene in the maintenance of cell structure and function." In April 2003, a team of researchers assembled by The Progeria Research Foundation (PRF), and including the National Human Genome Research Institute (NHGRI), one of the 27 institutes and centers that make up the National Institutes of Health (NIH), announced the discovery of the gene that causes Progeria. That study, published in the April 16th 2003 issue of Nature, found that the disease is not inherited, but instead is caused by chance mutations to the LMNA gene (Lamin A). The Lamin A protein is the structural scaffolding that holds the nucleus together, and is involved in gene expression and DNA replication.

89. Finding The Progeria Gene Opens Doors To Possible Cure As a direct result of the finding of the gene, the NIH and the progeria Research Foundation have invested about $1 million in progeria research. http://seattlepi.nwsource.com/specials/seth/190739_progeriagene.asp

Jump to Weather Traffic Mariners Seahawks ... Calendar NEWS Local Neighborhoods Sports Nation/World ... Special Reports COMMENTARY Opinion Columnists Letters David Horsey ... Forums COFFEE BREAK Horoscope TV Listings FIND IT! NWclassifieds Jobs Autos Real Estate ... Obituaries P-I ANYWHERE E-mail Newsletters News Alerts PDA Cell Phones ... RSS Feeds OUR AFFILIATES Thursday, September 16, 2004 Finding the progeria gene opens doors to possible cure By CAROL SMITH SEATTLE POST-INTELLIGENCER REPORTER Dr. Leslie Gordon of Tufts University School of Medicine was ecstatic the day she heard researchers had found the gene mutation that causes progeria for an instant. Then she thought: But that's not a cure. And it's a cure she's after. Gordon and her pediatrician husband, Scott Berns, who are the founders and force behind the Massachusetts-based Progeria Research Foundation, have an extra motivation for researching the disease. Their son Sampson, 7, was born with it. The two started the foundation in 1998 to catalyze the search for a treatment. "There was nothing going on," she said. Although the disease had long been considered a model for studying aging, no one was doing it because it was so rare, and there was no central repository for blood and tissue samples to facilitate research. In the century since it was first described, fewer than 100 papers had been written on the subject, she said. And the National Institutes of Health, a prime driver of basic medical research, had no money invested in it.

90. DermAtlas: Online Dermatology Image Library Dermatology Image,progeria,cataract, DermAtlas Dermatology Images progeria,hypogonadism,dermatology image,cataract images. http://dermatlas.med.jhmi.edu/derm/result.cfm?Diagnosis=2045175215

91. Progeria progeria is a disease that produces rapid aging starting in childhood. http://www.healthscout.com/ency/1/001657.html

92. CFP: MASSACHUSETTS 2002: HUMAN SERVICES: Progeria Research Foundation progeria Research Foundation. PRF was established in March 1999 to discover progeria affects both sexes and all races equally, but there is still too http://www.catalogueforphilanthropy.org/ma/2002/progeria_research_642.htm

MASSACHUSETTS 2002 HUMAN SERVICES HEALTH AND AGING - MEDICAL RESEARCH NATL HOME MA HOME ABOUT US WAYS TO CONTRIBUTE ... Girls And Women Health And Aging Starlight Children’s Foun... Boston Foundation for Sig... Cancer House of Hope Caribbean Foundation of B... ... Visiting Nurse Associatio... - Progeria Research Foundat... Silent Spring Institute Well-Being PO Box 3453 Peabody, MA www.progeriaresearch.org Kathleen Cody, Executive Director Progeria Research Foundation ID number: 02w NATURE CULTURE HUMAN SERVICES INTERNATIONAL ... SEARCH

93. Short Description Of Cell Lines. Pathology: Progeria Syndrome 176670 Pathology progeria syndrome 176670 OMIM record. By selecting the cell line name, you will receive the detailed description of the cell line http://www.biotech.ist.unige.it/cldb/pat216.html

Version Short description of cell lines. Pathology: progeria syndrome OMIM record By selecting the cell line name , you will receive the detailed description of the cell line By selecting one of the terms between parentheses, you will receive the list of all relevant cell lines You can search any term of the list by using the 'Find' utility of your browser IMG-1003 human skin, fibroblast MWCMG ... By Beatrice...

94. Decreased Levels Of “good” Cholesterol In Children With Progeria May Cause Pre Adiponectin may be helpful in finding treatments In a study published in the March issue of The Journal of Pediatrics, researchers found that decreased http://www.medicalnewstoday.com/medicalnews.php?newsid=20970

95. Gene Mutation Causes Progressive Changes To Cell Structure In Children With Prog progeria is a rare, fatal genetic condition characterized by an Although it is a rare disease, progeria has long been considered to be a model for http://www.medicalnewstoday.com/medicalnews.php?newsid=9293

96. Channel 5 - Review - Progeria: Little Princess The condition progeria only affects between 1 in 8 million (reported) children. There are only between 30 and 40 reported cases of progeria worldwide to http://www.dooyoo.co.uk/tv-channels/channel-5/1006470/

Home TV TV Channels Channel 5 Reviews Channel 5 Read 103 reviews Read Rate now: very good good average bad very bad Buy Top TV Sony KV-32FV15 32" TV Sony WEGA KV-28HX15... Panasonic TX-28DTM1... Review about Channel 5 Progeria: Little Princess Review from marcellep about Channel 5 Author's product rating Advantages SEE REVIEW Disadvantages NONE Summary: Full review Hi and thanks for reading this review on the little girl Hayley Okines and her condition Hutchinson-Gilford Progeria Syndrome. Possibly some people would have watched the television programme last night on channel 5 (09-05-05) If you did or did not please read on. Hayley Okines is a little princess aged 7, she lives in the UK with her family the only difference is that Hayley suffers from a condition called Progeria. Progeria Is an extremely rare genetic disease that accelerates the aging process about seven times the normal rate. So what does that mean, It means a child who is aged 10 and they are a sufferer of this rare condition will have similar respiratory, cardiovascular and arthritic conditions of a 70 year old would have. The condition Progeria only affects between 1 in 8 million (reported) children. There are only between 30 and 40 reported cases of Progeria worldwide to date.

97. Choroby Genetyczne - Progeria ZESPÓL WERNERA / (progeria HutchinsonaGilforda) / HGPS / Przedwczesny starczy wyglad - nazwa progeria u osób doroslych nazywana jest zespolem Wernera. http://www.republika.pl/chorobygenetyczne/Progeria.htm

STRONA G£ÓWNA CIEKAWE LINKI KSIÊGA GO¦CI STRONA G£ÓWNA ... Zespó³ Williamsa Progeria document.write("" + day + month); document.write(myweekday + ", " + year + ""); ZESPÓ£ WERNERA / (PROGERIA Hutchinsona-Gilforda ) / HGPS / Przedwczesny starczy wygl±d nazwa tej choroby wywodzi siê z jêzyka greckiego i oznacza "przedwczesn± staro¶æ". Zespó³ ten charakteryzujê siê przyspieszonym procesem starzenia. Dziedziczy siê jako cecha autosomalna dominuj±ca. Progeria u osób doros³ych nazywana jest zespo³em Wernera. U dzieci z progeri± pó¼niej formuj± siê zêby, maj± starszy wygl±d skóry (m.in. liczne zmarszczki), s± zwykle ³yse i kar³owate. Z tych¿e powodów wygl±daj± one o wiele starzej. Nos jest "¶ci±gniêty", policzki zapadniête (z powodu utraty tkanki t³uszczowej). Utrata tkanki t³uszczowej mo¿e byæ równie¿ przyczyn± owrzodzeñ na przedniej powierzchni goleni i na stopach.

98. Progeria It was Gilford who first suggested the term progeria for this condition. Another rare type of progeria, first detected in a brothersister pair, http://www.wrclarkbooks.com/downloads/means_chapter.html

CHAPTER FIVE Human Genetic Diseases That Mimic the Aging Process Genetic Syndromes in Man with Potential Relevance to the Pathobiology of Aging. His analysis of the existing medical and scientific literature had suggested that as many as seven thousand human genes might be involved in the degenerative processes associated with aging, but he concluded that probably no more than seventy, and perhaps as few as seven, of these genes controlled processes in the body that have a major impact on senescence. He excluded from consideration genes encoding specific diseases that might cause death either early or late in life; although death is clearly the endpoint of senescence, Martin was more interested in the process of senescence, as defined by studies in both animals and humans. One of the major conclusions Martin was able to reach as a result of his analysis was that although aging-like symptoms can be found in a number of different genetic diseases, no single disease can be said to mimic completely all of the known parameters of the human aging process. There is no single "aging gene" that determines human lifespan and regulates human senescence. Nevertheless, Martin identified ten well-known genetic diseases in which there was an accelerated progression of a large number of distinct aging traits (Table 5-1). Because each of these diseases involves only certain aspects of the aging process, he called them segmental progerias ; progeria is a Greek term meaning "early aging." Seven of these disorders are known or presumed single-gene defects; three are

99. Progeria Life Insurance Resources From Life Insurance .Net progeria life insurance Life Insurance resources and quotes from local agents on whole and term life insurance policies. Insurance education, calculators http://www.lifeinsurance.net/LifeInsurance/Progeria__life_insurance.htm

Home Site Map Education Resources Life Insurance Articles Insurance Carriers State Regulators Related Links ... Contact Us Progeria life insurance Life insurance policies are uniquely tailored to your actual life situation. Your specific health conditions will affect how various companies price your policy or even whether they will take you. Don't let a cookie cutter agency take you to the wrong company. We understand your situation and can get you a great solution your insurance needs. Our Customers are Saying... "Your agent called me within 24 hours and wasknowledgeable, kind and professional. My wife and I boughtinsurance policies from him... Thank you very much!" Jaime G., California Life Insurance.Net features hundreds of independent insurance agents, providing accurate term life quotes and universal life quotes from hundreds of top insurance carriers. Don't leave your family unprotected. Click Here Now: Get A Quote HERE!! A well-planned life insurance policy will not only cover all immediate cash needs, it will also replace your income so yourloved ones can maintain their standard of living. Learn more at our Life Insurance Education Center We've even created this page to provide quotes strictly relevant to Progeria life insurance.

100. Progeria Term Quote Resources From Life Insurance .Net progeria term quote Life Insurance resources and quotes from local agents on whole and term life insurance policies. Insurance education, calculators http://www.lifeinsurance.net/LifeInsurance/Progeria__term_quote.htm

Home Site Map Education Resources Life Insurance Articles Insurance Carriers State Regulators Related Links ... Contact Us Progeria term quote Life insurance policies are uniquely tailored to your actual life situation. Your specific health conditions will affect how various companies price your policy or even whether they will take you. Don't let a cookie cutter agency take you to the wrong company. We understand your situation and can get you a great solution your insurance needs. Life Insurance.Net features hundreds of independent insurance agents, providing accurate term life quotes and universal life quotes from hundreds of top insurance carriers. Whole Life Insurance is permanent life insurance protection for your entire life, usually to age 100. A Whole Life policy is contractually guaranteed not to lapse, provided that you pay sufficient premiums each year to keep the policy in force. Besides permanent lifetime insurance protection, Whole Life Insurance features a savings element that allows you to build cash value on a tax-deferred basis. A portion of the premiums you pay build up the savings element of the policy and are invested by the company. The interest rate return on your investment is added to the savings portion of the policy. This is how the policy builds cash value. In addition to crediting your policy with interest, "participating" policies issued by mutual insurance companies may also give you the opportunity to earn dividends. Dividends are a NON-guaranteed return of part of the premium intended to reflect a company’s favorable operating experience.

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